Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,686
- Phase 21,188
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Hepatocellular Carcinoma (HCC)114
- Colon Cancer112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Chinese University of Hong Kong56
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona190
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,606 total
- NCT06906016Recruiting
New blood tests for hepatitis B
This study looks at new blood tests (biomarkers) to better understand chronic hepatitis B and how it affects treatment decisions. It may help doctors find better ways to manage your condition.
Créteil, CréteilAges 18 years+ - NCT05828446Recruiting
Improving liver cancer screening for people at risk
This study looks at ways to improve screening for liver cancer in adults with long-term liver disease. It may help catch liver cancer earlier, which can make treatment easier.
Lausanne, Canton of VaudAges 18 years+ - NCT05646511RecruitingPhase 3
New chemotherapy timing tests for locally advanced rectal cancer
This Phase 3 trial compares two chemotherapy combinations given with surgery for locally advanced rectal cancer. It aims to find out which approach works better and is safer for shrinking and controlling the cancer before or around the time of treatment.
ChibaAges 18 years+ - NCT06190730Recruiting
Remote symptom collection for better recovery after surgery
This trial uses a phone or computer app to track your symptoms after gastrointestinal tumor surgery. It aims to improve your recovery by keeping your care team informed remotely.
Baltimore, MarylandAges 18 years+ - NCT07234825Recruiting
Trial of dairy-free diet with liquid nutrition for eosinophilic esophagitis
This study tests whether a dairy-free diet combined with a special liquid nutrition drink (called Kate Farms) can help children and young adults with eosinophilic esophagitis (a condition where certain white blood cells build up in the esophagus and cause trouble swallowing, pain, or vomiting). The goal is to see if this combination can reduce symptoms and improve quality of life.
Seattle, WashingtonAges 1–21 - NCT07235293RecruitingPhase 2
Testing a new drug combo for advanced colorectal cancer
This trial tests a new combination of two drugs (DSP107 and atezolizumab) compared to another drug (fruquintinib) for people with advanced colorectal cancer that hasn't responded to standard treatments. The goal is to find a more effective treatment option.
Aurora, ColoradoAges 18 years+ - NCT07231029RecruitingPhase 1
Study of TS-172 in people with reduced liver function
This study tests how an experimental drug (TS-172) is processed in the body by comparing people with mild to moderate liver disease to those with normal liver function. It may help doctors understand how to dose the drug safely for people with liver problems.
TokyoAges 18–75 - NCT07231705Recruiting
Plant-based formula for growth and tolerance in toddlers
This study tests how well toddlers (12-17 months old) tolerate and grow on a plant-based formula. It compares this new formula to standard ones for children who get most of their calories from formula.
Columbus, OhioAges 1 year–1.4 years - NCT07232875RecruitingPhase 3
New drug combo for first-line advanced pancreatic cancer
This trial tests a new drug (HRS-4642) combined with standard chemotherapy as a first treatment for advanced pancreatic cancer that has spread. It may help shrink tumors and extend life.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07238283RecruitingPhase 3
New liposome chemo combo for first-line pancreatic cancer
This trial tests a new form of chemotherapy (irinotecan liposome) combined with two other chemo drugs, compared to a standard treatment, for people with metastatic pancreatic cancer who haven't had chemo yet.
Beijing, Beijing MunicipalityAges 18–75 - NCT07239336RecruitingPhase 2
Study of DONQ52 for active celiac disease
This trial tests a new drug called DONQ52 in people with active celiac disease who still have symptoms despite following a gluten-free diet. The goal is to see if DONQ52 can help reduce damage to the small intestine and improve gluten-related symptoms.
Anniston, AlabamaAges 18–75 - NCT07232407RecruitingPhase 1
Study of a radioactive drug for advanced solid tumors
This trial tests a new radioactive drug (Lutetium-177 BL-ARC001) for people with advanced solid tumors, including stomach, bowel, and other cancers. It aims to see if the treatment is safe and how well it works.
