Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,230 recruiting studies in this area right now.
By phase
- Not applicable3,147
- Phase 21,063
- Phase 1819
- Phase 1/Phase 2442
- Phase 3425
- Phase 4238
- Phase 2/Phase 396
Top conditions
- Multiple Sclerosis343
- Multiple Myeloma332
- Asthma194
- Lymphoma182
- Rheumatoid Arthritis140
- Type 1 Diabetes133
- Atopic Dermatitis129
- Systemic Lupus Erythematosus125
- Acute Lymphoblastic Leukemia122
- HIV Infections116
- Chronic Lymphocytic Leukemia100
- Autoimmune Diseases81
- Follicular Lymphoma74
- Diabetes Mellitus, Type 169
- Hodgkin Lymphoma67
- Rheumatoid Arthritis (RA)66
- Leukemia64
- Type 1 Diabetes Mellitus63
Leading sponsors
- Institute of Hematology & Blood Diseases Hospital, China91
- National Institute of Allergy and Infectious Diseases (NIAID)90
- National Cancer Institute (NCI)73
- Assistance Publique - Hôpitaux de Paris70
- M.D. Anderson Cancer Center63
- Novartis Pharmaceuticals60
- AstraZeneca57
- City of Hope Medical Center47
- Mayo Clinic46
- Memorial Sloan Kettering Cancer Center44
Where studies are running
- California491
- Maryland195
- Alabama175
- Florida144
- Arizona142
- New York123
- Massachusetts119
- Texas118
- Illinois81
- Colorado77
Recruiting studies6,230 total
- NCT06664229Recruiting
Dementia and fall prevention program for older adults
This study tests a pressure sensor-based program to help prevent dementia and falls in older adults. If you are 65 or older, can walk independently, and have no dementia or other conditions that affect thinking, you may be able to join.
Seoul, SeoulAges 65 years+ - NCT06664411RecruitingPhase 2
Pola-ZR2P for untreated DLBCL
This trial tests a new combination of drugs (Pola-ZR2P) for people with a type of lymphoma called diffuse large B-cell lymphoma (DLBCL) who have not had chemotherapy yet. It aims to see if this treatment is safe and effective.
Beijing, Beijing MunicipalityAges 14 years+ - NCT06664918Recruiting
Milk ladder therapy for children with cow's milk allergy
This study tests whether a gradual 'milk ladder' approach (slowly introducing milk in increasing amounts) is safe and effective for children with cow's milk allergy. It may help your child eventually tolerate milk.
WarsawAges 1–5 - NCT06665646RecruitingPhase 1
HIV vaccine booster study for previous trial participants
This study tests a booster vaccine for HIV in people who were part of an earlier HIV vaccine trial. The goal is to see if it's safe and helps the immune system fight HIV better.
San Francisco, CaliforniaAges 18–60 - NCT06665607Recruiting
Foot muscle training for people with MS
This study tests whether training the small muscles in your feet can improve your walking and balance if you have multiple sclerosis (MS). It is for people with moderate disability, so you can still walk but may have some trouble.
ValladolidAges 18–70 - NCT06665815Recruiting
Screening close family for type 1 diabetes risk
This study screens close family members of people with type 1 diabetes for early signs of the condition. A simple blood test looks for special markers (autoantibodies) that can show if the immune system is starting to attack the pancreas. Finding these markers early may help doctors prevent or delay the onset of diabetes.
Petah TikvaAges 2–45 - NCT06665971RecruitingPhase 4
Dupilumab for esophagus muscle function in EoE
This trial tests if dupilumab, a weekly injection, can improve the muscle function of the esophagus in people with eosinophilic esophagitis (EoE) who haven't gotten better with acid-reducing medications. Researchers want to see if it helps with swallowing and reduces inflammation.
La Jolla, CaliforniaAges 22 years+ - NCT06666712RecruitingPhase 1
Chronic brain infusion of topotecan for recurrent glioma
This trial tests a treatment called topotecan that is delivered directly into the brain through a small tube (convection-enhanced delivery). It is for people whose IDH-mutant glioma has come back despite standard treatment. The goal is to see if this approach can help control the tumor.
New York, New YorkAges 18 years+ - NCT06668181RecruitingPhase 3
Study of bimekizumab for kids with certain types of juvenile arthritis
This trial tests a drug called bimekizumab in children and teens with specific types of juvenile arthritis (enthesitis-related arthritis or psoriatic arthritis). It aims to see how the drug works in the body and if it's safe. This may help those who haven't gotten enough relief from standard anti-inflammatory medicines.
