Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,057 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 381
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University52
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California39
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,057 total
- NCT06581510Recruiting
Comparing crown types for baby molars in children
This trial tests three different types of crowns for children's back baby teeth to see which one works best. The crowns are either custom-made from zirconia, 3D-printed resin, or ready-made zirconia. It may help if your child needs a crown on a lower or upper second baby molar.
CairoAges 5–8 - NCT06529601Recruiting
Digital vs. traditional lower tooth retainers after braces
This trial compares two types of retainers (wire bonded to the back of your lower front teeth) after braces. One retainer is made with a digital design (CAD/CAM), the other is made the traditional way.
FlorenceAges 13–20 - NCT06535867Recruiting
Comparing phone-based vs. in-person mouth cancer screening in rural India
This study compares two ways to find early signs of mouth cancer or conditions that could lead to cancer. One method uses a simple phone-based health check, and the other uses standard in-person screening. People in rural areas of Varanasi who are at risk—such as those who use tobacco or have mouth sores—may be able to join.
New York, New YorkAges 18 years+ - NCT06570499Recruiting
Comparing dental impression methods for full-arch implants
This trial compares three ways to take dental impressions for full-arch implant-supported prostheses: traditional putty, intraoral scanning, and digital photogrammetry. It aims to find which method is most accurate, which could help improve comfort and fit for people with multiple dental implants.
Liège, LiegeAges 18 years+ - NCT06552793Recruiting
Tooth Graft vs Bone Graft for Socket Preservation
This study tests a new way to preserve the shape of your gum and bone after a tooth is pulled in the front of your mouth. It compares using your own tooth (specially treated) versus a standard bone graft material to see which works better.
CairoAges 18–65 - NCT06529653Recruiting
Comparing two ways to widen the upper jaw bone for implants
This trial compares two methods to widen the upper front jaw bone so dental implants can be placed. One method uses a piece of your own bone, the other uses the existing bone to create more space. The goal is to find which technique works best for people with a narrow jaw ridge.
CairoAges 25–55 - NCT06583720RecruitingPhase 1
Light therapy and probiotics for bad breath
This trial tests a new approach for treating bad breath (halitosis) using a special light therapy combined with probiotics (good bacteria). It aims to see if this combination works better than standard treatments.
São Paulo, São PauloAges 18–60 - NCT06587048Recruiting
New bone window surgery for root canal infections
This trial tests a new way to perform root-end surgery using a special ultrasound device. It aims to treat infections at the tip of a tooth root by making a small opening in the bone, which may help you heal faster.
Rohtak, HaryanaAges 18–60 - NCT06399198Recruiting
Gum graft changes around dental implants
This study looks at how gum grafts change shape around dental implants. If you have a dental implant with thin gum tissue on the cheek side, this could help understand how to improve it.
IstanbulAges 18 years+ - NCT06449014Recruiting
Mini-implant palate expander for teens and adults
This study tests whether a new type of palate expander that uses small implants (mini-screws) can safely widen the upper jaw in people 16 and older. It may be an option for you if your upper jaw is too narrow, even if you have already stopped growing.
Anderlecht, Brussels CapitalAges 16 years+ - NCT06470217RecruitingPhase 2
Study of tirilizumab plus chemo for advanced oral cancer
This trial tests a combination of immunotherapy (tirilizumab) and two chemotherapy drugs (albumin-bound paclitaxel and cisplatin) for people with advanced but removable oral cancer. The goal is to see if this treatment shrinks the tumor before surgery and improves outcomes.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06342258RecruitingPhase 1
Sealant order: does it matter for children's teeth?
This study tests whether the order in which a dentist applies sealant to a child's molars affects how well the sealant works. It is for healthy children ages 5–14 who have permanent molars on both sides of their mouth and can cooperate during a dental visit.
Los Angeles, CaliforniaAges 5–14 - NCT06414863Recruiting
Palatal expansion with Invisalign in children and teens
This trial tests if the Invisalign Palatal Expander System can widen the upper jaw in children and teens with a narrow upper jaw or crossbite. It may help align the bite and avoid more invasive treatments.
San Francisco, CaliforniaAges 6–14 - NCT06461728Recruiting
Simple root canal heating method for infected teeth
This trial tests a new way to clean infected teeth by heating and activating the disinfecting liquid inside the tooth. It may help heal the infection at the tip of the root.
BeirutAges 18 years+ - NCT06453330Recruiting
Does H-PRF improve dental implant healing?
This trial tests whether a special blood concentrate called H-PRF helps dental implants heal faster and stay more stable in the jawbone. If you need an implant and meet the health and bone requirements, you may be able to join.
DublinAges 18 years+ - NCT06407271Recruiting
Implant crown shape and gum health study
This study tests whether the shape of the implant crown (the part above the gum) affects the health of the gum and bone around a single front tooth implant. It's for people with a missing upper front tooth, healthy gums, and thick gum tissue.
Budapest, Pest CountyAges 18 years+ - NCT06372561Recruiting
Melatonin vs MTA for treating tooth nerve in children
This trial compares two materials—melatonin and MTA (a commonly used dental material)—for treating the nerve of a child's permanent back tooth that has a cavity but isn't infected. The goal is to see which material works better to keep the tooth healthy.
IsmailiaAges 6–8 - NCT06442787Recruiting
New 3D Planning for Jaw Surgery
This study tests a new way to plan jaw surgery using 3D computer models, custom guides, and plates. It may help people with a certain type of jaw misalignment get more precise results from their surgery.
Istanbul, FatihAges 18–55 - NCT06273449Recruiting
Smart digital workflow for partial dentures
This trial tests a new, computer-assisted method for making partial dentures that fit more precisely. You may be eligible if you already have experience wearing a partial denture and are missing some teeth.
SingaporeAges 21 years+ - NCT06288477Recruiting
Comparing two treatments for baby molar teeth with deep decay
This study compares two treatments for baby molar teeth that have deep decay but are still healthy otherwise: a newer material called Neo-putty (a type of bioceramic material) versus a standard medicine called formocresol. The goal is to see which one works better to keep the tooth healthy and prevent further problems.
El-Sheikh Zayed City, Giza GovernorateAges 4–9 - NCT06226038Recruiting
Magnetic field effect on dental implant stability
This trial tests whether a static magnetic field can help make dental implants more stable. It may be an option if you need a dental implant and are generally healthy.
Bangkok, PayataiAges 18 years+ - NCT06307691Recruiting
Comparing two implant placement methods after tooth removal
This trial compares two ways of placing a dental implant right after a tooth is removed. One method ('osseodensification') gently compacts the bone, while the other uses a traditional drilling technique. The study wants to see which method gives better bone support and healing.
CairoAges 20–60 - NCT06038487Recruiting
Early vs. standard timing for upper jaw implant dentures
This trial compares placing implants in the upper jaw immediately versus waiting for healing, to see which approach works better for people who already wear full dentures. You may qualify if you have no upper teeth and your jawbone is healthy enough for implants without extra bone grafts.
Cleveland, OhioAges 21 years+ - NCT06067945Recruiting
Comparing Fit of All-Metal Crowns on Artificial Molars
This lab study is testing how well all-metal crowns fit on artificial upper back molars when made using the traditional lost-wax technique. It compares the crown's edge fit and internal adaptation to see which method works best.
Karachi, SindhAges Any age
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,057 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,953 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.