Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT06509230Recruiting
Predicting serious liver scarring in hepatitis B patients
This study looks at better ways to predict significant liver fibrosis (scarring) in people with chronic hepatitis B or non-alcoholic fatty liver disease. It aims to help avoid invasive tests like liver biopsy.
Hangzhou, ZhejiangAges 18–60 - NCT06510543Recruiting
Nutrition drink before and after esophageal cancer surgery
This study tests a special nutrition drink (ORAL IMPACT®) before and after esophageal cancer surgery. It aims to help patients who are malnourished get stronger and recover better.
Beijing, Beijing MunicipalityAges 18–80 - NCT06511284Recruiting
Nutrition therapy for swallowing problems after breathing tube removal
This study tests whether specialized nutrition therapy can help patients who have trouble swallowing after a breathing tube is removed. The goal is to improve recovery and quality of life for people who need a feeding tube after leaving the hospital.
Mexico CityAges 18 years+ - NCT06512480Recruiting
Robotic colorectal surgery with the Hugo RAS platform
This trial is testing a new robotic system (Hugo RAS) for planned colorectal surgeries, such as for colon or rectal cancer or diverticulosis. It aims to see how well the robot works alongside enhanced recovery programs to help you heal faster.
Elche, AlicanteAges 18 years+ - NCT05606822Recruiting
Vacuum endoscopy for leaks after esophagus stomach surgery
This trial studies an endoscopic vacuum treatment (a suction device placed through an endoscope) to help heal a leak after surgery where food/drink pathways were connected (an anastomosis). If you had an esophago-gastric leak, this treatment may be part of your care plan and is being studied for effectiveness and safety.
AmsterdamAges 18 years+ - NCT06113913RecruitingPhase 4
Switching from IV to under-the-skin infliximab after dose increase
This study tests if switching from a high-dose infliximab IV infusion to a daily or weekly injection under the skin works just as well. It is for people with inflammatory bowel disease who are already stable on IV infliximab.
Ghent, Oost-VlaanderenAges 18 years+ - NCT06525428RecruitingPhase 2
Adding radiation and immunotherapy to standard care for advanced colorectal cancer
This trial is testing a combination of standard chemotherapy, radiation therapy, and an immunotherapy drug (toripalimab) for people with metastatic colorectal cancer. It aims to see if adding radiation therapy and immunotherapy can help shrink tumors and improve outcomes.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT03222635Recruiting
Follow-up for certain early esophageal cancer found by endoscopy
This study follows people whose early esophageal adenocarcinoma was found during an endoscopy (ER) sample. The goal is to better understand what follow-up tests are needed based on higher-risk features and to watch for spread or incomplete removal.
SydneyAges 18 years+ - NCT06138028RecruitingPhase 2/Phase 3
Sintilimab plus chemo and radiation for advanced esophageal cancer
This trial tests a combination of an immunotherapy drug (sintilimab) plus chemotherapy followed by radiation therapy for advanced esophageal cancer that has spread. The goal is to see if this sequence can help shrink tumors and improve outcomes.
Qingdao, ShandongAges 18–80 - NCT05219903Recruiting
Study of children with eosinophilic gut disorders
This study looks at children ages 0–18 with eosinophilic gut disorders (EGIDs) to better understand these conditions and how they are managed. It may help doctors improve care by comparing real-world information from patients followed at participating hospitals.
PaviaAges birth–18 years - NCT06518434RecruitingPhase 2
Cannabis oil for advanced liver cancer study
This study tests if cannabis oil can help people with advanced liver cancer that cannot be treated with standard therapies. It is a small pilot study to see if the oil is safe and may improve symptoms or quality of life.
GroningenAges 18 years+ - NCT07793695RecruitingPhase 2
Zinc plus immune therapy for advanced liver cancer
This study tests whether adding zinc supplements to standard targeted and immunotherapy improves outcomes for people with advanced liver cancer. Zinc may help the immune system work better against cancer cells.
