Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,229 recruiting studies in this area right now.
By phase
- Not applicable3,142
- Phase 21,065
- Phase 1822
- Phase 1/Phase 2446
- Phase 3423
- Phase 4237
- Phase 2/Phase 394
Top conditions
- Multiple Sclerosis341
- Multiple Myeloma332
- Asthma194
- Lymphoma182
- Rheumatoid Arthritis142
- Type 1 Diabetes133
- Atopic Dermatitis128
- Systemic Lupus Erythematosus125
- Acute Lymphoblastic Leukemia123
- HIV Infections116
- Chronic Lymphocytic Leukemia100
- Autoimmune Diseases81
- Follicular Lymphoma74
- Diabetes Mellitus, Type 169
- Hodgkin Lymphoma67
- Rheumatoid Arthritis (RA)65
- Leukemia64
- Acute Myeloid Leukemia62
Leading sponsors
- Institute of Hematology & Blood Diseases Hospital, China91
- National Institute of Allergy and Infectious Diseases (NIAID)90
- National Cancer Institute (NCI)74
- Assistance Publique - Hôpitaux de Paris70
- M.D. Anderson Cancer Center63
- Novartis Pharmaceuticals63
- AstraZeneca57
- City of Hope Medical Center47
- Mayo Clinic46
- Memorial Sloan Kettering Cancer Center45
Where studies are running
- California492
- Maryland196
- Alabama176
- Florida143
- Arizona141
- New York123
- Massachusetts119
- Texas117
- Illinois82
- Colorado77
Recruiting studies6,229 total
- NCT03413683Recruiting
Studying frailty in older adults living with HIV
This study looks at frailty (feeling weak, having trouble with daily activities, or losing strength) in people age 50 and older who are living with HIV. It may help researchers understand frailty in HIV and how to better support older adults.
ShatinAges 50 years+ - NCT03414502RecruitingPhase 3
Predictors of Response to DMARDs in Rheumatoid Arthritis
This trial studies rheumatoid arthritis (RA) patients starting or adjusting DMARD medicines and looks for signs that predict who responds best. It may help doctors choose more effective treatment sooner.
Omaha, NebraskaAges 19 years+ - NCT03418038RecruitingPhase 2
Vitamin C with chemotherapy for certain relapsed blood cancers
This Phase 2 trial tests whether intravenous vitamin C (ascorbic acid) added to chemotherapy can improve outcomes for people with certain relapsed or treatment-resistant lymphomas or chronic myelomonocytic leukemia (CMML). It may help by boosting chemotherapy’s effectiveness and/or changing how the cancer responds.
Mankato, MinnesotaAges 18 years+ - NCT03422614Recruiting
Study immune-system disorders in people with primary immune problems
This study looks at what is happening in the immune system for people with an inherited (primary) immune problem. It may help researchers better understand the disease and how it works.
ZurichAges Any age - NCT03449706Recruiting
Tracking immune changes in early HIV
This study looks closely at how your immune system and HIV infection markers change right after a new HIV diagnosis. It may help doctors understand the earliest stages of HIV and improve how infections are measured and followed over time.
Ghent, Oost-VlaanderenAges 18–65 - NCT03452774Recruiting
AI matches your cancer tests to possible treatment trials
This trial uses an AI system to help match people with certain cancer types and specific tumor test results (like gene or protein markers) to relevant clinical trials. It may help you and your doctor find studies that fit your cancer biology faster.
Birmingham, AlabamaAges Any age - NCT03458520Recruiting
Kid PET/MR scan registry for solid tumor imaging
This study is a registry that collects images from children (and some adults) with suspected or confirmed solid tumors to help researchers learn how best to use PET/MR scans. It may help future patients by improving imaging and diagnosis planning.
Palo Alto, CaliforniaAges Up to 40 years - NCT03463564RecruitingPhase 4
Insulin pump versus insulin shots for type 1 diabetes control
This study compares an insulin pump to insulin shots to see which better improves blood sugar control and reduces swings in people with type 1 diabetes. You may be included if your diabetes is not well controlled despite education and you’ve had low blood sugar episodes.
NaplesAges 18–30 - NCT03473912Recruiting
Rheumatoid disease biobank study for adults
This study asks adults with a rheumatoid condition to join a biobank, which is a safe place to store health information and biological samples for future research. It may help researchers better understand rheumatoid conditions and develop better treatments.
Kfar SabaAges 18–120 - NCT03481881Recruiting
Drug dosing study in children getting routine medicines
This study measures how children’s bodies handle medicines they are already prescribed as standard care. It may help doctors choose safer, more accurate doses for children in the future.
