Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,230 recruiting studies in this area right now.
By phase
- Not applicable3,147
- Phase 21,063
- Phase 1819
- Phase 1/Phase 2442
- Phase 3425
- Phase 4238
- Phase 2/Phase 396
Top conditions
- Multiple Sclerosis343
- Multiple Myeloma332
- Asthma194
- Lymphoma182
- Rheumatoid Arthritis140
- Type 1 Diabetes133
- Atopic Dermatitis129
- Systemic Lupus Erythematosus125
- Acute Lymphoblastic Leukemia122
- HIV Infections116
- Chronic Lymphocytic Leukemia100
- Autoimmune Diseases81
- Follicular Lymphoma74
- Diabetes Mellitus, Type 169
- Hodgkin Lymphoma67
- Rheumatoid Arthritis (RA)66
- Leukemia64
- Type 1 Diabetes Mellitus63
Leading sponsors
- Institute of Hematology & Blood Diseases Hospital, China91
- National Institute of Allergy and Infectious Diseases (NIAID)90
- National Cancer Institute (NCI)73
- Assistance Publique - Hôpitaux de Paris70
- M.D. Anderson Cancer Center63
- Novartis Pharmaceuticals60
- AstraZeneca57
- City of Hope Medical Center47
- Mayo Clinic46
- Memorial Sloan Kettering Cancer Center44
Where studies are running
- California491
- Maryland195
- Alabama175
- Florida144
- Arizona142
- New York123
- Massachusetts119
- Texas118
- Illinois81
- Colorado77
Recruiting studies6,230 total
- NCT06458972Recruiting
Telitacicept for lupus: safety and effectiveness trial
This trial tests a new biologic drug called telitacicept for people with systemic lupus erythematosus (SLE). It aims to see how safe and effective the drug is and may offer a new treatment option for lupus.
Wuhan, HubeiAges 18–70 - NCT06459453Recruiting
Comparing two hand therapy techniques for rheumatoid arthritis
This study compares two gentle hand and wrist therapy techniques (Kaltenborn and Mulligan) to see which works better for people with rheumatoid arthritis. If you have limited wrist movement due to RA, you may be able to join.
Lahore, Punjab ProvinceAges 18–65 - NCT06460142Recruiting
Biomarker study for giant cell arteritis and polymyalgia rheumatica
This study is looking for biomarkers (biological clues) in people with newly diagnosed or flaring giant cell arteritis (GCA) or polymyalgia rheumatica (PMR). Participating may help researchers find better ways to diagnose and monitor these conditions.
Bonn, North Rhine-WestphaliaAges 18 years+ - NCT06460597Recruiting
Breathing techniques for asthma with mood issues
This study compares two gentle breathing methods—Papworth Technique and Pranayama (yogic breathing)—to see which helps people with asthma who also feel stressed, anxious, or down. If you have mild to moderate asthma and often feel negative moods, this trial could help you find a better way to manage both your breathing and your emotions.
Lahore, Punjab ProvinceAges 20–40 - NCT06460857Recruiting
Comparing two breathing exercises for asthma patients
This trial tests whether two different types of breathing and exercise programs—called MDRT and CEE—can improve lung function, chest expansion, and asthma control in people with asthma.
Lahore, Punjab ProvinceAges 35–60 - NCT06461481Recruiting
Follow-up strategies for de-escalating multiple sclerosis treatment
This study tests different ways of monitoring people with relapsing-remitting MS who are reducing or stopping their medication. It aims to find the safest follow-up approach and may help guide future treatment decisions for those with stable disease.
DüsseldorfAges 18 years+ - NCT06461741Recruiting
EMG biofeedback training for balance in MS
This study tests whether a special training method that uses muscle signals (called EMG biofeedback) can help people with MS improve their walking and balance. If you have problems with walking or balance and your MS is stable, you may be able to join.
Hamilton, OntarioAges 18–80 - NCT06462248RecruitingPhase 2
CAR-T therapy for B-cell blood cancers
This trial tests a new CAR-T cell therapy that targets a protein called CD19 on B-cell cancer cells. It is for children and adults with B-cell acute lymphoblastic leukemia or certain B-cell lymphomas that have not improved with standard treatments.
Hong KongAges 1 year+ - NCT06462417Recruiting
Testing arbidol for allergic rhinitis
This trial tests if arbidol, an antiviral medicine, can safely treat allergic rhinitis (hay fever). It might help if your nasal symptoms like sneezing or stuffiness are moderate to severe.
Wuhan, HubeiAges 18–65 - NCT06462365RecruitingPhase 1
Preventing GvHD after stem cell transplant for blood cancers
This trial tests a new way to prevent graft-versus-host disease (GvHD), a common complication after a stem cell transplant. It is for people with certain blood cancers who are getting a stem cell transplant from a half-matched family member or unrelated donor.
