Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07569679RecruitingPhase 2
Combination Chemotherapy and Immunotherapy for Biliary Tract Cancer
This trial tests a combination of chemotherapy drugs given directly into the liver, combined with two immunotherapy/targeted therapy drugs, for people with advanced biliary tract cancer (cancer of the bile ducts or gallbladder). The goal is to shrink tumors and improve survival in patients who have not received prior chemotherapy.
Xi'an, ShaanxiAges 18 years+ - NCT07573371Recruiting
Understanding bowel changes after rectal cancer surgery
This study helps doctors better understand and treat bowel control problems that can happen after rectal cancer surgery or other rectal treatments. If you've had this surgery or treatment, the study team wants to learn more about your recovery and test new ways to help.
AalborgAges 18 years+ - NCT07574398Recruiting
Growth and Development Study After Infant Liver Transplant
This study tracks how babies grow and develop after receiving a liver transplant. Researchers want to understand how transplantation affects children's physical growth and overall development in early infancy.
Shanghai, Shanghai MunicipalityAges Up to 1 year - NCT07575061Recruiting
Long-term study of survival factors in intestinal tuberculosis
This 15-year study follows patients with intestinal tuberculosis (a bacterial infection of the digestive tract) to understand what factors affect how long patients survive and live with this condition. The research may help doctors better predict outcomes and improve care for future patients.
Beijing, Beijing MunicipalityAges 18–100 - NCT07573943RecruitingPhase 4
ASC22 with Peg-IFN for chronic hepatitis B cure
This study tests whether a combination of two drugs (ASC22 and Peg-IFN) can help people with chronic hepatitis B achieve a functional cure. The goal is to see if this therapy can clear the virus and improve liver health.
Chongqing, Chongqing MunicipalityAges 18–60 - NCT07568626Recruiting
Understanding Hospital Stays After Endoscopy Procedures
This study looks at why some older patients need to stay in the hospital longer after a common digestive procedure called ERCP. Researchers want to understand the factors that affect recovery time, which may help improve care for future patients.
Xiamen, FujianAges 65 years+ - NCT07569419RecruitingEarly Phase 1
Testing Linaclotide for Cystic Fibrosis Bowel Function
This early-stage study tests whether a medication called linaclotide can help improve bowel function in people with cystic fibrosis. Researchers will use MRI scans and other tests to see how the medication affects your digestive system.
NottinghamAges 18–65 - NCT07576049Enrolling by invitation
Colorectal Cancer Treatment Experience Study
This research study looks at how colorectal cancer patients are treated and their outcomes at a major medical center in Rome. It helps doctors understand what approaches work best for patients like you.
RomaAges Any age - NCT07569705Recruiting
Nerve Stimulation to Help Breathing After Weight-Loss Surgery
This trial tests whether electrical nerve stimulation (a non-invasive, pain-relieving technique) can help improve breathing problems that sometimes occur after weight-loss surgery. The study measures how well your diaphragm—the muscle that helps you breathe—works after the procedure.
CairoAges 20–60 - NCT06601010Recruiting
PET scan to monitor immunotherapy in pancreatic cancer
This trial uses a special PET scan (68Ga-grazytracer) to see how well immunotherapy is working for pancreatic cancer. It may help your doctor understand if your treatment is effective.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06644274Recruiting
PET scan for tracking immunotherapy in gastrointestinal cancers
This trial uses a special PET scan called 68Ga-grazytracer to see how well immunotherapy is working in people with stomach, colon, or other gastrointestinal cancers. The goal is to find out if this scan can help doctors track your response to treatment.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06708572Recruiting
GCSF after Kasai surgery for biliary atresia
This study tests a medicine called GCSF (helps make white blood cells) in babies who have had Kasai surgery for biliary atresia. It aims to see if GCSF can improve liver function and overall outcomes.
