Clinical trials
Acute Respiratory Failure clinical trials
Below are recruiting acute respiratory failure clinical trials, each written for real people, not researchers. We’re tracking 172 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05689645RecruitingPhase 2
Drug trial for liver injury or liver failure
This Phase 2 trial tests an injection medicine (F573) to see if it can improve people with liver injury, drug-related liver damage, or liver failure. You may be screened with blood tests, liver stiffness measurements, and possibly symptom checks.
Beijing, Beijing MunicipalityAges 18–60 - NCT07603310Recruiting
PEEP levels in ARDS based on lung response
This study tests whether adjusting ventilator settings based on how well your lungs respond can improve oxygen and reduce damage in patients with moderate to severe ARDS, within the first 36 hours of diagnosis.
Rancagua, Región del Libertador General Bernardo O’HigginsAges 18 years+ - NCT05354141RecruitingPhase 3
Tested treatment with tiny lung particles for moderate to severe ARDS
This Phase 3 trial studies an “extracellular vesicle” treatment in people with moderate to severe ARDS, a serious lung breathing problem. The goal is to see whether the treatment can improve outcomes compared with standard care.
Phoenix, ArizonaAges 18–75 - NCT05795465RecruitingPhase 2
Study drug for people with acute respiratory distress syndrome
This Phase 2 trial tests GEn-1124 to see if it can improve outcomes in people with acute respiratory distress syndrome (ARDS). You may be eligible if the study drug can be started very soon after ARDS is diagnosed and if you meet the safety and health requirements.
Washington D.C., District of ColumbiaAges 18–85 - NCT07558538RecruitingEarly Phase 1
Inhaled Growth Factor Treatment for Severe Lung Failure
This early-stage trial tests whether an inhaled medication called recombinant human keratinocyte growth factor-2 (rh-KGF-2) can help patients with acute respiratory distress syndrome (ARDS)—a serious condition where the lungs cannot deliver enough oxygen to the blood. The drug is designed to help repair lung tissue damage.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06465498Recruiting
Lung ultrasound for heart failure congestion treatment
This trial tests whether using lung ultrasound to guide decongestion treatment improves outcomes for patients hospitalized with congestive heart failure. It may help doctors tailor your care more precisely.
Geneva, Canton of GenevaAges 18 years+ - NCT07307066Recruiting
Ventilation feedback study for lung protection in ARDS
This study tests a computer system that gives real-time breathing machine advice to help protect the lungs of patients with severe lung injury (ARDS). It may help doctors adjust the ventilator settings to cause less damage.
Qujing, YunnanAges 18–75 - NCT07576660RecruitingPhase 3
Dexamethasone for lung injury from sepsis
This trial tests whether the steroid dexamethasone can help people with sepsis who develop acute respiratory distress syndrome (ARDS), a severe lung injury. If you have an infection and need breathing support, this study may help find a better treatment.
Nanjing, JiangsuAges Any age - NCT07086755RecruitingPhase 2/Phase 3
Vadadustat treatment for lung injury from infection
This trial tests a pill called vadadustat for people with a serious lung condition called ARDS, which makes it hard to breathe. The drug may reduce inflammation and improve oxygen levels, helping patients recover without needing a breathing tube.
Houston, TexasAges 18 years+ - NCT07211529Recruiting
Nerve block during chest surgery to reduce complications
This trial tests whether a numbing injection near the spine (paravertebral block) given during keyhole chest surgery can lower the risk of problems after surgery. It might help patients recover more comfortably.
Wuhan, HubeiAges 18–80 - NCT06916585RecruitingPhase 2
Testing AS1501 for acute-on-chronic liver failure
This trial tests a new drug called AS1501 for people with acute-on-chronic liver failure (a sudden worsening of chronic liver disease). It aims to see if the drug can help improve liver function and reduce the need for a liver transplant. You may be eligible if you are in the early or middle stage of this condition and have a specific blood marker (high TRAIL level).
Shenzhen, GuangdongAges 18–75 - NCT07156669Recruiting
Safety and Performance of Novalung ECMO Kit and Xenios 2.0
This study is testing how well a special ECMO device (Novalung ultimate kit with Xenios 2.0) works for adults in the hospital and during ground transport. If you already need ECMO with this specific device, you may be able to join.
