Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,916 recruiting studies in this area right now.
By phase
- Not applicable4,936
- Phase 21,188
- Phase 1583
- Phase 3465
- Phase 1/Phase 2396
- Phase 4237
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer493
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer148
- Crohn Disease144
- Ulcerative Colitis140
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)107
- Liver Cancer101
- Lung Cancer99
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma89
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona174
- Texas148
- Florida135
- Massachusetts127
- Alabama123
- New York123
- Maryland87
- Ohio80
- Pennsylvania72
Recruiting studies7,916 total
- NCT06587152Enrolling by invitation
Robotic surgical system trial for chest and belly surgeries
This trial uses a robotic system to assist surgeons during chest and belly surgeries. It aims to see if the robot is safe and effective for procedures like hernia repair, gallbladder removal, or hysterectomy.
Hangzhou, ZhejiangAges 18–80 - NCT06583564Enrolling by invitation
ICG dye during surgery for stage III colorectal cancer
This study tests whether using a special dye during surgery helps people with stage III colorectal cancer stay cancer-free longer. The dye, called indocyanine green (ICG), makes tumors and lymph nodes glow under a special camera, helping surgeons remove them more precisely.
Changning, Shanghai MunicipalityAges 18 years+ - NCT06583395Enrolling by invitation
Meditation retreat study with fitness tracker
This trial studies people attending a 7-day meditation retreat to see how meditation affects well-being. You will wear a fitness tracker and answer surveys.
Palm Desert, CaliforniaAges 21 years+ - NCT06581120Enrolling by invitation
Stomach ultrasound study for diabetes and obesity
This study uses ultrasound to see how GLP-1 RA medications (like Ozempic) affect the stomach in people with type 2 diabetes and obesity. It may help doctors better understand how these medicines work.
Cincinnati, OhioAges 10–25 - NCT06563960Enrolling by invitation
Carbonated water for safer swallowing
This trial tests if carbonated water can help people who have swallowing problems (when liquid goes into the airway instead of the stomach). You will be given carbonated water and a swallowing exam to see if it reduces risk.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT06560879Enrolling by invitationPhase 2
Probiotics to prevent stomach problems in children with leukemia
This trial tests whether probiotics can help prevent stomach and gut side effects from chemotherapy in children with leukemia. If your child is between 6 and 17, in the right phase of treatment, and doesn't have any major gut issues, they may be eligible.
Mexico City, CoyoacanAges 6–17 - NCT06540508Enrolling by invitation
TACE with targeted immunotherapy for advanced liver cancer
This study looks at whether combining a liver-directed procedure called TACE with tiragolumab and targeted therapy works better for people with unresectable liver cancer that has not spread too far. Researchers will use blood and tissue tests to see how well the treatment works.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06540027Enrolling by invitation
Minimally invasive surgery for rectal cancer inflammation
This study looks at how different types of surgery (open, laparoscopic, or robotic) affect inflammation throughout the body in people with rectal cancer. It may help doctors understand which approach is gentler on your immune system.
IstanbulAges Any age - NCT06519448Enrolling by invitation
Testing a pill for non-alcoholic fatty liver disease
This trial tests a diabetes drug called empagliflozin to see if it can reduce fat and inflammation in the liver in people with a specific type of fatty liver disease called NASH. It may help if you have NASH and either have type 2 diabetes or don't have it.
PragueAges 18–75 - NCT06517264Enrolling by invitation
Treating mild diverticulitis without antibiotics as an outpatient
This trial tests if mild diverticulitis (a small infection in the colon) can be safely treated at home without antibiotics. If you have this condition and are otherwise healthy, you may be able to avoid a hospital stay.
MurciaAges 18–80 - NCT06509022Enrolling by invitation
Reflux study after esophageal cancer surgery
This study is for people who have had surgery for esophageal cancer. It uses a special test called PEPTEST to track acid reflux after surgery and find out what affects it.
BeijingAges Any age - NCT06475365Enrolling by invitation
Salt water gargling after neck surgery to help swallowing
This study tests whether gargling with salt water after multi-level neck fusion surgery can improve swallowing recovery. If you are having this surgery, the trial aims to find a simple, low-cost way to protect your swallowing function.
