Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,371 recruiting studies in this area right now.
By phase
- Not applicable978
- Phase 2168
- Phase 399
- Phase 146
- Phase 434
- Phase 1/Phase 232
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma80
- Dysphagia73
- Hearing Loss61
- Tinnitus31
- Hearing Loss, Sensorineural25
- Nasopharyngeal Carcinoma (NPC)24
- Allergic Rhinitis23
- Head and Neck Cancer22
- Oropharynx Cancer21
- Stroke20
- Sensorineural Hearing Loss18
- Nasopharyngeal Cancinoma (NPC)17
- Chronic Rhinosinusitis With Nasal Polyps15
- Oropharyngeal Cancer15
- Nasopharyngeal Cancer14
- Vestibular Schwannoma14
- Head and Neck Squamous Cell Carcinoma13
- Chronic Rhinosinusitis (CRS)12
Leading sponsors
- Sun Yat-sen University59
- Eye & ENT Hospital of Fudan University17
- Cairo University15
- Assistance Publique - Hôpitaux de Paris14
- NYU Langone Health14
- Mayo Clinic12
- National Cancer Institute (NCI)12
- Johns Hopkins University11
- Ming-Yuan Chen11
- Cochlear9
Where studies are running
- California62
- Maryland37
- New York35
- Florida30
- Massachusetts21
- Illinois20
- Texas18
- Arizona17
- Colorado16
- Alabama15
Recruiting studies1,371 total
- NCT06017895Recruiting
Doxepin rinse for severe swallowing pain during throat radiation
This trial tests a medicated mouth rinse (doxepin) to ease severe pain when swallowing, caused by radiation therapy for nasopharyngeal cancer. It aims to help patients who are currently receiving radiation and have mouth or throat sores.
Guangzhou, GuangdongAges 18 years+ - NCT06019130RecruitingPhase 2
Nivolumab for newly diagnosed nasopharyngeal cancer
This trial tests whether the immunotherapy drug nivolumab (Opdivo) can help treat nasopharyngeal cancer in both children and adults. It is for people who have just been diagnosed and have not yet received any cancer treatment.
AachenAges 3 years+ - NCT06023550Recruiting
Complicated Ear, Nose, and Throat Infections Study
This study looks at patients with complicated infections of the ear, nose, throat, or neck that are treated at a specific hospital in Slovenia. The goal is to learn more about these infections and how they are managed.
Ljubljana, LjubljanaAges Any age - NCT06026878RecruitingPhase 3
GNT induction treatment for advanced nasopharyngeal cancer
This trial tests a new drug combination called GNT given before standard chemoradiation for people with locally advanced nasopharyngeal cancer. It aims to improve treatment outcomes.
Xi'an, ShaanxiAges 18–75 - NCT06029270RecruitingPhase 2
Adding relatlimab to standard immunotherapy for nasopharyngeal cancer
This trial tests whether adding a new drug called relatlimab to the usual immunotherapy (nivolumab) helps people with nasopharyngeal cancer that has returned or spread. You will get standard chemotherapy plus nivolumab first, then if it works, you may be randomly assigned to get nivolumab alone or with relatlimab.
Dublin, CaliforniaAges 18 years+ - NCT06034080Recruiting
Cutting down unneeded antibiotics for children's ear infections
This study tests ways to help doctors avoid prescribing antibiotics when they are not needed for children with ear infections. If you are a parent of a child diagnosed with an ear infection or a healthcare provider, you may be able to join different parts of the study.
Denver, ColoradoAges 6 months–17 years - NCT06039631RecruitingPhase 2
Immuno-chemo before surgery and organ-sparing treatment for throat cancer
This trial tests whether adding immunotherapy before surgery, followed by either radiation or organ-preserving surgery, can improve outcomes for people with locally advanced laryngeal or hypopharyngeal cancer. It may help avoid complete removal of the voice box.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06039332Recruiting
Comparing ways to fit a bone conduction implant
This study compares two ways to adjust a BONEBRIDGE bone conduction implant for people with hearing loss. It aims to find which fitting strategy gives better sound quality and daily benefit.
MadridAges 18 years+ - NCT06040892Recruiting
Hearing in noise for children with two cochlear implants
This study tests if wearing two cochlear implants helps children hear speech better in noisy places. The goal is to improve listening skills in everyday situations like classrooms or playgrounds.
LyonAges 7–17 - NCT06053190Recruiting
Clear speech and memory in older adults
This study is testing whether listening to clear speech (slow, precise) helps older adults understand and remember sentences better. If you're between 60 and 90, right-handed, and a native English speaker, this trial may help you or your loved one learn more about how to improve communication as you age.