Duarte, CaliforniaAges 18 years+ - NCT06462768Recruiting
Study of immune cell activity in systemic sclerosis
This study looks at a specific type of immune cell activity (called neutrophil extracellular traps) in the blood of people with systemic sclerosis, other connective tissue diseases, and healthy volunteers. It aims to understand how these cells may be involved in the disease and could lead to better treatments.
ReimsAges 18 years+ - NCT06462807Recruiting
Improving HIV care in Philadelphia clinics
This study looks at how to improve HIV care and viral suppression by making the clinic environment better for both patients and staff. It may help you stay in care and keep your viral load undetectable.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06463379RecruitingPhase 3
Intravenous pulse therapy for tough juvenile arthritis
This trial tests whether a type of intravenous medicine (called pulse therapy) can help children with arthritis that hasn't improved after other treatments. It aims to bring the disease into remission.
CairoAges 2–18 - NCT06463743RecruitingPhase 2
Metformin for aging people with MS
This study tests whether metformin, a common diabetes drug, can help people with multiple sclerosis (MS) as they age. It may be used alone or added to your current MS treatment, and the goal is to see if it slows down aging-related changes in MS.
Buffalo, New YorkAges 55–75 - NCT06463717Recruiting
Stem cell transplant timing for multiple myeloma with no cancer cells left
This trial looks at people with newly diagnosed multiple myeloma who have no detectable cancer cells after initial treatment. It aims to see if these patients can do well without a stem cell transplant or with a delayed one, reducing unnecessary side effects.
Hangzhou, ZhejiangAges 18–70 - NCT06463886Recruiting
HIV medication support for Black women with trauma
This study explores ways to help Black women with HIV who have experienced trauma stick with their HIV medication. It looks at whether extra support can improve viral suppression and overall health.
Miami, FloridaAges 18 years+ - NCT06463938Recruiting
Laser vs. Laser plus paste for tooth sensitivity
This trial tests two treatments for tooth sensitivity: a laser device (Lasotronix) alone or combined with a special paste (CPP-ACP). The goal is to find which treatment works better to reduce pain from hot, cold, sweet, or touch.
Karachi, SindhAges 25–65 - NCT06464861RecruitingPhase 1
Sequential CD19 CAR-NK and CAR-T for B-cell lymphoma
This trial tests a new combination treatment: first, natural killer cells (NK cells) that are engineered to find CD19, followed by CAR-T cells (also targeting CD19). It is for people with B-cell lymphoma that has come back or not responded to standard treatments.
Hangzhou, ZhejiangAges 18–75 - NCT06464679RecruitingPhase 1
CD19 CAR NK cells for autoimmune diseases
This trial tests a new type of immune cell therapy (CD19 CAR NK cells) for people with certain autoimmune diseases that have not responded to standard treatments. The goal is to see if these cells can safely reduce disease activity.
ShanghaiAges 18–65 - NCT06464926Recruiting
Electrical stimulation for chronic nausea and vomiting
This study tests a device that sends mild electrical pulses to your stomach to help with chronic nausea and vomiting. It is for people who have had nausea for over 6 months, have normal stomach emptying, and have not found relief from standard medications.
Scottsdale, ArizonaAges 18 years+ - NCT06464991RecruitingPhase 3
Eque-cel for Lenalidomide-Refractory Multiple Myeloma
This study tests a new CAR-T cell therapy called Eque-cel for people with multiple myeloma that no longer responds to lenalidomide. It aims to see if this treatment can help control the disease after 1-2 prior therapies.
BeijingAges 18–75 - NCT06465147RecruitingPhase 1
Cell therapy for hard-to-treat lupus (REACT-01)
This trial tests a new type of cell therapy (CAR T-cells) to see if it can stop the immune system from attacking the body in severe lupus. It’s for people ages 2–30 whose lupus is not controlled by other treatments and who are willing to be treated at Seattle Children’s Hospital.
Seattle, WashingtonAges 2–30 - NCT06465316RecruitingPhase 1
Teclistamab plus iberdomide for relapsed multiple myeloma
This trial tests a combination of two drugs, teclistamab and iberdomide, for people with multiple myeloma that has come back or stopped responding to at least 4 prior treatments. The goal is to see if this combination can work when other options have failed.
Phoenix, ArizonaAges 18 years+ - NCT06466122RecruitingPhase 2
Pirtobrutinib plus Venetoclax for resistant CLL or SLL
This trial tests two oral targeted drugs—pirtobrutinib and venetoclax—for people with CLL or SLL whose disease has continued to grow despite taking a BTK inhibitor (such as ibrutinib, acalabrutinib, or zanubrutinib). The goal is to see if this combination can control the cancer when a BTK inhibitor alone is no longer working.
Columbus, OhioAges 18 years+
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,230 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,763 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.