Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,916 recruiting studies in this area right now.
By phase
- Not applicable4,936
- Phase 21,188
- Phase 1583
- Phase 3465
- Phase 1/Phase 2396
- Phase 4237
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer493
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer148
- Crohn Disease144
- Ulcerative Colitis140
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)107
- Liver Cancer101
- Lung Cancer99
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma89
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona174
- Texas148
- Florida135
- Massachusetts127
- Alabama123
- New York123
- Maryland87
- Ohio80
- Pennsylvania72
Recruiting studies7,916 total
- NCT06729736Enrolling by invitation
Faster recovery after colorectal cancer surgery
This trial is testing a program called ERAS (Enhanced Recovery After Surgery) to help patients recover faster after minimally invasive colorectal cancer surgery. It aims to improve your recovery and reduce hospital stay.
Seoul, SeoulAges 19 years+ - NCT06725095Enrolling by invitation
Enamel gel for gum inflammation around dental implants
This study tests whether a special enamel gel can reduce inflammation around dental implants. It might help if your implant has bleeding gums but no deeper infection.
Catania, CtAges 18–75 - NCT06722456Enrolling by invitation
Better ways to detect active IBD
This study tests non-invasive tools to find active inflammation in people with Crohn's disease or ulcerative colitis. You may need to give extra stool samples before your colonoscopy and calprotectin test.
Sherbrooke, QuebecAges 18 years+ - NCT06719622Enrolling by invitationPhase 2/Phase 3
Budesonide for Crohn's in the upper gut
This trial tests a budesonide liquid that targets inflammation in the esophagus, stomach, and duodenum (upper digestive tract) in children with Crohn's disease. It aims to see if this treatment can reduce inflammation in those areas without strong side effects.
KrakowAges 6–18 - NCT06712017Enrolling by invitation
Radioactive beads treatment for liver cancer in China
This study looks at how patients with liver cancer (HCC) respond to a treatment called SIR-Spheres, which are tiny radioactive beads placed in the liver. It is for people who received this treatment in 2023 or early 2024 and were checked for tumor response within six months after treatment.
Guangzhou, GuangdongAges 18 years+ - NCT06710314Enrolling by invitation
Metabolic syndrome and recovery after colorectal cancer surgery
This trial studies how metabolic syndrome (a mix of high blood pressure, diabetes, and other factors) changes after colorectal cancer surgery. It aims to understand why some people's metabolic syndrome gets better after their tumor is removed, which could lead to better treatments.
Chongqing, Chongqing MunicipalityAges 18 years+ - NCT06707922Enrolling by invitation
Long-term follow-up for hepatitis B treatment
This study follows patients who completed a previous trial of peginterferon alfa-2b and tenofovir for chronic hepatitis B. It checks long-term health and offers further treatment options based on your response to the earlier therapy.
BeijingAges 18 years+ - NCT06707714Enrolling by invitation
Metabolic benefits after stomach cancer surgery
This study looks at how stomach cancer surgery affects metabolic syndrome (high blood pressure, diabetes, and related conditions). It aims to understand why some patients see improvements in these conditions after surgery.
Chongqing, Chongqing MunicipalityAges 18 years+ - NCT06690216Enrolling by invitationPhase 1/Phase 2
PET scan study for PD-L1 in certain cancers
This trial tests a new PET imaging agent, [18F]AlF-NOTA-PCP2, to detect PD-L1 protein in tumors. It may help guide treatment decisions for people with glioblastoma, head and neck, lung, or esophageal cancer.
Jinan, ShandongAges 18 years+ - NCT06685939Enrolling by invitation
Comparing recovery after two types of pancreatic cancer surgery
This study compares two surgeries for pancreatic cancer: laparoscopic (keyhole) pancreaticoduodenectomy and open pancreaticoduodenectomy. It aims to see which approach leads to fewer complications during recovery.
ShanghaiAges 19 years+ - NCT06679972Enrolling by invitation
Impact of pregnancy liver condition on baby's breathing
This study looks at how a pregnancy liver condition (intrahepatic cholestasis) affects the baby's breathing after birth. It compares newborns whose mothers had this condition (and took medication for it) with newborns whose mothers did not have any liver issues during pregnancy.
