Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT05472922Recruiting
Small stomach bypass surgery for weight loss
This trial compares a “mini” gastric bypass procedure to help with weight loss in adults who qualify for bariatric (weight-loss) surgery. It’s testing whether the approach works well and is safe for people who meet the study requirements.
AlmeloAges 18 years+ - NCT07438106RecruitingPhase 2
HRS-4642 with chemo to shrink pancreatic cancer before surgery
This trial tests a new drug, HRS-4642, combined with a two-drug chemotherapy (nab-paclitaxel and gemcitabine) for people with locally advanced pancreatic cancer that has not spread. The goal is to shrink the tumor enough so it can be surgically removed.
NanjingAges 18–75 - NCT06885385RecruitingPhase 2
Study of JS207 with or without JS015 and chemo for colorectal cancer
This trial tests a new drug combination (JS207 with or without JS015) along with chemotherapy for people with advanced colorectal cancer that has not spread to other parts of the body. It aims to see if the treatment is safe and helps shrink tumors.
Beijing, Beijing MunicipalityAges 18–75 - NCT07109713Recruiting
Cranberry products and women's health study
This trial tests if cranberry-based products can affect the natural balance of bacteria in the female body. It aims to understand how diet might support women's health.
Chicago, IllinoisAges 18–45 - NCT07049952RecruitingPhase 2/Phase 3
A feeding study for babies learning to eat
This study tests if a device (taVNS) placed on the ear can help babies born after 39 weeks who are having a hard time learning to eat by mouth. It may help them improve their feeding skills.
Charleston, South CarolinaAges 9 months–1 year - NCT06100055Recruiting
Small vs large volume rectal irrigation for constipation
This study compares two different ways of using a water-based treatment (rectal irrigation) to help people with long-term constipation caused by trouble emptying the bowels. It looks at whether using more or less water works better.
LondonAges 18 years+ - NCT06099119RecruitingPhase 4
PERT for pancreatic enzyme insufficiency in pancreatic cancer
This trial tests if a pancreatic enzyme replacement therapy (PERT) helps weight loss caused by tumors in the head of the pancreas. It may improve nutrition for people with advanced pancreatic cancer.
Milan, MilanAges 18 years+ - NCT06097637Recruiting
Removing large stalked colon polyps: a comparison of two methods
This study compares two ways to remove large, stalked polyps in the colon. One method uses water to lift the polyp before cutting it, and the other uses a small metal clip and a hot snare. The goal is to find which technique is safer and more effective.
Ningbo, ZhejiangAges 18–75 - NCT07679542RecruitingPhase 1/Phase 2
Dihydroartemisinin for metabolic fatty liver disease
This trial tests whether dihydroartemisinin, a malaria drug that may reduce liver fat, helps people with metabolic fatty liver disease. It is for adults aged 18 to 45 who have a fatty liver and at least one metabolic problem like overweight, high blood pressure, or diabetes.
Nanjing, JiangsuAges 18–45 - NCT07694778Recruiting
Functional dyspepsia in rural Bangladesh
This study looks at how common functional dyspepsia (stomach discomfort without a clear cause) is among adults living in a rural area of Bangladesh. It aims to understand who is affected and what factors might be involved.
DhakaAges 18 years+ - NCT07704255RecruitingPhase 4
Fecal transplant for stubborn H. pylori infection
This study tries a fecal microbiota transplant (placing healthy donor stool into your gut) to get rid of stubborn H. pylori infection that hasn't been cured by standard treatments. It's for people who have failed several rounds of therapy and have a stomach condition that makes eradication important.
Chengdu, SichuanAges 18–80 - NCT07635316Recruiting
Treatment patterns and outcomes in neuroendocrine tumors
This study examines how doctors treat gastroenteropancreatic neuroendocrine tumors (rare slow-growing cancers of the stomach, pancreas, or intestines) and how patients respond. Researchers will review medical records from 2018–2025 to understand which treatments work best and help improve care for future patients.
