Pulmonology
Lungs & breathing clinical trials
Asthma, COPD, and other conditions that affect the lungs and breathing. We’re tracking 6,618 recruiting studies in this area right now.
By phase
- Not applicable4,293
- Phase 2848
- Phase 1470
- Phase 3423
- Phase 1/Phase 2310
- Phase 4207
- Phase 2/Phase 367
Top conditions
- Lung Cancer424
- Asthma194
- Non Small Cell Lung Cancer189
- Non-Small Cell Lung Cancer179
- Non-small Cell Lung Cancer171
- Obstructive Sleep Apnea156
- COPD143
- Breast Cancer109
- COVID-19107
- Pulmonary Hypertension100
- NSCLC95
- Chronic Obstructive Pulmonary Disease90
- Colorectal Cancer86
- Cystic Fibrosis78
- Interstitial Lung Disease78
- Pneumonia78
- Ovarian Cancer74
- Acute Respiratory Distress Syndrome72
Leading sponsors
- Assistance Publique - Hôpitaux de Paris79
- AstraZeneca65
- Mayo Clinic53
- M.D. Anderson Cancer Center46
- National Cancer Institute (NCI)40
- VA Office of Research and Development39
- Chinese University of Hong Kong36
- Shanghai Chest Hospital36
- University Health Network, Toronto36
- Riphah International University34
Where studies are running
- California389
- Alabama174
- Arizona154
- Massachusetts128
- Florida117
- New York113
- Maryland110
- Texas89
- Pennsylvania84
- Colorado71
Recruiting studies6,618 total
- NCT05134467Recruiting
Protocol-based weaning from the ventilator in ICU patients
This study looks at a step-by-step plan to help patients come off the breathing machine (mechanical ventilator) and checks how well it works. If you’re an ICU patient on the ventilator for at least two days, you may be eligible to follow their protocol.
SeoulAges 19–99 - NCT05222087RecruitingPhase 1
Radiation for newly diagnosed metastatic lung cancer without driver mutations
This early study tests whether a specific kind of radiation can be safely given to people with newly diagnosed metastatic lung cancer when cure isn’t possible. It’s meant to see how well the treatment can be delivered and how it affects outcomes in a specific genetic group of tumors.
Southport, QueenslandAges 18 years+ - NCT04720339Recruiting
Testing blood DNA changes in lung cancer on immunotherapy
This study checks whether tiny bits of tumor DNA in the blood can be measured over time in people with non-small cell lung cancer who are receiving immunotherapy. It aims to see if these blood tests can help track the cancer response or changes during treatment.
BesançonAges 18 years+ - NCT05233228RecruitingPhase 2
Phone-based coaching to help you quit smoking in Laos
This study tests a mobile phone program that gives personalized help to support quitting smoking. If you’re eligible, it may help you plan a quit date and stick with quitting using the app.
ChampasakAges 18–65 - NCT04912596Recruiting
Tested albuterol inhaler compared to a standard inhaler for mild asthma
This study checks whether a new albuterol inhaler works the same way as a reference inhaler in adults with stable, mild asthma. It may help you (and others) by confirming that the inhaler delivers the right effect and is safe to use.
AhmedabadAges 20–65 - NCT05382728RecruitingPhase 3
Test drug for EGFR-mutant lung cancer without prior treatment
This Phase 3 trial studies TY-9591 in people with locally advanced or metastatic non-small cell lung cancer (NSCLC) that has specific EGFR gene changes. It’s for those who haven’t had earlier medicines for advanced lung cancer, and it aims to see if the drug works better or safer than the comparison treatment.
Changsha, HunanAges 18–80 - NCT04761393Recruiting
Testing a lung protein in COPD sputum samples
This study looks at a lung protein called MMP12 in sputum (mucus) to better understand COPD. It may help researchers learn which COPD changes are linked to disease severity and lung damage.
Hamilton, OntarioAges 40–85 - NCT05147597Recruiting
Study tests a Turkish questionnaire for lung scarring
This study checks whether a Turkish version of a symptom questionnaire works reliably for people with idiopathic pulmonary fibrosis. It may help clinics better understand symptoms and track changes over time.
Istanbul, ÜsküdarAges 18 years+ - NCT04665739RecruitingPhase 2
Lutetium Lu-177 for lung carcinoid tumors with somatostatin receptors
This trial tests lutetium Lu 177 dotatate, a targeted radiation treatment, for advanced lung neuroendocrine (carcinoid) tumors that have a specific marker called somatostatin receptors. It may help shrink tumors by delivering radiation directly to cancer cells that “light up” on a special scan.
Birmingham, AlabamaAges 18 years+ - NCT05394831RecruitingPhase 1/Phase 2
Study of an EGFR-targeted drug for advanced lung cancer
This trial tests a new drug (JIN-A02) in people with advanced or metastatic non-small cell lung cancer (NSCLC) whose cancer has specific EGFR mutations. It mainly checks whether the treatment is safe and tolerable, and how the body handles the drug, with possible benefit depending on your mutation type.
