Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT05990218Recruiting
AI for finding right-sided colon polyps
This trial tests whether artificial intelligence can help doctors find polyps on the right side of the colon during a colonoscopy, especially for doctors with different levels of experience.
Bangkok, BangkokAges 40–80 - NCT06710067Recruiting
Urine chemicals for diagnosing disease
This study looks at chemicals in urine to help find new ways to diagnose diseases. You give one urine sample and answer a few questions—no treatment or long-term follow-up needed.
Encinitas, CaliforniaAges 18 years+ - NCT07563738RecruitingPhase 1/Phase 2
ODM-212 with cancer immunotherapy for advanced solid tumors
This trial tests a new drug called ODM-212 combined with existing cancer treatments for mesothelioma, pancreatic cancer, or lung cancer with a specific genetic mutation. The study aims to find the right dose and see if adding ODM-212 helps these treatments work better.
Irving, TexasAges 18 years+ - NCT07564505RecruitingPhase 4
Adalimumab Safety and Effectiveness in Children With Crohn's Disease
This study tracks how well and how safely a medicine called adalimumab works in children ages 6–17 with moderate-to-severe Crohn's disease (a condition causing inflammation in the digestive tract). Your child's doctor has already decided adalimumab is appropriate for them, and this study simply collects information about how they respond to it.
Guangzhou, GuangdongAges 6–17 - NCT07567131Recruiting
Understanding sun sensitivity in rare porphyria disorders
This study tracks how your body reacts to sunlight if you have erythropoietic protoporphyria (EPP) or X-linked protoporphyria (XLP)—rare genetic conditions that cause painful skin reactions to sun exposure. Researchers will use special devices and daily logs to better understand your symptoms and how light affects your skin.
Boston, MassachusettsAges 12 years+ - NCT07564466RecruitingPhase 2
SKB571 treatment for gastrointestinal tumors
This study tests a new drug called SKB571 in people with stomach, intestinal, or related cancers. The goal is to see if it can shrink tumors and help patients live longer.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT07563309Recruiting
Testing a new rapid HIV, hepatitis B, and syphilis test
This study evaluates a new rapid blood test that checks for HIV, hepatitis B, and syphilis all at once. Researchers want to make sure the test works well, is easy to use, and gives accurate results.
Johannesburg, GautengAges 18 years+ - NCT02434445Recruiting
Blood and urine tests to predict kidney failure in cirrhosis
This study checks new blood and urine tests to predict who with advanced liver scarring (cirrhosis) will develop hepatorenal syndrome, a serious kidney problem. The results may help doctors spot risk earlier, especially for people being referred for a liver transplant.
Hong KongAges 18–90 - NCT05064124Recruiting
Real-time healthcare system during colonoscopy for colon cancer
This study tests a new real-time healthcare system meant to improve how doctors find and monitor colon cancer risk during colonoscopy. You might be able to take part if you are scheduled for a non-emergency colonoscopy and meet other safety and medical criteria.
LondonAges 18 years+ - NCT05859750RecruitingPhase 2
AK104 plus chemotherapy for advanced pancreatic cancer
This trial tests AK104 (an antibody medicine) given with standard chemotherapy as the first treatment for advanced pancreatic ductal cancer. It aims to see whether this combination works better and is safe for people with cancer that has spread or is advanced.
Beijing, Beijing MunicipalityAges 18–75 - NCT06259396Recruiting
8x5 Diet for Bile Acid Diarrhea
This trial tests a special 8-hour eating window (8x5 Diet) for people with bile acid diarrhea. It aims to see if this diet can help manage symptoms when medication alone is not enough.
Manchester, Greater ManchesterAges 18 years+ - NCT07562659RecruitingPhase 2
Blood Test to Guide Chemotherapy After Colon Cancer Surgery
This study helps doctors decide whether you need chemotherapy after colon cancer surgery by checking for cancer DNA in your blood. The goal is to give chemotherapy only to patients who truly need it, based on what the blood test shows.
