Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,686
- Phase 21,188
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Hepatocellular Carcinoma (HCC)114
- Colon Cancer112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Chinese University of Hong Kong56
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona190
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,606 total
- NCT07166588Enrolling by invitation
Precision medicine study for inflammatory bowel disease
This study looks at using precision medicine to treat inflammatory bowel disease (IBD) in people who are newly diagnosed or already being monitored. It aims to find better ways to manage the condition.
Seoul, SeoulAges 10 years+ - NCT07165470Recruiting
Pre-packaged low-residue diet for IBD colonoscopy prep
This study tests whether a ready-to-eat low-residue diet (a diet that leaves very little waste in your colon) helps people with IBD prepare for a colonoscopy. It may make the prep easier and more effective than standard bowel-cleansing drinks.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07167342RecruitingPhase 4
Can a probiotic prevent polyp regrowth after colonoscopy?
This trial tests whether taking a probiotic called Clostridium Butyricum after colon polyp removal can lower the chance of polyps coming back. It is looking for people who had adenomas removed and are not already taking certain supplements or antibiotics.
Qingdao, ShandongAges 18–75 - NCT07171593Enrolling by invitation
High protein drink for Crohn's with muscle loss
This trial tests if a high protein oral nutrition drink with HMB can help people with active Crohn's disease who also have muscle loss (sarcopenia). The goal is to see if it improves muscle strength and overall health.
Guangzhou, GuangdongAges 18–50 - NCT07167264Recruiting
Nutrition app for recovery after pancreatic cancer surgery
This trial tests an AI-powered app that helps with nutrition after pancreatic cancer surgery. It aims to improve your recovery by giving personalized dietary guidance.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07165184Recruiting
Lymph node spread in esophageal cancer study
This study looks at how often cancer has spread to lymph nodes in people with esophageal squamous cell carcinoma. It may help doctors plan better treatment. You may be eligible if your cancer hasn't spread to other organs and you haven't had another cancer.
Shanghai, Shanghai MunicipalityAges 20–85 - NCT04037007Recruiting
Fistulotomy during ERCP to open the bile duct entrance
This trial looks at whether a specific small procedure during ERCP helps doctors reach and drain the bile duct when gallstones or bile duct narrowing are suspected. It may help people avoid getting stuck during the procedure and improve how successfully the bile duct can be reached.
Mexico City, Mexico CityAges 18–90 - NCT06950814Recruiting
Impact of extra treatment after surgery for liver cancer
This study looks at whether additional treatment after liver surgery (like chemotherapy or radiation) can help people with a rare and aggressive liver cancer called primary hepatic sarcomatoid carcinoma (PHSC). It only includes people who had surgery and no other cancer treatments before that.
Chengdu, SichuanAges 18 years+ - NCT06950827Recruiting
Recovery after right liver surgery for liver cancer
This trial looks at how well patients do after surgery to remove the right half of the liver for a specific type of liver cancer. It helps doctors understand what leads to the best recovery after this operation.
Chengdu, SichuanAges 18 years+ - NCT04503265RecruitingPhase 1/Phase 2
AMXI-5001 study for advanced cancers that won’t respond
This Phase 1/2 trial tests AMXI-5001 in people with advanced cancers that have progressed or stopped responding to standard treatments. It’s mainly designed to find the safest dose and see early signs the treatment might work.
Los Angeles, CaliforniaAges 18 years+ - NCT04734821Recruiting
Fluorescent imaging during stomach or esophagus surgery
This study tests whether a special fluorescent camera during surgery can help surgeons better operate on resectable (removable) stomach or esophagus cancer. It may help improve how surgery is guided, with the goal of safer and more accurate tumor removal.
StrasbourgAges 18 years+ - NCT06121622Recruiting
Personalized 3D models for pancreatic neuroendocrine tumors
This study is testing a new way to make 3D models in the lab that look like your specific tumor. The goal is to better understand pancreatic neuroendocrine tumors and find personalized treatments.
