Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT06766578RecruitingPhase 2
Low-dose radiation plus immunotherapy and chemo before gastric cancer surgery
This trial tests a new combination of low-dose radiation, an immunotherapy drug (tirelizumab), and chemotherapy (SOX) given before surgery for locally advanced gastric or gastroesophageal junction cancer. The goal is to see if this approach can shrink tumors more effectively.
Jinan, ShandongAges 18–75 - NCT06764875RecruitingPhase 3
New drug combo for HER2-positive stomach cancer
This trial tests a new immunotherapy called rilvegostomig combined with standard chemotherapy and a targeted therapy (trastuzumab deruxtecan) for people with advanced HER2-positive stomach or gastroesophageal junction cancer that has not been treated before.
Anchorage, AlaskaAges 18 years+ - NCT06761846RecruitingPhase 2
Immunotherapy and chemo after stomach cancer surgery
This trial tests whether adding the immunotherapy drug sintilimab to standard chemotherapy after surgery can help prevent stage III stomach or gastroesophageal junction cancer from coming back. You may qualify if you had D2 surgery and your tumor tested positive for PD-L1.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07529119Recruiting
Mango and Chia Drink Effects on Gut Health in Children
This study tests whether a special drink made with mango and chia seeds can improve gut bacteria health in children who are overweight or obese. Researchers want to see if this drink might help with weight and digestion.
Coronel OviedoAges 8–16 - NCT04996511Recruiting
Short-stay colon surgery optimization study
This study looks at how to improve care and planning for people having colon surgery as a short hospital stay. It may help hospitals run the process more smoothly and safely.
LahtiAges 18–100 - NCT06762405RecruitingPhase 3
Testing dostarlimab with short radiation for MSI rectal cancer
This trial tests a new approach: giving the immunotherapy drug dostarlimab along with a short course of radiation before surgery, with the goal of avoiding surgery in many patients. It is for people with a specific type of rectal cancer (MSI-H or dMMR) that has not spread to other organs.
DijonAges 18 years+ - NCT07230769Recruiting
Bougie size effect on stomach sleeve surgery results
This trial compares different bougie sizes during laparoscopic sleeve gastrectomy to see which works best. It's for adults with obesity (BMI 30+ with related health issues or BMI 35+), who have not had prior stomach surgery and have minimal acid reflux.
Alexandria, Alexandria GovernorateAges 18–70 - NCT07041229Enrolling by invitation
Comparing two ways to remove large colon polyps
This trial is for people with large (20-60 mm), non-cancerous colon growths on a wide base. It compares two endoscopic removal methods—ESD and EMR—to see which works best.
MoscowAges 18–100 - NCT07232875RecruitingPhase 3
New drug combo for first-line advanced pancreatic cancer
This trial tests a new drug (HRS-4642) combined with standard chemotherapy as a first treatment for advanced pancreatic cancer that has spread. It may help shrink tumors and extend life.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07231120RecruitingPhase 1
Testing SXRN injection for cancer-related weight loss
This trial tests a new injection called SXRN for people with advanced cancer who have lost weight and appetite (cancer cachexia). The goal is to see if it is safe and might help improve weight and appetite.
Beijing, Beijing MunicipalityAges 18–75 - NCT07238309Recruiting
Comparing two ways to reinforce stomach stapling during gastric bypass
This trial tests two methods—oversewing stitches versus surgical clips—to lower the chance of bleeding after a type of gastric bypass surgery called one anastomosis gastric bypass. If you qualify, you may help find the safest technique.
Cairo, Cairo GovernorateAges 18–80 - NCT07531615Recruiting
Abdominal Pressure Monitoring During Hernia Repair Surgery
This study measures abdominal pressure before, during, and after hernia repair surgery to understand how the body responds to treating hernias. It may help doctors improve surgical techniques and patient recovery.
