Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT06189898Recruiting
Using scans to find radiation-sensitive esophageal cancer
This study tests whether a special imaging scan (functional imaging) can identify which esophageal cancers respond best to radiation. If you have stage II–IVA esophageal cancer and meet the health criteria, joining may help personalize your treatment.
BerlinAges 18 years+ - NCT06190639RecruitingPhase 2
Sintilimab after surgery for node-positive esophageal cancer
This trial tests whether giving the immunotherapy drug Sintilimab after surgery can help prevent esophageal cancer from coming back. It is for people whose cancer had spread to lymph nodes and who have already had their tumor removed.
Hangzhou, ZhejiangAges 18 years+ - NCT06194708Recruiting
Why some temporary stomas are never reversed after rectal cancer surgery
This trial looks at why some people who had a temporary stoma (a bag for waste) after rectal cancer surgery never get it reversed. It collects information from medical records to find patterns that might explain this.
Beijing, Beijing MunicipalityAges 18–100 - NCT04235114RecruitingPhase 1/Phase 2
PET scan test for EGFR-positive cancers using an antibody tracer
This study tests a special PET scan agent (an antibody tracer) to help doctors see EGFR-positive cancers without needing invasive procedures. It is mainly for early testing (Phase 1/2) to understand how well it works for imaging.
Saskatoon, SaskatchewanAges 18–80 - NCT05140746Recruiting
Predicting how well chemotherapy works before stomach surgery
This study looks for ways to predict whether neoadjuvant chemotherapy (chemo given before surgery) will work well in people with locally advanced stomach cancer. It may help doctors choose the best treatment plan sooner based on your test results.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05557448RecruitingPhase 2
N-Acetylcysteine treatment for serious acetaminophen overdose
This Phase 2 trial studies whether TYNADOTE® can treat people who have taken a harmful acetaminophen (Tylenol) overdose while checking safety. It may be considered if your overdose is high enough to put you at risk for liver injury and you can follow the treatment and follow-up visits.
Taipei, Beitou DistrictAges 20 years+ - NCT05245474RecruitingPhase 2
Before-surgery chemoradiation plus PD-1 for locally advanced rectal cancer
This trial studies giving long-course radiation and chemotherapy before surgery, plus an immunotherapy medicine (PD-1) to help the tumor shrink more. It’s for people with stage II or III rectal cancer that has not spread to distant organs.
Beijing, Beijing MunicipalityAges 18–75 - NCT06204484Recruiting
MRD-guided Chemo Timing for Early Colon Cancer
This trial is for people with early-stage colon cancer (stage II high-risk or stage III low-risk) that is not MSI-H. It uses a blood test (MRD) to see if you can safely delay or skip extra chemotherapy after surgery, based on whether the test finds any leftover cancer cells.
Guangzhou, GuangdongAges 18–70 - NCT06201065RecruitingPhase 3
Targeted therapy and immunotherapy for advanced liver cancer
This trial tests a combination of two drugs (lenvatinib and toripalimab, a type of immunotherapy) plus a special chemotherapy infusion directly into the liver artery for people with advanced liver cancer that has not been treated before. The goal is to see if adding the immunotherapy helps shrink tumors better than the standard combination.
Guangzhou, GuangdongAges 18–75 - NCT06190665Recruiting
Bead type comparison for liver cancer TACE
This trial compares two types of tiny beads used in a liver cancer treatment called TACE to see which works better. If you have liver cancer that needs TACE and your liver is still working fairly well, you may be able to join.
Beijing, Beijing MunicipalityAges 18–80 - NCT05872685RecruitingPhase 2
Perioperative chemo plus serplulimab for specific stomach cancers
This Phase 2 trial tests whether adding serplulimab (an immune medicine) to standard chemotherapy before and/or around surgery can improve outcomes for people with certain locally advanced stomach cancer. You may get serplulimab or a placebo, and researchers will compare results to see if the immune add-on helps.
Hangzhou, ZhejiangAges 18–80 - NCT07868068Recruiting
Detecting GI bleeding with HemoPill during endoscopy
This study tests a small pill (HemoPill) that detects bleeding in the stomach or intestines during an upper endoscopy. It might help doctors find the source of bleeding more quickly and accurately.
