Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07261228Recruiting
Comparing carbon footprint of diagnostic vs. therapeutic upper endoscopy
This study looks at how much carbon dioxide is released during upper endoscopy, comparing people having a diagnostic procedure for stomach discomfort versus those having treatment for a bleeding ulcer. It may help understand which type of procedure has a bigger environmental impact.
BangkokAges 20–80 - NCT07265271Recruiting
Study to detect liver cancer early using blood tests
This study is looking for people with or without liver cancer to test a new way to find liver cancer early using blood or tissue samples. It aims to help catch the disease sooner.
Duarte, CaliforniaAges 18 years+ - NCT07268820RecruitingPhase 4
Nighttime heartburn treatment for erosive GERD
This trial tests a treatment for nighttime heartburn caused by GERD, a condition where stomach acid damages the esophagus. It is for adults who have had nighttime heartburn for more than 3 months and have been diagnosed with erosive GERD.
AnsanAges 19 years+ - NCT07268131Recruiting
TITAN-HCC: Testing immunotherapy plus TACE for liver cancer beyond standard criteria
This trial tests a combination of an immunotherapy drug (QL1706) and a liver-directed procedure (TACE) before and after surgery for people with liver cancer that is larger or more advanced than the usual transplant criteria. The goal is to see if this approach can help shrink the tumor and improve outcomes.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07265544Recruiting
Liver disease study using advanced tissue analysis
This study uses advanced techniques to analyze liver tissue samples from people with various liver conditions. It aims to better understand how liver diseases develop and progress, which may help improve future treatments.
Guangzhou, GuangdongAges Any age - NCT07263061Recruiting
Recovery of albumin after major liver and pancreas surgery
This trial tracks how quickly your albumin (a protein in your blood) returns to normal after major surgery on your liver, pancreas, or bile ducts, to see if that predicts your recovery. It may help doctors understand how you are healing.
New Delhi, National Capital Territory of DelhiAges 13–80 - NCT07266493RecruitingPhase 2
Envafolimab plus chemo for esophageal cancer before surgery
This trial tests a new immunotherapy drug (Envafolimab) combined with standard chemotherapy before surgery for esophageal cancer that has not spread far. The goal is to see if this combination can shrink tumors and improve outcomes.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07267117Recruiting
Heart valve disease progression and outcomes study
This study is following people with heart valve disease (leaky or narrowed valves) to understand how the disease changes over time and what problems it may cause. It does not test a new treatment, but helps doctors learn more about valve disease progression.
Fuzhou, FujianAges 18 years+ - NCT07267806RecruitingPhase 3
Camrelizumab and Apatinib with or without chemo for advanced liver cancer
This trial tests a combination of two drugs (camrelizumab and apatinib) with or without standard chemotherapy for advanced liver cancer that cannot be treated with surgery or has gotten worse after local treatments. The goal is to see if the combination helps control the cancer better.
Guangzhou, GuangdongAges 18 years+ - NCT07267260RecruitingPhase 2
Vonoprazan to prevent ulcers after variceal banding
This trial tests whether vonoprazan can reduce ulcers caused by a procedure that ties off enlarged veins in the esophagus (variceal band ligation). It is meant for people with liver cirrhosis who are scheduled to receive this treatment.
Lahore, Punjab ProvinceAges 18–75 - NCT07262840Recruiting
Health behavior change for people at high risk for colorectal cancer
This trial tests a program to help people at high risk for colorectal cancer change their health behaviors to lower their risk. It might help you if you are worried about your risk and want to make positive changes.
Shenyang, LiaoningAges 1.5 years–6.7 years - NCT07268846Recruiting
Prebiotic supplement before colorectal cancer surgery
This trial tests if taking a postbiotic supplement before surgery for colorectal cancer can improve recovery. It may help patients with adenocarcinoma of the large intestine prepare for their operation.
São Paulo, São PauloAges 18 years+ - NCT07263880RecruitingPhase 1/Phase 2
Clostridium Butyricum for stricturing Crohn's disease
This trial tests a bacteria called Clostridium butyricum to see if it can help people with a type of Crohn's disease that causes narrowing in the right colon or ileocecal area. It may offer a new option for those not on strong immune-suppressing medications.
RomaAges 18–85 - NCT07262515Recruiting
Blood tests and genes for alcoholic hepatitis recovery
This study looks at blood samples and genetic information from people with acute alcoholic hepatitis to understand why some recover better than others. It aims to find better ways to predict and improve outcomes.
ParisAges 18 years+ - NCT07265297RecruitingPhase 3
Hydroxychloroquine for fatty liver disease with inflammation
This trial tests if hydroxychloroquine, a medicine used for other conditions, can reduce liver inflammation in people with fatty liver disease. It aims to help those whose fatty liver has caused ongoing liver damage.
Taipei, TaiwanAges 18 years+ - NCT07263386RecruitingPhase 2
Immunotherapy plus chemo for PD-L1-positive stomach cancer
This trial tests whether adding the immunotherapy drug sintilimab to standard chemotherapy (SOX) after surgery helps prevent stomach cancer from returning. It’s for people whose tumors have a protein called PD-L1 and who had cancer in at least 7 lymph nodes.
Nanjing, JiangsuAges 18–75 - NCT07260006Recruiting
Bismuth therapy for H. pylori ulcers in children
This trial tests whether adding bismuth to standard treatment works better for children with stomach ulcers caused by H. pylori infection. If your child has been diagnosed with an H. pylori ulcer, this study could help find the best medicine.
Can ThoAges 5–15 - NCT07264556Recruiting
Comparing three anesthesia types for colorectal cancer surgery
This trial compares three types of anesthesia during colorectal cancer surgery to see how they affect the body's immune response and cancer cells. It may help find the safest and most effective anesthesia option for people having this operation for the first time.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07264036Recruiting
Nasal Speech After Head and Neck Cancer Treatment Study
This study is for people who have had treatment for head or neck cancer and now have a nasal-sounding voice. It tests a procedure to help improve speech by adding a small amount of filler material to the back of the throat.
Charlottesville, VirginiaAges 18 years+ - NCT07268196Recruiting
How a liver transplant affects sexual function
This study looks at how a liver transplant affects a person's sex life and sexual function. It includes married men who either are waiting for a transplant or have already had one with a healthy working liver.
New Delhi, National Capital Territory of DelhiAges 18–60 - NCT07266363Recruiting
Blood test for early detection of esophageal cancer
This study is testing a blood test to detect esophageal squamous cell cancer early. Researchers are looking for a pattern of molecules in the blood that could signal the presence of this cancer.
Monrovia, CaliforniaAges 18 years+ - NCT07267468Recruiting
App and nutrition plan for swallowing recovery after stroke
This study tests a mobile health program combining rehabilitation exercises and a personal nutrition plan to help people recover from swallowing problems (dysphagia) after a stroke. The goal is to see if using the app improves swallowing and quality of life.
Algeciras, CadizAges 18 years+ - NCT07268365Recruiting
Using a cap on the endoscope for upper GI bleeding
This trial tests if placing a small plastic cap on the tip of the endoscope helps doctors treat bleeding ulcers in the stomach or duodenum more effectively. It is for people who are actively bleeding from an ulcer and need an emergency endoscopy.
Amiens, PicardieAges 18 years+ - NCT07267078RecruitingPhase 2
Tuvonralimab and Iparomlimab before surgery for bile duct cancer
This trial tests two immunotherapy drugs (Tuvonralimab and Iparomlimab) given before surgery to shrink bile duct cancers that are borderline removable. The goal is to make the tumor easier to remove completely and improve outcomes.
Beijing, Beijing MunicipalityAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.