Clinical trials
Acute Respiratory Failure clinical trials
Below are recruiting acute respiratory failure clinical trials, each written for real people, not researchers. We’re tracking 179 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06369584Recruiting
Prone Position for Children on ECMO with Severe ARDS
This trial tests if lying face-down (prone position) helps children with severe ARDS who are already on ECMO, a machine that supports the heart and lungs. It aims to see if this position improves recovery.
Beijing, Beijing MunicipalityAges 1 month–18 years - NCT04903262Recruiting
Extra CO2 removal to protect lungs in moderate ARDS
This study tests an “extra-CO2 removal” breathing support approach to help protect the lungs in people with moderate ARDS, a serious lung injury. You would be on a ventilator for a short time, and the team would check whether this approach improves breathing outcomes while aiming to be safer for the lungs.
BolognaAges 18–100 - NCT05075161RecruitingPhase 3
Pirfenidone to help prevent lung scarring in ARDS
This Phase 3 trial tests whether pirfenidone can prevent or reduce lung scarring (fibrosis) in adults with ARDS who are within about a week of their illness starting. It may help by lowering harmful inflammation and the body’s scarring response.
Milan, MIAges 18 years+ - NCT05640635Recruiting
Testing inflammation changes in people on ECMO
This study looks at inflammation during ECMO (a heart-lung bypass machine) and while people are being weaned off it. It may help doctors better understand which patients are improving safely during ECMO and when to reduce support.
Tübingen, Baden-WurttembergAges 18 years+ - NCT06039501Recruiting
The Family Perspectives Project Pilot Trial
This study looks at how to improve communication between families and the care team when a loved one is on a breathing machine in the intensive care unit. It may help families feel more supported and involved in care decisions.
Los Angeles, CaliforniaAges 18 years+ - NCT06052436RecruitingPhase 1/Phase 2
Treg cell therapy for COVID-19 and acute respiratory distress
This trial tests a new cell therapy using Treg cells from thymic tissue to calm an overactive immune response in severe COVID-19 and ARDS. It aims to improve breathing and reduce inflammation.
Madrid, MadridAges 18–65 - NCT06387823Recruiting
Testing Sivelestat Sodium and Dexamethasone for Severe ARDS
This trial tests a combination of two medicines (Sivelestat Sodium and Dexamethasone) to see if they can help people with severe lung injury (ARDS) who need a breathing machine. It is for patients whose condition has just worsened and who are on a ventilator early in their illness.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06454006Recruiting
Light therapy for patients on breathing machines
This study tests a light therapy (called PBMT-sMF) on people in the ICU who need a breathing machine. It aims to see if the treatment helps muscles and recovery.
Porto Alegre, Rio Grande do SulAges 21 years+ - NCT06477861Recruiting
Elastic power predicts ARDS severity and death risk
This study looks at a new way to predict how serious ARDS (a severe lung injury from pneumonia) is and the chance of death. Doctors will measure something called "elastic power" to see if it helps guide treatment for patients on a breathing machine.
Banhā, Al QalubeyahAges 18–65 - NCT07309783Recruiting
Lung imaging to guide breathing support in ARDS
This trial uses a special lung imaging technique (EIT) to guide ventilator settings for people with ARDS. It may help improve breathing support and reduce lung injury.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06578468Recruiting
Using exhaled oxygen to prevent low oxygen during emergency intubation
This trial tests a method to measure oxygen in the air you breathe out during emergency intubation. It aims to help doctors prevent low oxygen levels in patients at high risk, such as those with pneumonia, sepsis, or obesity.
Minneapolis, MinnesotaAges 18 years+ - NCT06709456Recruiting
Draining fluid from lungs in the ICU
This trial tests whether draining fluid that builds up around the lungs helps patients with breathing problems in the intensive care unit. You may be eligible if you are in the ICU, have at least 2 cm of fluid on an ultrasound or CT scan, and need extra oxygen or a breathing machine.
