Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,874 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,178
- Phase 1584
- Phase 3466
- Phase 1/Phase 2389
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer294
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)103
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University89
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California465
- Arizona175
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,874 total
- NCT06807073Recruiting
Closing the wound after large colon polyp removal
This study compares closing the wound after removing a large colon polyp to leaving it open. The goal is to see if closing the area reduces bleeding or other problems.
Montreal, QuebecAges 18 years+ - NCT07270809Recruiting
Chronic liver disease with organ failure: early outcomes study
This study follows patients with chronic liver disease who are hospitalized non-electively for organ failure, to understand the course of illness and outcomes over six months. It may help doctors improve care for similar patients.
New Delhi, National Capital Territory of DelhiAges 18–70 - NCT06051617RecruitingPhase 3
Testing seladelpar for PBC with compensated cirrhosis
This study tests an experimental oral drug called seladelpar for people with PBC who also have cirrhosis that is well-controlled. The goal is to see if it helps improve liver health and manage symptoms without causing serious side effects.
Birmingham, AlabamaAges 18 years+ - NCT07655375Recruiting
Study of UCB8600 on gut mast cells in IBS and colorectal cancer
This study looks at how a medicine called UCB8600 affects certain immune cells (mast cells) in the gut. It is for people having colorectal cancer surgery and for patients with irritable bowel syndrome (IBS). The goal is to understand how the medicine works in the body and if it can help with IBS symptoms.
Leuven, Vlaams-BrabantAges 18–65 - NCT07749326Recruiting
Comparing two stomach bypass surgeries for advanced stomach cancer
This trial compares two surgical methods to bypass a blocked stomach outlet caused by advanced stomach cancer, helping patients eat and digest food more easily. It aims to see which operation gives better relief with fewer complications.
Changwon, Gyeongsangnam-doAges 20–85 - NCT06596954Recruiting
Lymphocyte-sparing radiation for esophageal cancer
This trial tests a special type of radiation therapy that aims to spare your immune cells (lymphocytes) while treating esophageal cancer. It may help patients with locally advanced esophageal squamous cell carcinoma who are in good overall health.
Shanghai, ChinaAges 18–80 - NCT04117100Recruiting
Study registry for advanced endoscopy treatments
This study keeps a record of people who choose an advanced endoscopy procedure (like ESD, EMR, advanced polypectomy, POEM, or treatment for Zenker’s). It aims to learn about real-world outcomes and safety, which may help improve care for future patients.
Montreal, QuebecAges 18 years+ - NCT06880523RecruitingPhase 2
Adding lenvatinib to immunotherapy for liver cancer
This trial tests adding lenvatinib (a targeted therapy pill) to a combination of two immunotherapy drugs (durvalumab and tremelimumab) for people with liver cancer that cannot be removed by surgery. The goal is to see if the three-drug approach works better than the two immunotherapy drugs alone.
Calgary, AlbertaAges 18 years+ - NCT07750535Recruiting
Liver fat and scarring in wheat-sensitive patients
This study looks at whether people with non-celiac wheat sensitivity or other digestive conditions have more fat in their liver or liver scarring. It aims to understand if wheat-related issues are linked to liver health.
Palermo, PalermoAges 18–65 - NCT07636304Enrolling by invitationEarly Phase 1
Brain stimulation for inflammatory bowel disease remission
This study tests whether a non-invasive device that stimulates the vagus nerve (a major nerve in your neck) can affect brain function in people whose IBD is in remission. Researchers want to understand if this stimulation might help reduce inflammation or improve symptoms in the future.
Gdansk, Pomeranian VoivodeshipAges 18 years+ - NCT06043427RecruitingPhase 2
Testing paclitaxel and ramucirumab with or without zanidatamab for HER2+ stomach cancer
This trial tests adding a new drug (zanidatamab) to standard chemotherapy (paclitaxel and ramucirumab) for people with advanced HER2-positive stomach, gastroesophageal junction, or esophageal cancer that has worsened after previous treatment. It aims to see if the combination works better.
Calgary, AlbertaAges 18 years+ - NCT07639853Enrolling by invitation
Doctor feedback survey on Concerto Versa coils
This study gathers feedback from doctors who use Concerto Versa detachable coils (small metal devices that help treat brain aneurysms). The survey helps improve how these coils work and are used.
