Clinical trials
Acute Respiratory Failure clinical trials
Below are recruiting acute respiratory failure clinical trials, each written for real people, not researchers. We’re tracking 172 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06790875Recruiting
Comparing two ventilator settings for lung health in ARDS
This study tests two methods of adjusting a ventilator to see which one may better protect the lungs of patients with ARDS. It will help doctors learn how to set the machine to reduce strain on the lungs.
Wuhan, HubeiAges 18–80 - NCT07414108Recruiting
Predicting response to breathing support in COPD
This study looks at whether nighttime breathing problems can predict long-term success with a non-invasive breathing machine in people with COPD who have high carbon dioxide levels in their blood. The goal is to help doctors decide who will benefit most from this therapy.
BolognaAges 18 years+ - NCT07309783Recruiting
Lung imaging to guide breathing support in ARDS
This trial uses a special lung imaging technique (EIT) to guide ventilator settings for people with ARDS. It may help improve breathing support and reduce lung injury.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07313644Recruiting
Finding best breathing support for lung injury after trauma or surgery
This study tests a way to set breathing machine pressures using electrical imaging of the lungs. It aims to find the best settings for patients with lung injury after trauma or major surgery, helping them breathe better with less damage.
HanoiAges 18–90 - NCT04903262Recruiting
Extra CO2 removal to protect lungs in moderate ARDS
This study tests an “extra-CO2 removal” breathing support approach to help protect the lungs in people with moderate ARDS, a serious lung injury. You would be on a ventilator for a short time, and the team would check whether this approach improves breathing outcomes while aiming to be safer for the lungs.
BolognaAges 18–100 - NCT06709456Recruiting
Draining fluid from lungs in the ICU
This trial tests whether draining fluid that builds up around the lungs helps patients with breathing problems in the intensive care unit. You may be eligible if you are in the ICU, have at least 2 cm of fluid on an ultrasound or CT scan, and need extra oxygen or a breathing machine.
AalborgAges 18 years+ - NCT06967207Recruiting
Electrical imaging lung monitor for ARDS outcomes
This study tests if a special imaging technique (Electrical Impedance Tomography or EIT) can help doctors better predict outcomes in people with severe lung injury (ARDS). The goal is to use regular, safe lung scans to guide breathing treatment.
Guangzhou, GuangdongAges 18–80 - NCT06971042Recruiting
Using lung ultrasound to find ARDS early in ventilated patients
This study compares lung ultrasound with CT scans to detect ARDS (a serious lung injury) early in patients on a breathing machine. The goal is to see if ultrasound can provide a faster, safer way to diagnose ARDS.
TantaAges 22–80 - NCT06039501Recruiting
The Family Perspectives Project Pilot Trial
This study looks at how to improve communication between families and the care team when a loved one is on a breathing machine in the intensive care unit. It may help families feel more supported and involved in care decisions.
Los Angeles, CaliforniaAges 18 years+ - NCT06854627Recruiting
Comparing two ways of lying face down for ARDS patients
This study compares lying face down continuously for a long time versus lying face down for shorter periods each day. It is for patients with moderate to severe ARDS (a serious lung condition) who are on a breathing machine. The goal is to see which approach helps the lungs recover better.
Buenos AiresAges 18 years+ - NCT06454006Recruiting
Light therapy for patients on breathing machines
This study tests a light therapy (called PBMT-sMF) on people in the ICU who need a breathing machine. It aims to see if the treatment helps muscles and recovery.
Porto Alegre, Rio Grande do SulAges 21 years+ - NCT06052436RecruitingPhase 1/Phase 2
Treg cell therapy for COVID-19 and acute respiratory distress
This trial tests a new cell therapy using Treg cells from thymic tissue to calm an overactive immune response in severe COVID-19 and ARDS. It aims to improve breathing and reduce inflammation.
Madrid, MadridAges 18–65 - NCT04966624Recruiting
Ultrasound-guided breathing strategy for new focal ARDS
This study tests a way to guide ventilator settings using lung ultrasound pictures in adults with very new, localized ("focal") ARDS. The goal is to see whether this approach improves care for people who just started needing a breathing machine.