AalborgAges 18 years+ - NCT06790875Recruiting
Comparing two ventilator settings for lung health in ARDS
This study tests two methods of adjusting a ventilator to see which one may better protect the lungs of patients with ARDS. It will help doctors learn how to set the machine to reduce strain on the lungs.
Wuhan, HubeiAges 18–80 - NCT06854627Recruiting
Comparing two ways of lying face down for ARDS patients
This study compares lying face down continuously for a long time versus lying face down for shorter periods each day. It is for patients with moderate to severe ARDS (a serious lung condition) who are on a breathing machine. The goal is to see which approach helps the lungs recover better.
Buenos AiresAges 18 years+ - NCT06967207Recruiting
Electrical imaging lung monitor for ARDS outcomes
This study tests if a special imaging technique (Electrical Impedance Tomography or EIT) can help doctors better predict outcomes in people with severe lung injury (ARDS). The goal is to use regular, safe lung scans to guide breathing treatment.
Guangzhou, GuangdongAges 18–80 - NCT06971042Recruiting
Using lung ultrasound to find ARDS early in ventilated patients
This study compares lung ultrasound with CT scans to detect ARDS (a serious lung injury) early in patients on a breathing machine. The goal is to see if ultrasound can provide a faster, safer way to diagnose ARDS.
TantaAges 22–80 - NCT07313644Recruiting
Finding best breathing support for lung injury after trauma or surgery
This study tests a way to set breathing machine pressures using electrical imaging of the lungs. It aims to find the best settings for patients with lung injury after trauma or major surgery, helping them breathe better with less damage.
HanoiAges 18–90 - NCT02464696Recruiting
Noninvasive breathing support to avoid tube breathing in cancer
This trial studies a mask-based breathing treatment (noninvasive ventilation) for people with cancer and serious breathing trouble, to see if it can prevent the need for intubation (putting a breathing tube in). If you qualify, the goal is to help you breathe better without invasive airway support when possible.
Houston, TexasAges 18 years+ - NCT07414108Recruiting
Predicting response to breathing support in COPD
This study looks at whether nighttime breathing problems can predict long-term success with a non-invasive breathing machine in people with COPD who have high carbon dioxide levels in their blood. The goal is to help doctors decide who will benefit most from this therapy.
BolognaAges 18 years+ - NCT07503509Recruiting
Study of high PEEP in noninvasive ventilation
This study tests whether using higher pressure settings (PEEP) on a noninvasive breathing mask can help people with low oxygen levels. The doctors will measure the pressure inside your esophagus to guide the treatment.
Chongqing, Chongqing MunicipalityAges 18–100 - NCT07511582RecruitingPhase 2
Steroids for severe breathing problems in the ICU
This study tests whether a corticosteroid (a type of anti-inflammatory medicine) can help people with severe breathing problems or serious infections who have a specific 'hyperinflammatory' pattern. If you are in the ICU on a ventilator, this trial may be an option for you.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07522450Recruiting
Sleep monitoring in critically ill patients on breathing support
This study measures sleep quality in patients hospitalized in intensive care who need help breathing. Researchers will use EEG (brain wave monitoring) to see if tracking sleep helps improve patient care and outcomes.
RouenAges 18 years+ - NCT07645534RecruitingPhase 1
Testing a New Antiviral Medicine Formulation in Healthy Adults
This study compares two versions of an antiviral medicine called Ingavirin to see how your body processes them and whether they are safe. Researchers will give you the medicine on an empty stomach and after eating to understand how food affects how your body absorbs it.
Saint PetersburgAges 18–45 - NCT07419360Recruiting
Draining fluid from lungs in heart failure
This study tests whether draining fluid from around the lungs can help people with heart failure who are in the hospital. It looks at how this procedure affects breathing and recovery.
Albany, New YorkAges 18 years+
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Common questions
- Are there clinical trials for acute respiratory failure?
- Yes. Clin2 currently lists 179 recruiting acute respiratory failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acute respiratory failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acute respiratory failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.