Bucharest, BucharestAges 1 hour–4 weeks - NCT06679478Enrolling by invitation
Early walking after stomach or bowel surgery
This study tests whether a structured early walking plan helps people recover faster after open gastrointestinal surgery. You will use a phone app to track your steps.
KütahyaAges 18–80 - NCT06671418Enrolling by invitationPhase 3
Stenting vs drainage for blocked bile ducts from cancer
This study compares two ways to open blocked bile ducts near the liver due to cancer that cannot be removed. One method uses a stent placed through the skin (percutaneous stenting), and the other uses a tube placed through a scope (endoscopic drainage). The goal is to see which approach works better for relieving jaundice and improving quality of life.
RotterdamAges Any age - NCT06657001Enrolling by invitation
Personalized nutrition study for gut health
This study uses information from your gut bacteria (microbiome) to create personalized nutrition advice. It is for people with gut conditions like IBD, IBS, or celiac disease, as well as healthy volunteers.
Rochester, MinnesotaAges 18 years+ - NCT06649825Enrolling by invitation
Vitamin B1 for familial adenomatous polyposis
This trial tests whether taking vitamin B1 can help people with familial adenomatous polyposis (FAP) reduce the number of polyps in their colon or rectum. It is designed for people who still have most of their bowel and have more than 10 polyps.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06647264Enrolling by invitation
Study on computer-aided risk prediction for liver and gallbladder surgery
This study uses a computer program to help doctors predict risks and outcomes for patients having laparoscopic liver or gallbladder surgery. It may help improve how doctors plan and manage your care before, during, and after surgery.
Guangzhou, GuangdongAges 18–80 - NCT06639126Enrolling by invitation
Thyme extract for functional gut issues
This trial tests whether a wild thyme extract can help with functional gastrointestinal disorders (common digestive problems without a clear cause). It focuses on the extract's anti-inflammatory and metabolism-related effects.
Granada, GranadaAges 18–75 - NCT06634186Enrolling by invitation
Fiber-rich diet for liver cirrhosis patients
This study tests whether eating more dietary fiber can improve outcomes for people with liver cirrhosis and high blood pressure in the liver (portal hypertension). If you have cirrhosis, adding fiber to your diet might help.
Hanover, Lower SaxonyAges 18 years+ - NCT06624189Enrolling by invitation
Liver cancer screening decision support for cirrhosis patients
This trial tests a tool to help doctors and patients decide when to screen for liver cancer. It is for people with cirrhosis who have not had imaging in the last 6 months.
New York, New YorkAges 18 years+ - NCT06610695Enrolling by invitation
Bile acid PET/CT scan for genetic liver disorders
This study uses a special PET/CT scan with a tracer called 11C-Csar, which is similar to bile acid, to see how well your liver handles bile. It is for healthy people and those with genetic liver diseases that cause cholestasis (slowed bile flow). The goal is to improve diagnosis and understanding of these conditions.
AarhusAges 18 years+ - NCT06603987Enrolling by invitationPhase 1/Phase 2
Testing a new drug combination for recurrent solid tumors
This early-phase trial tests a new combination of drugs (CICS-1 and SPM-011) along with a special imaging scan to see if they can help people with hard-to-treat cancers that have come back. It may be an option if standard treatments are no longer working.
Osaka, OsakaAges 18–85 - NCT06603519Enrolling by invitation
Can a diet reduce inflammation after a colonoscopy?
This study tests whether a special diet can help reduce inflammation and improve gut health after a colonoscopy. It is for people who are getting a repeat colonoscopy because they've had polyps before.
San Diego, CaliforniaAges 18 years+ - NCT06597955Enrolling by invitation
Colorectal Cancer Screening Decision Aid Study
This study is testing a tool to help people decide about getting screened for colorectal cancer. If you are between 45 and 75, get care at certain health systems (like IU Health), and are due for screening, you may be able to join.
Indianapolis, IndianaAges 18 years+ - NCT06591468Enrolling by invitationPhase 2/Phase 3
Prednisone Plus Ursodeoxycholic Acid for PBC Patients
This trial tests adding prednisone (a steroid) to ursodeoxycholic acid (a bile acid medicine) for people with primary biliary cholangitis who have a specific type of liver inflammation. The goal is to see if the combination works better at controlling the disease than standard care.
Guangzhou, GuangdongAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,916 recruiting gastroenterology studies from the U.S. registry right now, out of 12,516 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.