Clinical trials
Acute Respiratory Failure clinical trials
Below are recruiting acute respiratory failure clinical trials, each written for real people, not researchers. We’re tracking 179 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06526598Recruiting
Breathing support tailored to your effort in the ICU
This trial tests a new way of adjusting breathing machine support based on how hard you are breathing. It may help people with low oxygen levels who need a ventilator.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06699433Recruiting
AI virtual pediatric patient training for primary care doctors
This trial uses artificial intelligence to create virtual standardized pediatric patients. It helps train doctors who work in primary care settings, like community health centers and clinics.
Guiyang, GuizhouAges Any age - NCT06921655Recruiting
Using pressure and muscle measurement to avoid too much breathing help in the ICU
This study tests a new way to adjust the breathing machine settings for patients who are awake and breathing on their own but still need support. The goal is to avoid giving too much help, which can make the breathing muscles weak.
Trento, TrentoAges 18 years+ - NCT07047092RecruitingPhase 3
CPAP vs. NIV for sleep apnea in COPD after breathing failure
This trial compares two breathing devices (CPAP and NIV) for people with both COPD and sleep apnea who recently needed breathing help in the hospital. The goal is to see which device works better at preventing future breathing emergencies.
ParisAges 18–84 - NCT07615010RecruitingPhase 2
agenT-797 Plus Standard Care for Severe Pneumonia With Respiratory Failure
This trial tests whether adding an experimental drug called agenT-797 to standard pneumonia treatment helps patients in the ICU who have severe pneumonia and serious difficulty breathing (acute hypoxemic respiratory failure). The drug is designed to help the immune system fight severe infection.
San Francisco, CaliforniaAges 18 years+ - NCT05689645RecruitingPhase 2
Drug trial for liver injury or liver failure
This Phase 2 trial tests an injection medicine (F573) to see if it can improve people with liver injury, drug-related liver damage, or liver failure. You may be screened with blood tests, liver stiffness measurements, and possibly symptom checks.
Beijing, Beijing MunicipalityAges 18–60 - NCT05354141RecruitingPhase 3
Tested treatment with tiny lung particles for moderate to severe ARDS
This Phase 3 trial studies an “extracellular vesicle” treatment in people with moderate to severe ARDS, a serious lung breathing problem. The goal is to see whether the treatment can improve outcomes compared with standard care.
Phoenix, ArizonaAges 18–75 - NCT07603310Recruiting
PEEP levels in ARDS based on lung response
This study tests whether adjusting ventilator settings based on how well your lungs respond can improve oxygen and reduce damage in patients with moderate to severe ARDS, within the first 36 hours of diagnosis.
Rancagua, Región del Libertador General Bernardo O’HigginsAges 18 years+ - NCT06047405Recruiting
Comparing two breathing machine settings for high carbon dioxide failure
This trial tests two different ways of setting a noninvasive breathing machine (BiPAP) to help patients with high carbon dioxide levels in the blood due to respiratory failure. It aims to find which setting works better for patients at Lenox Hill Hospital.
New York, New YorkAges 18 years+ - NCT05795465RecruitingPhase 2
Study drug for people with acute respiratory distress syndrome
This Phase 2 trial tests GEn-1124 to see if it can improve outcomes in people with acute respiratory distress syndrome (ARDS). You may be eligible if the study drug can be started very soon after ARDS is diagnosed and if you meet the safety and health requirements.
Washington D.C., District of ColumbiaAges 18–85 - NCT07558538RecruitingEarly Phase 1
Inhaled Growth Factor Treatment for Severe Lung Failure
This early-stage trial tests whether an inhaled medication called recombinant human keratinocyte growth factor-2 (rh-KGF-2) can help patients with acute respiratory distress syndrome (ARDS)—a serious condition where the lungs cannot deliver enough oxygen to the blood. The drug is designed to help repair lung tissue damage.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06465498Recruiting
Lung ultrasound for heart failure congestion treatment
This trial tests whether using lung ultrasound to guide decongestion treatment improves outcomes for patients hospitalized with congestive heart failure. It may help doctors tailor your care more precisely.
