Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,957 recruiting studies in this area right now.
By phase
- Not applicable1,542
- Phase 2142
- Phase 384
- Phase 181
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma73
- Periodontal Diseases50
- Dental Caries45
- Head and Neck Cancer35
- Gingivitis33
- Oral Cancer31
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Maryland21
- Massachusetts21
- Florida20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,957 total
- NCT06308328Recruiting
Mucosal contouring study for oral pain from radiation
This study tests a new way to reduce mouth and throat pain caused by radiation therapy for nasopharyngeal cancer. It may help if you are currently getting radiation or chemoradiation and have mouth sores.
Guangzhou, GuangdongAges 18 years+ - NCT06307691Recruiting
Comparing two implant placement methods after tooth removal
This trial compares two ways of placing a dental implant right after a tooth is removed. One method ('osseodensification') gently compacts the bone, while the other uses a traditional drilling technique. The study wants to see which method gives better bone support and healing.
CairoAges 20–60 - NCT06313450Recruiting
Lower radiation for nose cancer after immunotherapy and chemo
This trial tests whether giving a lower dose of radiation to the main tumor is safe and effective for people with nasopharyngeal cancer (a type of nose/throat cancer) who first receive a combination of immunotherapy (toripalimab) and chemotherapy. It aims to reduce side effects while still controlling the cancer.
Guangzhou, GuangdongAges 18–70 - NCT06321939Recruiting
Tracking EBV DNA in Blood for Nasopharyngeal Cancer
This trial studies whether tracking levels of Epstein-Barr virus DNA in your blood can help guide treatment for non-metastatic nasopharyngeal cancer. You would get standard radiation and maybe chemotherapy, with extra blood tests to see how the virus levels change.
Changsha, HunanAges 18 years+ - NCT05399589Recruiting
Dental implant study using Nobel parallel implants in back teeth
This trial looks at how well a specific type of dental implant works in the back of the mouth (upper or lower). It may help patients by testing whether this implant-and-connector setup leads to good results without needing extra bone procedures.
Hangzhou, ZhejiangAges 18–70 - NCT06173167Recruiting
Same-day zirconia crowns for back teeth
This study tests a new type of same-day zirconia crown made in the dentist's office. It compares two different zirconia materials for strength and durability, and aims to see which one works best for back teeth.
Ann Arbor, MichiganAges 18 years+ - NCT06347640Recruiting
Blood clot treatment for dead permanent teeth
This trial is testing a new way to save a dead tooth by using a special blood clot (platelet-rich fibrin) to help the tooth heal itself. It is for adults who have a permanent tooth that is dead and infected at the root tip, but still has a good chance of being saved.
IrbidAges 12–60 - NCT05221450Recruiting
Study of what affects root canal treatment outcomes
This study looks at which factors can change how well root canal (endodontic) treatment works. It may help improve future care by understanding what leads to better healing.
LjubljanaAges 18 years+ - NCT06282497Recruiting
New radiation technique to reduce dry mouth in nasopharyngeal cancer
This trial compares a new radiation technique designed to reduce dry mouth (xerostomia) with standard radiation for people with nasopharyngeal cancer. It aims to see if the new approach can protect saliva glands while still treating the cancer effectively.
Zhongshan, GuangdongAges 18–70 - NCT06407271Recruiting
Implant crown shape and gum health study
This study tests whether the shape of the implant crown (the part above the gum) affects the health of the gum and bone around a single front tooth implant. It's for people with a missing upper front tooth, healthy gums, and thick gum tissue.
Budapest, Pest CountyAges 18 years+ - NCT06191107Recruiting
Partial dentures made of PEEK
This trial tests partial dentures made of a special plastic (PEEK). It may be an option if you need a removable partial denture held by clasps.
HeidelbergAges 18–75 - NCT06408337RecruitingPhase 1/Phase 2
Biocleft for cleft palate repair in children
This trial tests a new treatment called BIOCLEFT, made from your child's own cheek cells, to help repair a complete cleft palate on one side. It aims to see if the treatment is safe and works better than standard surgery.