Salt Lake City, UtahAges 60–90 - NCT06055816RecruitingPhase 2
Gemcitabine plus two targeted drugs for older adults with nasopharyngeal cancer
This trial tests a combination of three drugs—chemotherapy (gemcitabine), a blood-vessel blocker (Endostar), and an immunotherapy (Envafolimab)—for older adults with advanced nasopharyngeal cancer that hasn't been treated yet. The goal is to see if this mix works better than standard care for patients aged 65 and up.
Hangzhou, ZhejiangAges 65 years+ - NCT06058767Recruiting
Hearing screening for preschoolers
This study offers a free hearing screening for children aged 2 to 6 who attend a community preschool. The goal is to find any hearing issues early so children can get the help they need.
San Francisco, CaliforniaAges 2–6 - NCT06059261RecruitingPhase 2
Envafolimab plus chemoradiation and endostatin for advanced nasopharyngeal cancer
This trial tests a combination of a new immunotherapy (envafolimab) with standard chemoradiation and a drug that blocks blood vessel growth (endostatin) for people with advanced nasopharyngeal cancer that hasn't been treated before. The goal is to see if this combination works better than the usual treatment.
Chongqing, Chongqing MunicipalityAges 18–65 - NCT06062368Recruiting
Reducing dizziness during high-power MRI scans
This study tests a way to reduce dizziness (vertigo) some people feel during a very powerful MRI scan. It looks at whether a small change can make the scan more comfortable.
Baltimore, MarylandAges 18 years+ - NCT06069531Recruiting
Probiotic or White Pomegranate for Vaginal Health
This study tests whether taking a probiotic (Lactobacillus Johnsonii) or a white pomegranate extract can improve vaginal health in women with an imbalance in vaginal bacteria. It aims to find a natural way to support a healthy vaginal environment.
TaichungAges 20–45 - NCT06072495Recruiting
Understanding Why Some Cleft Palate Repair Patients Have Ongoing Speech Issues
This study uses special MRI scans to help doctors understand why some children who had cleft palate surgery still have difficulty with certain speech sounds. By looking at how the muscles in the back of the throat work, researchers hope to improve future surgical techniques and speech outcomes.
AmiensAges 7–12 - NCT06072924Recruiting
Tongue exercise for stroke-related swallowing problems
This study tests if a special tongue exercise can help improve swallowing for people who recently had a stroke. It's designed for those still having trouble swallowing after their stroke.
Cincinnati, OhioAges 18 years+ - NCT06076304RecruitingPhase 4
Comparing treatments for acute sinusitis
This trial tests whether nasal steroids, nasal irrigation, or oral antibiotics work best for acute sinusitis. It may help if you have ongoing sinus symptoms or a 'double-sickening' pattern after a cold.
Los Angeles, CaliforniaAges 18–75 - NCT06077643Recruiting
Support groups for people after voice box removal
This trial tests whether joining workshops and exchange groups helps people who have had their voice box removed (a total laryngectomy) feel better supported. You would attend four sessions at Bichat Hospital to share experiences and learn from others.
ParisAges 18 years+ - NCT06080503Recruiting
Comparing shorter vs. standard radiation for early vocal cord cancer
This study tests if a shorter course of radiation (hypofractionated) works as well as the standard longer course for people with early-stage cancer of the vocal cords. The goal is to find a treatment that is more convenient and has similar results.
Dallas, TexasAges 18 years+ - NCT06088953Recruiting
Early hearing check for memory clinic patients
This study looks at how to detect hearing loss early in people with mild to moderate memory problems. It may help understand if hearing issues affect thinking skills.
LilleAges 50 years+ - NCT06088381RecruitingPhase 2
HPV-related throat cancer treatment based on tumor DNA levels
This trial tests if monitoring cancer DNA left in your blood after surgery can help decide if you need additional treatment. It is for people with HPV-positive oropharynx (throat) cancer who have a certain amount of cancer DNA detected before surgery.
Baltimore, MarylandAges 18 years+ - NCT06092957RecruitingPhase 3
Reduced radiation after chemo-immunotherapy for high-risk nasopharyngeal cancer
This trial tests whether a lower dose of radiation, with or without additional chemo-immunotherapy, works as well as the standard full-dose chemoradiation for people with advanced nasopharyngeal cancer who had a complete response after initial chemo-immunotherapy.
Guangzhou, GuangdongAges 18–70 - NCT06093061RecruitingPhase 2
Maintenance therapy for high-risk nasopharyngeal cancer
This trial tests a combination of two drugs—tislelizumab (an immunotherapy that helps your immune system fight cancer) and capecitabine (a chemo pill taken daily)—as maintenance therapy after initial chemotherapy for high-risk nasopharyngeal cancer. The goal is to see if this approach can lower the chance of cancer coming back.
SingaporeAges 21–99
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,371 recruiting otolaryngology studies from the U.S. registry right now, out of 2,216 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.