Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,874 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,178
- Phase 1584
- Phase 3466
- Phase 1/Phase 2389
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer294
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)103
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University89
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California465
- Arizona175
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,874 total
- NCT06850493Recruiting
Ketogenic Diet Before Weight-Loss Surgery
This study tests whether following a ketogenic diet (a low-carb, high-fat eating plan) before weight loss surgery can improve your health and recovery. You will be asked to follow the diet for a few weeks before your scheduled Roux-en-Y gastric bypass.
Veldhoven, North BrabantAges 18–65 - NCT06855355Enrolling by invitation
Can CBM588 help prevent colon polyp return?
This study tests a dietary supplement called CBM588 to see if it helps prevent new colorectal polyps from coming back. You may be eligible if you have had polyps removed before and recently found new ones.
Kaohsiung City, TaiwanAges 18 years+ - NCT06794931Recruiting
Mediterranean diet for advanced colorectal cancer during chemo
This study tests whether a modified Mediterranean diet can help people with advanced colorectal cancer who are starting chemotherapy. It aims to see if the diet improves treatment side effects and quality of life.
Vimercate, MBAges 18–80 - NCT06782594RecruitingPhase 2
Mosapride injection for bowel recovery after surgery
This trial tests an injectable medicine, mosapride citrate, to help the gut start working again after laparoscopic intestinal surgery. It may reduce bloating, pain, and time to first bowel movement.
Feixian, ShandongAges 18–75 - NCT06772064Recruiting
Rifaximin for bloating caused by SIBO
This study tests whether the antibiotic rifaximin can relieve bloating in people with small intestinal bacterial overgrowth (SIBO). If you have chronic bloating and a positive SIBO breath test, this trial may be a good fit.
Jinan, ShandongAges 18–70 - NCT06756009Recruiting
Eye scans to check liver disease and transplant outlook
This study uses advanced eye scans to see if your eyes can give clues about your chronic liver disease and how well you might do after a liver transplant. If you have advanced liver disease or cirrhosis, and are maybe waiting for a transplant, you may join.
Guangzhou, GuangdongAges 18 years+ - NCT06752031Recruiting
Improving hospital-to-home transition after colorectal surgery
This study aims to improve the process of transitioning from hospital to home after colorectal surgery in older adults. It tests a new care coordination approach to help patients recover safely and avoid complications.
Salem, MassachusettsAges 65 years+ - NCT06756022Recruiting
Dolasetron to prevent nausea from chemo in kids with leukemia
This trial tests if a medicine called dolasetron can prevent chemotherapy-related nausea and vomiting in children with acute lymphoblastic leukemia (ALL). It may help kids feel better during their first round of treatment.
Hefei, AnhuiAges 2–17 - NCT06749730RecruitingPhase 2
Study of four drugs for advanced bile duct cancer
This trial tests a combination of four drugs (adebrelimab, apatinib, gemcitabine, and cisplatin) as a first treatment for people with advanced or metastatic bile duct cancer that cannot be removed by surgery. The goal is to see if this combination helps shrink or control the cancer.
ZhengzhouAges 18–80 - NCT06777914Recruiting
Genes linked to rare liver disease and cancer risk
This study looks at whether certain family-related genes make people more likely to develop liver or bile duct cancers without a clear cause. If you had surgery or a transplant for one of these cancers and have had unexplained high liver enzymes or itching, this trial may help find genetic clues.
Bologna, BolognaAges 1 year+ - NCT06796218Recruiting
Arabic mobility test after abdominal surgery
This study tests how well a new Arabic version of a mobility scale works for people recovering from abdominal surgery. If you are between 40 and 60 years old and can read Arabic, you may be able to help.
Al MansurahAges 40–60 - NCT06727851Enrolling by invitation
Improving ERCP quality in endoscopy
This study looks at ways to improve the quality of ERCP, a procedure that uses a flexible tube with a camera to look at the bile and pancreatic ducts. It is open to adults who can understand the study information and are having their first ERCP during this hospital stay.
WarendorfAges 18 years+ - NCT06794541RecruitingPhase 2
Testing eravacycline for kids with serious belly infections
This trial tests an antibiotic called eravacycline for children (ages 8–17) with serious belly infections. The medicine is given through an IV in the hospital to see if it is safe and tolerable.
