Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT06619561RecruitingPhase 2
Testing vimseltinib for chronic graft versus host disease
This trial tests a new drug called vimseltinib for people with active chronic graft versus host disease (cGVHD) that hasn't gotten better after at least two prior treatments. The goal is to see if vimseltinib can help control the condition.
Duarte, CaliforniaAges 18 years+ - NCT06619808Recruiting
Hyperbaric oxygen for fatty liver disease
This trial tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people with fatty liver disease caused by metabolic issues. It may reduce liver fat and improve liver health.
Nanjing, JiangsuAges 18–75 - NCT06620627Recruiting
Blood test for early cancer detection before colonoscopy
This study is testing a new blood test that might help find cancer early. If you are 40 or older and planning a routine screening colonoscopy, you may be able to join. You will give a blood sample before the colonoscopy, and the researchers will see if the test can detect signs of cancer.
Austin, TexasAges 40 years+ - NCT06620848RecruitingPhase 2
A trial of HRS-4642 alone or with adebrelimab for advanced bile duct cancer
This trial tests a new drug, HRS-4642, either by itself or combined with another drug called adebrelimab, for people whose advanced bile duct cancer has come back or gotten worse after standard treatment. The goal is to see if this combination can shrink tumors or slow the cancer's growth.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06621173RecruitingEarly Phase 1
Gene therapy for advanced colorectal cancer (dMMR/MSI-H)
This trial tests a new gene therapy (HNF4α SrRNA) given through a vein for people with advanced colorectal cancer that has a specific genetic marker (dMMR or MSI-H). It's for those who have already tried standard treatments without success or couldn't take them.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06621277Recruiting
Improving care for young adults with GI cancer
This study aims to improve care for younger adults (ages 18-50) with gastrointestinal (GI) tumors. Researchers will test ways to better support patients during and after treatment. If you are 18-50 and being treated for a GI tumor at Heidelberg University Hospital, you may be able to join.
Heidelberg, Baden-WurttembergAges 18 years+ - NCT06621563RecruitingPhase 1
Study of HS-20117 Combination Therapy for Advanced Solid Tumors
This early-phase trial tests a new drug (HS-20117) combined with other drugs for people with advanced solid tumors. It aims to see if the combination is safe and effective, especially for cancers that have not responded to other treatments.
TianjinAges 18–75 - NCT06621706Recruiting
Gastric volume in diabetic vs. non-diabetic women before c-section
This study uses ultrasound to compare the amount of fluid in the stomach right before a planned cesarean section. It looks at women with diabetes and those without to see if there is a difference, which can help make anesthesia safer.
Banī Suwayf, Beni Suweif GovernorateAges 18–40 - NCT06622031Recruiting
TIPS with lenvatinib and immunotherapy for advanced liver cancer
This trial combines a procedure called TIPS (which helps relieve pressure in the liver) with two drugs—lenvatinib (a targeted therapy) and a PD-1 inhibitor (an immunotherapy)—for people with advanced liver cancer that has spread into the main vein of the liver. It aims to see if this combination can help control the cancer and improve symptoms.
Beijing, None SelectedAges 18–75 - NCT06623071Recruiting
HBV viral load test validation study
This study is testing a new blood test that measures the amount of hepatitis B virus (HBV) in your body. It helps see if the test works as well as current approved tests.
Frépillon, Ile de FranaceAges 18 years+ - NCT06623396RecruitingPhase 1
CAR T-cell therapy for stomach and esophagus cancer
This trial tests a new treatment called CAR T-cell therapy that targets a protein called mesothelin found on some cancer cells. It is for people with advanced or recurrent cancer of the stomach or esophagus that has spread or come back after prior treatment.
Basking Ridge, New JerseyAges 18 years+ - NCT06623474Recruiting
Fat markers in blood for liver cancer study
This study is for people having liver cancer surgery. It will look at certain fats in your blood to see if they can help doctors understand and track liver cancer better.
