Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT05935384Recruiting
Blood tests to track response to cancer therapy
This study follows how cancer responds to standard (usual) treatment by using blood samples and de-identified health data. It may help researchers understand whether “liquid biopsy” blood testing can reflect how well therapy is working.
Skokie, IllinoisAges 18 years+ - NCT05936073Recruiting
Study of patient data for people with HDV infection
This study looks at patient information (your health data) for adults who test positive for HDV. You may help researchers better understand HDV by allowing their team to collect and use your data.
LimogesAges 18 years+ - NCT05935618Recruiting
Occupational therapy rehab for frail older adults with swallowing trouble
This trial tests an occupational therapy–based rehabilitation program to help frail older adults with swallowing problems work more safely and comfortably. You may be considered if your swallowing screen results fall in a specific range and you can participate in the therapy and consent process.
HvidovreAges 65 years+ - NCT05937477Recruiting
AI tool study to predict chemotherapy side effects and symptoms
This study tests an artificial-intelligence (AI) tool in a phone app that helps predict side effects and symptoms from chemotherapy. It may help patients and their care team plan and respond to side effects more effectively.
Seoul, GangnamguAges 20 years+ - NCT05937178Recruiting
Real-World Study to Optimize Hepatitis B Tablet Treatment
This study looks at how to best use existing hepatitis B “nucleotide-analog” tablets in everyday care. It may help tailor when to start, and whether to continue or adjust treatment, based on your test results.
Hefei, AnhuiAges 18–80 - NCT05937815Recruiting
Study of Trikafta on Gut-Lung Connection in CF
This study is looking at how a new combination medicine (Trikafta) affects the lungs and gut in people with cystic fibrosis who carry the DeltaF508 mutation. It aims to understand how the medicine works in the body.
BordeauxAges 6–17 - NCT05937438RecruitingPhase 1/Phase 2
Radiation then immunotherapy after esophagus surgery
This trial studies giving radiation right after esophagus surgery, followed by immunotherapy, to keep the cancer from coming back. It is for people with a specific type and stage of esophageal squamous cell carcinoma.
Hefei, AnhuiAges 18–75 - NCT05938166Recruiting
Training foreign caregivers with an augmented reality system
This study tests whether an augmented reality (AR) training system can help foreign care workers learn how to provide care. It involves Indonesian caregivers training for caring for older adults in Kaohsiung, with tests based on the older adult’s ability to follow instructions.
Kaohsiung City, Sanmin DistAges 21–65 - NCT05938309Recruiting
Safety study of laparoscopic surgery for large stomach GISTs
This study looks at how safe laparoscopic surgery is for stomach GISTs that are 5 cm or larger. If you’re eligible and choose to participate, your team will plan and perform surgery and track safety outcomes.
Fuzhou, FujianAges 18–75 - NCT05938322Recruiting
Ketogenic diet during pelvic cancer radiation treatment
This trial studies whether a very low-carbohydrate (ketogenic) diet can be followed safely while you receive neoadjuvant radiation for locally advanced rectal cancer. It may help researchers understand effects related to nutrition and treatment tolerance during radiation.
RomeAges 18–75 - NCT05938465RecruitingPhase 1/Phase 2
Live probiotic trial to reduce frequent bowel movements
This Phase 1/2 study tests EXE-346, a live probiotic given to people with an IPAA pouch who have frequent bowel movements. It aims to see if the treatment can safely lower how often you have bowel movements each day.
Los Angeles, CaliforniaAges 18 years+ - NCT05939401Recruiting
Tissue study during and after anal cancer treatment
This study looks at how anal cancer tissue and samples change during and after treatment. Your participation may help doctors understand treatment response, especially for people with newly diagnosed or returning anal cancer.
GothenburgAges 18 years+ - NCT05939661RecruitingPhase 2
Total treatment before surgery for early rectal cancer
This Phase 2 study tests a “total neoadjuvant” approach, meaning you receive cancer treatment before surgery, to improve safety and effectiveness for rectal cancer. It may help by shrinking the tumor and planning a more effective operation, while researchers carefully track side effects.
OsakaAges 18 years+ - NCT05939687RecruitingPhase 3
Mesh placement to help prevent complications after bowel surgery
This Phase 3 trial tests whether placing a protective mesh during stoma closure can lower the risk of complications after low anterior resection surgery. It may help people heal more safely and reduce stoma-related problems.
MoscowAges 18–85 - NCT05941507RecruitingPhase 1/Phase 2
TROP2 antibody drug with anti–PD-1 for advanced solid tumors
This early-phase study tests an antibody-drug (an ADC) that targets TROP2, given by itself and together with an anti–PD-1 medicine. It’s for people with advanced solid cancers that have not responded to standard treatments, aiming to shrink tumors and improve control of the disease.
Los Angeles, CaliforniaAges 18 years+ - NCT05942807Recruiting
Study of biliary tract cancer and care experiences
This is an observational study for adults with biliary tract cancer that looks at existing clinical information. It may help doctors understand the disease better and improve future care, without using a new treatment in a required way.
Roma, RomeAges 18 years+ - NCT05942833Recruiting
Quality of life study in left-sided diverticulitis
This study looks at how treatment affects quality of life in people with left-sided diverticulitis, including repeat episodes or complicated attacks. It may help doctors understand what improves day-to-day well-being and recovery for different diverticulitis situations.
Linz, AustriaAges 18 years+ - NCT05943210Recruiting
Molecular testing of rectal cancer after short-course radiation
This study looks at molecular (tumor biology) features of rectal cancer in people receiving standard short-course radiation. Your tissue and/or samples may be used to better understand the cancer and how it responds to treatment.
Chicago, IllinoisAges 18–90 - NCT05943444Recruiting
Compares two ways to preserve bowel function after rectal surgery
This trial compares two surgical techniques to see which one better preserves anal function after surgery for low rectal cancer. If you may be eligible for anal-preserving surgery, it may help your care team choose the approach that best protects bowel control.
Guangzhou, GuangdongAges 18–75 - NCT05944237RecruitingPhase 1/Phase 2
Early trial for advanced cancers using HTL0039732
This is a Phase 1/2 study testing how well HTL0039732 works and is tolerated in people with advanced solid tumors that have not responded to standard treatments. It may help by offering a new treatment option and learning which cancer types and body markers respond best.
CambridgeAges 18 years+ - NCT05947669RecruitingPhase 3
Infliximab for diarrhea or colitis from immune cancer therapy
This trial studies whether infliximab can treat stomach inflammation in the colon (colitis) or frequent diarrhea caused by immune checkpoint cancer drugs. It aims to improve symptoms safely for adults with certain solid cancers.
AalborgAges 18 years+ - NCT05949268Recruiting
Video capsule test to find bleeding in the small intestine
This trial studies whether a swallowable camera capsule can detect bleeding in the small intestine when standard scopes (up the stomach and through the colon) haven’t found the cause. If your bleeding source is suspected but not seen on those tests, this could help identify where the bleeding is coming from.
Freiburg im BreisgauAges 18 years+ - NCT05950503Recruiting
MRI to assess liver spread from colon cancer
This trial studies how well MRI can evaluate liver metastases (spread to the liver) from colorectal cancer. If you have measurable liver lesions, your MRI results may help doctors better track and plan care.
RomaAges 18–85 - NCT05951751Recruiting
Study of stopping mother-to-baby transmission after birth
This study tests a program meant to reduce how infections can pass from a mother to her baby during and after delivery. It enrolls mothers at selected maternity hospitals during a post-birth checkup.
Bobo-DioulassoAges Any age
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.