Hefei, AnhuiAges 18–75 - NCT06519500Recruiting
Growing tumor models from gastrointestinal neuroendocrine tumor surgery
This study takes tumor tissue from people having surgery for a certain type of gut or pancreas cancer (neuroendocrine tumors). The tissue is used to grow tiny 3D models called organoids in the lab, which can help researchers learn more about the tumor and find better treatments.
RomeAges 18 years+ - NCT07792980Recruiting
Study of gut bacteria in colon cancer surgery
This study uses AI to analyze gut bacteria (microbiome) in people with colon cancer before and after surgery, to see how it relates to the effectiveness of a treatment called MPRO. It may help improve recovery and outcomes.
Seoul, SeoulAges 20–80 - NCT07800754Recruiting
Stomach and esophageal cancer care in Greece
This study is for people with stomach or esophageal cancer in Greece. It is not a treatment study; it simply looks at how patients are diagnosed and treated in regular practice, so participating won't change your care.
AlexandroupoliAges 18–130 - NCT07793227RecruitingPhase 3
Testing a new hepatitis A vaccine in healthy people
This trial tests a new hepatitis A vaccine in healthy people aged 1 year and older. It aims to see how well the vaccine prevents hepatitis A and checks for any side effects.
HanoiAges 1 year+ - NCT07795164RecruitingPhase 3
Study of pemvidutide for liver scarring from MASH
This study tests an investigational medicine called pemvidutide to see if it can reduce liver scarring in people with MASH (a liver condition linked to excess weight and metabolic issues). It may help improve liver health and potentially slow or reverse the condition.
North Little Rock, ArkansasAges 18–75 - NCT04481256Recruiting
Immunotherapy with chemoradiation for esophageal cancer
This trial tests adding medicines that block TGF-beta and PD-L1 to standard chemoradiation for esophageal squamous cell cancer that can’t be removed with surgery. It aims to improve control of the cancer where it sits, while keeping treatment safe.
AmsterdamAges 18 years+ - NCT06523582Recruiting
Genetic study of neuroendocrine tumors in Mexican patients
This study aims to find genetic causes of neuroendocrine tumors in Mexican patients. By understanding your DNA, researchers hope to improve diagnosis and treatment for people with these rare conditions.
Mexico City, Mexico CityAges 18 years+ - NCT06230536Recruiting
Study of esophageal function in achalasia after POEM treatment
This trial uses a special swallowing test (high-resolution manometry with impedance) to see how well the esophagus clears food and liquid after a POEM procedure for achalasia. It may help doctors understand if the treatment is working properly.
PessacAges 18 years+ - NCT07794410Recruiting
Comparing imaging methods for diagnosing perianal fistulas
This study compares four different imaging methods (including ultrasound, MRI, and an exam under anesthesia) to see which is most accurate in detecting and classifying perianal fistulas. It aims to improve diagnosis and treatment planning for people with this condition.
Hyderabad, TelanaganaAges 18–75 - NCT07800598RecruitingPhase 4
Allopurinol to prevent liver disease complications
This study tests if allopurinol, a medicine that lowers uric acid, can help prevent serious complications in people with advanced liver disease. It may reduce the risk of problems like fluid buildup or confusion.
Dhaka, ShahbaghAges 18–70 - NCT07794787Recruiting
Predicting kidney problems in liver cirrhosis with fluid buildup
This study aims to create a formula to predict which patients with liver cirrhosis and fluid in the belly might develop kidney issues. It uses routine lab tests to help doctors identify risks early and plan better care.
New Delhi, National Capital Territory of DelhiAges 18–65 - NCT07797816RecruitingPhase 2
Targeted drug combo with radiation for advanced bile duct cancer
This trial tests a combination of two chemotherapy drugs and an immunotherapy drug, followed by targeted radiation, in people with bile duct or gallbladder cancer that cannot be removed with surgery. The goal is to see if this approach can shrink tumors and improve outcomes.
Nanjing, JiangsuAges 18–80
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.