Durham, North CarolinaAges birth–20 years - NCT03494296Recruiting
Low-dose decitabine plus COP for relapsed lymphoma
This trial studies whether a low-dose chemotherapy medicine (decitabine) combined with a COP chemotherapy regimen can help adults whose diffuse large B-cell lymphoma (DLBCL) has come back or did not respond to treatment. It may be an option if you have measurable disease and can meet key safety and health requirements.
Harbin, HeilongjiangAges 18 years+ - NCT03505216Recruiting
Child lung symptom clinic registry for Swiss families
This study collects information from children and teens (up to age 16) who are seen in a children’s lung clinic for breathing or respiratory problems in Switzerland. The goal is to better understand these conditions in everyday care, which may help improve future diagnosis and treatment.
ViennaAges birth–16 years - NCT03509961RecruitingPhase 2
Reducing total body radiation for children with leukemia transplants
This study looks at whether some children and young adults with B-ALL can safely get a transplant without total body irradiation (TBI), based on special leukemia test results. It’s meant to help lower radiation-related risks while keeping leukemia control strong.
Birmingham, AlabamaAges 1–25 - NCT03512132Recruiting
Test HDL function in type 1 diabetes with kidney changes
This study looks at how well “good cholesterol” (HDL) works in people with type 1 diabetes, especially when kidney tests show early or more advanced damage. Researchers will compare different groups (normal, micro-, and macro-albumin in urine) to better understand HDL’s role and how it may relate to kidney health.
DijonAges 18 years+ - NCT03516617RecruitingPhase 2
Acalabrutinib with or without obinutuzumab for early CLL/SLL
This Phase 2 trial studies whether acalabrutinib, and optionally adding obinutuzumab, can control early-stage chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). It aims to see how well these treatments work and how safe they are in people who have not had prior treatment.
Scottsdale, ArizonaAges 18 years+ - NCT03517579Recruiting
Personalized treatment for Graves and certain thyroid cancers
This trial tests a personalized approach to treat thyroid disorders, either Graves’ disease or certain thyroid cancers that may need radioactive iodine treatment. It may help by matching treatment to your specific test results and needs.
Baltimore, MarylandAges 21–65 - NCT03523221RecruitingPhase 1
Dexamethasone to prevent a second anaphylaxis reaction
This trial tests whether a dose of dexamethasone (a steroid medicine) can help stop anaphylaxis symptoms from returning after the first episode. It focuses on children with mild to moderate anaphylaxis in the emergency department.
DohaAges 3 months–14 years - NCT03524222Recruiting
Home hospital care for adults after sudden illness
This trial tests whether certain adults can safely receive hospital-level care at home instead of staying in the hospital, using a home care team. It may help you recover in your own home if your condition fits their plan and you have support at home.
Boston, MassachusettsAges 18 years+ - NCT03523975RecruitingPhase 1/Phase 2
Testing venetoclax, lenalidomide, and rituximab for new mantle cell lymphoma
This early-phase study tests a combination of venetoclax, lenalidomide, and rituximab in people newly diagnosed with mantle cell lymphoma. It aims to control the lymphoma and see how safe and effective this approach is for newly treated patients.
Duarte, CaliforniaAges 18 years+ - NCT03528226Recruiting
Exercise program to improve blood vessel function in type 1 diabetes
This trial studies whether an exercise training program can improve how well your blood vessels work in people with type 1 diabetes. It may help assess benefits beyond blood sugar control.
LilleAges 18–50 - NCT03533816RecruitingPhase 1
Gamma delta T-cell infusion after stem cell transplant
This early-phase study tests giving a special immune-cell treatment after an allogeneic (donor) stem cell transplant, plus a medication given after transplant to help the new immune system work better. It may help prevent or treat cancer returning after transplant.
Westwood, KansasAges 18–65 - NCT03539692Recruiting
Screening to join food allergy tests with a food challenge
This study checks whether you’re a safe and willing candidate to take part in food allergy clinical studies at one location. It helps decide who can safely undergo the “gold standard” food challenge to confirm or rule out food allergy.
Palo Alto, CaliforniaAges 1 week–90 years - NCT03538899RecruitingPhase 1/Phase 2
Gene therapy for children with an Artemis SCID immune problem
This early-phase study tests an “autologous” gene therapy, meaning they use the child’s own cells, adjusted with a working gene, to help restore immune function. It is for babies and children with Artemis-deficient SCID, aiming to improve T-cell immunity and reduce the need for lifelong infection risk management.
San Francisco, CaliforniaAges 2 months+ - NCT03539705Recruiting
Food Allergy Registry for People of All Ages
This study is a food allergy registry where you can share your experiences and information. It may help researchers better understand food allergies across different ages.
Palo Alto, CaliforniaAges birth–100 years
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,229 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,721 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.