Orange, CaliforniaAges 18 years+ - NCT04662658RecruitingPhase 1/Phase 2
Testing a special MRI gas scan of healthy lungs
This study tests a special MRI scan that uses a “hyperpolarized” gas to look at how well the lungs are working. It’s likely looking for safe imaging results and clear lung measurements in people without lung disease.
Charlottesville, VirginiaAges 18 years+ - NCT05526950Recruiting
Check cytokine filtration for people getting double lung transplants
This study tests a method during double lung transplant surgery to remove certain immune signals (“cytokines”) that may help the transplanted lungs heal. It’s only for adults who are having a planned double lung transplant at the study sites.
Lund, Skåne CountyAges 18–80 - NCT05113017Recruiting
Radiation after surgery for early lung cancer you can’t remove
This trial studies whether a focused form of radiation called SBRT can safely treat remaining lung cancer nodules after surgery. It may help people whose leftover tumor spots can’t be removed by more surgery, aiming to control the cancer while limiting side effects.
Changsha, HunanAges 18–75 - NCT04670523Recruiting
Remove chest tube on day 0 after minor lung surgery
This trial tests whether it is safe to take out a chest tube right on the day of surgery (day 0) after certain small, camera-assisted lung/pleura procedures. It may help reduce time the tube stays in and improve comfort, as long as your specific surgery and recovery risk fit the study plan.
BernAges 18–99 - NCT04696575RecruitingPhase 2
Lamivudine added to chemoimmunotherapy for extensive-stage lung cancer
This trial tests whether adding lamivudine to standard chemoimmunotherapy can improve outcomes for people with extensive-stage small cell lung cancer. It aims to see if this combination controls the cancer better than standard treatment alone.
Buffalo, New YorkAges 18 years+ - NCT05609877Recruiting
Testing LISA breathing treatment for very preterm newborns
This trial is studying whether giving a lung “surfactant” medicine through a thin tube (called LISA) helps very premature babies with breathing problems. It aims to see if this approach improves care for babies born around 24 to 30 weeks gestation who still need oxygen support.
AalborgAges 6 months–7 months - NCT04469842RecruitingEarly Phase 1
Long-acting tacrolimus after lung transplant
This early-stage study tests a long-acting form of tacrolimus (a common anti-rejection medicine) soon after lung transplant. It aims to see if it can be used safely and effectively for people receiving lung transplants at Vanderbilt (VUMC).
Nashville, TennesseeAges 18 years+ - NCT05738720Recruiting
Home breathing rehab to reduce COPD flare-ups and hospital visits
This trial tests whether a breathing and exercise program done at home can lower COPD flare-ups and the chance of needing hospital care. It may help people with more severe COPD manage breathlessness and stay stable.
IstanbulAges 18–75 - NCT05394220Recruiting
Testing pleural fluid to learn causes of fluid buildup
This study uses a sample taken from the fluid around the lungs to understand what is causing the fluid to collect. It may help doctors learn better ways to diagnose infections versus other causes.
Hong KongAges 18 years+ - NCT04216121Recruiting
Testing a focused radiation approach for limited cancer spread
This trial looks at using a targeted form of radiation (LAT, often like SBRT) for people whose lung cancer has spread in only a few places while on osimertinib. It aims to control those “limited progression” spots and help you stay on the same medicine longer.
LeuvenAges 18 years+ - NCT05347563Recruiting
Using a chest sensor to improve ventilation in sick children
This trial tests whether a special chest sensor (called electrical impedance tomography, or EIT) can help doctors distribute breathing support more effectively in children with sudden breathing failure. It may help optimize ventilation while the child is being monitored in intensive care or during anesthesia.
Bron, RhoneAges birth–18 years - NCT05599412Recruiting
Tracking safety of Lorviqua in ALK-positive lung cancer
This study is collecting real-world safety information about Lorviqua (lorlatinib) in adults in Korea who have ALK-positive metastatic non-small cell lung cancer. It helps monitor side effects and safe use after the medicine is already on the market.
SeoulAges 18 years+ - NCT04144569RecruitingPhase 2
PD-1 plus pyrotinib for HER2-mutated lung cancer after chemo
This trial tests a combination treatment—PD-1 plus pyrotinib—in people with advanced lung cancer that has a specific HER2 “insertion” genetic change. It may help if your first standard chemotherapy did not work and you still have measurable tumors to track.
Changsha, HunanAges 18–75 - NCT03431064Recruiting
Ultrasound test during surgery to predict fluid needs in children
This study looks at a specific breathing maneuver done while your child is on a ventilator during surgery, and uses ultrasound-related measurements to predict whether they’ll need extra fluids. If it works, it may help doctors give the right amount of fluid and avoid problems from too little or too much.
Boston, MassachusettsAges Up to 17 years
Common questions
- How many lungs & breathing clinical trials are recruiting?
- Clin2 is tracking 6,618 recruiting pulmonology studies from the U.S. registry right now, out of 10,521 we cover in this area in total.
- What does “Lungs & breathing” cover here?
- Asthma, COPD, and other conditions that affect the lungs and breathing. We group each study into lungs & breathing based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a lungs & breathing trial near me?
- Use the search to filter lungs & breathing studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.