Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT01789229Recruiting
Tumor and inflammation sample bank for one specific condition
This study builds a secure “tumor sample bank” using tissue collected from people who currently have one diagnosed condition, either cancer (malignant disease) or an ongoing inflammatory condition. Your samples could help researchers study your disease and develop better treatments in the future.
ViennaAges 18 years+ - NCT05798962Recruiting
Study of muscle repair changes after calf or hamstring injury
This study looks at what is happening inside muscle tissue after calf or hamstring injuries (new, long-term, or after an Achilles tendon rupture). It may help researchers understand why injuries come back and how muscle healing could be improved.
CopenhagenAges 18 years+ - NCT05785793Recruiting
Autoimmune hepatitis study for people in China
This study follows people with autoimmune hepatitis (a condition where the immune system attacks the liver) and requires key blood test results at diagnosis. It may help doctors better understand this disease and how it progresses in patients in China.
Shanghai, Shanghai MunicipalityAges 14 years+ - NCT04998552Recruiting
CyberKnife radiation for certain pancreatic cancer patients after chemotherapy
This trial studies how safe CyberKnife is when used to treat some borderline resectable or locally advanced pancreatic cancers after chemotherapy. It may help patients by targeting the tumor with precise radiation, while researchers closely watch for side effects.
Pennington, New JerseyAges 18 years+ - NCT05243082Recruiting
Ultrasound-guided heating treatment for pancreatic neuroendocrine tumors
This trial tests a procedure that uses an endoscope and ultrasound to heat (radiofrequency ablate) pancreatic neuroendocrine tumors. It may help shrink tumors while aiming to be a less invasive option.
OsloAges 18 years+ - NCT03052283Recruiting
Abdominal symptom score test for people with cystic fibrosis
This trial helps create and check a patient-friendly questionnaire that measures abdominal (belly) involvement in cystic fibrosis. It may help your care team better track symptoms over time.
Brandenburg an der HavelAges Any age - NCT05793203Recruiting
Tests noninvasive checks to spot liver transplant complications early
This study looks at how well noninvasive tests (tests that don’t require surgery or taking tissue) can detect complications after a liver transplant. It may help patients and teams find problems earlier using safer, easier monitoring.
RomeAges 18–75 - NCT05797077RecruitingPhase 3
After-surgery blood test–guided therapy for colon cancer liver spread
This Phase 3 trial tests whether an added “maintenance” treatment after liver surgery can help prevent colorectal cancer from coming back. It is only for people whose blood test (ctDNA) still shows signs of cancer after their operation.
Guangzhou, GuangdongAges 18–75 - NCT04047953Recruiting
Chemo for stomach cancer to make tumors easier to remove
This trial tests a combination chemotherapy plan—paclitaxel (albumin-bound), oxaliplatin, and S-1 given before surgery—to try to shrink stomach cancer and improve the chance of successful tumor removal. It is for people whose cancer is locally advanced or has spread, but might still be resectable (removable) in certain cases.
Beijing, Beijing MunicipalityAges 18–75 - NCT05800054Recruiting
Nutrition support program for people with esophageal cancer
This trial tests whether an “NST whole-course” nutrition management plan can improve nutrition status and reduce side effects during treatment for stage II–III esophageal cancer. It may help you stay stronger and tolerate cancer therapy better by carefully monitoring and adjusting nutrition.
Nanjing, JiangsuAges 18–75 - NCT05802459Recruiting
Check how two bowel-reconstruction options affect daily life
This study looks at how surgeons rebuild the esophagus using either a jejunum (small intestine) or a colon (large intestine) piece, and how that affects your day-to-day function and quality of life. It may help doctors choose the approach that best supports recovery and independence for patients needing esophageal reconstruction.
BarcelonaAges 18 years+ - NCT05802394Recruiting
Using blood tests to track cancer after pancreatic treatment
This trial studies whether a blood test (ctDNA, a DNA signal from tumors) can help track how pancreatic cancer responds during planned conversion therapy. It may help doctors spot treatment response earlier and guide next steps.