Cairo, Menofia GovernorateAges 3 weeks–1 year - NCT06665971RecruitingPhase 4
Dupilumab for esophagus muscle function in EoE
This trial tests if dupilumab, a weekly injection, can improve the muscle function of the esophagus in people with eosinophilic esophagitis (EoE) who haven't gotten better with acid-reducing medications. Researchers want to see if it helps with swallowing and reduces inflammation.
La Jolla, CaliforniaAges 22 years+ - NCT06675825Recruiting
New cap for expanding narrow esophagus in kids
This trial tests a new cap that helps doctors widen a narrowed part of the esophagus (the tube that carries food from the mouth to the stomach) in children. The cap is used during a scope procedure to make the dilation safer and easier.
RomeAges birth–18 years - NCT06723197RecruitingPhase 4
Comparing treatment lengths for H. pylori infection
This trial compares different lengths of treatment with two or four medications to see which works best for clearing H. pylori, a stomach bacteria that can cause ulcers. It is for people who have not been treated for this infection before.
Jinan, ShandongAges 18–70 - NCT06727981Recruiting
Immunotherapy as first treatment for stomach cancer
This trial tests immunotherapy as the first treatment for people with advanced or locally advanced stomach cancer. It may help if you haven't had any prior anti-cancer therapy and are starting treatment soon.
Jinan, ShandongAges 18–100 - NCT06338215Recruiting
Moderate drinking vs. abstention advice for adults
This study compares two approaches for adults who drink regularly: advice on drinking in moderation vs. advice to stop drinking entirely. The goal is to see which approach better prevents major diseases and early death over time.
Pamplona, NavarreAges 50–75 - NCT03901235RecruitingPhase 1/Phase 2
Stem cell injections for Crohn’s lesions that won’t heal
This study tests injections of stem cells placed directly into Crohn’s affected tissue. It may help people whose Crohn’s disease lesions have not responded to standard medicines and biologic therapies.
Liège, LiègeAges 18 years+ - NCT06242418RecruitingPhase 2
ctDNA-Guided Chemo for Stage III Colon Cancer
This trial tests whether checking for cancer DNA in your blood (ctDNA) can help doctors decide if you need extra chemotherapy after surgery for stage III colon cancer. It aims to personalize treatment and avoid unnecessary chemo.
Guiyang, GuizhouAges 18–75 - NCT06430983Recruiting
Relearning liver cancer: a study of recurrent cases
This trial studies patients with liver cancer, including both the common type (hepatocellular carcinoma) and other types. It aims to understand the cancer better by collecting blood samples and medical information.
Nanjing, JiangsuAges 18–75 - NCT06602167Recruiting
Acupuncture and acupressure to prevent hand-foot syndrome from capecitabine
This trial tests if electroacupuncture combined with self-administered acupressure can prevent hand-foot syndrome, a common side effect of the chemotherapy drug capecitabine. It is for people with gastrointestinal or breast cancer who are starting capecitabine for the first time.
Xining, QinghaiAges 18–85 - NCT06731439Recruiting
Starting feeds on day 1 for very small premature babies
This study is for very premature babies (weighing about 2 pounds or less) to see if starting small feedings on the first day of life helps them reach full feeds sooner. If your baby is very small and otherwise healthy, this option may help them grow faster.
Memphis, TennesseeAges 1 minute–6 hours - NCT06729944Recruiting
Genetic testing study for bile duct cancers
This trial looks at how well a modern genetic test (next-generation sequencing) works when analyzing tissue samples from people with bile duct cancer. The goal is to see if this test can help doctors better understand these tumors.
BolognaAges 18 years+ - NCT04278287RecruitingPhase 1/Phase 2
Chemoradiation study for unresectable esophageal cancer
This Phase 1/2 trial tests a treatment plan using chemotherapy plus radiation for esophageal squamous cell cancer that cannot be removed with surgery. It may help shrink or control the cancer and guide safer dosing, but it’s only for people with specific tumor stage, health status, and blood test results.
Anyang, HenanAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.