Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT02332785Recruiting
Study for people with serrated colon polyps
This study follows people who have serrated polyps in the colon to learn more about these growths. It may help doctors better understand what they are and how to manage them.
Houston, TexasAges Any age - NCT07267806RecruitingPhase 3
Camrelizumab and Apatinib with or without chemo for advanced liver cancer
This trial tests a combination of two drugs (camrelizumab and apatinib) with or without standard chemotherapy for advanced liver cancer that cannot be treated with surgery or has gotten worse after local treatments. The goal is to see if the combination helps control the cancer better.
Guangzhou, GuangdongAges 18 years+ - NCT06782685RecruitingPhase 1/Phase 2
New chemo combo for advanced pancreatic cancer
This trial compares two combinations of chemotherapy drugs for people with advanced pancreatic cancer whose first treatment stopped working. The study tests whether adding oxaliplatin and bevacizumab to liposomal irinotecan works better than a standard combination.
BeijingAges 18–75 - NCT07607249Enrolling by invitation
Floating Needle Treatment for Stomach Issues After Knee Surgery
This trial tests whether a traditional Chinese acupuncture technique called 'floating needle' can help with stomach and bowel problems that sometimes happen after knee surgery under general anesthesia. You would receive this treatment along with standard post-surgery care to see if it reduces nausea, constipation, or other digestive issues.
Guangzhou, GuangdongAges 18 years+ - NCT07271147Recruiting
Nerve stimulation plus sedative for post-op nausea
This study tests whether combining a very mild nerve stimulation (taVNS) with a sedative (dexmedetomidine) can reduce nausea and vomiting after laparoscopic surgery. It may be a good option if you are scheduled for keyhole surgery and want to feel better afterward.
Nantong, JiangsuAges 18–65 - NCT07623902Recruiting
Testing a Tongue Scan to Detect Colorectal Polyps
This study tests whether a new tongue-scanning tool called Gixam can help find advanced colorectal polyps in people with negative stool tests. If it works, it might offer a simpler screening option alongside colonoscopy.
Orlando, FloridaAges 45–84 - NCT07502053Recruiting
Can a dye help prevent a pancreas leak after Whipple surgery?
This trial tests if using a special dye during surgery can reduce the risk of a pancreatic fistula (a leak from the pancreas) after a Whipple procedure. The dye helps the surgeon see blood flow to the remaining pancreas, which may improve healing.
Girona, GironaAges 18 years+ - NCT07263386RecruitingPhase 2
Immunotherapy plus chemo for PD-L1-positive stomach cancer
This trial tests whether adding the immunotherapy drug sintilimab to standard chemotherapy (SOX) after surgery helps prevent stomach cancer from returning. It’s for people whose tumors have a protein called PD-L1 and who had cancer in at least 7 lymph nodes.
Nanjing, JiangsuAges 18–75 - NCT06775951Recruiting
Colonoscopy use: a look at its impact
This trial studies how well colonoscopies are used in normal care. It aims to understand the medical and economic effects of doing colonoscopies for the right reasons.
BolognaAges 18 years+ - NCT06697067Recruiting
Comparing two ways to close belly incisions after emergency surgery
This study compares two different stitch techniques to close the belly wall after emergency surgery for a hole in the stomach or intestines. It aims to see which method leads to better healing and fewer wound problems.
Lahore, Punjab ProvinceAges 18–60 - NCT07512427RecruitingPhase 1/Phase 2
Testing OPK-88006 for Fatty Liver Disease
This trial tests a new experimental drug called OPK-88006 to see if it can help treat MASH, a serious liver condition linked to excess fat buildup. The study has two parts: one with healthy volunteers to check safety, and one with people who have signs of fatty liver disease.
Miami, FloridaAges 18–75 - NCT04271488RecruitingPhase 1
Study drug levels in people with mild or moderate liver problems
This Phase 1 study measures how tasurgratinib (E7090) and its breakdown product move through the body in people with mild or moderate liver impairment. It aims to understand appropriate dosing and safety considerations for liver impairment.