Geneva, Canton of GenevaAges 18 years+ - NCT07307066Recruiting
Ventilation feedback study for lung protection in ARDS
This study tests a computer system that gives real-time breathing machine advice to help protect the lungs of patients with severe lung injury (ARDS). It may help doctors adjust the ventilator settings to cause less damage.
Qujing, YunnanAges 18–75 - NCT05181696Recruiting
Study of chest X-ray severity scores in ICU COVID-19 pneumonia
This study reviews past chest X-rays from people who were hospitalized in the ICU for COVID-19 pneumonia caused by SARS-CoV-2. It aims to see how well a chest X-ray severity scoring system reflects how sick the lungs were.
OsijekAges 18–90 - NCT07086755RecruitingPhase 2/Phase 3
Vadadustat treatment for lung injury from infection
This trial tests a pill called vadadustat for people with a serious lung condition called ARDS, which makes it hard to breathe. The drug may reduce inflammation and improve oxygen levels, helping patients recover without needing a breathing tube.
Houston, TexasAges 18 years+ - NCT07211529Recruiting
Nerve block during chest surgery to reduce complications
This trial tests whether a numbing injection near the spine (paravertebral block) given during keyhole chest surgery can lower the risk of problems after surgery. It might help patients recover more comfortably.
Wuhan, HubeiAges 18–80 - NCT06916585RecruitingPhase 2
Testing AS1501 for acute-on-chronic liver failure
This trial tests a new drug called AS1501 for people with acute-on-chronic liver failure (a sudden worsening of chronic liver disease). It aims to see if the drug can help improve liver function and reduce the need for a liver transplant. You may be eligible if you are in the early or middle stage of this condition and have a specific blood marker (high TRAIL level).
Shenzhen, GuangdongAges 18–75 - NCT06203405Recruiting
Sedation guided by breathing effort in ICU patients
This trial tests a new way to manage sedation (medication to keep you calm and comfortable) for people on a breathing machine. The goal is to see if adjusting sedation based on your breathing effort leads to better outcomes and shorter time on the machine.
Bangkok, BangkokAges 18 years+ - NCT03515031Recruiting
Compare two oxygen masks for breathing failure from pneumonia
This trial compares two ways of giving oxygen—high-flow nasal tubes versus a Venturi face mask—for adults with pneumonia causing acute breathing failure. It aims to see which method works better to improve breathing and recovery.
BergamoAges 18 years+ - NCT06114667Recruiting
Nasal high flow vs. mask for COPD flare-up
This study compares two types of breathing support for people having a severe COPD flare-up with high carbon dioxide and acidic blood. It tests if a gentle air flow through the nose (nasal high flow) works as well as a mask (non-invasive ventilation) to help you breathe better.
Montpellier, MontepllierAges 18–85 - NCT07437846Recruiting
How lung pressure settings affect breathing effort in ICU patients
This trial looks at how different breathing support settings (called PEEP) affect how hard your lungs have to work when you are on a breathing machine. The goal is to find the best setting to make breathing easier for you.
Santiago, Santiago MetropolitanAges 18 years+ - NCT06684379RecruitingPhase 1/Phase 2
Two Doses of PRS CK STORM for Severe Viral Pneumonia
This study tests a new drug called PRS CK STORM to see if it can safely calm the body's overactive immune response (cytokine storm) in people with severe pneumonia from COVID-19, flu, or RSV who need oxygen. It aims to reduce inflammation and improve recovery.
Alcalá de Henares, MadridAges 18 years+ - NCT04220463Recruiting
Hypnosis during noninvasive breathing support for ICU lung illness
This trial tests whether hypnosis can help people in the ICU who need noninvasive breathing support (breathing help without a tube) for breathing flare-ups related to COPD and/or obesity. It aims to make this treatment easier and safer while you are awake.
Rennes, Brittany RegionAges 18 years+ - NCT04966624Recruiting
Ultrasound-guided breathing strategy for new focal ARDS
This study tests a way to guide ventilator settings using lung ultrasound pictures in adults with very new, localized ("focal") ARDS. The goal is to see whether this approach improves care for people who just started needing a breathing machine.
DijonAges 18 years+
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Common questions
- Are there clinical trials for acute respiratory failure?
- Yes. Clin2 currently lists 179 recruiting acute respiratory failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acute respiratory failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acute respiratory failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.