East Hanover, New JerseyAges 18–110 - NCT07612748Recruiting
Comparing two endoscopic treatments for small rectal neuroendocrine tumors
This study compares two minimally invasive endoscopic techniques—ESD and EPMR—for removing small neuroendocrine tumors (slow-growing hormone-producing tumors) in the rectum. The goal is to see which approach works better and is safer for patients.
Changchun, JilinAges 18 years+ - NCT07611903Recruiting
Oxygen delivery methods during endoscopy procedure
This trial compares two different ways of delivering oxygen through your nose during an endoscopy procedure (ERCP, which examines your bile ducts and pancreas). The study tests whether one method keeps your oxygen levels safer or more comfortable than the other.
Kocaeli, UmuttepeAges 18–84 - NCT07618650Enrolling by invitation
Pain Relief Blocks for Children After Appendix Surgery
This study compares two different injection techniques to reduce pain after appendix removal surgery in children ages 7–12. Both techniques use ultrasound (sound waves) to guide a numbing medication to nerves near the surgical area, and researchers want to see which works better.
TantaAges 7–12 - NCT07627217Recruiting
Understanding MNGIE disease progression and natural history
This study collects information from patients with MNGIE (a rare genetic condition affecting how cells break down certain molecules) to better understand how the disease develops and progresses over time. By learning more about your experience, researchers hope to develop better treatments.
CambridgeAges Any age - NCT07650344Recruiting
AI Tool to Detect Flat Colon Polyps During Screening
This study tests whether artificial intelligence can help doctors spot certain flat polyps (called sessile serrated lesions) during routine colonoscopy screening. Finding these polyps early may help prevent colorectal cancer.
SingaporeAges 40–80 - NCT07684326RecruitingPhase 2/Phase 3
Can dapagliflozin help liver cirrhosis with fluid buildup? (Phase 2/3 randomized trial)
This trial tests a diabetes pill (dapagliflozin) to see if it helps people with liver cirrhosis and fluid buildup (ascites). The goal is to improve fluid balance and possibly reduce hospital stays.
GizaAges 18 years+ - NCT07616830Recruiting
Recovery Outcomes After Temporary Midline Stoma Surgery
This study tracks how well patients recover after temporary stoma surgery (a surgically created opening for waste drainage) placed through a midline incision. Researchers want to understand healing, complication rates, and quality of life to improve surgical outcomes.
Asyut, Asyut GovernorateAges 18 years+ - NCT07639281Enrolling by invitation
Opioid Education for Ventral Hernia Repair Surgery
This study teaches patients about opioid pain medication before hernia repair surgery. It aims to help patients make informed decisions about pain management and understand safer opioid use.
Lexington, KentuckyAges 18–85 - NCT07608653Recruiting
Minimally invasive surgery for recurrent groin hernias
This trial tests a keyhole (laparoscopic) surgical technique to repair inguinal hernias that have returned after previous surgery. The goal is to evaluate how well this approach works and what outcomes patients experience.
SohagAges Any age - NCT07611266Recruiting
Predicting colorectal adenoma recurrence using combined medicine approach
This study helps predict which patients with colorectal adenomas (pre-cancerous growths) are at higher risk of them coming back or turning into cancer. Researchers will use both Western medical tests and Traditional Chinese Medicine patterns to create a prediction tool that may guide your follow-up care.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07540845Recruiting
Regular Diet After Colorectal Surgery
This study tests whether patients can safely eat a regular diet right after colorectal surgery (surgery to remove part of the colon or rectum), rather than waiting. Researchers want to see if this speeds up recovery and improves outcomes.
New York, New YorkAges 18 years+ - NCT07575295Recruiting
New technique for controlling bleeding during swallowing tube surgery
This trial tests two different methods to prevent bleeding during a minimally invasive procedure (POEM) that treats swallowing problems caused by achalasia or esophageal motility disorders. The study compares a newer underwater technique with the standard approach to see which works better at managing blood vessels during the procedure.
Hyderabad, TelanganaAges 18–65
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.