Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT05984810RecruitingPhase 2
Using a glowing dye to help see pancreatic cancer during surgery
This trial tests whether a special dye (SGM-101) can help surgeons see remaining cancer cells during surgery for pancreatic cancer that has been treated before surgery. It may lead to more complete removal of the tumor.
LeidenAges 18 years+ - NCT06350370Recruiting
Colorectal Cancer Outcomes with NOSES Surgery
This study tracks patients with colon or rectal cancer who have a special type of surgery called natural orifice specimen extraction surgery (NOSES). The goal is to see how well patients do short-term and long-term after this procedure.
Beijing, Beijing MunicipalityAges 18–75 - NCT06354218RecruitingPhase 2
Serplulimab plus chemoradiation for older adults with esophageal cancer
This trial tests a new immunotherapy drug called serplulimab combined with standard chemotherapy and radiation for older adults with locally advanced esophageal cancer. It aims to see if this combination can help shrink tumors and improve outcomes without prior cancer treatment.
Nanjing, JiangsuAges 75 years+ - NCT06353672Recruiting
Robotic liver tumor removal safety study
This study is testing how safe and doable it is to use a robot to remove liver tumors. It may help researchers find a better way to perform liver surgery with fewer complications.
Hangzhou, ZhejiangAges 18–80 - NCT06241326Recruiting
Immunotherapy for liver cancer study
This trial tests immunotherapy-based combinations for liver cancer. It may help if your doctor thinks this treatment could benefit you.
Nanjing, JiangsuAges 18 years+ - NCT06354530RecruitingPhase 2/Phase 3
Study of pre-surgery therapy for advanced esophageal cancer
This trial tests a combination of drugs (anlotinib, immunotherapy, and chemotherapy) given before surgery for esophageal cancer that has not spread to other organs. The goal is to see if this approach shrinks the tumor and improves outcomes.
Chongqing, None SelectedAges 18–80 - NCT06361316Recruiting
Liposomal irinotecan with chemo after pancreatic cancer surgery
This trial tests a combination of three chemotherapy medicines (liposomal irinotecan, oxaliplatin, and tegafur) given after surgery to remove pancreatic cancer. The goal is to see if this treatment helps prevent the cancer from coming back.
Nanjing, JiangsuAges 18–75 - NCT05718440Recruiting
Checking risk factors for urinary and related issues
This study looks at why some adults with spinal dysraphism develop problems with bladder, bowel, and/or sexual function. It gathers information during a one-day visit to help doctors better understand risk factors.
ParisAges 18 years+ - NCT05187312Recruiting
Registry for advanced endoscopy procedures
This study is a registry that collects information about people who need an endoscopy procedure. It may help doctors learn which approaches work best and improve care over time.
StockholmAges 18 years+ - NCT05714124Recruiting
Testing liver procedures to treat tumors when surgery isn’t possible
This trial studies different ways to place treatments inside the liver to control liver tumors when they can’t be removed with surgery or ablation. It may help certain people by improving how well the tumor is treated while keeping liver function safer.
MilanAges 18 years+ - NCT06363006RecruitingPhase 1
Cardonizumab plus TKI for advanced liver cancer after prior treatment
This trial tests a combination of an immunotherapy drug (Cardonizumab) and a targeted therapy pill (TKI) for people with advanced liver cancer whose prior treatment has stopped working. The goal is to see if this second-line combination can help shrink tumors or slow the disease.
Beijing, Beijing MunicipalityAges 18–75 - NCT05485077Recruiting
Study of colorectal cancer screening in adults 40+
This study follows people age 40 and older to see how well colorectal cancer screening works in everyday community care. You may answer risk and follow-up questions over time, and the study looks for any cancer diagnoses that happen outside the study hospitals.
Beijing, Beijing MunicipalityAges 40 years+ - NCT03465982Recruiting
Timing surgery after chemotherapy and radiation for rectal cancer
This trial studies the best time to do surgery after you finish chemotherapy and radiation for rectal cancer. It may help improve how well minimally invasive surgery works and how safely it can be done.