Stony Brook, New YorkAges 22 years+ - NCT07862075RecruitingPhase 4
Inebilizumab for type 1 autoimmune pancreatitis
This trial tests a new treatment called inebilizumab for type 1 autoimmune pancreatitis, a condition where the immune system attacks the pancreas. The goal is to see if this treatment can reduce symptoms and prevent damage to the pancreas and other organs.
ShanghaiAges 18 years+ - NCT07857941RecruitingPhase 2
New treatments for functional dyspepsia symptoms
This trial tests new ways to ease the stomach pain, bloating, or burning that comes with functional dyspepsia—a condition where your stomach feels upset but tests like an endoscopy look normal. The treatment aims to help your gut, liver, and brain work together better, which may reduce your symptoms.
Hualien CityAges 18–64 - NCT06205472RecruitingPhase 2
Radiation after liver cancer surgery with narrow margins
This trial tests whether adding a type of radiation (SIB radiotherapy) after liver cancer surgery can improve outcomes for patients whose tumors were removed with very narrow clear margins (less than 1 cm). It may help reduce the chance of cancer coming back in the remaining liver.
BeijingAges 18 years+ - NCT06123494RecruitingPhase 3
A trial of SHR-A1811 for HER2-positive gastric cancer
This trial tests a new drug, SHR-A1811, for people with HER2-positive stomach or gastroesophageal junction cancer that has worsened after initial treatment. It aims to see if this drug can help when standard anti-HER2 therapy stops working.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06210178Recruiting
New way to measure liver pressure without needles
This study tests a new, non-invasive method (using an MRI) to estimate pressure in the veins of the liver. If successful, it could replace the need for a catheter procedure for patients being evaluated for a liver transplant.
Leiden, South HollandAges 18–75 - NCT05265169Recruiting
Tested microwave ablation to treat liver metastases from colon cancer
This study tests whether a specific heating treatment (microwave ablation) can completely destroy small colon cancer spots in the liver. It may help patients who have limited liver tumors and need a precise, minimally invasive option.
Miami, FloridaAges 18 years+ - NCT06208917RecruitingPhase 3
Comparing two ways to give ondansetron for chemo nausea in kids
This trial compares two forms of ondansetron (a nausea medicine) — a dissolving film you put in the mouth versus a needle injection — to see which works better in preventing nausea and vomiting caused by chemotherapy in children with solid tumors.
Guangzhou, GuangdongAges 6 months–18 years - NCT02735057RecruitingPhase 1/Phase 2
Testing chemo and radiation for older esophagus cancer patients
This trial studies how well chemotherapy plus radiation works for people age 75 and older with esophagus cancer. It’s testing whether this treatment approach is safe and effective in an older age group.
BesançonAges 75–100 - NCT06215040Recruiting
Treatment for silent common bile duct stones
This trial is for people who have a stone in the main bile duct (the tube that carries bile from the liver) but do not have symptoms like fever or belly pain. It tests how well different treatments work for these ‘silent’ stones.
Daegu, Gyungsangbok-doAges 18–85 - NCT05867225Recruiting
Synthetic mesh versus surgery alone for large hiatal hernia repair
This trial compares using a synthetic, dissolvable mesh versus doing hiatal hernia surgery without mesh during laparoscopic repair. It aims to see which approach better controls symptoms and improves outcomes for people with large, symptomatic hiatal hernias.
BayonneAges 18 years+ - NCT05969041RecruitingPhase 1
Early-phase drug trial for advanced epithelial cancers
This Phase 1 study tests a new drug (MT-302) in adults with advanced or metastatic epithelial cancers that have worsened or stopped responding to standard treatment. The goal is to see how the drug works and whether it is safe for people with limited options.
Darlinghurst, New South WalesAges 18 years+ - NCT06212635Recruiting
Bleeding risk in liver cirrhosis and liver cancer
This trial studies bleeding problems in people with advanced liver cirrhosis or liver cancer. It aims to improve understanding of when blood transfusions or treatments are needed.
Stockholm, HuddingeAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.