BeijingAges 18 years+ - NCT05802407Recruiting
ctDNA blood test monitoring after pancreatic cancer surgery
This study looks at whether a special blood test (ctDNA) can detect tiny amounts of pancreatic cancer left after surgery. It may help doctors monitor who is at higher risk of cancer coming back, so they can tailor follow-up and treatment timing.
BeijingAges 18 years+ - NCT04192825Recruiting
Crohn’s anal drainage care study
This trial studies different care and management approaches for people with Crohn’s disease who have an anal infection or drainage area and are planning a drainage procedure. It may help improve how care is planned around the drainage procedure and follow-up.
RennesAges 18 years+ - NCT05247112Recruiting
Tracking antibiotic resistance in H. pylori infections in Korea
This study looks at how resistant H. pylori (a stomach germ) is to different antibiotics in Korea. It uses stomach endoscopy samples to test which antibiotics may or may not work, helping guide future treatment choices.
Seongnam-si, Gyeonggi-doAges Any age - NCT05813015RecruitingPhase 3
Testing S-1 after stomach cancer surgery with or without sequence therapy
This Phase 3 study compares two ways of giving S-1 medicine after curative stomach cancer surgery in stage III disease. It aims to see whether the sequential approach improves outcomes while keeping treatment safe.
Hanzhou, ZhejiangAges 18–75 - NCT05815082RecruitingPhase 3
ctDNA-guided chemo after liver surgery for colon cancer
This trial checks whether giving chemotherapy after surgery only for people whose blood test (ctDNA) shows no remaining cancer can help prevent the cancer from coming back. It is for people with colon cancer that has spread to the liver who had the tumor fully removed.
Guangzhou, GuangdongAges 18–75 - NCT05687357RecruitingPhase 2
Tislelizumab plus chemoradiation before surgery for stomach cancer
This Phase 2 trial studies giving tislelizumab (an immune therapy) together with pre-surgery chemoradiation for locally advanced stomach or GEJ (esophagus-stomach junction) adenocarcinoma. It compares this approach to the standard treatment (chemoradiation plus surgery) to see if it improves outcomes.
Wuhan, HubeiAges 18–75 - NCT04647097Recruiting
Quit smoking and alcohol to prevent pancreatitis coming back
This trial is studying whether stopping alcohol and quitting smoking can help keep acute pancreatitis from returning. It’s for people whose pancreatitis happened because of alcohol, and who smoke every day.
PécsAges 18–80 - NCT05577845Recruiting
Ramosetron vs loperamide for bowel symptoms after rectal surgery
This trial compares two medicines—ramosetron and loperamide—to see which works better for severe bowel control problems after low anterior rectal surgery. It may help people with major LARS (low anterior resection syndrome) choose a safer, more effective treatment.
Seoul, Jongro-guAges 19 years+ - NCT04087421RecruitingPhase 3
Transanal irrigation vs glycerol suppositories for LARS
This trial compares two ways to help bowel control in people with low anterior resection syndrome (LARS) after low rectal surgery. It aims to see which option works better when standard treatments have not helped enough.
AarhusAges 18 years+ - NCT05276557RecruitingPhase 3
Kids study of a breath test to check H. pylori
This Phase 3 study tests whether a urea breath test (a safe breath test) works well and is safe for children ages 3–17. It may help doctors find and manage an H. pylori infection without using repeated samples.
Doral, FloridaAges 3–17 - NCT05681689RecruitingPhase 3
Check how well a urea breath test works after H. pylori treatment
This Phase 3 study tests whether a urea breath test can confirm that H. pylori infection has been cleared after recent treatment. If the test works well, it may help doctors confirm cure without needing invasive procedures.
Doral, FloridaAges 18 years+ - NCT05848609Recruiting
Quality of life study for older adults having robotic colon surgery
This study looks at how older people feel and function after robotic surgery for colorectal cancer. It may help doctors understand what to expect and how to better support quality of life during recovery.
BrusselsAges 70 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.