Endocrinology & metabolism
Hormones & metabolism clinical trials
Diabetes, obesity, thyroid, and other conditions of the body’s hormones and metabolism. We’re tracking 7,639 recruiting studies in this area right now.
By phase
- Not applicable5,357
- Phase 2608
- Phase 1562
- Phase 3419
- Phase 4318
- Phase 1/Phase 2289
- Phase 2/Phase 386
Top conditions
- Obesity618
- Ovarian Cancer337
- Pancreatic Cancer290
- Type 2 Diabetes277
- Diabetes192
- Diabetes Mellitus184
- Diabetes Mellitus, Type 2171
- Hypertension138
- Type 1 Diabetes132
- Metabolic Syndrome127
- Obesity & Overweight125
- Breast Cancer112
- Overweight106
- Cardiovascular Diseases104
- Amyotrophic Lateral Sclerosis101
- Pancreas Cancer91
- Colorectal Cancer90
- Endometrial Cancer89
Leading sponsors
- Mayo Clinic87
- Novo Nordisk A/S64
- University of Colorado, Denver53
- Assistance Publique - Hôpitaux de Paris52
- M.D. Anderson Cancer Center42
- Eli Lilly and Company41
- Massachusetts General Hospital41
- IRCCS Azienda Ospedaliero-Universitaria di Bologna40
- National Taiwan University Hospital40
- Cairo University38
Where studies are running
- California523
- Maryland178
- Alabama175
- Arizona171
- Florida165
- Texas159
- Massachusetts151
- New York142
- Colorado115
- Pennsylvania114
Recruiting studies7,639 total
- NCT01962415RecruitingPhase 2
Reduced-intensity stem cell transplant for non-cancer disorders
This trial tests whether a gentler (reduced-intensity) conditioning treatment before a stem cell transplant works for non-cancer diseases. It uses specific donor stem cell matches and checks heart, lung, liver, and kidney function to help lower transplant stress while still aiming for benefit.
Pittsburgh, PennsylvaniaAges 2 months–55 years - NCT05040360RecruitingPhase 2
Chemotherapy after surgery for high-risk pancreatic NET tumors
This Phase 2 trial studies whether giving chemotherapy after surgery can lower cancer recurrence risk in people with high-risk pancreatic neuroendocrine tumors (NETs). It may help you by testing an added treatment after the tumor has been removed.
Anchorage, AlaskaAges 18 years+ - NCT05493605Recruiting
MRI study of heart involvement in Wilson disease
This study looks at whether Wilson disease affects the heart, using MRI scans (and possibly contrast dye). Your results may help doctors better understand cardiac (heart) involvement and how it progresses in Wilson disease.
ParisAges 18 years+ - NCT05470504RecruitingPhase 2
Pegvisomant for severe insulin resistance from rare fat or gene problems
This Phase 2 study tests pegvisomant, a medicine that blocks growth hormone, to see if it can improve severe insulin resistance in people with a specific genetic cause or a rare fat distribution condition. If you fit the rare diagnosis, the study may help clarify whether growth-hormone blocking can improve blood sugar and related health markers.
Bethesda, MarylandAges 18–70 - NCT05463120Enrolling by invitation
Follow-up study of early growth and puberty timing
This study follows families from an earlier infant feeding study to better understand what affects when puberty starts. It looks at growth and hormone-related health information to explain differences in pubertal development.
Bethesda, MarylandAges 8–100 - NCT05116943Recruiting
ALS and related brain disease biospecimen biobank
This study builds a blood and spinal fluid (lumbar puncture) sample library from people with ALS, ALS-FTD, or similar neurodegenerative diseases. Your samples help researchers study these conditions, even if you are not receiving a new treatment.
Jacksonville, FloridaAges 18 years+ - NCT05503797RecruitingPhase 2
Study of FORE8394 for cancers with BRAF changes
This trial tests a new drug, FORE8394, for people whose cancers have a change in the BRAF gene. It may be an option if you have a solid tumor or brain tumor that has not responded to other treatments.
Beverly Hills, CaliforniaAges 8 years+ - NCT05492799Enrolling by invitationPhase 4
Study of AX 250 for MPS IIIB in children
This Phase 4 trial studies how safe, tolerable, and helpful ICV AX 250 is for people with MPS IIIB. It is for participants who already finished a prior AX 250 study and meet specific health and eligibility checks.
Oakland, CaliforniaAges Any age - NCT05489211RecruitingPhase 2
Testing a cancer drug for advanced solid tumors
This Phase 2 study tests the drug Dato-DXd (alone or with other cancer medicines) in people with advanced solid tumors. It looks for tumor shrinkage and how safely the treatment can be given.
Los Angeles, CaliforniaAges 18–130 - NCT05485961RecruitingPhase 2/Phase 3
Clazakizumab for kidney failure patients on dialysis
This study tests an experimental drug called clazakizumab (CSL300) to see if it can reduce inflammation and lower the risk of heart problems in people with kidney failure who are on dialysis. It may help if you have diabetes or heart disease and have high inflammation levels.