Milan, MIAges 18 years+ - NCT05182463RecruitingPhase 4
Peginterferon test for inactive chronic hepatitis B
This trial studies whether pegylated interferon can help people with inactive chronic hepatitis B stay stable or improve outcomes. You may qualify if your virus levels and liver blood tests are currently low and you’ve never used antiviral treatments.
Guangzhou, GuangdongAges 18–60 - NCT06420440RecruitingPhase 2
Pre-surgery treatment for liver cancer at high risk of return
This study tests a treatment given before surgery for liver cancer that is at high risk of coming back. You would receive a combination of chemotherapy directly into the liver artery (HAIC), a targeted pill (lenvatinib), and an immunotherapy drug (a PD-1 inhibitor) — if a computer model predicts you might benefit.
Xiangyang, HubeiAges 18–75 - NCT06562348RecruitingPhase 2
ctDNA monitoring test for metastatic GI cancer treatment
This trial tests whether using a ctDNA blood test along with standard CT scans can help guide treatment decisions for people with incurable metastatic gastrointestinal cancer. It may help doctors decide sooner whether a treatment is working.
AarhusAges 18 years+ - NCT02047994RecruitingPhase 4
Testing and treatment for H. pylori to prevent stomach cancer death
This trial studies whether testing for an infection called H. pylori and using simple blood/screening tests (pepsinogen testing) can help prevent stomach cancer and reduce stomach-cancer-related deaths. You would be followed for health outcomes to see if the approach works better than standard care.
RigaAges 40–64 - NCT06300879Recruiting
New surgery technique for upper stomach or junction cancer
This study tests a new surgical technique for removing cancer in the upper stomach or where the stomach meets the esophagus. It aims to see if this technique is safe and effective for people with early-stage adenocarcinoma who haven't had other cancer treatments.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06953921Recruiting
Liver disease and confusion: does albumin level matter?
This study looks at whether low albumin levels in the blood are linked to more severe confusion caused by liver disease. It may help doctors understand how to better manage hepatic encephalopathy.
SohagAges 18 years+ - NCT06169163Recruiting
Breath test for esophageal squamous cell cancer
This study looks at chemicals in your breath to see if they can help detect a type of esophageal cancer (squamous cell carcinoma) early. You may join if you have untreated squamous cell esophageal cancer, or if you are having a routine endoscopy for stomach issues and your results are normal or show a benign condition.
London, Greater LondonAges 18–90 - NCT06954311Recruiting
Drug monitoring for children with IBD
This study monitors levels of certain medications (infliximab, adalimumab, vedolizumab, ustekinumab) in children with inflammatory bowel disease to see if adjusting the dose helps them feel better. It aims to improve treatment outcomes.
FeldkirchAges birth–18 years - NCT06892990Recruiting
Better imaging for inflammation in bowel disease
This trial tests a new imaging technique that may help doctors see inflammation more clearly during colonoscopy in people with Crohn's disease or ulcerative colitis. The technique is called Texture and Color Enhancement Imaging (TXI).
Ulm, Baden-WurttembergAges 18 years+ - NCT06364176RecruitingPhase 2
Adding losartan to improve Trikafta response in CF
This study tests whether adding the blood pressure medication losartan can help the standard CF drug Trikafta work better by reducing inflammation. It's for people with CF who still have high sweat chloride levels despite taking Trikafta.
Kansas City, KansasAges 12 years+ - NCT06104631Recruiting
Testing a treatment for IBS-like symptoms in Crohn's remission
This study tests whether a new treatment can reduce IBS-like symptoms, such as belly pain and bloating, in people whose Crohn's disease is in remission. It aims to improve your quality of life without targeting active Crohn's inflammation.
LiègeAges 18–75 - NCT07162701Recruiting
Body composition study for inflammatory bowel disease
This study looks at body composition (fat and muscle) in people with Crohn's disease or ulcerative colitis. It tests if a new way to monitor body changes can help guide treatment with biologic or JAK inhibitor medicines.
BarcelonaAges 18–64
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 12,023 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.