Pulmonology
Lungs & breathing clinical trials
Asthma, COPD, and other conditions that affect the lungs and breathing. We’re tracking 6,618 recruiting studies in this area right now.
By phase
- Not applicable4,293
- Phase 2848
- Phase 1470
- Phase 3423
- Phase 1/Phase 2310
- Phase 4207
- Phase 2/Phase 367
Top conditions
- Lung Cancer424
- Asthma194
- Non Small Cell Lung Cancer189
- Non-Small Cell Lung Cancer179
- Non-small Cell Lung Cancer171
- Obstructive Sleep Apnea156
- COPD143
- Breast Cancer109
- COVID-19107
- Pulmonary Hypertension100
- NSCLC95
- Chronic Obstructive Pulmonary Disease90
- Colorectal Cancer86
- Cystic Fibrosis78
- Interstitial Lung Disease78
- Pneumonia78
- Ovarian Cancer74
- Acute Respiratory Distress Syndrome72
Leading sponsors
- Assistance Publique - Hôpitaux de Paris79
- AstraZeneca65
- Mayo Clinic53
- M.D. Anderson Cancer Center46
- National Cancer Institute (NCI)40
- VA Office of Research and Development39
- Chinese University of Hong Kong36
- Shanghai Chest Hospital36
- University Health Network, Toronto36
- Riphah International University34
Where studies are running
- California389
- Alabama174
- Arizona154
- Massachusetts128
- Florida117
- New York113
- Maryland110
- Texas89
- Pennsylvania84
- Colorado71
Recruiting studies6,618 total
- NCT05490901Recruiting
Test exercise heart pressure measurements with an ultrasound
This study looks at how well two heart tests taken during exercise—direct heart pressure measurement and an ultrasound—can explain shortness of breath with activity. It may help doctors better diagnose what’s causing your symptoms.
SeoulAges 19 years+ - NCT05586906Recruiting
Breath test to detect lung transplant problems early
This trial looks at a simple, noninvasive breath test to spot early lung transplant dysfunction after a lung transplant. Because it focuses on testing after the transplant, it may help your care team catch issues earlier.
ZurichAges 18 years+ - NCT05511987Recruiting
Thopaz+ digital chest tube vs standard drainage in kids
This study compares a digital chest tube drainage system (called Thopaz+) to the usual (analog) drainage in children who need a chest tube. The goal is to see if the digital system works better or is easier for recovery after a pneumothorax or lung surgery.
Oklahoma City, OklahomaAges birth–17 years - NCT05190211Recruiting
Video exercise therapy for idiopathic pulmonary fibrosis
This study tests whether telerehabilitation (supervised exercise/therapy by video or remote tools) can help people with idiopathic pulmonary fibrosis (IPF) improve breathing and function. You may be able to take part if your condition has been stable and you haven’t recently done a pulmonary rehab program.
Istanbul, ZeytinburnuAges 18–75 - NCT05412810Recruiting
Test air-biomarker changes during ICU breathing machine use
This study looks for chemical “biomarkers” in samples taken during ICU care to better understand what happens during mechanical ventilation. It may help future care by identifying signs that could guide safer breathing-machine treatment.
Columbus, OhioAges 18–110 - NCT05188092Recruiting
Lung ultrasound to guide fluid removal in ICU patients
This trial tests whether using a quick scan of the lungs (lung ultrasound) helps ICU teams safely remove the right amount of extra body fluid. It aims to improve care for people who have just been put on a breathing machine but are expected to need it longer than a day.
Arnhem, GelderlandAges 18 years+ - NCT05144633Recruiting
AI and sound checks to help adults with sudden breathing problems
This trial tests whether an artificial intelligence tool and quick lung sound exams can better help doctors manage adults who arrive at the emergency room or are newly admitted with sudden worsening breathing and new oxygen needs. It may help by improving how lung problems are recognized early.
Louisville, KentuckyAges 18–100 - NCT04712877Recruiting
Blood and tumor testing to choose the right lung cancer treatment
This trial tests tumor tissue and a blood sample to help doctors pick the most personalized treatment for people with suspected lung cancer. It may help ensure you get therapy matched to your specific tumor characteristics, especially when the cancer might be surgically removed.
Davis, CaliforniaAges Any age - NCT04912960Recruiting
PEEP breathing support for adults with acute lung failure
This trial studies whether a specific breathing setting called PEEP can help adults whose lungs are failing and who need a breathing machine. Doctors will compare outcomes in patients who fit this critical illness pattern and are safe for the required positioning and ventilator settings.
Las Palmas de Gran Canaria, Las PalmasAges 18 years+ - NCT04992780RecruitingPhase 2
Hypo-fractionated radiation versus standard radiation for lung cancer
This study compares two different radiation schedules for stage III non-small cell lung cancer, both combined with chemotherapy and immunotherapy. It aims to see whether giving radiation in a different way can work as well (or better) and be safe while treating the cancer.