ShanghaiAges 18–80 - NCT07562503RecruitingPhase 2
Blood Test to Guide Colorectal Cancer Follow-Up Treatment
This trial tests whether a special blood test that detects cancer DNA can help doctors decide if you need additional chemotherapy after colorectal cancer surgery. The goal is to personalize treatment based on your individual risk rather than giving chemotherapy to everyone.
ShanghaiAges 18–80 - NCT07568223Recruiting
Testing artisanal bread tolerance in bread-sensitive adults
This study compares how your body responds to artisanal (handmade) bread versus conventional store-bought bread if you've experienced discomfort after eating regular bread. Researchers will track symptoms and measure markers in your blood and stool to understand why artisanal bread might be better tolerated.
BobignyAges 18–65 - NCT07561138Recruiting
Nutrition and Exercise Training Before Liver Transplant
This study tests whether eating better and doing gentle exercise before your liver transplant can help you stay healthier and recover better after surgery. You'll work with a nutrition expert and exercise specialist to prepare your body for transplant.
Athens, AtticaAges 18–70 - NCT07560566RecruitingPhase 2
Preventing Hand-Foot Skin Reaction in Liver Cancer Treatment
This study tests whether a topical anti-inflammatory cream (indomethacin) applied preventively to hands and feet can reduce a painful skin side effect called hand-foot syndrome that occurs in advanced liver cancer patients taking sorafenib. If effective, it could help patients tolerate their cancer medication better.
TaipeiAges 18 years+ - NCT07561840Recruiting
Exercise Training After Stomach or Esophagus Cancer Surgery
This study tests whether a guided exercise program helps people recover better after surgery for esophageal or gastric (stomach) cancer. Researchers will track your strength, fitness, and quality of life over time.
Hirakata, OsakaAges 18 years+ - NCT07561060RecruitingPhase 1/Phase 2
Immunotherapy plus chemotherapy for early rectal cancer
This trial tests whether adding an immunotherapy drug called tislelizumab to standard chemotherapy and radiation can help patients with early-stage rectal cancer (cancer within 3 cm of the opening of the rectum) avoid surgery or improve surgery outcomes. The goal is to see if this combination is safe and effective.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07562711RecruitingPhase 2
Blood Test to Guide Chemotherapy After Colon Cancer Surgery
This study uses a simple blood test to detect cancer DNA after surgery for early-stage colon cancer. The goal is to help doctors decide whether chemotherapy is truly needed based on the blood test results, rather than giving it to everyone.
ShanghaiAges 18–80 - NCT07564609Enrolling by invitation
Infliximab injection therapy outcomes in inflammatory bowel disease
This study tracks how patients with Crohn's disease or ulcerative colitis respond to infliximab (a biologic medication) given as injections under the skin after an initial IV dose. Researchers want to understand which patients benefit most and for how long.
AmiensAges 18 years+ - NCT07564947Enrolling by invitation
Reishi Mushroom for Fatty Liver Disease
This study tests whether Ganoderma lucidum (reishi mushroom) can improve liver health and reduce inflammation in people with fatty liver disease. Researchers will measure how it affects your liver function and antioxidant levels.
Peshawar, Khyber PakhtunkhwaAges 35–49 - NCT07565714Recruiting
AI-Guided Imagery Therapy for Anxiety and Childhood Memories
This research tests a new computer-assisted therapy that helps people with anxiety process difficult childhood memories involving parental criticism. The AI guides you through imagining and reworking these memories to reduce anxiety symptoms.
Poznan, WielkopolskaAges 18–35 - NCT07567716Enrolling by invitation
Study of How Advanced Esophageal Cancer Spreads After Surgery
This research examines tissue samples from patients who had surgery to remove advanced esophageal cancer in the neck or chest area. The study aims to understand how the cancer invaded surrounding tissues, which may help doctors better treat similar patients in the future.
ShanghaiAges Any age - NCT07559968Recruiting
Comparing two types of stents for bile duct cancer blockage
This study compares two different metallic stent designs to help keep bile ducts open in patients with advanced bile duct cancer. You would already have a temporary drainage tube in place and be scheduled for a permanent stent, so this trial tests which stent type works better.
Seoul, SeoulAges 19 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.