Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,874 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,178
- Phase 1584
- Phase 3466
- Phase 1/Phase 2389
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer294
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)103
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University89
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California465
- Arizona175
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,874 total
- NCT07227168RecruitingPhase 1
Study of STRO-004 for advanced solid tumors
This trial tests a new drug called STRO-004 for people with advanced solid tumors (cancers that have spread or come back). It aims to see if the drug is safe and effective for those who have already tried other treatments.
San Diego, CaliforniaAges 18 years+ - NCT07038538Recruiting
Better method for placing feeding tubes in children
This study tests a better way to place a thin tube from the nose to the stomach (nasogastric tube) in hospitalized children. The goal is to make the procedure safer and more comfortable for kids who need it for feeding or medicine.
Shanghai, MinhangAges Up to 18 years - NCT07081802Recruiting
Acupuncture and herbs for bowel recovery after surgery
This study tests whether a special type of acupuncture (transcutaneous electrical acupoint stimulation) along with traditional Chinese medicine can help your bowels recover faster after abdominal surgery. It is for people having surgery on the liver, gallbladder, pancreas, stomach, or intestines.
Beijing, Beijing MunicipalityAges 18–80 - NCT07082439RecruitingPhase 2
Pembrolizumab and Odetiglucan for Liver-Dominant Colorectal Cancer
This study tests a combination of two drugs, pembrolizumab and odetiglucan, in people whose colorectal cancer has spread mainly to the liver and has not responded to standard treatments. The goal is to see if this combination can shrink or slow the growth of liver tumors.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07014046Recruiting
Simple bed exercises after colorectal surgery
This study tests if doing simple leg and foot exercises while in bed after colorectal surgery can help your bowels start working again sooner and reduce bloating and discomfort.
Hong KongAges 18 years+ - NCT07060638RecruitingPhase 2
Combination therapy for severe alcoholic hepatitis
This trial tests a combination of treatments for people with severe alcohol-related liver disease (alcoholic hepatitis) that has not responded to standard care. The goal is to improve liver function and help you stop drinking.
Indianapolis, IndianaAges 18–70 - NCT07032974Recruiting
Comparing biopsy needles for pancreatic masses
This trial compares three different types of needles used during an endoscopic ultrasound to see which one gets the best tissue sample for diagnosing a solid pancreatic mass. It may help you if you need a tissue sample of your pancreas.
Bangkok, BangkokAges 18 years+ - NCT06959589Enrolling by invitationPhase 2
Combination therapy for KRAS G12C mutated colorectal cancer
This trial tests a new drug combination (IBI351, cetuximab, and FOLFIRI) as first treatment or as a second treatment after standard chemotherapy for people with KRAS G12C mutated colorectal cancer that has spread. The goal is to see if it works well and is safe.
Hangzhou, ZhejiangAges 18–75 - NCT06915337Recruiting
Magnet connection for gastric surgery
This study tests a new way to connect your stomach to your small intestine during gastric surgery using a special magnetic device. It may help people who need this type of surgery, but you must meet certain health and location requirements.
Santiago, Huechuraba, Región MetropolitanaAges 22 years+ - NCT06927258Enrolling by invitation
Herbal Granule After Polyp Removal
This trial tests whether a Chinese herbal medicine (Changyanning Granule) can help people recover after having colorectal polyps removed during a colonoscopy. It may reduce inflammation or help the healing process.
Hangzhou, ZhejiangAges 18–80 - NCT06974500Recruiting
Bowel stimulation before ileostomy closure surgery
This study tests a stimulation program for the bowel loop before surgery to close an ileostomy. It may help your bowel get ready and improve recovery after the procedure.
MadridAges 18 years+ - NCT06957626Recruiting
Predicting polyp return after removal
This study aims to develop a tool using gut bacteria and metabolites to predict if high-risk colon polyps will come back after removal. If you are between 40 and 75 and have had certain types of colon polyps removed, you may be able to help us build better prediction methods.
