Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,916 recruiting studies in this area right now.
By phase
- Not applicable4,936
- Phase 21,188
- Phase 1583
- Phase 3465
- Phase 1/Phase 2396
- Phase 4237
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer493
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer148
- Crohn Disease144
- Ulcerative Colitis140
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)107
- Liver Cancer101
- Lung Cancer99
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma89
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona174
- Texas148
- Florida135
- Massachusetts127
- Alabama123
- New York123
- Maryland87
- Ohio80
- Pennsylvania72
Recruiting studies7,916 total
- NCT05047289Enrolling by invitation
Registry study for a new stomach pacemaker
This study records outcomes for people who need a new implanted stomach electrical stimulation device for severe stomach emptying problems (gastroparesis) that haven’t improved with usual treatments. It may help doctors learn which patients benefit most and how to manage the device over time.
Indianapolis, IndianaAges 18–80 - NCT05001009Enrolling by invitation
Goals of care conversation support for certain serious illnesses
This study helps primary care clinicians and their patients have structured “goals of care” conversations (about what matters most and care preferences). It may help you get clearer, earlier planning—especially if you have a serious illness and higher risk of hospitalization or death.
Palo Alto, CaliforniaAges 18 years+ - NCT04984772Enrolling by invitation
HIV and hepatitis B coinfection follow-up study in Europe
This study follows people who have both HIV and hepatitis B over time to better understand how the infection responds after starting treatment. Your information (and sometimes stored blood samples) helps researchers track changes from the start of therapy to about 2 years later.
Ages 16 years+ - NCT04984447Enrolling by invitation
Imaging the small intestine using a tube through the nose
This study uses a thin tube placed through the nose to take pictures of the small intestine. It aims to improve how the gut can be safely viewed without traditional scopes.
Boston, MassachusettsAges 18–60 - NCT04960566Enrolling by invitation
Behavior therapy for reflux symptoms tied to stress responses
This study tests a behavioral approach for people with GERD whose reflux symptoms keep coming back even after they tried an acid-blocking medicine (a PPI). It aims to help by targeting stress-related body responses that may worsen symptoms.
Chicago, IllinoisAges 18–80 - NCT04930289Enrolling by invitation
Lung transplant registry for better donor lung preservation
This study builds a worldwide database to track and improve how donor lungs are preserved before transplant. Your information may help doctors choose and manage donor lungs more effectively.
Phoenix, ArizonaAges Any age - NCT04880876Enrolling by invitationPhase 3
Oral IBS-D medicine trial for kids and teens
This trial tests whether an oral medicine (eluxadoline) can help children and teens with IBS-D, a condition that causes stomach pain and frequent loose stools. It’s a Phase 3 study, meaning it’s designed to confirm benefits and safety.
Corona, CaliforniaAges 6–17 - NCT04841057Enrolling by invitation
Study of blood and stool changes after weight-loss surgery
This study looks at how your body’s metabolism changes after a specific weight-loss surgery (gastric bypass). It may help researchers better understand what to expect and how to tailor care, while requiring blood draws and stool samples before and after surgery.
Columbia, MissouriAges 18–80 - NCT04814693Enrolling by invitation
Endoscopic removal of pancreatic dead tissue: two technique options
This trial compares two ways of clearing “walled-off” dead tissue in the pancreas using an endoscope—one is standard tools, the other is the EndoRotor® system. It aims to see which approach is safer and works better after you’ve already had drainage.
Birmingham, AlabamaAges 18 years+ - NCT04693754Enrolling by invitation
Collecting results for ultrasound-guided tumor treatment
This trial is a database study that collects information from people who are referred for a procedure using endoscopic ultrasound and heat energy to treat a tumor or enlarged lymph nodes. Your data may help doctors learn how well this treatment works in different situations.
Indianapolis, IndianaAges 14 years+ - NCT04677699Enrolling by invitation
Testing blood for signs of celiac disease and diabetes
This study screens children’s blood to look for signs of celiac disease and type 1 diabetes. It may help doctors understand who is developing these conditions early.
