Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT07798401RecruitingPhase 2
Tongue training device for swallowing problems after stroke
This study tests a special tongue-training device that gives you feedback to help improve swallowing after a stroke or similar condition. It uses a computer and a small sensor in your mouth to guide your exercises.
Foshan, GuangdongAges 18–80 - NCT07797959Recruiting
Thread acupuncture plus standard reflux treatment
This study tests whether adding thread-embedding acupuncture to standard acid-reducing medication helps people with gastroesophageal reflux disease (GERD) feel better. It may offer an extra option for managing symptoms like heartburn and regurgitation.
Ho Chi Minh CityAges 18–60 - NCT07797816RecruitingPhase 2
Targeted drug combo with radiation for advanced bile duct cancer
This trial tests a combination of two chemotherapy drugs and an immunotherapy drug, followed by targeted radiation, in people with bile duct or gallbladder cancer that cannot be removed with surgery. The goal is to see if this approach can shrink tumors and improve outcomes.
Nanjing, JiangsuAges 18–80 - NCT07800598RecruitingPhase 4
Allopurinol to prevent liver disease complications
This study tests if allopurinol, a medicine that lowers uric acid, can help prevent serious complications in people with advanced liver disease. It may reduce the risk of problems like fluid buildup or confusion.
Dhaka, ShahbaghAges 18–70 - NCT07795294Recruiting
Swallowing exercises for head and neck cancer patients
This trial tests a swallowing exercise program for people getting chemoradiotherapy for head and neck cancer. The goal is to help you swallow better and reduce side effects from treatment.
CairoAges 20–60 - NCT07795645Recruiting
AI model training for stomach, heart, and brain diseases
This study is testing an artificial intelligence (AI) system that learns from your medical records to better understand and possibly help with diseases like stomach issues, heart problems, and strokes. It may improve how doctors use information from your visit to guide your care.
BeijingAges 18 years+ - NCT07796113RecruitingPhase 2
Study of adebrelimab plus famitinib and chemo before surgery for esophageal cancer
This trial tests a combination of an immunotherapy drug (adebrelimab) and a targeted therapy (famitinib) with chemotherapy before surgery for esophageal cancer. The goal is to see if this approach can shrink the tumor and improve surgical outcomes.
Xi'an, ShannxiAges 18–75 - NCT07793487Enrolling by invitation
Testing a special dairy drink for gut and metabolic health
This study tests whether a special dairy product can help improve symptoms in people with irritable bowel syndrome or early signs of metabolic syndrome. Participants must be at a healthy weight and not have other major health conditions or be on certain diets.
WarsawAges 18 years+ - NCT07799935Recruiting
Tumor ablation after chemo for advanced pancreatic cancer
This study tests a procedure called irreversible electroporation (IRE), which uses electric pulses to destroy cancer cells, after chemotherapy for advanced pancreatic cancer that hasn't spread. It aims to control the tumor and improve outcomes in people who are not eligible for surgery.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT07795749RecruitingPhase 2
Intraperitoneal paclitaxel with systemic therapy for gastrointestinal cancer with peritoneal spread
This study tests a treatment that combines chemotherapy given directly into the abdomen (intraperitoneal) with standard systemic chemotherapy for people whose gastrointestinal cancer has spread to the lining of the abdomen (peritoneal carcinomatosis). It aims to control the cancer and improve how patients feel.
Orange, CaliforniaAges 18 years+ - NCT07793799Enrolling by invitation
Comparing brain stimulation treatments for swallowing problems after stroke
This study tests three non-invasive brain stimulation methods to see if they can help improve swallowing after a stroke. If you have swallowing difficulties due to a stroke, this research might offer a new way to support your recovery.
IstanbulAges 18 years+ - NCT07797673RecruitingPhase 1
Stem cell therapy for babies with biliary atresia
This trial tests a new treatment using stem cells from umbilical cord blood or tissue, given to infants with biliary atresia during their Kasai surgery. The goal is to improve liver function and reduce the need for a liver transplant.
Jakarta Pusat, DKI JakartaAges 4 weeks–3 months - NCT07794618Recruiting
Video review of safe appendix surgery for children
This study looks at videos of appendix removal surgery in children to see if they can help make surgery safer. If your child is having this surgery, the video may help doctors learn how to prevent problems.
Kayseri, KayseriAges 5–17 - NCT07795528Recruiting
Blood test to monitor colon cancer after surgery
This trial uses a simple blood test to look for tiny bits of tumor DNA after colon cancer surgery. If found, it may help doctors catch any remaining cancer early and guide further treatment.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06525909Recruiting
Immune status in chronic hepatitis B
This study looks at how the immune system changes over time in people with chronic hepatitis B. It will help doctors better understand the stages of the disease to guide treatment decisions.
Wuhan, HubeiAges 18–50 - NCT06536998Recruiting
Liver Cancer Imaging and Tumor Study
This study looks at how liver cancer appears on CT or MRI scans and how it connects with the tumor's biology. It aims to find better ways to understand and treat liver cancer by linking imaging features with the tumor environment.
Wuhan, HubeiAges 18 years+ - NCT03488953Recruiting
Two-step liver surgery using a living donor transplant
This study looks at a specialized liver transplant approach using a living donor, for people with colorectal cancer that has spread only to the liver and cannot be removed by standard surgery. It’s meant for cases where chemotherapy has helped stop or shrink the tumors, to improve the chance of successful treatment.
JenaAges 18 years+ - NCT06513598Recruiting
Finding infection signs after abdominal cancer surgery
This study looks for ways to better predict and catch infections after major abdominal cancer surgery. If you are having surgery for certain cancers (esophagus, stomach, pancreas, liver, bile ducts, colon, or rectum), the researchers will check your blood and other samples for early signs of infection so they can start treatment sooner.
VilniusAges 18 years+ - NCT06524245Recruiting
Predicting Colorectal Cancer Recurrence with Portal Vein Blood
This study looks at blood from a special vein near your liver (portal vein) to find markers that might predict if colorectal cancer will come back. The goal is to create a better way to identify patients who may need closer monitoring after surgery.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06454578RecruitingPhase 2
Study of adebrelimab plus apatinib after liver cancer surgery
This trial is testing a combination of two drugs (adebrelimab and apatinib) after liver cancer surgery to see if it can lower the chance of the cancer returning. It is for people whose tumors had high-risk features.
Jinan, ShandongAges 18 years+ - NCT05651724Recruiting
MASH screening study for people with diabetes or obesity
This study screens participants for MASH (a type of liver fat inflammation) using information about your health and risk factors. It may help you and your care team learn whether you could have MASH and need follow-up.
Brussels, Vlaams-brabantAges 18–75 - NCT06532110Recruiting
Gut bacteria study in chronic digestive diseases
This study looks at the bacteria in your gut (the microbiome) in people with chronic gut conditions. Researchers want to understand how gut bacteria differ in these conditions to help improve treatments.
Hamilton, OntarioAges 18–75 - NCT06090110Recruiting
Vagus nerve stimulation for irritable bowel syndrome
This study tests whether a gentle electrical device that stimulates the vagus nerve can help relieve symptoms of irritable bowel syndrome. If you have IBS and are between 18 and 75, you may be able to join.
Maastricht, LimburgAges 18–75 - NCT04534543Recruiting
Imaging scans to personalize chemotherapy for liver spread of bowel cancer
This trial tests whether special liver imaging can help doctors choose or guide the best chemotherapy for people with liver metastases from gastrointestinal cancer. The study focuses on comparing imaging-based information with outcomes during common chemo treatments like CAPOX or FOLFOX.
AmsterdamAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.