Los Angeles, CaliforniaAges 8–17 - NCT06721884RecruitingPhase 1/Phase 2
Artemisia annua for small intestinal bacterial overgrowth (SIBO)
This trial tests whether a supplement made from Artemisia annua (sweet wormwood) can help people with SIBO, a gut condition. You will take the supplement or a placebo for 5 weeks and have breath tests and blood draws to see how it affects your symptoms.
Portland, OregonAges 18 years+ - NCT06675136RecruitingPhase 1
Nab-paclitaxel PIPAC with paclitaxel and ramucirumab for stomach cancer spread to belly lining
This trial tests a new way to deliver chemotherapy directly into the belly for stomach cancer that has spread to the lining of the abdomen (peritoneal metastases). It also combines two standard chemotherapy drugs. The goal is to see if this approach can help people whose cancer progressed after first treatment.
Duarte, CaliforniaAges 18 years+ - NCT06621979Recruiting
Study of fundoplicature after omega gastric bypass
This study checks if a second surgery to wrap the top of the stomach (fundoplicature) works well for people who had severe heartburn after a specific type of gastric bypass. If you had this second surgery in the last 2 years and your heartburn is better, you may be eligible.
CornebarrieuAges 18 years+ - NCT06642857Recruiting
Predicting treatment response for advanced stomach cancer
This trial uses advanced testing to predict how well stomach cancer responds to chemotherapy combined with immunotherapy. It may help find the best treatment for advanced or metastatic stomach or gastroesophageal junction cancer that hasn't been treated yet.
Hangzhou, ZhejiangAges 18–75 - NCT06678477Recruiting
Comparing 3D vs. standard colonoscopy after positive stool test
This study compares a new 3D colonoscopy with the standard colonoscopy to see which one finds polyps better in people who had a positive stool test (FIT). If you're 40 or older and had a positive FIT, this trial may help improve how colorectal cancer is detected.
Hsinchu, TaiwanAges 40 years+ - NCT06588777Recruiting
Two Nerve Blocks for Pain After Gallbladder Surgery
This study compares two types of nerve blocks for pain relief after laparoscopic gallbladder surgery. If you take part, you will receive either an ultrasound-guided M-TAPA block or a quadratus lumborum block, and the researchers will measure how well each controls your pain.
CairoAges 21–71 - NCT06649292RecruitingPhase 3
Study of SHR-A1904 for gastric cancer with CLDN18.2
This trial tests a new drug called SHR-A1904 against standard treatments for people with advanced stomach or gastroesophageal junction cancer that has already been treated once. It is for those whose tumors are positive for a protein called CLDN18.2.
Guangzhou, GuangdongAges 18–75 - NCT06636864Enrolling by invitation
Morphine injection for better recovery after colon cancer surgery
This trial tests if giving a single injection of morphine into the spinal fluid can improve how well you feel and recover after laparoscopic surgery for colorectal cancer. The morphine is given through a spinal needle before surgery, and it may help control pain during and after the procedure.
Guangzhou, GuangdongAges 18 years+ - NCT06612411RecruitingEarly Phase 1
Testing a probiotic for diarrhea-predominant IBS
This trial tests whether a specific probiotic (Bacillus subtilis) can help relieve symptoms in people with diarrhea-predominant irritable bowel syndrome (IBS). The study also looks at whether the probiotic works by increasing a natural chemical called hypoxanthine in the body.
NanjingAges 16–80 - NCT06661291Recruiting
Using Pip App to Help Surgery Recovery
This study tests a smartphone app called Pip that helps you prepare for and recover from surgery. It is for people who have certain types of planned surgeries, like abdominal, spine, or joint replacement, and have a smartphone or tablet.
New Castle, PennsylvaniaAges 18 years+ - NCT06682533Recruiting
Comparing tegoprazan and PPI for H. pylori treatment
This trial compares two different types of stomach-acid-lowering medicines — tegoprazan and a proton pump inhibitor (PPI) — to see which works better at clearing H. pylori infection. It's for people who have not been treated for H. pylori before and can safely have a stomach scope.
SeoulAges 20–80
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,874 recruiting gastroenterology studies from the U.S. registry right now, out of 12,294 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.