Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT05403242RecruitingPhase 1/Phase 2
Study drug RC48-ADC plus S-1 for advanced HER2 stomach cancers
This Phase 1/2 study tests RC48-ADC (an antibody-drug treatment) together with S-1 (a chemotherapy medicine) in people with advanced stomach or esophagus/gastroesophageal junction cancer. It’s mainly for cancers with HER2 testing results of IHC 2+ and FISH-negative, and aims to find a safe dose and how well the treatment works as a first treatment option.
BeijingAges 18 years+ - NCT05319067Recruiting
Gut bacteria study in toddlers on long-term reflux antibiotics
This study compares gut bacteria (microbiome) in toddlers who take an antibiotic to prevent urine infections for vesicoureteral reflux, versus other similar children. It may help researchers understand how long-term antibiotic use and reflux affect gut health and future risk.
MontpellierAges 1–3 - NCT05618392Recruiting
Pain check after feeding tube placement
This trial studies how much pain people feel after a radiology-guided feeding tube is placed through the skin while you’re awake with local numbing medicine. It also looks at factors that might help predict pain, to improve comfort for future patients.
ValenceAges 18 years+ - NCT05597488Recruiting
Measuring pressure to predict varice treatment response
This study checks whether a special ultrasound-guided measurement of blood pressure in your liver can help predict how well endoscopic treatment (banding varices or injecting bleeding sites) will work. It aims to improve outcomes by identifying who is more likely to respond.
Hong Kong, Hong KongAges 18–75 - NCT05473793Recruiting
Dried vegetables study for constipation and gut bacteria
This study tests whether eating a dried vegetable can improve bowel habits and change gut bacteria. It may help people who feel their bowel function is not working well and have hard or infrequent stools.
Wageningen, GelderlandAges 20–80 - NCT05430035RecruitingEarly Phase 1
HIPEC for high-risk gallbladder cancer after surgery
This early-phase study tests whether a treatment called HIPEC is safe and feasible in people with high-risk gallbladder adenocarcinoma after surgery. HIPEC delivers chemotherapy directly into the abdomen during the operation to lower the chance of cancer coming back.
Morgantown, West VirginiaAges 18 years+ - NCT05585814RecruitingPhase 2
New chemo plus immunotherapy before rectal surgery
This trial tests a combination of chemo, a medicine that blocks blood vessel growth, and an immune checkpoint drug given before rectal cancer surgery. It’s for people with locally advanced rectal cancer without distant spread, to try to shrink the tumor and improve surgical results.
ShanghaiAges 18–75 - NCT05363345Recruiting
Test of two types of baskets to remove bile duct stones
This trial compares two tools used during an endoscopy to remove large stones from the common bile duct (the tube that carries bile from the liver to the gut). It may help find which basket works better and safer for stone removal after a balloon dilation procedure (EPLBD).
Komagane, NaganoAges Any age - NCT05476263Recruiting
Negative pressure wound therapy for esophagus or rectum
This trial studies whether a device called Suprasorb CNPendo helps healing of certain full-thickness (through-and-through) injuries or wounds in the esophagus or rectum. It may be an option if your medical team is already considering negative pressure wound therapy for these specific problems.
BerlinAges 18 years+ - NCT05515315RecruitingPhase 2
Immunotherapy plus chemo then chemoradiation for esophageal cancer
This Phase 2 study tests whether adding tislelizumab (an immunotherapy drug) to chemotherapy before a combined course of chemotherapy and radiation can better treat locally advanced, non-surgable esophageal squamous cell cancer. It’s for adults who cannot have surgery and may help shrink the cancer and improve control of the disease.
Fuzhou, FujianAges 18–70 - NCT05344417Recruiting
Low-pressure gas during colon surgery to reduce post-surgery gut slowdown
This study compares a low-pressure way of filling the abdomen with gas during certain colon surgeries. It aims to see whether this helps the bowel “wake up” faster after surgery (less postoperative ileus).
Columbus, OhioAges 18 years+ - NCT05276557RecruitingPhase 3
Kids study of a breath test to check H. pylori
This Phase 3 study tests whether a urea breath test (a safe breath test) works well and is safe for children ages 3–17. It may help doctors find and manage an H. pylori infection without using repeated samples.
