Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT05203120Recruiting
Proton beam radiation for liver cancer that can’t be removed
This study tests proton beam radiation for people with liver cancer that is still inside the liver but cannot be treated with surgery or a small-needle procedure. Proton beams aim to better target the tumor while reducing radiation to nearby organs.
Herlev, Capital RegionAges 18 years+ - NCT05818072Recruiting
Biopsy approach study for Barrett-like esophagus changes
This study looks at how common certain esophagus lining changes are, what increases risk, and which biopsy sampling method works best. It may help improve how doctors take tissue samples when Barrett’s esophagus is suspected.
Kaohsiung CityAges 20 years+ - NCT05645055Recruiting
Biologic treatment for bowel narrowing in Crohn’s disease
This trial studies biologic medicines to treat Crohn’s disease that causes bowel narrowing (“strictures”) without needing immediate surgery. It may help reduce symptoms and complications by targeting the immune-driven inflammation behind the narrowing.
Nanjing, JiangsuAges 16–65 - NCT05640609RecruitingPhase 1/Phase 2
Stomach cancer study using chemo plus immunotherapy plus targeted drug
This Phase 1/2 trial tests a combination treatment for advanced or metastatic stomach and food-pipe (gastroesophageal junction) cancer: a chemotherapy regimen (CapeOX) plus the immunotherapy drug sintilimab and the targeted drug bevacizumab. It aims to see how well this combination controls the cancer and how safely it can be given.
ChengduAges 18–70 - NCT05862337RecruitingPhase 3
New immune plus anti-cancer pills to prevent liver cancer returning
This Phase 3 trial studies anlotinib capsules plus penpulimab (an immune therapy) to help prevent hepatocellular carcinoma from coming back after it has been fully removed or fully destroyed. It may help high-risk patients lower the chance of recurrence and improve survival.
Bengbu, AnhuiAges 18–75 - NCT05316103Recruiting
Optical biopsy of rectal scars after cancer treatment
This trial tests a targeted “optical biopsy” (using a special light-based exam to sample tissue) to better assess rectal scars after standard chemotherapy and radiation before surgery. It may help surgeons choose the most appropriate way to operate on rectal cancer.
Guangzhou, GuangdongAges 18–80 - NCT04721873RecruitingPhase 2
Weight-loss medicine for people with ulcerative colitis
This study tests whether a weight-loss medication, along with usual ulcerative colitis care, can help people who have both ulcerative colitis and obesity. It focuses on people with active symptoms or who need ongoing steroid medicine, and it also checks safety with heart, blood, infection, and mental-health screenings.
La Jolla, CaliforniaAges 18–80 - NCT05861505RecruitingPhase 3
Treatment for new liver spread from colon cancer recurrence
This Phase 3 trial studies a treatment approach for people whose colorectal cancer has come back in the liver within 12 months and can be treated with local procedures. It aims to see whether the study treatment can improve outcomes compared with standard care for people with a limited number of liver tumors.
AmsterdamAges 18 years+ - NCT05855031Recruiting
Liver care support for people getting alcohol-use treatment
This trial looks at liver-focused care for people receiving outpatient treatment for alcohol dependence or alcohol-related harmful drinking. It may help by checking and improving how your liver health is supported while you stay in alcohol-use treatment.
KøgeAges 18–110 - NCT05853094Recruiting
Testing different ways to create a stoma after rectal cancer surgery
This trial looks at how different stoma (opening in the belly) approaches affect recovery after curative rectal cancer surgery. It may help doctors choose the safest, most comfortable option for bowel function and healing after surgery.
ShanghaiAges 18–80 - NCT05867134Recruiting
Activity limits after one-sided groin hernia surgery
This trial studies how restricting or allowing activities after surgery for a one-sided inguinal hernia affects recovery and outcomes. It may help determine the safest activity plan while you heal.
Aurora, ColoradoAges 18–99 - NCT04959604Recruiting
Fluorescent dye mapping to find lymph nodes in colon cancer
This trial studies whether a fluorescent dye used during an exam can help doctors map (find) lymph nodes in colon cancer. It may help improve how surgeons plan treatment and decide what to remove.
