Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,916 recruiting studies in this area right now.
By phase
- Not applicable4,936
- Phase 21,188
- Phase 1583
- Phase 3465
- Phase 1/Phase 2396
- Phase 4237
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer493
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer148
- Crohn Disease144
- Ulcerative Colitis140
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)107
- Liver Cancer101
- Lung Cancer99
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma89
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona174
- Texas148
- Florida135
- Massachusetts127
- Alabama123
- New York123
- Maryland87
- Ohio80
- Pennsylvania72
Recruiting studies7,916 total
- NCT05540197Enrolling by invitation
Test whether arginine affects early results after islet transplant
This trial studies whether taking arginine changes how well people do soon after an islet transplant. It may help improve early outcomes and guide care for people who are getting ready for this treatment.
Leiden, South HollandAges 16 years+ - NCT05531630Enrolling by invitation
Xylitol versus saline rinses for sinus symptoms in adults with CF
This study compares two kinds of nasal rinse packets—xylitol versus plain saline—to see which better reduces sinus symptoms. It may help adults with cystic fibrosis and long-term sinus inflammation feel better with routine, at-home nasal care.
LeuvenAges 18 years+ - NCT05508633Enrolling by invitationPhase 2
Alverine test to lower high pressure in the liver
This trial studies alverine to lower portal hypertension, which is high blood pressure in the liver that can happen with cirrhosis. If it works safely, it may reduce pressure-related complications in people with confirmed liver scarring.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05501028Enrolling by invitation
Audio-recorded gut symptom interview to help diagnose FGIDs
This trial uses natural-language conversations (spoken interactions) to improve how clinicians evaluate and diagnose functional gastrointestinal disorders, a group of conditions that affect the gut. If you are scheduled for a GI clinic visit or a diagnostic endoscopy, your recorded responses may help build better evaluation tools.
Boston, MassachusettsAges 18 years+ - NCT05497219Enrolling by invitation
Testing normal swallowing measurements using video X-rays
This study helps researchers create reference (baseline) values for how swallowing looks on video X-ray. You may qualify if you have no swallowing problems, or if you have a diagnosed swallowing-related condition with significant symptoms.
Gainesville, FloridaAges 18 years+ - NCT05492565Enrolling by invitation
Follow-up study for people on HIV prevention pills
This study follows adults who are at high risk of getting HIV while they take HIV prevention pills (PrEP). It aims to learn how well PrEP fits real-life use in people at risk and who may need extra care.
Seville, AndalusiaAges 18 years+ - NCT05443321Enrolling by invitation
Health information sharing during hospital transfers
This trial studies whether sharing patients’ health information between hospitals during transfers can improve outcomes. You may be included if you are moved from a specific partner hospital to Brigham and Women’s Hospital and admitted to certain hospital units.
Boston, MassachusettsAges 18 years+ - NCT05441475Enrolling by invitationPhase 2
Trial for advanced liver cancer using ABSK-011 plus atezolizumab
This Phase 2 study tests ABSK-011 combined with either atezolizumab or the usual care in people with advanced or unresectable liver cancer. It aims to see if the treatment helps shrink tumors and control the cancer when standard options aren’t working or can’t be used.
Hubei, Shanghai MunicipalityAges 18 years+ - NCT05433948Enrolling by invitation
Testing ways to diagnose mild brain changes in liver disease
This study looks at how well simple brain tests can detect early (minimal) thinking changes related to liver cirrhosis. It may help doctors spot these changes sooner and diagnose the condition more accurately.
EsbjergAges 18–90 - NCT05431946Enrolling by invitation
Palliative care support for people with liver cirrhosis
This trial studies a palliative care approach—comfort-focused support aimed at improving quality of life—for people with liver cirrhosis. It may help by addressing symptoms and planning care together with you and your family.
EsbjergAges 18 years+ - NCT05404503Enrolling by invitation
Check how often bile-duct cancer happens in choledochal cysts
This study looks at how frequently cholangiocarcinoma (bile-duct cancer) occurs in people with choledochal cysts (a swelling of bile ducts). It mainly uses existing imaging records to understand risk in a hospital population.