Kansas City, KansasAges 18 years+ - NCT05004714Recruiting
Head Start asthma program study for staff and caregivers
This study helps test an approach to improve asthma care for children in Head Start. You may be able to help by participating as a Head Start staff member or caregiver and allowing audio recording of your input.
District Heights, MarylandAges 18 years+ - NCT05280132Recruiting
Testing quick tests to shorten antibiotics in severe COPD flare
This trial checks whether using fast test results (PCR from samples, a blood marker called procalcitonin, and sputum appearance) can safely reduce how long you need antibiotics during a severe COPD flare. It may help you receive fewer days of antibiotics while still controlling the infection risk.
ParisAges 18 years+ - NCT04738422Enrolling by invitationPhase 2
Measuring airway acidity using exhaled air breath tests
This trial studies how “airway pH” (how acidic your breathing tubes are) changes after you drink or inhale an alkaline buffer, using special breath measurements. It may help researchers better understand and measure airway inflammation in people with lung conditions or in healthy non-smokers.
Indianapolis, IndianaAges 18–60 - NCT04848025Recruiting
Custom 3D stents made for blocked airways
This trial studies a computer-planned, custom-made 3D stent to open up narrow, blocked areas of the main airway near the chest. It may help reduce breathing trouble and cough, and prevent complications from the blockage.
Toulouse, ToulouseAges 18 years+ - NCT04787822Enrolling by invitation
Follow-up for people in a lung transplant research group
This study checks long-term health and well-being in people who previously joined a lung transplant research study. It may help doctors understand long-term changes after transplant and improve future care.
Birmingham, AlabamaAges 13 years+ - NCT05140525RecruitingPhase 3
BPA plus CTEPH medicines to improve heart strain
This trial tests whether starting specific medicines for CTEPH and then doing balloon pulmonary angioplasty (BPA) can improve how well the right side of the heart is working. It may help people who cannot have surgery (PTE) and are newly starting CTEPH/PAH-targeted treatment.
Durham, North CarolinaAges 18 years+ - NCT05126589Recruiting
COVID-19 respiratory sample testing using virus genetic clues
This study looks at respiratory samples from adults after COVID-19 to better understand what viruses may be present and how they change over time. If you live in Hong Kong and can consent, you may be able to help researchers learn from your samples and symptoms.
Hong Kong, Hong KongAges 18 years+ - NCT04886401Recruiting
Study predicting response to pembrolizumab in advanced lung cancer
This study looks back at prior treatment to learn which patients with advanced non-small cell lung cancer (NSCLC) are more likely to respond to pembrolizumab, an immune therapy given up front. The results may help doctors better predict who benefits from this treatment.
BrestAges Any age - NCT05139719RecruitingPhase 2
HEC585 trial for slowing lung scarring decline
This Phase 2 study tests whether HEC585 can slow the decline in lung function in people with progressive fibrosing interstitial lung disease (PF-ILD). It may help preserve breathing capacity and breathing tolerance over time.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05110066Recruiting
Compare two procedures for chronic lung blood-clot pressure
This study compares balloon pulmonary angioplasty versus pulmonary endarterectomy for people with chronic thromboembolic pulmonary hypertension (high blood pressure in the lungs due to long-lasting blood clots). It may help find which procedure works better for improving symptoms and lung circulation after treatment.
AarhusAges 18–79 - NCT04966624Recruiting
Ultrasound-guided breathing strategy for new focal ARDS
This study tests a way to guide ventilator settings using lung ultrasound pictures in adults with very new, localized ("focal") ARDS. The goal is to see whether this approach improves care for people who just started needing a breathing machine.
DijonAges 18 years+ - NCT04893785RecruitingPhase 2
Cabozantinib plus temozolomide for advanced neuroendocrine lung tumors
This Phase 2 study tests whether combining cabozantinib with temozolomide can control advanced lung or gastrointestinal neuroendocrine tumors that have grown after prior treatments. It also closely monitors safety, including blood counts, organ function, and other side effects.
Naples, CampaniaAges 18 years+ - NCT05069441Recruiting
Predicting breathing trouble after removing a breathing tube
This study looks at patients who are ready to have their breathing tube removed and checks how to predict who might struggle after extubation. It’s observational, meaning your care won’t be changed—researchers are gathering information to improve future predictions.
ChongqingAges 18 years+ - NCT04782752Recruiting
Radiation before lung transplant to help stop lung cancer spread
This study tests a focused, low-dose type of radiation given before a lung transplant. The goal is to help your immune system recognize and attack cancer cells (called “radiovaccination”) and improve outcomes for people who cannot get curative treatment with surgery or SBRT alone.
Toronto, OntarioAges 18 years+
Common questions
- How many lungs & breathing clinical trials are recruiting?
- Clin2 is tracking 6,618 recruiting pulmonology studies from the U.S. registry right now, out of 10,521 we cover in this area in total.
- What does “Lungs & breathing” cover here?
- Asthma, COPD, and other conditions that affect the lungs and breathing. We group each study into lungs & breathing based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a lungs & breathing trial near me?
- Use the search to filter lungs & breathing studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.