CalgaryAges 2–18 - NCT06668649Recruiting
Polish fatigue scale study for MS, ALS, or stroke
This study tests a Polish version of a scale that measures how tired people feel. It's for people with MS, ALS, or stroke, or healthy volunteers.
Krakow, Lesser Poland VoivodeshipAges 18 years+ - NCT06668792RecruitingPhase 2
Study of BCD-248 for returning multiple myeloma
This trial tests a new treatment called BCD-248 for people whose multiple myeloma has come back or stopped responding to at least two prior treatments. It aims to see if it is safe and effective.
KaliningradAges 18 years+ - NCT06669949Recruiting
Studying the natural history of SPLIS disease
This study collects health information from people with SPLIS to better understand the condition over time. It may include your siblings if they also have SPLIS, and data from patients who have passed away.
San Francisco, CaliforniaAges Any age - NCT06670625Recruiting
Diet and activity counseling for infants at risk for type 1 diabetes
This study tests whether a program of diet and activity advice for families can lower the risk of type 1 diabetes in infants who have a higher genetic chance of developing it. It aims to find simple, everyday ways to help protect your child.
MalmöAges 3 months–4 months - NCT06671054RecruitingPhase 2
Testing AP1189 for newly diagnosed active rheumatoid arthritis
This study tests an oral drug called AP1189 for people just diagnosed with active rheumatoid arthritis who haven't yet taken standard arthritis medicines. You may be able to take part if your disease is very active and you're ready to try a new treatment option.
Cutler Bay, FloridaAges 18 years+ - NCT06675422RecruitingPhase 1/Phase 2
JY231 injection for active lupus
This trial tests an investigational drug called JY231 for people with active systemic lupus erythematosus (SLE) that is not well controlled with standard treatments. The goal is to see if JY231 can reduce lupus activity and improve symptoms.
Kunming, YunnanAges 14–75 - NCT06675955RecruitingPhase 3
Extension study to keep taking ocrelizumab for multiple sclerosis
This extension study continues treatment with ocrelizumab for people with multiple sclerosis who are already taking it as part of a parent trial, to see how MS affects physical function over a longer time. It helps ensure you can keep receiving ocrelizumab even if it's not available where you live.
Amiens Cedex1Ages 18 years+ - NCT06676007Recruiting
Early use of a targeted budesonide for IgA nephropathy
This trial tests starting a special form of budesonide (Nefecon) early in people with IgA nephropathy, a kidney disease. The goal is to see if it can reduce protein in the urine and protect kidney function.
Chengdu, SichuanAges 18–75 - NCT06676384RecruitingPhase 4
Testing additional drugs for IgA nephropathy in South Asian patients
This trial is testing if adding another approved drug to standard treatment can slow kidney function decline in people with IgA nephropathy. It aims to find better options for South Asian adults with this condition.
Nadiād, GujaratAges 18–65 - NCT06676410RecruitingPhase 2
Testing Codivir plus standard HIV treatment in new patients
This trial tests a new investigational drug called Codivir added to standard HIV treatment for people who have never taken HIV medications before. It aims to see if adding Codivir helps control the virus better and is safe.
São PauloAges 18 years+ - NCT06676579RecruitingPhase 2
Avacopan for active IgA kidney disease with crescents
This trial tests if avacopan, a targeted anti-inflammatory drug, can safely treat a severe form of IgA nephropathy (IgAN) where small crescents form in the kidney filters. It may help reduce protein leakage and preserve kidney function.
Jacksonville, FloridaAges 18 years+ - NCT06676618Recruiting
Exercise training for multiple sclerosis patients
This study tests a multimodal exercise program for people with multiple sclerosis. It aims to improve mobility, strength, and overall well-being through guided exercises you can do at home.
Istanbul, BuyukcekmeceAges 20–65 - NCT06676631RecruitingPhase 1
NK cells plus rituximab for active lupus
This study tests whether combining immune cells (NK cells) with rituximab can help people with hard-to-treat lupus or lupus-related kidney disease. It is for patients whose lupus is still active despite standard treatments.
Guangzhou, GuangdomgAges 18–65 - NCT06676657Recruiting
Closed loop with context-aware insulin delivery for type 1 diabetes
This study tests a smart insulin pump system that adjusts automatically during exercise. It aims to make managing blood sugar easier and safer.
Portland, OregonAges 18–100 - NCT06678191Recruiting
Triple combo inhaler study for uncontrolled asthma
This study tests a fixed triple combination inhaler (Trimbow) for people whose asthma is not well controlled with their current treatment. It looks at how well this inhaler works in everyday life over time.
BékéscsabaAges 18 years+
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,230 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,763 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.