HuelvaAges Any age - NCT05338866Enrolling by invitation
Chemo plus targeted high-dose radiation for low rectal cancer
This trial tests whether combining chemotherapy with high-dose radiation guided by MRI (a special scan) can better treat low rectal cancer. It may help shrink the tumor and improve local control while targeting the tumor more precisely.
Guangzhou, GuangdongAges 18–80 - NCT05287737Enrolling by invitation
After TPIAT and blood-sugar sensor study
This study looks at outcomes after a procedure called TPIAT (total pancreatectomy with islet auto-transplantation), which aims to improve insulin function and blood-sugar control. It may help doctors better understand how people do over time after the procedure.
Leiden, South HollandAges 16 years+ - NCT05248919Enrolling by invitation
Study treatment for hepatitis C that did not work before
This trial looks at hepatitis C treatment for people whose last antiviral medicines did not fully clear the virus. It may help by testing a study drug approach for people in Pakistan who still have active hepatitis C infection.
Karachi, SindhAges 18–100 - NCT05233631Enrolling by invitation
Registry for people who had endoscopic ultrasound
This trial is a registry that collects information from people who undergo a procedure called endoscopic ultrasound (also known as EUS) at the study center. It helps doctors understand what care is used and what outcomes happen over time.
Dallas, TexasAges 18 years+ - NCT05216133Enrolling by invitation
Study WTC lung and reflux markers using noninvasive tests
This study looks at blood “biomarkers” and breathing/acid-reflux measurements in FDNY workers exposed to the 9/11 site to understand airway disease, Barrett’s esophagus, and reflux. It may help identify which people have hidden (underdiagnosed) reflux or lung involvement after 9/11.
New York, New YorkAges 37–90 - NCT05204446Enrolling by invitation
Behavior program for teens with celiac disease
This study tests a behavioral (coaching-style) program to help teens manage celiac disease. It may help by supporting teens and their parent/guardian with habits and coping skills.
Washington D.C., District of ColumbiaAges 12–16 - NCT05195944Enrolling by invitationPhase 4
Semaglutide versus sitagliptin after liver transplant for diabetes
This trial compares two diabetes medicines—semaglutide and sitagliptin—in people who have had a liver transplant and have type 2 diabetes (or diabetes after transplant). It’s looking to see which medicine works better and is safe for blood sugar control in the transplant setting.
Toronto, OntarioAges 18 years+ - NCT05192603Enrolling by invitation
Low FODMAP vs SSRD diet for IBS symptoms
This study compares two dietary approaches to see which one helps improve symptoms in people with irritable bowel syndrome (IBS). You may be asked to follow a specific diet plan and report how you feel over the study period.
MalmöAges 18–70 - NCT05171335Enrolling by invitationPhase 2
Lenvatinib plus TACE before transplant for large liver cancer
This trial tests whether taking lenvatinib (a targeted pill) before a liver procedure called TACE can help people with large hepatocellular carcinoma (HCC) get better results while waiting for a liver transplant. It may help shrink or control the cancer without stopping transplant plans.
Houston, TexasAges 18 years+ - NCT05115877Enrolling by invitation
Looking back at treatment outcomes for stomach or gut diseases
This study looks at past care for adults who had non-cancer or cancer of the gastrointestinal (stomach and intestines) tract and compares treatment outcomes. It may help improve how doctors manage these conditions in the future.
Richardson, TexasAges 18 years+ - NCT05102981Enrolling by invitation
Compare emergency versus planned stoma recovery and quality of life
This trial studies how having a stoma made in an emergency versus as a planned procedure may affect your day-to-day life and recovery. It may help doctors better understand which approach leads to better quality of life.
GothenburgAges 18 years+ - NCT05084937Enrolling by invitation
Study on celiac disease from teens into adulthood
This trial looks at how people with celiac disease transition from childhood into adulthood, using questionnaires. It also includes people without celiac disease for comparison, to help researchers understand similarities and differences during these teen years.
KuopioAges 13–19 - NCT05082077Enrolling by invitation
Liver transplant donor data registry for better organ preservation
This study builds a global registry that tracks how donor livers are matched and preserved for transplant. It may help improve how doctors keep donor livers viable before surgery by learning from real-world cases.
Birmingham, AlabamaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,916 recruiting gastroenterology studies from the U.S. registry right now, out of 12,516 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.