HamburgAges 18–100 - NCT05083247RecruitingPhase 2
Pre-surgery chemotherapy plus targeted radiation for borderline pancreatic cancer
This trial studies whether giving chemotherapy before surgery, and possibly adding a focused high-dose radiation treatment, can improve outcomes for people with borderline resectable pancreatic cancer. It aims to shrink or control the cancer and help more patients get to surgery safely.
AntwerpAges 18 years+ - NCT05870969Recruiting
Digital monitoring to catch liver cancer risk early
This study tests a digital (computer/phone-based) system to help track people with higher risk of liver cancer so cancers can be found earlier. It may help by guiding regular check-ins and making early diagnosis more efficient.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05797467RecruitingPhase 3
After-surgery chemo plus targeted therapy for colon cancer
This Phase 3 trial studies whether adding targeted therapy to standard chemotherapy after surgery helps people with stage T3-4, N2 colon cancer live longer or have fewer cancer returns. You would be assigned to receive chemotherapy with targeted therapy or chemotherapy alone, based on the study plan.
Guangzhou, GuangdongAges 18–75 - NCT05608200RecruitingPhase 3
Lenvatinib plus immunotherapy with TACE versus standard TACE
This study compares a stronger treatment plan (lenvatinib plus sintilimab plus TACE) against a standard plan (lenvatinib plus TACE) for advanced liver cancer. It aims to see which plan works better to control tumors and help patients live longer.
Guangzhou, GuangdongAges 18–75 - NCT04183608RecruitingPhase 4
Telemonitoring and education to guide treatment for ulcerative colitis
This trial tests whether “treat-to-target” care—guided by regular symptom checks, telemonitoring, and patient education—works better than standard follow-up when starting adalimumab for ulcerative colitis. It aims to help control inflammation more effectively and reduce flare-ups.
Cholet, Maine Et LoireAges 18–75 - NCT05683730Recruiting
Intermittent calorie restriction for mild to moderate Crohn’s
This trial studies whether planned periods of eating fewer calories can help people with mild to moderate Crohn’s disease. It requires stable Crohn’s treatment and monitoring for weight and health changes during the study.
Vandœuvre-lès-Nancy, CHRU de NancyAges 18–65 - NCT04519151RecruitingPhase 2
Pembrolizumab plus lenvatinib for ovarian cancer that returned
This Phase 2 trial tests whether pembrolizumab plus lenvatinib can shrink ovarian cancer that has come back after platinum chemotherapy. You may be eligible if your cancer returned after a certain “time off” from prior treatment and you meet key health and safety requirements.
Ramat GanAges 18 years+ - NCT05244629Recruiting
Compare two stents for chronic artery-related gut pain
This trial tests whether an uncovered stent or a covered stent works better for treating chronic mesenteric ischemia (reduced blood flow to the intestines from artery narrowing). It’s meant for adults with symptoms and scans showing significant narrowing in a specific gut artery.
København ØAges 18 years+ - NCT05922306RecruitingEarly Phase 1
Testing continuous vs pulsed treatment for chronic hepatitis B
This early-phase study compares two ways of giving treatment for chronic hepatitis B: continuous antiviral therapy versus pulsed treatment. It may help find a schedule that works well and is tolerable for people with hepatitis B.
Hefei, AnhuiAges 18–60 - NCT05368168Recruiting
Early nerve stimulation to reduce rectal surgery after-effects
This trial tests whether starting a specific nerve stimulation treatment soon after rectal surgery can lower how often and how long a post-surgery bowel problem lasts. It may help patients recover with fewer symptoms after a low rectal anastomosis.
Vigo, PontevedraAges 18 years+ - NCT05917431RecruitingPhase 2
Radiation plus immunotherapy and targeted pills for liver cancer
This Phase 2 trial studies whether a combination of SBRT (focused radiation) plus tislelizumab and regorafenib can control unresectable or limited-spread liver cancer. It may help by attacking tumors in the liver and immune system to improve shrinkage and control of disease.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05919433Recruiting
Program to find people with primary biliary cholangitis
This trial is testing a “find patients who are missing from care” program for people with primary biliary cholangitis (PBC). It may help connect you to follow-up sooner if you’ve been hard to reach through usual clinic records.
Terrassa, BarcelonaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.