Seattle, WashingtonAges 1 day–7 years - NCT04646187Enrolling by invitationPhase 4
Lowering biologic doses for Crohn’s and ulcerative colitis
This trial tests whether people with Crohn’s disease or ulcerative colitis who are currently well-controlled can safely use less-frequent anti-TNF medicine. It may help reduce treatment intensity while keeping inflammation under control.
GhentAges 12–25 - NCT04579211Enrolling by invitation
Urine testing to skip repeated NTM sputum checks in cystic fibrosis
This study looks at whether a urine test (instead of repeated sputum—mucus—from the lungs testing) can help determine who with cystic fibrosis does not have certain lung germs called NTM. If the urine test works, it could reduce the need for lung sample testing while still keeping people safe.
Denver, ColoradoAges 18 years+ - NCT04565704Enrolling by invitation
Imaging checks on biopsy samples during routine scopes
This study uses special optical imaging during routine upper or lower endoscopy to look at biopsy tissue and compare what the images show with standard lab microscope results. It may help improve how doctors spot abnormal tissue during procedures.
Boston, MassachusettsAges 18 years+ - NCT04561791Enrolling by invitation
Testing a swallowable scope for early detection of Barrett’s esophagus
This study checks whether a special swallowable “camera capsule” test done in primary care can find early warning changes called Barrett’s esophagus. If it works well, it could make screening easier for people at risk.
Boston, MassachusettsAges 18–75 - NCT04539717Enrolling by invitation
Fast MRI test for liver cancer screening
This study tests a quicker MRI screening approach for people with cirrhosis to look for liver cancer early. It may help make liver cancer checkups faster and easier while still finding cancers when they are small.
Los Angeles, CaliforniaAges 18 years+ - NCT04466189Enrolling by invitation
Pancreatic cancer patients receiving proton beam treatment
This study follows people with pancreatic cancer who are planning to receive proton beam therapy. It’s meant to learn about their care and outcomes after this treatment, and you would join by agreeing to participate.
Goyang-si, Gyeonggi-doAges 19 years+ - NCT04466124Enrolling by invitation
Study of liver cancer patients getting proton beam therapy
This study follows people with liver cancer who are scheduled to receive proton beam therapy. It looks at how patients do after treatment and what to expect going forward.
Goyang-si, Gyeonggi-doAges 19 years+ - NCT04457193Enrolling by invitation
TIF surgery after successful Barrett’s ablation
This trial looks at outcomes after a procedure called TIF to help control reflux after Barrett’s esophagus has been fully treated with endoscopic ablation. You might benefit if you still have abnormal acid reflux and want an option other than lifelong acid-suppressing medication.
Baltimore, MarylandAges 18–75 - NCT04306380Enrolling by invitation
TIF patient registry for people treated at Indiana University
This study keeps information on people who already had a TIF procedure at Indiana University. It helps researchers learn from past treatments and may improve future care.
Indianapolis, IndianaAges 13 years+ - NCT04296630Enrolling by invitation
Social media for colorectal cancer screening
This study looks at whether social media messages can encourage people in Ontario to get screened for colorectal cancer. If you use Facebook and are in the right age range, you may be able to take part.
Toronto, OntarioAges 55–64 - NCT04275167Enrolling by invitation
Swallowable camera to look at the small intestine in kids
This study uses a capsule camera (a tiny camera you swallow) to help doctors see the small intestine in children with poor growth, or in some adults who are already scheduled for a scope. It may help researchers better understand what’s causing malnourishment when the reason is unclear.
KarachiAges 6 months–70 years - NCT04246970Enrolling by invitation
Training program before and after liver transplant
This trial studies a structured exercise and training program before and after liver transplantation to help people recover better. You may be able to benefit if you’re getting an elective liver transplant and can safely participate in the training plan.
Valencia, ValenciaAges 18 years+ - NCT04234139Enrolling by invitation
Study of severe alcoholic hepatitis patients before early liver transplant
This study follows people with severe alcoholic hepatitis who are being considered for an early liver transplant before they’ve been sober for 6 months. It aims to better understand this group’s situation and ethics/safety as early transplantation plans are made.
Baltimore, MarylandAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,916 recruiting gastroenterology studies from the U.S. registry right now, out of 12,516 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.