Erfurt, BavariaAges 18 years+ - NCT06203405Recruiting
Sedation guided by breathing effort in ICU patients
This trial tests a new way to manage sedation (medication to keep you calm and comfortable) for people on a breathing machine. The goal is to see if adjusting sedation based on your breathing effort leads to better outcomes and shorter time on the machine.
Bangkok, BangkokAges 18 years+ - NCT06114667Recruiting
Nasal high flow vs. mask for COPD flare-up
This study compares two types of breathing support for people having a severe COPD flare-up with high carbon dioxide and acidic blood. It tests if a gentle air flow through the nose (nasal high flow) works as well as a mask (non-invasive ventilation) to help you breathe better.
Montpellier, MontepllierAges 18–85 - NCT07437846Recruiting
How lung pressure settings affect breathing effort in ICU patients
This trial looks at how different breathing support settings (called PEEP) affect how hard your lungs have to work when you are on a breathing machine. The goal is to find the best setting to make breathing easier for you.
Santiago, Santiago MetropolitanAges 18 years+ - NCT07346118Recruiting
Guided fluid management in severe kidney failure using ultrasound
This study tests a new way to manage fluids in patients with acute kidney injury who are receiving a type of dialysis called continuous renal replacement therapy. The method uses ultrasound to check blood flow in the veins and kidneys to guide fluid decisions, which may help recovery.
BangkokAges 18 years+ - NCT06684379RecruitingPhase 1/Phase 2
Two Doses of PRS CK STORM for Severe Viral Pneumonia
This study tests a new drug called PRS CK STORM to see if it can safely calm the body's overactive immune response (cytokine storm) in people with severe pneumonia from COVID-19, flu, or RSV who need oxygen. It aims to reduce inflammation and improve recovery.
Alcalá de Henares, MadridAges 18 years+ - NCT04220463Recruiting
Hypnosis during noninvasive breathing support for ICU lung illness
This trial tests whether hypnosis can help people in the ICU who need noninvasive breathing support (breathing help without a tube) for breathing flare-ups related to COPD and/or obesity. It aims to make this treatment easier and safer while you are awake.
Rennes, Brittany RegionAges 18 years+ - NCT07701096Enrolling by invitation
Home breathing support monitoring for advanced COPD
This study tests a home monitoring system that watches how well noninvasive breathing support (a mask that helps you breathe) works for people with severe COPD. The system sends early warnings to your care team if your breathing patterns change, which may help prevent flare-ups.
BeijingAges 18 years+ - NCT05640635Recruiting
Testing inflammation changes in people on ECMO
This study looks at inflammation during ECMO (a heart-lung bypass machine) and while people are being weaned off it. It may help doctors better understand which patients are improving safely during ECMO and when to reduce support.
Tübingen, Baden-WurttembergAges 18 years+ - NCT07645534RecruitingPhase 1
Testing a New Antiviral Medicine Formulation in Healthy Adults
This study compares two versions of an antiviral medicine called Ingavirin to see how your body processes them and whether they are safe. Researchers will give you the medicine on an empty stomach and after eating to understand how food affects how your body absorbs it.
Saint PetersburgAges 18–45 - NCT07522450Recruiting
Sleep monitoring in critically ill patients on breathing support
This study measures sleep quality in patients hospitalized in intensive care who need help breathing. Researchers will use EEG (brain wave monitoring) to see if tracking sleep helps improve patient care and outcomes.
RouenAges 18 years+ - NCT07511582RecruitingPhase 2
Steroids for severe breathing problems in the ICU
This study tests whether a corticosteroid (a type of anti-inflammatory medicine) can help people with severe breathing problems or serious infections who have a specific 'hyperinflammatory' pattern. If you are in the ICU on a ventilator, this trial may be an option for you.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07503509Recruiting
Study of high PEEP in noninvasive ventilation
This study tests whether using higher pressure settings (PEEP) on a noninvasive breathing mask can help people with low oxygen levels. The doctors will measure the pressure inside your esophagus to guide the treatment.
Chongqing, Chongqing MunicipalityAges 18–100
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Common questions
- Are there clinical trials for acute respiratory failure?
- Yes. Clin2 currently lists 172 recruiting acute respiratory failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acute respiratory failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acute respiratory failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.