Decatur, AlabamaAges 18 years+ - NCT05503927Enrolling by invitation
Study of Wegovy safety during pregnancy
This study looks at health outcomes for pregnant women and their babies after taking Wegovy or other weight-loss medicines. It may help understand if these medicines are safe during pregnancy.
Ann Arbor, MichiganAges 15–50 - NCT04164641Recruiting
Test software-guided walking analysis to help prevent foot ulcers
This study checks whether a computer system that analyzes your walking can help change gait (how you walk) to reduce the chance of diabetic foot ulcers coming back or leading to amputation. It is meant for adults who have had a healed diabetic foot ulcer before.
Baltimore, MarylandAges 18–90 - NCT05391126Recruiting
Genetic test helps choose drug dosing for pancreas or colon cancer
This study tests whether using a genetic test to guide medication doses works better than standard dosing for people with certain pancreas or colon cancers. It may help by tailoring treatment more precisely to your tumor’s genetic features.
Lexington, KentuckyAges 18 years+ - NCT05481697Recruiting
Track weight changes and check with a cancer blood test
This study looks at whether closely tracking small, unplanned weight loss—along with a one-time blood test (Galleri)—can help find cancer earlier. It may help people who notice changes in weight without knowing why.
Cleveland, OhioAges 40–80 - NCT05491005Recruiting
eHealth program to help type 2 diabetes go into remission
This trial tests an online (eHealth) program to help people with early type 2 diabetes reach diabetes remission. It may help by supporting lifestyle and diabetes management with less in-person care.
JönköpingAges 20–70 - NCT05473637Recruiting
Study causes of small vessel brain disease in stroke and memory issues
This trial looks at people who may have “small vessel” problems in the brain, which can cause stroke, memory trouble, walking changes, movement symptoms, or headaches. It may help researchers better understand the genetic and non-genetic causes, which could improve future diagnosis and treatment.
TaipeiAges 18 years+ - NCT05484570Recruiting
Study of how rare DNA repair disorders affect the body over time
This natural history study follows people with specific DNA repair disorders to better understand symptoms and how they change over time. It may help researchers plan future treatments by mapping what complications to expect and when.
Minneapolis, MinnesotaAges 6 months+ - NCT05499702RecruitingPhase 2
Glucagon test after dieting in type 2 diabetes
This Phase 2 study tests how glucagon affects sugar and fat handling in the liver after a short period of calorie restriction. It may help researchers understand metabolic changes in people with type 2 diabetes and guide future treatments.
Rochester, MinnesotaAges 25–65 - NCT05498974Recruiting
Type 1 diabetes study for people with insulin dependence
This study is looking for people with type 1 diabetes to better understand the condition and how it may be managed. You might qualify if you were diagnosed by a specialist and are insulin-dependent under certain conditions.
Lanzhou, GansuAges Any age - NCT05478707RecruitingPhase 2
Treating small blood vessel problems in type 1 diabetes
This study tests whether two different treatment strategies can improve the function of the tiny blood vessels in people with type 1 diabetes. It aims to find a way to prevent or reduce diabetes-related complications.
Orlando, FloridaAges 18–40 - NCT05463289Recruiting
AI helps children with diabetes get eye exams
This study tests an AI-based way to help check children’s eyes for signs of diabetic retinopathy (diabetes-related eye disease). It may improve how quickly and consistently eye screening is done for kids with diabetes.
Baltimore, MarylandAges 8–21 - NCT05482321Recruiting
Pancreas ultrasound imaging study in type 1 diabetes
This study checks whether a special ultrasound scan can clearly picture the pancreas in people with type 1 diabetes and in non-diabetes control participants. It may help researchers better understand the pancreas in diabetes.
Aurora, ColoradoAges 18–65 - NCT05460000RecruitingPhase 2
Niraparib after early ovarian cancer chemo—short vs long
This trial tests whether taking niraparib (a maintenance anti-cancer pill) for a shorter time after 3 cycles of platinum chemotherapy works as well as taking it after 6 cycles. It is for people with advanced ovarian cancer that has been fully removed (no visible tumor) and is “HRD-positive,” meaning it has certain DNA repair weaknesses.
InnsbruckAges 18 years+ - NCT05502133Recruiting
Finding genes that affect acute intermittent porphyria
This study aims to find genes that may affect acute intermittent porphyria (AIP), a rare genetic condition that can cause sudden, severe attacks. By studying blood, saliva, and urine from family members, researchers hope to better understand and possibly improve treatment for this condition.
New York, New YorkAges 12 years+
Common questions
- How many hormones & metabolism clinical trials are recruiting?
- Clin2 is tracking 7,639 recruiting endocrinology & metabolism studies from the U.S. registry right now, out of 12,048 we cover in this area in total.
- What does “Hormones & metabolism” cover here?
- Diabetes, obesity, thyroid, and other conditions of the body’s hormones and metabolism. We group each study into hormones & metabolism based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a hormones & metabolism trial near me?
- Use the search to filter hormones & metabolism studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.