El Paso, TexasAges 22 years+ - NCT07754721Recruiting
Diet and lifestyle program for chronic acid reflux
This study tests a comprehensive program that combines diet and lifestyle changes to help people with chronic acid reflux (heartburn, acid regurgitation, or chest pain) feel better. It looks at how these changes can improve your overall health and reduce symptoms.
Hualien City, TaiwanAges 18–79 - NCT07755384Recruiting
Stomach and throat exam study at high altitude
This study looks at what doctors see in the upper digestive tract (stomach and food pipe) of people living at high altitude, using a sedated endoscopy (a camera tube down the throat while you sleep). It helps understand how high altitude affects the digestive system.
Yushu, QinghaiAges 18 years+ - NCT07550088RecruitingPhase 2
Combination therapy for colorectal cancer with liver tumors
This study tests a combination of three drugs for patients with colorectal cancer that has spread to the liver. The goal is to see if this combination can shrink tumors and help patients live longer.
La Jolla, CaliforniaAges 18 years+ - NCT07159048Recruiting
Heat therapy for liver tumors
This trial tests a heat-based treatment for liver cancer tumors that uses multiple methods to destroy cancer cells. It may help people with liver tumors that haven't spread and who are healthy enough for treatment.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07722494RecruitingPhase 3
Investigational drug plus bevacizumab for advanced colorectal cancer
This trial tests a new drug combined with a standard treatment for advanced colorectal cancer that has not responded to earlier therapies. It aims to see if the combination can help slow the cancer's growth.
Wuhan, WuhanAges 18 years+ - NCT07756476Recruiting
Fluid treatment guided by heart response for acute pancreatitis
This study tests whether giving IV fluids based on how your heart responds can improve recovery from acute pancreatitis, compared with usual care. It may help your body handle fluids better during treatment.
Los Angeles, CaliforniaAges 18–75 - NCT03965234RecruitingPhase 1/Phase 2
Lung infusion for colorectal cancer that has spread to the lungs
This trial tests a procedure where chemotherapy is delivered directly into the lungs during surgery to remove or destroy lung tumors. It aims to reduce the chance of cancer returning after surgery for people with colorectal cancer that has spread to the lungs.
Buffalo, New YorkAges 18 years+ - NCT07527910RecruitingPhase 2
Study of ALN-PNP with or without tirzepatide for fatty liver disease
This trial tests a new drug, ALN-PNP, alone or with tirzepatide in people with a specific genetic type of fatty liver disease. It aims to see if the combination reduces liver fat.
Coronado, CaliforniaAges 18–75 - NCT03884075RecruitingPhase 2
Semaglutide study for fatty liver and how sugar affects the liver
This Phase 2 study tests how semaglutide (a diabetes medication also used for weight) affects fatty liver and the liver’s response to sugar. It may help people with non-alcoholic fatty liver disease understand whether the drug improves liver fat and related changes.
Bethesda, MarylandAges 18–100 - NCT07488299Recruiting
Study of acid-reducing drug in pancreatic necrosis drainage
This trial tests whether giving a type of acid-reducing drug (called a PPI) affects the outcome of endoscopic drainage for walled-off pancreatic necrosis (WON). It aims to see if the drug helps or harms recovery.
Jinan, ShandongAges 18–80 - NCT05534087RecruitingPhase 3
Blood test guided chemo after colon cancer surgery
This study tests whether giving additional (adjuvant) chemotherapy based on a special blood test—circulating tumor DNA (ctDNA)—can lower the risk of colon cancer coming back. It targets people with stage II–III colon cancer whose blood test is positive for minimal residual disease (MRD) after completing standard chemo.
BusanAges 19–75 - NCT03959800Recruiting
Study of the causes of childhood liver tumors
This study looks at why childhood liver tumors happen by using samples and information from children who have had a liver tumor and from their close family members. It may help researchers understand the biology of these tumors and guide better treatments in the future.
Pittsburgh, PennsylvaniaAges birth–99 years
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,874 recruiting gastroenterology studies from the U.S. registry right now, out of 12,294 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.