Hakata, FukuokaAges 20–79 - NCT07717554Recruiting
Virtual yoga for diabetic stomach-pain relief
This study tests if virtual yoga classes can help people with diabetes and gastroparesis (slow stomach emptying) feel better. It looks at whether yoga can ease symptoms like nausea, bloating, and stomach pain.
Columbus, OhioAges 18–65 - NCT05927857RecruitingPhase 1/Phase 2
Testing three medicines for advanced stomach cancer after first treatment
This study tests whether a combination of ramucirumab, nal-IRI (irinotecan liposome), and trifluridine/tipiracil can work better as a second treatment for metastatic stomach cancer. It may help people whose cancer has returned or progressed after only one prior treatment plan.
Taipei, Taiwan/TaipeiAges 20–80 - NCT07628205Enrolling by invitationPhase 2
Botulinum Toxin to Help Close Large Belly Wall Hernias
This study tests whether injecting botulinum toxin (Botox) before surgery can help close large holes in the belly wall by relaxing the muscles and making it easier to bring the edges together. This might reduce complications and improve healing after surgery.
Legnano, MilanoAges 18 years+ - NCT07632079RecruitingPhase 2
Fast-Track Radiation and Chemotherapy for Esophageal Cancer
This study tests a shorter course of combined radiation therapy and chemotherapy (using drugs called paclitaxel and carboplatin) to treat esophageal cancer with the goal of curing it. The faster treatment schedule may help patients finish therapy sooner while still being effective.
AmsterdamAges 18 years+ - NCT07047729Recruiting
Early vs. standard eating after emergency bowel surgery
This trial compares two different ways of starting to eat after emergency bowel surgery: one group begins eating earlier than usual, and the other follows the standard timing. The goal is to see which approach helps you recover faster with fewer problems.
Lahore, Punjab ProvinceAges 18 years+ - NCT07517627Recruiting
Best timing for gallbladder surgery after bile duct stone removal
This study compares when to schedule gallbladder removal surgery after a procedure to clear stones from your bile duct. The goal is to find the safest and most effective timing for your treatment.
Lahore, Punjab ProvinceAges 14–70 - NCT07695649Recruiting
Minimally invasive surgery for grade 3 hemorrhoids
This study tests a less invasive surgery for severe hemorrhoids (grades 3 and 4). If you have not had hemorrhoid surgery before and do not have other anal problems, you may be able to join.
Palma de MallorcaAges 18 years+ - NCT07252999Recruiting
Hernia sac treatment comparison in boys under 18
This trial compares two ways of handling the hernia sac during surgery for boys with an inguinal hernia. The goal is to see which method leads to better recovery and fewer problems.
Ratchathewi, BangkokAges 1 day–18 years - NCT06864377Enrolling by invitation
Ventral Hernia Improvement of Treatment and Life
This study is testing a new way to treat and improve life with a ventral hernia (a hernia in the belly area). It's for people with an incisional hernia or a parastomal hernia.
KøgeAges 18 years+ - NCT06675227Recruiting
Comparing drinks for colonoscopy prep: Electrolyte beverages vs water
This trial looks at whether using electrolyte drinks instead of water to mix your colonoscopy prep medicine (sodium phosphate or polyethylene glycol) makes the prep easier or more effective. It may help you feel less bloated or nauseated during bowel preparation.
Chongqing, Chongqing MunicipalityAges 18 years+ - NCT07453823Recruiting
Synbiotic for gut health in overweight adults
This trial tests a combination supplement (a synbiotic) to see if it can improve gut function and gut bacteria in middle-aged and older adults who are overweight and have constipation. If eligible, you take the supplement daily and report how your digestion feels.
Cork, BlackpoolAges 50–70 - NCT05923086RecruitingPhase 2
Preventing stomach and gut problems after a specific gynecologic surgery
This Phase 2 study tests a plan to reduce stomach and bowel side effects after a gynecologic operation done with a longitudinal laparotomy (a specific type of incision). It uses a peridural catheter (a small tube for numbing medicine) to help prevent gastrointestinal disturbance after surgery.
BonnAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.