Los Angeles, CaliforniaAges 18–80 - NCT06471309Enrolling by invitation
Theta burst TMS for swallowing problems after stroke
This trial tests a type of brain stimulation called theta burst transcranial magnetic stimulation (TMS) to see if it can help people who have trouble swallowing after a stroke. It is designed for people who had their first stroke within the last 2 weeks to 6 months and are right-handed.
Zhengzhou, HenanAges 18–80 - NCT06464835Enrolling by invitation
Brain stimulation and swallowing therapy for post-stroke swallowing problems
This trial tests whether combining two types of brain stimulation (iTBS and NMES) can improve swallowing problems after a stroke. If you have had trouble swallowing for at least two weeks but no longer than six months after your stroke, you may be able to join.
Zhengzhou, HenanAges 18–80 - NCT06463223Enrolling by invitation
Liver imaging study for children with obesity
This study uses MRI scans to look at the livers of children with obesity, to find early signs of liver problems. It may help doctors understand how to protect the liver in children.
Gothenburg, Västra Götaland CountyAges 9–14 - NCT06462521Enrolling by invitation
Comparing two ways to remove large polyps during a colonoscopy
This study compares two methods for removing larger polyps (flat growths) found during a colonoscopy. It tests if one technique works as well or better than the other for people with certain types of polyps.
Indianapolis, IndianaAges 18 years+ - NCT06460402Enrolling by invitation
Ice packs and warm baths after hemorrhoid surgery
This trial tests whether using ice packs and warm baths after hemorrhoid surgery helps wounds heal faster and reduces pain more than standard care. If you are having surgery to remove hemorrhoids, this study may offer a simple, gentle way to help you recover.
Kaohsiung CityAges 18–80 - NCT06458998Enrolling by invitation
Improving cancer screening for veterans
This study looks at ways to help veterans get screened for liver cancer (hepatocellular carcinoma) and colorectal cancer. The goal is to see if certain programs or tools can make it easier for veterans to complete these important cancer screenings.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06443996Enrolling by invitation
Sleep, mood, and colorectal cancer recovery study
This study looks at how your sleep quality and emotional well-being before surgery might affect your recovery from colorectal cancer. By filling out questionnaires, you help doctors learn whether these factors play a role in the cancer coming back.
ShanghaiAges 18–80 - NCT06437288Enrolling by invitationPhase 4
Light-activated drug therapy for returning esophageal cancer
This trial tests a treatment called hematoporphyrin photodynamic therapy (a light-activated drug) for people with esophageal cancer that has come back or not fully gone away after prior treatment. It aims to see if this therapy can safely destroy remaining cancer cells in the inner layers of the esophagus.
Guangzhou, GuangdongAges 18–80 - NCT06434376Enrolling by invitationEarly Phase 1
Personalized immune therapy for ctDNA-positive colorectal cancer
This trial tests a personalized immune therapy (like a custom vaccine) for people with colorectal cancer that has a positive ctDNA MRD test after surgery. It aims to use the body's own immune system to target any remaining cancer cells and prevent the cancer from coming back.
Wenzhou, ZhejiangAges 18–80 - NCT06424769Enrolling by invitation
Managing Inflammatory Bowel Disease with Text Message Surveys
This study aims to improve care and reduce health gaps for people with inflammatory bowel disease using text-message surveys to track symptoms and guide better disease management.
Scottsdale, ArizonaAges 13 years+ - NCT06422988Enrolling by invitation
Probiotics for preventing severe NEC in premature babies
This study looks at whether giving probiotics (good bacteria) to very premature babies (born before 32 weeks) can lower the risk of a serious gut problem called necrotizing enterocolitis (NEC). The researchers will review medical records of babies born between 2016 and 2022 in England and Wales.
LondonAges Up to 7 months - NCT06409741Enrolling by invitation
Preventing gallbladder attacks after pancreatitis without surgery
This trial tests whether a procedure using an endoscope (a thin, flexible tube) can help prevent future gallbladder problems in people who have had pancreatitis from gallstones but cannot have surgery.
Alicante, AlicanteAges Any age
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,916 recruiting gastroenterology studies from the U.S. registry right now, out of 12,516 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.