BeijingAges 40–75 - NCT06904378RecruitingPhase 1/Phase 2
New drug combo for advanced pancreatic cancer
This trial tests a new drug called ONT01 combined with two standard chemo drugs (gemcitabine and nab-paclitaxel) for people with pancreatic cancer that has spread and is no longer responding to first treatment. The goal is to see if this new combination can help control the cancer.
St Louis, MissouriAges 18 years+ - NCT06808971RecruitingPhase 2
Perioperative drug combo for advanced stomach cancer
This study tests a combination of four drugs given before and after surgery for a type of stomach or throat-stomach cancer that can be removed. The drugs are adebrelimab (immunotherapy), nab-paclitaxel, oxaliplatin, and tegafur. The goal is to see if this combination works better than standard treatments.
BeijingAges 18–75 - NCT06879860Enrolling by invitation
Comparing stitch vs no stitch for groin hernia repair
This study compares two ways to fix a mesh during groin hernia surgery: 3D patch with one stitch versus no stitches at all. It aims to see which method leads to less long-term pain and fewer hernias coming back. If you have a first-time, moderately large groin hernia, you may qualify.
Nanchong, SichuanAges 18–80 - NCT06850454RecruitingPhase 3
Olanzapine vs placebo for nausea from first chemo
This study tests if the drug olanzapine (commonly used for nausea) can help prevent vomiting in people receiving moderately strong chemotherapy for the first time. It may be a good fit if you're about to start treatment with oxaliplatin, irinotecan, or carboplatin and haven't had severe nausea treatments before.
Bangkok, BangkokAges 18 years+ - NCT06850688Recruiting
Remote monitoring after colorectal surgery
This trial tests a remote monitoring system to keep an eye on patients after colorectal surgery. It aims to see if this helps recovery and reduces hospital readmissions.
AngersAges 18 years+ - NCT06830304Enrolling by invitation
Boosting gastrointestinal cancer screening for high-risk adults
This study tests a new way to encourage people at high risk for gastrointestinal cancer to get screened. It compares different methods to see which works best, helping catch cancer early when it's easier to treat.
Chongqing, Chongqing MunicipalityAges 45–74 - NCT06887621RecruitingPhase 2
Adding oral amisulpride to prevent nausea after gynecologic surgery
This trial tests if adding a medication called amisulpride to standard anti-nausea drugs can better prevent vomiting and nausea after gynecologic surgery. It is for women at high risk of postoperative nausea.
São Paulo, São PauloAges 18 years+ - NCT06865924Recruiting
Understanding genetic causes in atypical PSC using liver cells
This study creates mini-livers (colangioids) from tiny tissue samples to find genetic reasons for atypical primary sclerosing cholangitis (aPSC), a rare liver disease. It aims to help doctors better understand and diagnose the condition.
Milan, MIAges 18–90 - NCT06853756Recruiting
Comparing two airway devices in children having orthopedic surgery
This trial compares two types of breathing tubes (I-gel and Ambu AuraGain) used during anesthesia to see which one causes less air to enter the stomach. It is for children ages 2-12 having planned orthopedic surgery.
Tanta, El-GharbiaAges 2–12 - NCT06867419Recruiting
Metabolic effects on fatty liver disease score
This study looks at how certain features of your metabolism affect a simple score (called the FAST score) in people with fatty liver disease (MASLD). It aims to help doctors better understand and manage the condition.
Tanta, GharbyeaAges 18 years+ - NCT06848842RecruitingPhase 2
Ivonescimab and chemotherapy for colorectal cancer that spread only to the liver
This trial tests a new drug called ivonescimab combined with chemotherapy for people whose colorectal cancer has spread only to the liver and cannot be surgically removed right away. The goal is to see if this combination can shrink the tumors enough to allow surgery or other treatments.
BeijingAges 18 years+ - NCT06824688Recruiting
Comparing robotic surgery types for rectal cancer
This trial compares two robotic surgery methods for rectal cancer: using one small incision (single-port) versus several small incisions (multi-port). The goal is to see which approach offers better outcomes while preserving the sphincter (the muscle that controls bowel movements).
ChongqingAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,874 recruiting gastroenterology studies from the U.S. registry right now, out of 12,294 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.