DijonAges 18 years+ - NCT05075161RecruitingPhase 3
Pirfenidone to help prevent lung scarring in ARDS
This Phase 3 trial tests whether pirfenidone can prevent or reduce lung scarring (fibrosis) in adults with ARDS who are within about a week of their illness starting. It may help by lowering harmful inflammation and the body’s scarring response.
Milan, MIAges 18 years+ - NCT02464696Recruiting
Noninvasive breathing support to avoid tube breathing in cancer
This trial studies a mask-based breathing treatment (noninvasive ventilation) for people with cancer and serious breathing trouble, to see if it can prevent the need for intubation (putting a breathing tube in). If you qualify, the goal is to help you breathe better without invasive airway support when possible.
Houston, TexasAges 18 years+ - NCT07419360Recruiting
Draining fluid from lungs in heart failure
This study tests whether draining fluid from around the lungs can help people with heart failure who are in the hospital. It looks at how this procedure affects breathing and recovery.
Albany, New YorkAges 18 years+ - NCT04427826RecruitingPhase 1/Phase 2
Morphine to prevent early NIV failure in COPD flare-ups
This trial studies whether morphine can help people with a COPD flare-up avoid “non-invasive ventilation” (breathing support through a mask) failing early. The goal is to reduce how often people need escalation of care soon after starting NIV.
Grenoble, Isère, Auvergne-Rhône-AlpesAges 18 years+ - NCT07583446RecruitingPhase 2/Phase 3
Istaroxime for acute heart failure with low blood pressure
This trial tests an investigational drug called istaroxime for people hospitalized with acute heart failure and low blood pressure (cardiogenic shock). The drug aims to improve heart function and stabilize blood pressure, potentially helping you feel better and recover.
YerevanAges 18–80 - NCT07347275Recruiting
Liver dialysis for severe acute-on-chronic liver failure
This trial tests a new liver dialysis device called DIALIVE 2.0 for people with acute-on-chronic liver failure (a sudden, severe worsening of chronic liver disease). If you qualify, the device will help filter your blood, similar to kidney dialysis, to support your liver while it tries to recover.
London, Greater LondonAges 18–70 - NCT06890039RecruitingPhase 2
Study of a new treatment for severe alcoholic hepatitis
This trial tests an experimental drug for people with severe alcoholic hepatitis that did not improve with steroids. Participants should have a moderate level of organ failure, but not require a breathing tube or kidney dialysis.
London, Greater LondonAges 18–75 - NCT06652776Enrolling by invitation
Italian COPD patient registry study
This study is creating a registry to better understand Chronic Obstructive Pulmonary Disease (COPD) in Italian patients. It will collect information from people with COPD to improve care and research.
Milan, MilanAges 40 years+ - NCT07678086Recruiting
Breathing tube pressure and sore throat in children's appendix surgery
This trial tests whether carefully managing the pressure in the breathing tube during surgery can help prevent a sore throat in children after they have their appendix removed by keyhole surgery. It may help your child have a more comfortable recovery.
Ankara, YenimahalleAges 6–18 - NCT05952999Enrolling by invitation
Studying Hospital-At-Home care done from home
This trial looks at how well a “Hospital at Home” program works when people start from the emergency department or are already in the hospital and can be cared for at home. It may help teams improve care at home for certain medical conditions and situations.
Peoria, IllinoisAges 18 years+ - NCT06916481Recruiting
Pneumonia subtypes based on lung bacteria
This study looks at the germs in your lungs to understand why some people's pneumonia doesn't get better with standard antibiotics. If you are hospitalized with pneumonia and have just started treatment, you may be asked to provide a sputum sample so researchers can study your lung microbiome.
ClichyAges 18 years+
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Common questions
- Are there clinical trials for acute respiratory failure?
- Yes. Clin2 currently lists 172 recruiting acute respiratory failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acute respiratory failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acute respiratory failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.