Psychiatry
Mental health clinical trials
Depression, anxiety, and other mental-health and behavioral conditions. We’re tracking 7,780 recruiting studies in this area right now.
By phase
- Not applicable6,422
- Phase 2492
- Phase 1251
- Phase 3240
- Phase 4212
- Phase 1/Phase 294
- Phase 2/Phase 369
Top conditions
- Anxiety387
- Depression382
- Alzheimer Disease339
- Autism Spectrum Disorder240
- Dementia227
- Mild Cognitive Impairment198
- Schizophrenia184
- Major Depressive Disorder173
- Insomnia159
- Cognitive Impairment150
- Alcohol Use Disorder145
- Opioid Use Disorder142
- Stress117
- PTSD105
- Mental Health99
- Autism94
- Suicidal Ideation89
- Mild Cognitive Impairment (MCI)88
Leading sponsors
- VA Office of Research and Development105
- Yale University87
- Massachusetts General Hospital77
- Stanford University68
- Assistance Publique - Hôpitaux de Paris64
- Johns Hopkins University62
- University of California, Los Angeles58
- University of Pennsylvania53
- The University of Hong Kong51
- Karolinska Institutet50
Where studies are running
- California520
- Massachusetts267
- New York256
- Texas209
- Maryland176
- Pennsylvania171
- Florida149
- Alabama118
- Arizona108
- Illinois104
Recruiting studies7,780 total
- NCT06585449RecruitingPhase 1
Study of ALN-HTT02 for Huntington's disease
This trial tests an experimental drug called ALN-HTT02 for people with Huntington's disease. The goal is to see if it can help manage symptoms. Participants must have stage 2 or early stage 3 Huntington's disease.
EdmontonAges 25–70 - NCT06584357Recruiting
Digital and blood markers linked to brain scans in older adults
This study is looking for older adults (60–90) who are either cognitively normal, have mild cognitive impairment (MCI), or have mild-to-moderate Alzheimer's dementia. It aims to see how digital tests and blood-based markers relate to brain scans (amyloid and tau PET). You will need a study partner, undergo MRI and PET scans, and give blood samples.
Atlantis, FloridaAges 60–90 - NCT06585787RecruitingPhase 3
Testing KarXT for psychosis in Alzheimer’s disease
This study tests an investigational medication (KarXT) for treating psychosis—hallucinations or delusions—in people with Alzheimer’s disease. It aims to see if the drug can reduce these symptoms safely and effectively.
Chandler, ArizonaAges 55–90 - NCT06585709Recruiting
Brain stimulation for opioid use disorder treatment
This trial tests if brain stimulation can help people starting buprenorphine for opioid use disorder. It aims to improve treatment outcomes and support recovery.
Durham, North CarolinaAges 18 years+ - NCT06593652Recruiting
How caregivers can help teens with alcohol use
This study looks at how involving caregivers in a brief talk with a primary care provider might help teens who are drinking alcohol or using other substances. It aims to find better ways to support teens and their families.
Indianapolis, IndianaAges 12–17 - NCT06597591Recruiting
Virtual reality training to improve self-control in memory loss patients
This study tests whether a virtual reality training game can help improve your ability to stop yourself or control impulses, which can be affected in early memory problems. You will use a VR headset to practice these skills in a safe, fun environment.
NiceAges 60 years+ - NCT06593353Recruiting
Improving opioid use disorder care for people leaving jail
This study tests a system to improve care for people with opioid use disorder as they leave jail and return to the community. It aims to help patients stay in treatment and avoid interruptions.
Seattle, WashingtonAges 18–110 - NCT06587919Enrolling by invitation
Brain training for pain after trauma
This trial tests a brain-training technique called EEG-neurofeedback to help people with ongoing pain after a traumatic event. It aims to retrain overactive brain networks to reduce pain and distress.
OdenseAges 18 years+ - NCT06584448Recruiting
Drinking, acetate, and stress study
This study looks at how acetate (a substance produced when the body breaks down alcohol) affects stress and drinking. It tests if giving acetate can help people with alcohol use disorder (AUD) reduce their drinking.
New Haven, ConnecticutAges 18–60 - NCT06592677Recruiting
Early support after trauma
This trial tests if early support from a municipal crisis team can help people who have been through a traumatic event. It may be a good option if you have symptoms of post-traumatic stress and want to see if extra support soon after the event can help you feel better.
Asker, AskerAges 16–99 - NCT06584110Recruiting
Buddy-up exercise program for dementia and caregiver
This study tests a buddy-up program where a person with mild to early moderate dementia and their family caregiver do physical activities together using video calls. It aims to see if exercising together helps both their health and well-being.