Chengdu, SichuanAges 18 years+ - NCT06247046RecruitingPhase 3
Probiotic powder for IBS-D (SK08) trial
This study tests a new probiotic powder (SK08) to see if it reduces belly pain and diarrhea in people with IBS-D (irritable bowel syndrome with diarrhea). It lasts several months and involves taking the study powder twice a day.
Wuxi, JiangsuAges 18–70 - NCT06571981Recruiting
Comparing regular and portable ultrasounds for viral hepatitis
This study compares a regular ultrasound done in the hospital with a small, portable ultrasound device for people with viral hepatitis. The goal is to see if the portable device works as well as the standard machine, which could make ultrasounds easier to get.
Lausanne, Canton of VaudAges 18 years+ - NCT06908746Recruiting
Citrate Anticoagulation in Dialysis for Liver and Kidney Failure
This trial looks at whether a blood thinner called citrate is safe and effective in patients who have both kidney and liver failure while on continuous dialysis in the ICU. It may help guide treatment for people with serious organ problems.
Edegem, AntwerpAges 18 years+ - NCT07230379Recruiting
Comparing two treatments for first-time uncomplicated appendicitis
This trial tests a newer, less invasive procedure called ERAT against standard laparoscopic appendectomy for adults with a first episode of uncomplicated appendicitis. The goal is to see which approach works better with fewer risks.
Chongqing, ChingqingAges 18 years+ - NCT07238309Recruiting
Comparing two ways to reinforce stomach stapling during gastric bypass
This trial tests two methods—oversewing stitches versus surgical clips—to lower the chance of bleeding after a type of gastric bypass surgery called one anastomosis gastric bypass. If you qualify, you may help find the safest technique.
Cairo, Cairo GovernorateAges 18–80 - NCT07230795Enrolling by invitation
AI-guided colorectal cancer screening for adults 45-49
This trial tests whether a computer program can help more adults ages 45-49 get screened for colorectal cancer. If you are due for screening and see a Penn Medicine doctor, you may be able to join.
Philadelphia, PennsylvaniaAges 45–49 - NCT07235228Recruiting
Synbiotic supplement for irritable bowel syndrome
This trial tests whether a synbiotic (a mix of probiotics and prebiotics) called Vivatlac can improve gut health in people with moderate to severe irritable bowel syndrome (IBS). If you have IBS and are not already taking probiotics or antibiotics, you may be able to join.
JarocinAges 18–65 - NCT07235215Recruiting
Testing Vivatlac for Irritable Bowel Syndrome
This study tests a product called Vivatlac to see if it can help people with Irritable Bowel Syndrome (IBS). If you have moderate-to-severe IBS and haven't taken probiotics or antibiotics recently, you may be able to join.
JarocinAges 18–65 - NCT07237516Recruiting
Study of Zymfentra for people with Crohn's or colitis
This study follows adults with inflammatory bowel disease who are starting or switching to Zymfentra. Researchers will track your health over the next year to see how the medicine works in real life.
New Haven, ConnecticutAges 18 years+ - NCT07239479Recruiting
Dexmedetomidine and desflurane for laparoscopic colon surgery
This study tests a combination of two drugs (dexmedetomidine and desflurane) used during keyhole colon surgery to see if it helps with recovery. It is designed for generally healthy adults having a planned laparoscopic colectomy.
Ho Chi Minh City, Ho Chi MinhAges 18–65 - NCT07239245RecruitingPhase 2
TACE plus immunotherapy for high-risk liver cancer before surgery
This trial tests whether a combination of two therapies—targeted chemotherapy delivered directly to the liver (TACE) plus immunotherapy (atezolizumab) and a targeted drug (bevacizumab)—can keep liver cancer from coming back after surgery. It is for people whose tumors can be surgically removed but are at high risk of recurrence.
Beijing, Beijing MunicipalityAges 18–75 - NCT07231601Recruiting
Laparoscopic surgery for Crohn's disease of the small intestine
This trial tests a specific laparoscopic (keyhole) surgery technique for Crohn's disease affecting the last part of the small intestine. It aims to see if removing more of the fatty tissue around the bowel leads to better outcomes. If you have Crohn's disease needing surgery in this area, you may be eligible.
Piraeus, AtticaAges 16 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 12,023 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.