Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT02649647Recruiting
Surgery plan for rectal cancer after chemo-radiation
This trial looks at a specific type of rectal surgery after you’ve already finished chemo-radiation, aiming to remove the tumor while trying to preserve the anal sphincter (muscle control). It’s meant for people whose cancer can be safely operated on and who don’t have spread to distant organs.
Guangzhou, GuangdongAges 18–75 - NCT06158919Recruiting
Immunotherapy Plus Targeted Therapy and Chemo for Stomach Cancer
This trial tests a combination of immunotherapy (PD-1 inhibitor), a targeted drug (fruquintinib), and chemotherapy as a first treatment for advanced stomach or gastroesophageal junction cancer that is HER2-negative. It aims to see if this combination can shrink tumors and help people live longer.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT04792892Recruiting
Study of quality of life after new anal cancer diagnosis
This study looks at how people’s day-to-day functioning and quality of life change after an anal cancer diagnosis. It mainly enrolls adults recently diagnosed to understand outcomes early on.
GothenburgAges 18 years+ - NCT05360277RecruitingPhase 2
Maintenance immunotherapy and chemo after surgery for metastatic colon cancer
This Phase 2 trial studies tislelizumab plus capecitabine given after surgery to help prevent metastatic colorectal cancer from coming back. It may be an option if you recently had surgery that removed visible disease and you have good overall health.
Guangzhou, GuangdongAges 18–80 - NCT03908684Recruiting
Ultrasound tests to predict early response to prostate and head/neck radiation
This study uses special ultrasound imaging to look for early signs of how well radiation treatment is working in prostate, rectum, and head/neck cancers. It may help doctors spot response sooner and adjust care earlier if needed.
Toronto, OntarioAges Any age - NCT06159478RecruitingPhase 2
Testing binimetinib for BRAF fusion brain tumors and pancreatic cancer
This trial tests a targeted drug, binimetinib, for people with low-grade glioma (a type of brain tumor) or pancreatic cancer that has a specific genetic change called a BRAF fusion. The drug aims to block signals that help these tumors grow.
Kashiwa, ChibaAges 12 years+ - NCT06155383RecruitingPhase 2
Surgery and immunotherapy combo for stomach cancer
This trial tests a combination of three drugs (Disitamab Vedotin, Toripalimab, and XELOX) given before and after surgery for gastric or gastroesophageal junction cancer. The goal is to see if this treatment helps shrink the tumor and prevent it from coming back.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06173986RecruitingPhase 1/Phase 2
Immunotherapy plus chemoradiation for advanced esophageal cancer
This trial tests whether adding immunotherapy to standard chemoradiation can help people with unresectable locally advanced esophageal cancer. It aims to improve outcomes for those who cannot have surgery.
ShanghaiAges 18–75 - NCT05427383RecruitingPhase 2/Phase 3
KN026 plus chemo for HER2-positive stomach cancer after first treatment failure
This trial tests KN026 together with chemotherapy in people with HER2-positive advanced stomach (or gastro-esophageal junction) cancer that has already grown despite first-line treatment with trastuzumab plus chemotherapy. It may help by targeting HER2 while also using chemotherapy to control the cancer.
BeijingAges 18 years+ - NCT07855029Recruiting
Quality of life after hepatitis B treatment outcomes
This study looks at how different outcomes of chronic hepatitis B treatment affect patients' quality of life. It includes people who have been functionally cured, those still on treatment, those who relapsed, and healthy controls to compare.
GuangzhouAges 18–65 - NCT06155318Recruiting
PET scan for neuroendocrine tumors
This trial tests a special PET scan to better evaluate gastroenteropancreatic neuroendocrine tumors (GEP-NETs). It may help your doctor see where the tumors are in your body.
MilanAges 18 years+ - NCT05991102Recruiting
Radiofrequency treatment with Lonsurf and Avastin for advanced colorectal cancer
This trial tests if adding a special radiofrequency treatment to the drugs Lonsurf (TAS-102) and Avastin (bevacizumab) can help people whose colorectal cancer has spread to the liver and has not responded to previous treatments. It is for patients with limited options who have already tried at least two standard chemotherapy regimens.