Guangzhou, GuangdongAges 18–80 - NCT06624215Recruiting
Acute Appendectomy Study Comparing Robotic and Laparoscopic Surgery
This study looks back at records of adults who had emergency appendix surgery (robotic or laparoscopic) for acute appendicitis. It aims to compare outcomes of different surgical approaches to help doctors choose the best option.
Columbus, OhioAges 22 years+ - NCT06625138Recruiting
Latex vs non-latex banding for hemorrhoids
This study compares two types of rubber bands (one made of latex, one not) used to treat internal hemorrhoids. It may help find the better option for people with grade 2-3 hemorrhoids.
Pasadena, CaliforniaAges 18 years+ - NCT06625775RecruitingPhase 1
Study of BBO-10203 for advanced solid tumors
This trial tests a new drug called BBO-10203, alone or combined with other cancer treatments, for people with certain advanced breast, colorectal, or lung cancers. It aims to see if the drug is safe and effective.
Duarte, CaliforniaAges 18 years+ - NCT06626269Recruiting
Biomarkers for immunotherapy in digestive and gynecological cancers
This study looks for new markers in the blood or tumor that could predict how well immunotherapies work for advanced digestive and gynecological cancers. It includes people getting immunotherapy, chemotherapy, or targeted therapy, and also those with certain liver or abdominal metastases that can be surgically removed after chemo.
BesançonAges 18 years+ - NCT06627556RecruitingPhase 1
Single and multiple dose study of H021 in healthy people
This trial tests an investigational drug called H021 in healthy volunteers. It aims to understand how the body processes the drug at different dose levels. This study may help determine safe dosing for future trials.
Melbourne, VictoriaAges 18–55 - NCT06628661Recruiting
Liver cancer surgery: long-term outcomes by tumor size
This study looks at people with a single liver cancer tumor that can be removed by surgery. It checks how tumor size (especially larger than 6.5 cm) and signs of tumor invasion into blood vessels affect long-term outcomes over 10 years.
TaoyuanAges 18–80 - NCT06628674Recruiting
Online videos for recovery after rectal cancer surgery
This trial tests if watching online interactive videos can help people who have had surgery for stage I to III rectal cancer deal with common bowel problems after treatment. Your participation could lead to better support tools for other patients.
Taoyuan, 中和區Ages 20 years+ - NCT06629051Recruiting
Long-term follow-up after berberine treatment trial
This study checks on people who took berberine in an earlier trial to see how they are doing 6 years later. It helps researchers understand the long-term effects of the treatment.
ShanghaiAges Any age - NCT06629194Recruiting
Comparing tests to tell intestinal TB from Crohn's disease
This study looks at different scoring systems to help doctors tell the difference between intestinal tuberculosis (a bacterial infection) and Crohn's disease (a chronic inflammatory condition). If you have ulcers in your ileum or colon and are undergoing a colonoscopy, you may be able to help doctors improve how they diagnose these conditions.
Bangkok Noi, BangkokAges 18 years+ - NCT06630013Recruiting
Ultrasound test for swallowing problems in patients with a tracheostomy
This study tests if a new ultrasound score can help diagnose swallowing disorders in patients who are difficult to wean from a breathing tube and have a tracheostomy. It may help doctors better assess swallowing without more invasive tests.
Beuvry, BeuvryAges 18 years+ - NCT06630234RecruitingPhase 1/Phase 2
Testing a new drug for advanced GIST with specific gene changes
This trial tests a new targeted therapy drug, DCC-3009, for people with advanced GIST that has a specific gene mutation (KIT or PDGFRA). It's for those who have already tried other targeted treatments and need a new option.
Scottsdate, ArizonaAges 18 years+ - NCT06630624RecruitingPhase 1/Phase 2
IP-001 with ablation for colorectal liver metastases
This trial tests whether adding the drug IP-001 to tumor ablation (microwave or irreversible electroporation) helps control colorectal cancer that has spread to the liver. The goal is to find the best dose and see how the immune system responds.
Amsterdam, North HollandAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.