Granada, Spain/GranadaAges 10 months–1.2 years - NCT06409923RecruitingPhase 1
Comparing Herbst vs Invisalign for jaw alignment in teens
This trial compares two different braces (a Herbst appliance and Invisalign MA) to see which works better for teenagers whose upper jaw is too far forward. It's for kids who are still growing and have a specific type of overbite.
AnderlechtAges Up to 15 years - NCT06122805Recruiting
Electric vs. Manual Toothbrush for Kids with Cleft Lip/Palate
This study compares a special dual-light electric toothbrush to a regular manual toothbrush for kids and teens with cleft lip or palate who wear braces. The goal is to see which brush keeps teeth cleaner and gums healthier during orthodontic treatment and after oral surgery.
Los Angeles, CaliforniaAges 6–20 - NCT05167656Recruiting
Manual therapy for one-sided jaw pain
This study compares two types of hand-based therapy to see which helps people with jaw (temple/ear-area) pain on one side. You may be eligible if your jaw pain has lasted more than a month and you have not had recent jaw-related treatment or procedures.
Alcalá de Henares, MadridAges 18–75 - NCT05415111Recruiting
Gum graft treatment to improve inflammation around dental implants
This trial tests whether adding a soft-tissue gum graft procedure can improve healing and reduce inflammation in moderate to severe peri-implantitis (inflammation and tissue damage around a dental implant). It may help patients by targeting both the gum tissue and the area around the implant that is bleeding or has deep pockets.
FrankfurtAges 18 years+ - NCT06019130RecruitingPhase 2
Nivolumab for newly diagnosed nasopharyngeal cancer
This trial tests whether the immunotherapy drug nivolumab (Opdivo) can help treat nasopharyngeal cancer in both children and adults. It is for people who have just been diagnosed and have not yet received any cancer treatment.
AachenAges 3 years+ - NCT06226038Recruiting
Magnetic field effect on dental implant stability
This trial tests whether a static magnetic field can help make dental implants more stable. It may be an option if you need a dental implant and are generally healthy.
Bangkok, PayataiAges 18 years+ - NCT06414863Recruiting
Palatal expansion with Invisalign in children and teens
This trial tests if the Invisalign Palatal Expander System can widen the upper jaw in children and teens with a narrow upper jaw or crossbite. It may help align the bite and avoid more invasive treatments.
San Francisco, CaliforniaAges 6–14 - NCT06410833RecruitingPhase 4
Combination therapy for resistant Sjögren's in children
This trial tests a combination of two medicines, rituximab then belimumab, for children and teens with Sjögren's syndrome that hasn't improved with other treatments. The goal is to see if this two-step approach can better control symptoms like joint pain, skin rashes, and blood problems.
Beijing, Beijing MunicipalityAges 5–18 - NCT06417502Recruiting
China pediatric rheumatic disease registry study
This study collects information from children with rheumatic and immune system diseases in China to better understand these conditions. By participating, you help researchers learn more about how to diagnose and treat these diseases.
Beijing, Beijing MunicipalityAges Up to 18 years - NCT04444869RecruitingPhase 2
Lower-dose radiation with chemotherapy for low-risk HPV throat cancer
This trial tests whether a less intense (lower-dose) radiation plan, combined with chemotherapy, can control HPV-positive oropharyngeal (throat) cancer with fewer side effects. It targets people considered “low-risk” based on tumor size and lymph node involvement.
Columbia, MissouriAges 18 years+ - NCT07852806Recruiting
Bone marrow cells for repairing severe jaw bone defects
This trial tests whether using your own bone marrow cells can help repair severe bone loss in the jaw. It may offer a new way to rebuild bone for people who need a bone graft.
Nanjing, JiangsuAges 16–60 - NCT07851857RecruitingPhase 3
Short course of antibiotics after head and neck cancer surgery
This trial tests whether giving antibiotics for one day after head and neck surgery works just as well as giving them for longer to prevent infections. It might help you have a smoother recovery with fewer side effects from antibiotics.
São Paulo, São PauloAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,957 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,729 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.