Hong KongAges 18 years+ - NCT06597981Recruiting
Sport stacking program for mild dementia and caregivers
This trial tests a fun sport stacking activity for people with mild dementia and their family caregivers. It aims to improve well-being and connection through a simple, home-based program.
ChongqingAges 18 years+ - NCT06597942RecruitingPhase 1/Phase 2
Brain stimulation for Alzheimer's disease
This study tests whether a new type of brain stimulation (called repetitive transcranial magnetic stimulation, or rTMS) with a larger coil can improve memory and thinking in people with mild to moderate Alzheimer's disease. It involves multiple sessions of rTMS and MRI scans.
Los Angeles, CaliforniaAges 55–100 - NCT06597305Enrolling by invitation
CBT for adults with anorexia nervosa
This trial tests a 20-session cognitive-behavioral therapy (CBT) designed specifically for adults with anorexia nervosa. You will attend regular therapy sessions and complete questionnaires to see if this treatment helps improve your eating habits and overall well-being.
Boston, MassachusettsAges 18 years+ - NCT06599099Recruiting
Deep brain stimulation for depression that hasn't responded to other treatments
This trial tests if deep brain stimulation (a surgical implant that sends gentle electrical pulses to a specific area of the brain) can help people with bipolar I disorder who are currently in a severe depressive episode and have not found relief from multiple treatments.
Boston, MassachusettsAges 22–64 - NCT06585618Recruiting
Pediatric Deep Brain Stimulation Registry
This study creates a list of children who already have or plan to get Deep Brain Stimulation (DBS) to see how it helps with movement problems. Joining helps doctors learn more about how DBS works in kids.
Boston, MassachusettsAges birth–18 years - NCT06594913Recruiting
Eating Disorders Genetics Study
This study looks at genes linked to eating disorders. It compares people who have had certain eating disorders (like anorexia or bulimia) with people who have never had any eating problems, to find genetic differences.
Chapel Hill, North CarolinaAges 12–99 - NCT06597864Recruiting
A pilot study of 7-step therapy for self-disorder in early psychosis
This trial tests a new type of talk therapy that helps people with early psychosis explore unusual experiences with their sense of self. It might be a good fit if you've been diagnosed with a psychotic disorder within the last 3 years or have psychosis risk syndrome, and you're motivated to work on these experiences.
Sandvika, BærumAges 18–39 - NCT06593093RecruitingPhase 1/Phase 2
Continuing buprenorphine after an overdose emergency
This study tests a bundled approach to help adults who have had an opioid overdose and are starting buprenorphine in the emergency department continue their recovery after being discharged. It is for people who want to stay on buprenorphine and need support after leaving the hospital.
Birmingham, AlabamaAges 19 years+ - NCT06595251Recruiting
Fit2Play park study for better health
This trial looks at health programs in Miami-Dade parks. If you are already in the Fit2Play study, your data will be used to learn how these programs help people get healthier.
Miami, FloridaAges 6–14 - NCT06587230Recruiting
Tealeaf-NC: Teacher-led support for students in North Carolina
This study tests the Tealeaf program, where teachers and school staff work together to support students who may be struggling emotionally or behaviorally. It aims to help students in kindergarten through 8th grade who have elevated scores on a behavior and emotions questionnaire.
Chapel Hill, North CarolinaAges 5–99 - NCT06591754Enrolling by invitation
Personality disorder therapy study at Karolinska
This trial tests a special talk therapy (ISTDP) for people with personality disorders. It aims to see if the therapy helps in a psychiatric clinic setting.
StockholmAges 18 years+ - NCT06585631Recruiting
Collaborative care for young men with HIV and substance use
This study looks at how to better support young men living with or at risk for HIV while also addressing substance use. You'll work with a care team that helps you stay healthy and connected to services.
Baltimore, MarylandAges 15–29 - NCT06597695RecruitingPhase 1/Phase 2
Ketamine group therapy for Spanish-speaking adults with depression
This trial tests whether ketamine-assisted group therapy can help Spanish-speaking Latinx adults with major depression. You would receive ketamine in a supportive group setting, with the goal of improving your mood and quality of life.
Chelsea, MassachusettsAges 18–64
Common questions
- How many mental health clinical trials are recruiting?
- Clin2 is tracking 7,780 recruiting psychiatry studies from the U.S. registry right now, out of 12,430 we cover in this area in total.
- What does “Mental health” cover here?
- Depression, anxiety, and other mental-health and behavioral conditions. We group each study into mental health based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mental health trial near me?
- Use the search to filter mental health studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.