Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,896 recruiting studies in this area right now.
By phase
- Not applicable4,922
- Phase 21,186
- Phase 1581
- Phase 3466
- Phase 1/Phase 2394
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer492
- Gastric Cancer297
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer147
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer98
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic74
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California462
- Arizona177
- Texas149
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,896 total
- NCT06722183RecruitingPhase 2
Futibatinib plus chemo-immunotherapy for advanced colorectal cancer
This trial tests a new combination of drugs (futibatinib plus chemo-immunotherapy) for people with advanced colorectal cancer who have not had prior treatment. It aims to see if this combination can shrink tumors or slow their growth.
AmbergAges 18 years+ - NCT06722534Recruiting
Celecoxib to prevent polyps from growing in Peutz-Jeghers Syndrome
This trial is testing if the medication celecoxib can stop or slow the growth of polyps in people with Peutz-Jeghers Syndrome (PJS). It may help reduce the need for surgery and lower the risk of complications.
Xi'an, ShaanxiAges 8 years+ - NCT06723236RecruitingPhase 1
Study of MGC028 for Advanced Solid Tumors
This study tests a new drug called MGC028 for people with certain advanced solid tumors that have not responded to standard treatments. The goal is to see if the drug is safe and effective.
San Francisco, CaliforniaAges 18 years+ - NCT06725121RecruitingPhase 1/Phase 2
Radiation and immunotherapy for advanced liver cancer before transplant
This trial tests combining radiation therapy with immunotherapy (AtezoBev) before a liver transplant for advanced liver cancer. The goal is to see if this approach can shrink tumors and make transplant possible for more people.
London, OntarioAges 18–70 - NCT06726161RecruitingPhase 1/Phase 2
Targeted radiation therapy for advanced liver cancer
This trial tests a new way to find and treat liver cancer that cannot be removed by surgery. First, a special dye (RYZ811) is used to see if your cancer cells have a marker called GPC3. If they do, you may receive a targeted radiation treatment (RYZ801) that seeks out those cells. This trial is for people whose liver cancer has grown despite receiving at least one prior therapy.
Birmingham, AlabamaAges 18 years+ - NCT06726642Recruiting
Blood test study for people with inherited cancer risk
This study looks for DNA fragments in blood of people with certain inherited cancer syndromes. It may help find cancer earlier or guide better monitoring. You would give blood samples every 4 months (if in the experimental group).
Vancouver, British ColumbiaAges Up to 90 years - NCT06727253Recruiting
Glycan supplement study for Crohn's disease after surgery
This trial tests whether a glycan supplement can prevent Crohn's disease from coming back after surgery to remove the diseased part of the small and large intestine. It may help people who have had this specific surgery and are not taking certain other treatments.
Lisbon, Lisbon DistrictAges 18–75 - NCT06727422RecruitingPhase 2
Rifaximin plus NAC for IBS with diarrhea
This trial tests whether a combination of two medications—rifaximin (a gut antibiotic) and NAC (a supplement that helps break down mucus)—can reduce belly pain and diarrhea in people with IBS whose symptoms are not well controlled. It may be an option if other treatments haven't worked well enough.
Los Angeles, CaliforniaAges 18 years+ - NCT06727877Recruiting
Predicting bowel disease in premature babies using gut bacteria
This study looks at the gut bacteria of premature babies to see if changes can predict a serious bowel condition (ulcero-necrotizing enterocolitis). It aims to use artificial intelligence to help doctors catch it early.
Clermont-FerrandAges Up to 1 day - NCT06728072RecruitingPhase 2
Adding antibiotics to first chemo for advanced colorectal cancer
This trial tests whether adding a short course of antibiotics to your standard first chemotherapy for stage 4 colorectal cancer can improve treatment. The antibiotics target certain gut bacteria that might affect how well the chemo works.
Richmond, VirginiaAges 18 years+ - NCT06728878Recruiting
Lymph node spread after total stomach removal for stomach cancer
This study looks at where cancer spreads in the short stomach area after total stomach removal surgery. It aims to understand lymph node and tumor deposits better to help guide future treatment decisions.
Hangzhou, ZhejiangAges 18–85 - NCT06728891Recruiting
Analyzing tumor deposits after stomach cancer surgery
This study looks at cancer cell deposits found in the area where the right and left stomach-supporting tissues meet, after surgery for stomach cancer. It may help doctors understand how cancer spreads and improve future treatment.
