Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07559968Recruiting
Comparing two types of stents for bile duct cancer blockage
This study compares two different metallic stent designs to help keep bile ducts open in patients with advanced bile duct cancer. You would already have a temporary drainage tube in place and be scheduled for a permanent stent, so this trial tests which stent type works better.
Seoul, SeoulAges 19 years+ - NCT07565454Recruiting
Survey about liver and pancreas surgery training programs
This study asks surgeons and surgical trainees about their experiences in liver, pancreas, and bile duct surgery fellowship programs. The survey helps improve training and understand what works best in these specialized programs.
Dallas, TexasAges Any age - NCT07559864RecruitingPhase 2
Regorafenib plus Envafolimab for treatment-resistant gastrointestinal stromal tumors
This study tests a combination of two drugs (regorafenib and envafolimab) for gastrointestinal stromal tumors (a type of stomach/bowel cancer) that have stopped responding to standard treatments. The trial compares this combination to other doctor-selected treatments to see if it slows tumor growth.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07560488RecruitingPhase 2
Immunotherapy and Chemotherapy Combination for Advanced Liver Cancer
This trial tests a combination of four treatments (two immunotherapy drugs, a blood-vessel-blocking drug, and chemotherapy delivered directly to the liver) to shrink unresectable (inoperable) advanced liver cancer and potentially make it removable by surgery. The goal is to help patients who have never had cancer treatment before.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT07561814Recruiting
Predicting Pancreatic Cancer Treatment Outcomes Using Medical Images and Data
This study builds a computer model to predict how well pancreatic cancer patients will respond to surgery and what their long-term outcomes might be. Researchers use CT scans, blood tests, and medical records from patients who had pancreatic cancer surgery to teach the model to recognize patterns that help predict outcomes.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07566559Recruiting
Rectal Cancer Treatment Before Surgery Study
This study follows real-world treatment of locally advanced rectal cancer (cancer that has grown into nearby tissues but hasn't spread to distant organs) in patients who receive chemotherapy and/or radiation before surgery. Researchers track how different treatment approaches work to help improve outcomes.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07562490RecruitingPhase 2
Blood Test to Guide Chemotherapy After Colorectal Cancer Surgery
This study tests whether a special blood test (looking for cancer DNA) can help doctors decide if you need chemotherapy after colorectal cancer surgery. The goal is to avoid unnecessary chemotherapy while making sure patients who need it get treated.
ShanghaiAges 18–80 - NCT07559825Recruiting
Understanding Early-Onset Colorectal Cancer in Younger Patients
This study looks at colorectal cancer in younger patients who wouldn't normally be screened. Researchers want to understand how this cancer develops in people under the typical screening age.
Dallas, TexasAges 35 years+ - NCT07560540Recruiting
Nutrition Support Before and After Pancreatic Surgery
This study tests whether a special nutrition plan before and after Whipple surgery (a major operation for pancreatic or bile duct cancer) helps patients recover faster and feel better. Researchers want to see if eating the right nutrients beforehand makes surgery easier on your body.
LahoreAges 18 years+ - NCT06558227RecruitingPhase 2
ZG005 with bevacizumab vs sintilimab with bevacizumab for advanced liver cancer
This trial tests a new drug combination (ZG005 plus bevacizumab) against a standard combination (sintilimab plus bevacizumab) in people with advanced liver cancer that has spread or cannot be surgically removed. The goal is to see which combination works better and is safe.
Chengdu, SichuanAges 18–75 - NCT06715540RecruitingPhase 1
Study of a new drug for healthy male volunteers
This trial tests a new medicine called BCD-261 in healthy men to see if it is safe and how the body processes it. Participants will receive increasing doses and be monitored for about 4 months.
Saint PetersburgAges 18–45 - NCT06725121RecruitingPhase 1/Phase 2
Radiation and immunotherapy for advanced liver cancer before transplant
This trial tests combining radiation therapy with immunotherapy (AtezoBev) before a liver transplant for advanced liver cancer. The goal is to see if this approach can shrink tumors and make transplant possible for more people.
