Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT06114836Recruiting
Feeding therapy for GERD in infants born early
This study tests whether a special feeding method can help infants in the NICU who have been diagnosed with GERD (acid reflux) using a probe that measures acid and non-acid reflux. It aims to find a treatment that may reduce reflux symptoms without medication.
Columbus, OhioAges 1 day–8 months - NCT06039800Recruiting
Hernia surgery outcomes at Shouldice Hospital
This study asks patients who had hernia surgery at Shouldice Hospital about their recovery and results. It helps doctors understand how well the surgery works.
Thornhill, OntarioAges 16 years+ - NCT06036862Recruiting
Treating rectal narrowing with a tube through the anus
This trial tests a procedure using a thin, flexible tube with a camera to fix a narrowing (stenosis) where the colon is reconnected after rectal cancer surgery. It may help people who have trouble with bowel movements due to this narrowing.
Guangzhou, GuangdongAges 18–70 - NCT05972655RecruitingPhase 2
Testing shorter rectal radiation with chemotherapy plus immunotherapy
This Phase 2 study tests whether a shorter course of radiation, combined with chemotherapy (CAPOX) and an immunotherapy drug (tislelizumab), can control middle and low rectal cancer. It may also help people who strongly want to keep their anus, if the cancer and overall health fit the study rules.
Hanzhou, ZhejiangAges 18–75 - NCT05733689RecruitingPhase 1
Testing new pre-surgery treatment for stomach and esophagus cancer
This Phase 1 trial tests how well a tailored (response-adapted) chemotherapy plan works before surgery for stomach or gastroesophageal junction cancer. It aims to improve treatment planning while checking early safety.
Orange, CaliforniaAges 18 years+ - NCT05804136Recruiting
Suture types compared after abdominal surgery closure
This trial compares two different suture materials used to close the abdominal wall after certain types of open abdominal surgery. It aims to see which suture type does a better job at healing and preventing problems at the incision site.
Ghent, Oost-VlaanderenAges 18 years+ - NCT05878015Enrolling by invitationPhase 4
IV acetaminophen for small bowel blockage symptoms
This Phase 4 study tests whether giving acetaminophen through a vein helps people with a small bowel obstruction (a blockage in the intestines) that is causing abdominal pain. It’s looking for a benefit in pain control and how people do during treatment.
Jacksonville, FloridaAges 18 years+ - NCT05863208Recruiting
AI helps doctors see better during colonoscopy
This study tests whether an AI system can improve how doctors detect and evaluate findings during outpatient colonoscopies. You may be eligible if you are having a scheduled sedated colonoscopy and do not have certain bowel conditions or bleeding risks.
Kaohsiung CityAges 40 years+ - NCT05705557Recruiting
Test of a clip system during open liver surgery
This trial studies a new clip system (ABSOLOK™) used during open liver operations. It aims to improve how surgeons control or manage parts of the liver during surgery.
Roma, RMAges 18 years+ - NCT05854303Recruiting
Stopping opioids’ effects on swallowing in esophagus problems
This study looks at how stopping opioid pain medicines affects esophagus function (the tube that carries food to the stomach), including in people with or without symptoms. It may help researchers understand what changes to expect after opioid cessation in a pain rehabilitation program.
Rochester, MinnesotaAges 18 years+ - NCT05735964Recruiting
Using dye to guide repair surgery for baby’s esophagus
This trial studies whether a special IV dye (indocyanine green, or ICG) can help surgeons during an operation to fix a baby’s esophagus blockage with an abnormal connection to the windpipe. It may help improve how the repair is done, but eligibility depends on baby’s safety factors for using the dye.
BirminghamAges Up to 1 year - NCT05677282RecruitingPhase 4
Single-dose antibiotics for sudden watery diarrhea
This trial compares rifaximin or azithromycin (both antibiotics) taken as a single dose, with loperamide to control symptoms. It’s for people with recent, watery diarrhea who can be treated and followed as an outpatient, to see which option works better and is safer.
DjiboutiAges 18–60 - NCT05813015RecruitingPhase 3
Testing S-1 after stomach cancer surgery with or without sequence therapy
This Phase 3 study compares two ways of giving S-1 medicine after curative stomach cancer surgery in stage III disease. It aims to see whether the sequential approach improves outcomes while keeping treatment safe.