Nice, Alpes-MaritimesAges 18 years+ - NCT07076212RecruitingPhase 2
Comparing two chemo combos for advanced pancreatic cancer
This study compares two chemotherapy combinations for people with advanced (locally advanced or metastatic) pancreatic cancer that hasn't been treated yet. The goal is to see which combination works better and has fewer side effects.
Charleston, South CarolinaAges 18 years+ - NCT07534241Recruiting
Reishi Mushroom for Fatty Liver Disease
This study tests whether reishi mushroom (a type of fungus) can improve liver health in people with metabolic dysfunction-associated fatty liver disease—a condition where fat builds up in the liver. Researchers want to see if this natural supplement can reduce liver inflammation and improve blood sugar and cholesterol levels.
LahoreAges 35–65 - NCT06930118RecruitingPhase 2
Study of 4 drugs for advanced colorectal cancer
This trial tests a combination of four drugs for people with advanced colorectal cancer who have already tried at least two other treatments. The goal is to see if this new mix can help shrink tumors or slow the cancer's growth.
ShanghaiAges 18 years+ - NCT06696209Recruiting
Best way to measure time during an upper GI endoscopy
This trial compares two ways of measuring time during an upper GI endoscopy (a camera test that looks at your esophagus, stomach, and the start of your small intestine) to see which one helps doctors find possible cancers better. The goal is to improve how these exams are done for people who need them for diagnosis or monitoring.
CoimbraAges 18 years+ - NCT07066540Recruiting
Trial of Reamberin for Viral Stomach Infections in Children
This trial tests if the drug Reamberin, given through an IV, can help children aged 1 to 6 recover faster from a viral stomach infection. It's for kids who need fluids through a vein and have symptoms like vomiting, fever, and tiredness.
ChelyabinskAges 1–6 - NCT07685353Recruiting
Genes and graft fat after liver transplant study
This study looks at how genetic differences between liver donors and recipients affect fat buildup in the new liver after transplantation. It may help doctors understand why some transplanted livers develop steatosis (fatty liver) after the surgery.
New DelhiAges 18 years+ - NCT06223893Recruiting
Smartphone app to improve care after cirrhosis hospitalization
This study tests how well a smartphone app helps people with cirrhosis who have been hospitalized for sudden liver problems. It aims to improve care and access to treatment after you go home.
BirminghamAges 18 years+ - NCT05428267Recruiting
Sexual function study for people with cirrhosis
This study looks at sexual dysfunction in people who have cirrhosis (scarring of the liver). It may help researchers understand causes and better care for sexual problems in this condition.
ParisAges 18 years+ - NCT05015283Recruiting
Gastric bypass type surgery to help type 2 diabetes go into remission
This study compares two kinds of weight-loss surgeries to see which helps people with type 2 diabetes reach diabetes remission more safely. It may help if your diabetes is not well controlled and your care team recommends one of these operations.
Beijing, Beijing MunicipalityAges 18–65 - NCT06698692Recruiting
Preventing low blood counts with trilaciclib after chemoradiation for esophageal cancer
This trial tests an investigational drug called trilaciclib that is given before chemoradiation to help protect your bone marrow and reduce side effects like low blood counts. It is for people with a specific type of esophageal cancer who have finished their main treatment.
Nanjing, JiangsuAges 18 years+ - NCT06128018Recruiting
Endoscopic vs surgical bypass for stomach blockage
This study compares two ways to help with gastric outlet obstruction (a blockage in the stomach or small intestine) caused by a tumor. It tests if a procedure using an endoscope (a long, flexible tube with a camera) is as good as surgery to help you eat and drink more comfortably.
Orlando, FloridaAges 18 years+ - NCT06715384Recruiting
Testing a new camera tool to measure colon polyps
This trial tests a computer-assisted measurement system during a colonoscopy to see if it can more accurately measure polyps. You might consider this if you are scheduled for a routine colonoscopy for screening or monitoring.
Shanghai, Shanghai MunicipalityAges 18–85
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.