Hangzhou, ZhejiangAges 18–85 - NCT06730009RecruitingPhase 1/Phase 2
NK cell therapy after surgery for pancreatic or bile duct cancer
This trial tests whether adding natural killer (NK) cell therapy to standard chemotherapy after surgery can help prevent pancreatic or bile duct cancer from coming back. It is for patients who have had their tumor completely removed and are now ready for adjuvant chemotherapy.
TainanAges 18 years+ - NCT06730373RecruitingPhase 2
RC48, sintilimab, and S-1 for advanced HER2-positive stomach cancer
This trial tests a combination of three drugs—RC48 (a targeted therapy), sintilimab (an immunotherapy), and S-1 (a chemotherapy pill)—as a first treatment for advanced HER2-positive stomach cancer that has not been treated before. The goal is to see if this triple therapy works better than current options.
Zhengzhou, HenanAges 18–75 - NCT06731855Recruiting
Recovery study: blood markers in newborns after intestine surgery
This study looks at blood markers in newborns after major stomach or intestine surgery. It aims to understand recovery and could help improve care for babies with similar conditions.
Liverpool, MerseysideAges Up to 5 days - NCT06731894RecruitingPhase 2
Cannabis for nerve pain after chemotherapy in breast and colon cancer survivors
This trial tests whether a cannabis-based product can reduce nerve damage (neuropathy) caused by chemotherapy in people who have finished treatment for breast or colon cancer. It focuses on survivors who still have pain, numbness, or tingling in their hands or feet.
Duarte, CaliforniaAges 18 years+ - NCT06731998Recruiting
Improving pain control after cancer surgery
This study compares different methods of managing pain after minimally invasive surgery for abdominal cancers. It aims to find which approach works best to reduce pain and improve recovery.
Pittsburgh, PennsylvaniaAges 18–89 - NCT06732856RecruitingPhase 1/Phase 2
Zolbetuximab plus chemo before stomach cancer surgery
This trial tests a new drug called zolbetuximab combined with chemotherapy (docetaxel, oxaliplatin, S-1) before surgery for people with locally advanced stomach cancer that has a specific protein (CLDN18.2). The goal is to see if this combination shrinks tumors enough to improve surgery outcomes.
SeoulAges 19 years+ - NCT06733038RecruitingPhase 3
Chemo plus Avastin with or without Tecentriq for advanced colorectal cancer
This trial tests whether adding the immunotherapy drug atezolizumab (Tecentriq) to standard chemotherapy (FOLFOXIRI) and bevacizumab (Avastin) is more effective as a first treatment for people with a specific type of metastatic colorectal cancer that has a high immune score and is mismatch repair proficient.
Brescia, BSAges 18–75 - NCT06734156Recruiting
Gut microbiome study in colorectal cancer patients
This study looks at how bacteria and other microbes in your gut are linked to colorectal cancer risk and outcomes. By collecting stool samples from people newly diagnosed with colorectal cancer, researchers hope to find patterns that could improve understanding and future treatments.
Lisbon, Lisbon DistrictAges 40–74 - NCT06735105Recruiting
Best MRI method for staging stomach cancer
This trial uses three different MRI scanning sequences to see which best helps stage (determine the spread of) stomach cancer. The goal is to improve how doctors plan treatment for gastric cancer.
KunmingAges 18–80 - NCT06735118Recruiting
Can AI help see chemo-related fatty liver?
This study uses a special MRI technique and artificial intelligence to see how chemotherapy may cause a fatty liver. It may help find liver changes early in people who have had chemo.
Kunming, YunnanAges 18–80 - NCT06735560Recruiting
PET scan with a tracer for liver, bile duct, or neuroendocrine tumors
This trial uses a special PET scan tracer (zirconium-labelled girentuximab) to see if it can find and track certain liver, bile duct, and pancreatic/intestinal neuroendocrine tumors. It may help doctors better understand your cancer and guide treatment decisions.
NantesAges 18 years+ - NCT06736678Recruiting
Nutritional drink to reduce side effects from pancreatic cancer treatment
This trial tests a special nutritional drink (oral immunonutrition) to see if it can reduce side effects from chemotherapy and radiation in people with pancreatic cancer. It may help you feel better during treatment if you are at risk for malnutrition.
Guangzhou, GuangdongAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,896 recruiting gastroenterology studies from the U.S. registry right now, out of 12,425 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.