Hanzhou, ZhejiangAges 18–75 - NCT05738616RecruitingPhase 3
Testing lenvatinib plus TACE and immunotherapy before liver surgery
This study tests whether a combination of the drug lenvatinib, a liver treatment called TACE, and the immunotherapy drug camrelizumab can shrink advanced hepatocellular carcinoma enough to make surgery (or “conversion resection”) possible. It may help some people live longer by improving the chance that the cancer can be removed.
Chengdu, SichuanAges 18–75 - NCT05738434RecruitingPhase 2
Testing immunotherapy plus targeted drug with short chemo for esophagus cancer
This Phase 2 study tests whether combining camrelizumab (immunotherapy) and apatinib (a targeted drug) with short-course chemotherapy can control advanced esophageal squamous cell carcinoma. It may help by improving cancer response and slowing disease growth if you’re eligible and haven’t had prior whole-body (systemic) anti-cancer treatment.
Zhengzhou, HenanAges 18–75 - NCT05761080RecruitingPhase 4
Care plan tested for kids with complicated appendicitis
This trial tests a “fast-track” recovery care plan for children after surgery for complicated appendicitis. It may help kids recover faster and with fewer problems after a laparoscopic appendectomy.
Barcelona, BarcelonaAges 2–17 - NCT05695040Recruiting
Diet workshop after bariatric surgery
This study tests whether a structured diet workshop, held about 15 days after bariatric (weight-loss) surgery, helps patients with their post-surgery eating plans. You may be invited to join the workshop if you are scheduled for surgery and can attend as required.
Clermont-FerrandAges 18 years+ - NCT05666154Recruiting
Testing a specific diet using a special camera for stomach symptoms
This study tests whether a tailored diet can improve symptoms in people with functional dyspepsia (stomach discomfort without a clear physical cause). It also uses a special in-hospital camera exam to look at the stomach lining and understand how the diet affects you.
LeuvenAges 18–70 - NCT05663775RecruitingPhase 2
Mesalamine to prevent bowel inflammation after melanoma immunotherapy
This study tests whether taking mesalamine can prevent colitis (bowel inflammation) in people with advanced melanoma who are treated with ipilimumab plus nivolumab. It may help reduce dangerous stomach or bowel side effects from this cancer treatment.
Edmonton, AlbertaAges 18 years+ - NCT05879159Recruiting
Faster home recovery after minimally invasive liver surgery
This trial studies an “enhanced recovery” plan to help some people go home sooner after minimally invasive (often robotic) liver surgery. It aims to improve comfort and outcomes while making early discharge possible for carefully selected patients.
Houston, TexasAges 18 years+ - NCT05715931RecruitingPhase 2
Surgery chemotherapy plus anti-HER2 and anti–immune therapy for HER2 stomach cancer
This Phase 2 trial tests adding chemotherapy plus trastuzumab and toripalimab around the time of surgery for HER2-positive, locally advanced stomach or esophagus-stomach junction cancer. It aims to shrink the cancer and reduce the chance it comes back by attacking it through more than one pathway.
Hangzhou, ZhejiangAges 18–80 - NCT05645055Recruiting
Biologic treatment for bowel narrowing in Crohn’s disease
This trial studies biologic medicines to treat Crohn’s disease that causes bowel narrowing (“strictures”) without needing immediate surgery. It may help reduce symptoms and complications by targeting the immune-driven inflammation behind the narrowing.
Nanjing, JiangsuAges 16–65 - NCT05651594RecruitingPhase 2
Propranolol with pembrolizumab and chemotherapy for esophageal cancer
This trial tests whether adding propranolol (a common blood-pressure/heart medicine) can improve outcomes when used with pembrolizumab plus standard chemotherapy. It is for people with advanced esophageal or gastroesophageal junction adenocarcinoma that cannot be removed with surgery.
Buffalo, New YorkAges 18 years+ - NCT05823311RecruitingPhase 3
Test lenvatinib and immunotherapy plus chemo for bile duct cancer
This Phase 3 study tests whether a combination of lenvatinib, an immunotherapy medicine (tislelizumab), and chemotherapy (gemcitabine plus cisplatin) works better for advanced bile duct cancer that cannot be fully removed by surgery. It may help people live longer or control the cancer for longer.
Hangzhou, ZhejiangAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.