BerlinAges 18 years+ - NCT06168786RecruitingPhase 2
New drug combo and radiation for advanced colorectal cancer
This trial tests a new combination of drugs (cadonilimab, fruquintinib) plus targeted radiation (SBRT) for people with advanced MSS colorectal cancer who have already tried several standard treatments. The goal is to see if this combination can help shrink tumors or slow disease progression.
Wuhan, HubeiAges 18–75 - NCT06178315Recruiting
Nerve block for pain from chronic pancreatitis
This trial tests a treatment where medication is injected near nerves in the belly to block pain signals. It may help people with long-term pain from chronic pancreatitis by reducing pain without surgery.
Orlando, FloridaAges 18 years+ - NCT04732546Recruiting
Study of reproductive health in women with uterine variations
This study looks at how certain uterine (womb) variations affect diagnosis, treatment choices, and reproductive outcomes. It may help doctors better understand these conditions and improve care for affected women.
Ghent, East FlandersAges Up to 45 years - NCT04894370RecruitingPhase 2
Trial tests immunotherapy plus chemotherapy and radiation for anal cancer
This Phase 2 trial studies a combination of immunotherapy (spartalizumab), chemotherapy (mDCF includes docetaxel), and radiation to treat metastatic or returning anal squamous cell cancer. It may help shrink tumors and improve outcomes compared with standard approaches, but eligibility is strict to keep participants safe.
BesançonAges 18 years+ - NCT05833594Recruiting
Immunonutrition plus chemoradiation for unresectable esophageal cancer
This trial studies whether adding an “immunonutrition” nutrition plan to standard chemoradiation can improve outcomes for people with locally advanced, unresectable esophageal squamous cell cancer. It may help the treatment work better by supporting the immune system during therapy.
HefeiAges 18–85 - NCT06061146RecruitingPhase 2
Tislelizumab plus chemoradiation for older esophageal cancer patients
This trial tests a combination of an immunotherapy drug (tislelizumab) with chemotherapy and radiation for older adults (70+) with advanced esophageal cancer that hasn't been treated before. The goal is to see if this approach can help control the cancer while keeping quality of life.
Tianjin, Tianjin MunicipalityAges 70–90 - NCT06176885RecruitingPhase 2
Immunotherapy plus chemo and targeted therapy for MSS colorectal cancer
This trial tests adding immunotherapy to standard chemotherapy and targeted therapy for people with metastatic colorectal cancer that is MSS (microsatellite stable) and cannot be removed with surgery. It aims to see if this combination helps shrink tumors and improve outcomes.
Jinhua, ZhejiangAges 18–75 - NCT05139524Recruiting
Fever and bleeding illness study in East and Central Africa
This study looks at people with fever or unexplained bleeding in East and Central Africa to learn more about illnesses like Rift Valley fever. By joining, you can help doctors understand and better treat these conditions.
Goma, North KivuAges 2 years+ - NCT07856212Recruiting
Maintenance treatment for advanced stomach cancer in Colombia
This study looks at people with advanced stomach cancer who received a maintenance treatment after initial therapy. The goal is to see how well this approach works in real-world patients in Colombia.
Bogotá, Bogota D.C.Ages 18 years+ - NCT05604560RecruitingPhase 2
New drug combo before surgery for resectable pancreatic cancer
This trial tests two drugs, tislelizumab and SX-682, given before surgery for people with pancreatic cancer that can be removed. The goal is to see if this combination shrinks tumors and improves outcomes.
Baltimore, MarylandAges 18 years+ - NCT05618145Recruiting
Join a national study database for primary sclerosing cholangitis
This study creates a national database for people diagnosed with primary sclerosing cholangitis (PSC). It may help researchers learn more about the condition by collecting health information from participants.
AnconaAges 17 years+ - NCT06185621Recruiting
Aspirin to prevent recurrent pancreatitis
This trial tests if taking aspirin daily can prevent repeated attacks of acute pancreatitis. It's for people who have had at least two episodes of pancreatitis in the past year that were not caused by a medical procedure.
Xi'an, ShaanxiAges 14–80
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.