Doral, FloridaAges 3–17 - NCT05267379Recruiting
Study of causes of pancreatitis after ERCP
This study looks at how genes and medication processing in the body may relate to getting pancreatitis after an ERCP procedure. If you are having an ERCP and meet the criteria, your data and possibly samples may help researchers understand who is at higher risk.
Nijmegen, GelderlandAges 18 years+ - NCT05378919RecruitingPhase 2
Testing new pre-surgery treatment for locally advanced rectal cancer
This Phase 2 trial compares a pre-surgery (neoadjuvant) treatment plan versus the standard plan for people with stage II–III rectal cancer. The goal is to see which approach works better and is safe before surgery.
KaunasAges 18 years+ - NCT05356520Recruiting
Which operation is best for Siewert type II stomach cancer
This trial compares different surgical approaches for removing Siewert type II cancer at the esophagus–stomach junction. It aims to find which operation works best for people who can have the tumor removed.
Xi'an, ShaanxiAges 18–75 - NCT05555888RecruitingPhase 2
Immunotherapy plus short-course radiation for early rectal cancer
This study tests whether combining immunotherapy with a short course of radiation given before surgery can improve outcomes in early-stage rectal cancer. It may help the immune system work better against the tumor before it is removed.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT05361551Recruiting
Test-guided liver ablation for up to five colorectal metastases
This study tests a planning and confirmation software tool during a needle-based liver procedure to treat colorectal cancer metastases. It aims to help doctors cover tumors more completely while reducing the chance of leaving tumor tissue behind.
Houston, TexasAges 18 years+ - NCT05563012RecruitingPhase 2
Short radiation plus chemo and PD-1 immunotherapy for stomach cancer
This Phase 2 trial tests whether giving a short course of radiation before surgery, along with chemotherapy and a PD-1 immunotherapy drug, can improve treatment outcomes for locally advanced stomach cancer. It may help shrink the tumor before surgery and strengthen the immune system’s attack on cancer.
Wuhan, HubeiAges 18–75 - NCT06645535Enrolling by invitation
Gut Bacteria and Blood Substances in Stiff Heart Failure
This study looks at how bacteria in your gut and certain substances in your blood relate to a type of heart failure called HFpEF (where the heart is stiff and doesn't relax well). It may help doctors understand the condition better and find new ways to treat it.
Naning, JiangsuAges 18 years+ - NCT05243082Recruiting
Ultrasound-guided heating treatment for pancreatic neuroendocrine tumors
This trial tests a procedure that uses an endoscope and ultrasound to heat (radiofrequency ablate) pancreatic neuroendocrine tumors. It may help shrink tumors while aiming to be a less invasive option.
OsloAges 18 years+ - NCT05546346Recruiting
Wearable magnet tracking for capsule endoscopy
This trial checks how well a wearable magnet tracking system can guide a capsule camera through your digestive tract. It may help doctors see where the capsule is in real time without changing the basic capsule endoscopy process.
Jinan, ShandongAges 18–75 - NCT05300269RecruitingPhase 2
Test drug SHR-1701 with chemo and radiation for rectal cancer
This trial studies whether adding SHR-1701 to standard chemotherapy and long-course radiation can improve treatment for locally advanced rectal cancer that can be removed by surgery. It’s mainly for people who have not had prior rectal cancer treatment and who fit several health and cancer-spread requirements.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05173246RecruitingPhase 2
First-line treatment study for advanced small cell esophageal cancer
This Phase 2 trial tests JS001 plus TP as a first treatment for people with advanced or unresectable small cell esophageal cancer. It aims to see how well this combination controls the cancer and improves outcomes compared with starting treatment with standard options.
Guangzhou, GuangdongAges 18–75 - NCT05169073Recruiting
Virtual reality practice for gallbladder removal surgery
This trial tests whether virtual reality training can help surgeons perform laparoscopic gallbladder removal more effectively. It is meant for people scheduled for planned (non-emergency) gallbladder surgery due to gallstones or long-term gallbladder inflammation.
BaselAges 22–45
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.