Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,050 recruiting studies in this area right now.
By phase
- Not applicable2,999
- Phase 21,056
- Phase 1792
- Phase 1/Phase 2437
- Phase 3435
- Phase 4233
- Phase 2/Phase 398
Top conditions
- Multiple Sclerosis330
- Multiple Myeloma327
- Asthma193
- Lymphoma178
- Rheumatoid Arthritis131
- Type 1 Diabetes130
- Atopic Dermatitis124
- Systemic Lupus Erythematosus119
- Acute Lymphoblastic Leukemia118
- HIV Infections106
- Chronic Lymphocytic Leukemia95
- Autoimmune Diseases77
- Follicular Lymphoma70
- Rheumatoid Arthritis (RA)68
- Diabetes Mellitus, Type 163
- Hodgkin Lymphoma63
- Leukemia63
- Mantle Cell Lymphoma62
Leading sponsors
- National Institute of Allergy and Infectious Diseases (NIAID)97
- Institute of Hematology & Blood Diseases Hospital, China85
- National Cancer Institute (NCI)74
- Assistance Publique - Hôpitaux de Paris65
- AstraZeneca63
- M.D. Anderson Cancer Center58
- Novartis Pharmaceuticals58
- Mayo Clinic49
- City of Hope Medical Center48
- Memorial Sloan Kettering Cancer Center45
Where studies are running
- California496
- Maryland199
- Alabama178
- Florida149
- Arizona148
- Massachusetts116
- New York116
- Texas112
- Illinois83
- Colorado82
Recruiting studies6,050 total
- NCT07480616Recruiting
Indonesian asthma breathing exercise for stable asthma
This study tests a special Indonesian breathing exercise program for adults with stable asthma. It aims to see if this routine helps improve your lung function and asthma control.
JakartaAges 18–65 - NCT07477015Recruiting
Study to find new antibodies in autoimmune encephalitis
This research study looks for new markers in the blood of people with autoimmune encephalitis (a condition where the immune system attacks the brain). It aims to better understand what causes the disease and find new ways to diagnose it.
Rome, RMAges 18 years+ - NCT07476339RecruitingPhase 4
Returning to HIV Care with Biktarvy
This trial tests the medication Biktarvy (bictegravir, emtricitabine, and tenofovir alafenamide) for people with HIV who have stopped taking their antiretroviral therapy (ART) for at least 12 weeks and are ready to restart treatment. It aims to see how well the medication works when restarting care.
Clearwater, FloridaAges 18 years+ - NCT07472972Recruiting
Personalized risk tracking for CD19 CAR T therapy
This study follows patients with relapsed or hard-to-treat B-cell lymphoma who are receiving CD19-directed CAR T cell therapy. Researchers collect blood and tissue samples to better understand each patient's unique risk profile, aiming to improve how the treatment is monitored and managed.
Zurich, Canton of ZurichAges Any age - NCT07477925Recruiting
Studying immune markers for CMV in pregnancy
This study looks at how the immune system responds to a first-time cytomegalovirus (CMV) infection during pregnancy. The goal is to find better ways to predict if the virus will pass to the baby.
Pavia, LombardyAges 18 years+ - NCT07472738Recruiting
Studying treatable traits in chronic airway diseases
This trial is studying people with chronic lung conditions, like COPD or asthma, to find treatable traits. It also includes healthy volunteers for comparison, to better understand what makes these diseases different and how to personalize treatment.
Beijing, Beijing MunicipalityAges 20–75 - NCT07474376Recruiting
Audio diary app for diabetes with other health conditions
This trial tests if using an audio diary app can help people with diabetes and at least one other health condition, like obesity or heart failure, manage their health better. You can join if you have a smartphone and can use the app and online surveys.
Atlanta, GeorgiaAges 65 years+ - NCT05540938RecruitingPhase 4
Testing WangBi granules for rheumatoid arthritis along with standard care
This trial studies whether WangBi granules help control rheumatoid arthritis symptoms when used by people already taking stable methotrexate and tofacitinib. It’s mainly for people with mild-to-moderate disease activity and specific diagnostic features.
BeijingAges 18–75 - NCT06096272Recruiting
Using augmented reality to help kids with cerebral palsy be more active
This trial tests if using an augmented reality game on a tablet can help children with cerebral palsy walk and move more each day. It could be an option if your child can walk on their own and doesn't have upcoming leg surgery.
Los Angeles, CaliforniaAges 5–18 - NCT06769191RecruitingEarly Phase 1
CD7 car-t, stem cell transplant, and kidney transplant for SIOD
This trial tests a sequence of treatments for SIOD (a genetic condition causing immune and kidney problems). First, you receive CD7 car-t cells, then a stem cell transplant from a family donor, followed by a kidney transplant from the same donor. The goal is to see if this approach is safe and can help your body accept the new kidney.
Hangzhou, ZhejiangAges Any age - NCT06778343Recruiting
Biomarkers study for inflammatory rheumatic diseases
This study is looking for people with ankylosing spondylitis, rheumatoid arthritis, or lupus to help find biomarkers that may make diagnosis easier. If you have one of these conditions and haven't tried biologic therapies, you may be able to join.