London, OntarioAges 18–70 - NCT06735118Recruiting
Can AI help see chemo-related fatty liver?
This study uses a special MRI technique and artificial intelligence to see how chemotherapy may cause a fatty liver. It may help find liver changes early in people who have had chemo.
Kunming, YunnanAges 18–80 - NCT06735105Recruiting
Best MRI method for staging stomach cancer
This trial uses three different MRI scanning sequences to see which best helps stage (determine the spread of) stomach cancer. The goal is to improve how doctors plan treatment for gastric cancer.
KunmingAges 18–80 - NCT05055648RecruitingPhase 3
Proton vs photon radiation for esophageal cancer before surgery
This trial compares proton therapy and standard photon therapy given before surgery for esophageal (or stomach–esophagus) cancer. It aims to see which radiation approach works better and is safer as part of a combined treatment plan.
LeuvenAges 18 years+ - NCT04920149RecruitingPhase 2
Mesalamine to help prevent colon cancer in Lynch syndrome
This trial tests whether mesalamine, a medicine used for bowel inflammation, can help prevent colorectal cancer in people with Lynch syndrome who do not currently have cancer. It may help by lowering the chance that new pre-cancer growths form over time.
AalborgAges 30 years+ - NCT06737549RecruitingPhase 4
Electroacupuncture and NGF for swallowing problems after stroke
This study tests whether a specific type of electroacupuncture (a gentle needle therapy with mild electrical pulses) plus a nerve growth factor injection can help people who have trouble swallowing after a recent stroke. The goal is to see if this combination improves swallowing function better than standard care.
Hangzhou, ZhejiangAges 18–80 - NCT06737666RecruitingPhase 1
Tong-Xie-Yao-Fang for Diarrhea-Predominant IBS
This trial tests an herbal formula called Tong-Xie-Yao-Fang for people with diarrhea-predominant irritable bowel syndrome (IBS-D). It aims to see if the treatment helps symptoms and how it works. Healthy volunteers are also needed for comparison.
Beijing, Beijing MunicipalityAges 18–70 - NCT06738329Recruiting
How seaweed additive carrageenan affects gut bacteria
This study tests whether carrageenan, a seaweed-based food ingredient, changes the balance of bacteria in your gut. It could help us understand how common food additives affect digestion and overall health.
Reading, ReadingAges 18–55 - NCT04687631RecruitingPhase 3
Study drug for colorectal cancer that spread to the liver
This Phase 3 trial tests a treatment approach for colorectal cancer that cannot be removed with surgery at first but has spread only to the liver. It is intended for people whose tumor is RAS/BRAF “wild-type” and who are well enough to do daily activities, to see if the treatment can control the cancer better.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05368974Recruiting
Pregnancy registry for hepatitis C treatment timing
This study is a pregnancy registry that collects information about people who have hepatitis C during pregnancy and took hepatitis C medicines early in pregnancy. It aims to better understand the safety and outcomes of treatment around conception.
Atlanta, GeorgiaAges Any age - NCT07551596RecruitingPhase 2
Two immunotherapy drugs for colorectal cancer with residual disease
This trial tests a combination of two immunotherapy drugs to see if they can stop colorectal cancer from returning after standard treatment. It is for people who still have cancer DNA in their blood after surgery and/or chemotherapy, which means they are at high risk of the cancer coming back.
New Orleans, LouisianaAges 18 years+ - NCT06107634Recruiting
Comparing hernia repair with and without stomach tuck
This study tests whether adding a procedure called gastropexy (tacking the stomach in place) to standard hernia repair helps prevent the hernia from coming back. It may be a good option for people having their first surgery for a paraesophageal hernia.
GothenburgAges 18 years+ - NCT06195332Recruiting
Comparing two hernia repair methods (open vs. camera-assisted)
This study compares two ways to fix a hernia that appears after a previous belly surgery: one uses a larger cut (open surgery) and the other uses smaller cuts and a camera. The goal is to see which approach leads to a better recovery.
MoscowAges 18–90
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.