Alessandria, ALAges 18 years+ - NCT04547725Recruiting
Surgery plus chemotherapy for stomach cancer in the belly lining
This study tests whether a thorough surgery to remove stomach cancer in the abdomen, followed by chemotherapy given through the belly and by vein, can improve outcomes. It’s for people newly diagnosed with stomach cancer that has limited spread to the belly lining.
TaipeiAges 20–75 - NCT06349278Recruiting
Surgery for pancreatic cancer with limited liver spread after chemo
This trial is for people with pancreatic cancer that has spread to the liver (3 spots or fewer). It tests whether removing both the original tumor and the liver spots after a specific chemotherapy (FOLFIRINOX) can be helpful. You may be eligible if the chemo shrinks the tumors enough and you are healthy enough for surgery.
Québec, QuebecAges 18 years+ - NCT06366828Recruiting
Predicting complications after esophageal cancer treatment
This study looks at past medical records of people with esophageal cancer who received chemotherapy and radiation before surgery. Researchers want to find better ways to predict who might have complications after surgery, so they can improve care for future patients.
Nijmegen, GelderlandAges 18–100 - NCT06368882RecruitingPhase 4
Peg-interferon for hepatitis B with fatty liver
This trial tests a medicine called peg-interferon for people who have both chronic hepatitis B and fatty liver. It aims to see if the treatment is safe and effective in helping your body fight the hepatitis B virus.
NingboAges 18–60 - NCT06371586RecruitingPhase 2
Neo-Sequence 2: New drug combo for advanced stomach cancer
This trial tests a new treatment plan for advanced stomach cancer using chemotherapy, anti-angiogenesis therapy (to cut off tumor blood supply), and immunotherapy (to help your immune system fight cancer). The goal is to see if this combination works better before surgery.
BeijingAges 18–75 - NCT06402188Recruiting
ColoSeal Device Study for Rectal Cancer Surgery
This study tests a new device called the ColoSeal ICD System that may help protect the reconnection of your bowel after surgery for rectosigmoid or rectal cancer. It is designed for people who are already scheduled for surgery that includes a temporary colostomy or ileostomy.
YerevanAges 18–70 - NCT06363825RecruitingPhase 2
New combination therapy for advanced liver cancer
This trial tests a combination of treatments for advanced liver cancer: a targeted therapy (apatinib), an immunotherapy (camrelizumab), and two local treatments (TAE and HAIC). It may be an option if you have a high tumor burden or a tumor thrombus in the portal vein and haven't had systemic treatment before.
FuzhouAges 18–80 - NCT06372132Recruiting
G-POEM vs PEG-J for gastroparesis treatment
This trial compares two treatments for gastroparesis: a procedure called G-POEM (which opens the stomach's outlet valve) and a feeding tube (PEG-J) that bypasses the stomach. It aims to see which is better at helping food move through the stomach.
Maastricht, Zuid-LimburgAges 18 years+ - NCT05068531Recruiting
Detecting early treatment failure in stage IV colon cancer
This study looks for early signs that treatment is not working in people with stage IV colon or rectal cancer that has spread only to the liver. It may help doctors adjust care sooner by using regular blood, stool, and tissue samples around liver procedures.
Montreal, QuebecAges 18 years+ - NCT05117723Recruiting
IPMN cyst database to help predict pancreatic cancer risk
This study collects information from people who have an IPMN cyst in the pancreas to help predict who may be at higher risk of pancreatic cancer. It may help your care team estimate risk and plan follow-up more effectively.
Fitzroy, VictoriaAges 18–90 - NCT06032676Recruiting
Surgeons’ views on infant bowel disease decisions
This study interviews surgeons who treat infants with a serious bowel condition called necrotising enterocolitis (NEC). Researchers want to understand how surgeons make decisions and how babies do afterward.
Southampton, HampshireAges Up to 4 months
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.