LisbonAges 18–65 - NCT06783101Recruiting
Smart Inhaler for Teens with Intellectual Disabilities and Asthma
This study tests a 'smart' inhaler that tracks when and how your child uses their asthma medicine. The goal is to help teens with intellectual or developmental disabilities manage asthma better at home.
Los Angeles, CaliforniaAges 10–17 - NCT06782789Recruiting
Study of Tafasitamab and Lenalidomide for aggressive B-cell lymphoma
This study looks back at medical records of people with relapsed or refractory diffuse large B-cell lymphoma who received a combination of two drugs (tafasitamab and lenalidomide) through a special access program. The goal is to learn how well the treatment worked and what side effects occurred.
Bologna, BolognaAges 18 years+ - NCT06782880Recruiting
Fecal transplant to prevent infections after liver transplant
This study tests if giving a fecal transplant (a procedure that transfers healthy bacteria from a donor's stool into your gut) before a liver transplant can lower the risk of serious infections after the surgery. It might help strengthen your immune system to fight off germs.
BolognaAges 18 years+ - NCT06783270RecruitingPhase 1
T-Cell Therapy for Advanced Melanoma
This trial tests a new T-cell therapy made from your own tumor (TILs), genetically edited to remove the PD1 checkpoint blocker. It may help your immune system fight melanoma that has not responded to standard treatments like anti-PD1 therapy.
Herlev, Capital RegionAges 18–75 - NCT06783816Recruiting
New immune cell therapy for blood cancers
This study tests a new type of CAR-T cell therapy designed to treat certain blood cancers (like leukemia, lymphoma, or multiple myeloma) that have come back or not responded to standard treatment. The cells are enhanced with IL-15 to help them work better.
Taiyuan, ShanxiAges Any age - NCT06785519RecruitingEarly Phase 1
CAR-T cell therapy for stubborn lupus kidney disease
This trial tests a new treatment using your own immune cells (called CAR-T cells) that are modified to target two proteins (CD19 and BCMA) on lupus cells. It is for people with lupus nephritis (kidney inflammation) that has not improved after trying multiple standard treatments.
Hangzhou, ZhejiangAges 18 years+ - NCT04807881RecruitingPhase 1
Study of keynatinib for certain hard-to-treat lymphomas
This Phase 1 trial tests keynatinib, a new medicine, in people with specific types of lymphoma that have returned or not responded to earlier treatment. It aims to find a safe dose and see whether it can shrink tumors in the brain or elsewhere in the body, depending on the group.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05421325RecruitingPhase 2
Vaccine-like immune treatment to prevent lung infections in seniors
This Phase 2 study tests a site-specific immune “booster” in people age 65 and older to help improve natural immunity and reduce respiratory (lung/airway) infections. You may be eligible if you can consent, are in an eligible living situation, and are not currently using certain immune-suppressing medicines.
Burnaby, British ColumbiaAges 65 years+ - NCT06779201Recruiting
Fasting and its effects on metabolism and immunity
This study looks at how fasting affects your body's metabolism and immune system. It may help researchers understand if planned periods of not eating can improve health.
BeijingAges 18–65 - NCT02253251Recruiting
Study genes linked to cancer risk and how they may be affected
This study looks at tiny genetic changes (called microRNA binding site mutations) to understand how they relate to cancer risk, prevention, and treatment. If you (or close family members) have had cancer, and you meet the study’s other requirements, your genetic information could help researchers learn how to better predict and manage cancer.
Los Angeles, CaliforniaAges 18 years+ - NCT06787989RecruitingPhase 1
BCMA-CD19 car T cell therapy for immune thrombocytopenia with autoimmune diseases
This trial tests a personalized cell therapy (CAR T cells) that targets two proteins (BCMA and CD19) on immune cells to treat low platelet counts (thrombocytopenia) that haven't improved with other treatments and are linked to autoimmune diseases like lupus or Sjogren's. The goal is to see if this therapy can safely raise your platelet levels and reduce bleeding symptoms.
Chengdu, SichuanAges 18–60 - NCT06307600RecruitingEarly Phase 1
CAR T-Cell Therapy for Relapsed or Refractory B-ALL
This trial tests a new CAR T-cell therapy (called RD06-03) for people whose B-cell acute lymphoblastic leukemia (B-ALL) has returned or hasn't responded to other treatments. It aims to see if the therapy is safe and can help fight the leukemia.
Hefei, AnhuiAges 3–70 - NCT07463521RecruitingPhase 3
Study of rozanolixizumab for ocular myasthenia gravis
This study tests an investigational medication called rozanolixizumab for people who have ocular myasthenia gravis (MG), where weakness is only in the eye muscles. The medicine is given as an injection under the skin and may help improve symptoms like drooping eyelids or double vision.
Scottsdale, ArizonaAges 18 years+
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,050 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,115 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.