Clinical trials
Brain clinical trials
Below are recruiting brain clinical trials, each written for real people, not researchers. We’re tracking 2,059 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06193759RecruitingPhase 1
Immune cell therapy for malignant pediatric brain tumors
This trial tests a new immune therapy using your child's own specially trained white blood cells to fight brain tumors. The treatment is given directly into the fluid around the brain, and it is for children with specific types of brain cancer.
Washington D.C., District of ColumbiaAges 1–30 - NCT06194929RecruitingPhase 1/Phase 2
Drug combo for melanoma that spread to the brain
This trial tests a combination of two or three drugs (defactinib, avutometinib, with or without encorafenib) to shrink brain tumors that started from skin melanoma. It may be an option for people whose melanoma has a specific genetic change and who have already tried immunotherapy.
Iowa City, IowaAges 18 years+ - NCT06243003RecruitingPhase 1/Phase 2
Brain radiation for SCLC with brain metastases
This trial tests a new radiation approach for people with small cell lung cancer that has spread to the brain. It combines whole-brain radiation that avoids the memory centers, followed by focused radiation to the tumors, while you also receive standard chemotherapy and immunotherapy.
ShanghaiAges 18 years+ - NCT06244472Recruiting
New brain scanner for fast brain imaging
This study uses a new type of brain scanner (MEG) to take very fast pictures of brain activity. It's for healthy people or those who've had a mild concussion recently.
BronAges 18–70 - NCT06247449Recruiting
MRI screening for brain metastases in aggressive breast cancer
This trial uses an MRI scan to look for early signs of breast cancer spreading to the brain in people with certain aggressive breast cancer types (triple-negative or HER2-positive) that are stage IIb or III. The goal is to find and treat brain metastases earlier, before they cause symptoms.
Toronto, OntarioAges 18 years+ - NCT06253871RecruitingPhase 1
Study of IAM1363 for HER2 Cancers
This trial tests a new oral drug called IAM1363 for people with HER2-altered cancers that have stopped responding to previous treatments. The goal is to see if the drug is safe and how well it works against these cancers.
La Jolla, CaliforniaAges 18 years+ - NCT06257056Recruiting
Deep brain stimulation for hard-to-treat schizophrenia
This trial tests whether deep brain stimulation (a device that sends electrical pulses to specific areas of the brain) can help people with schizophrenia whose symptoms have not improved with standard treatments. If you have ongoing psychosis and have tried several medications without success, this study may be an option for you.
Dallas, TexasAges 22–70 - NCT06279975Recruiting
Pupil test in patients being checked for brain death
This study uses a special camera to measure pupil reactions in patients being evaluated for brain death. The aim is to see if this test can help confirm the diagnosis of brain death more accurately.
Basel, Canton of Basel-CityAges 18 years+ - NCT06280300Recruiting
Better care planning for people with brain metastases
This study looks at whether a team-based approach to care can improve quality of life for people newly diagnosed with brain metastases from solid tumors. It aims to help coordinate your medical and support needs.
Burlington, VermontAges 18 years+ - NCT06282562Recruiting
High-intensity interval training for brain tumor patients
This study tests whether a high-intensity interval training program can help brain tumor patients feel fitter and more energetic. It's for people with stable tumors who aren't currently on treatment.
AmsterdamAges 18 years+ - NCT06282965RecruitingPhase 1/Phase 2
Angiotensin (1-7) for moderate to severe brain injury
This study tests a drug called Angiotensin (1-7) to see if it helps people recover from moderate to severe traumatic brain injury. It may reduce damage and improve healing when given shortly after the injury.
Tucson, ArizonaAges 18 years+ - NCT06283927Recruiting
Surgery vs. medical care for recurrent glioblastoma
This trial compares surgery to the best non-surgical treatment for people whose glioblastoma has come back. The goal is to see which approach helps people live longer with a better quality of life.
San Francisco, CaliforniaAges 18–90 - NCT06293300RecruitingPhase 2
Botulinum toxin for light sensitivity after brain injury
This study tests if botulinum toxin type A (Botox) can reduce long-term light sensitivity in people who have had a traumatic brain injury at least a year ago. You must have had light sensitivity for 6 months or more and not have had Botox for face or mouth conditions before.
Miami, FloridaAges 18 years+ - NCT06293638Recruiting
Brain changes during deep brain stimulation for essential tremor
This study looks at how deep brain stimulation (DBS) affects brain networks in people with essential tremor (ET). The goal is to understand the brain changes that happen during DBS treatment, which may help improve the therapy.
Cleveland, OhioAges 30–80 - NCT06298474Recruiting
BRAIN App for dementia support
This study is testing a new app (BRAIN App) designed to help people with dementia stay connected and engaged. Researchers want to see if the app can be useful for older adults who can still communicate and have not had a recent fast decline in health.
Winchester, MassachusettsAges 65 years+ - NCT06303921RecruitingEarly Phase 1
Study of a new brain imaging agent for Parkinson's disease
This trial uses a special PET scan to see how a new imaging agent (called 11C-M503) travels through the body and brain. It may help researchers better understand brain conditions like Parkinson's disease.
New Haven, ConnecticutAges 40–85 - NCT06314607Recruiting
Genetic study of brain lesions
This trial looks at the genetic and molecular features of brain lesions to better understand them. It may help find new ways to diagnose or treat these conditions.
ParisAges 18 years+ - NCT06315010RecruitingPhase 2
Repotrectinib for ROS1-positive lung cancer with brain spread
This clinical trial tests a new targeted therapy pill (repotrectinib) for people with ROS1-positive lung cancer that has spread to the brain. The pill is designed to enter the brain and attack cancer cells that other targeted treatments may not reach well.
GrazAges 18 years+ - NCT06319027RecruitingPhase 2
Can brain scans help predict glioblastoma progression?
This trial is testing whether certain details on brain scans can help doctors better predict how brain cancer (glioblastoma) will progress. You may be eligible if you are newly diagnosed with this type of cancer and plan to receive standard treatment.
Los Angeles, CaliforniaAges 18 years+ - NCT07049003RecruitingPhase 1
Deep brain stimulation for severe tremor
This trial tests a new type of deep brain stimulation (DBS) for people with severe tremor from essential tremor, multiple sclerosis, or cerebellar conditions who haven't improved with standard treatments. It targets a different brain area to see if it can reduce shaking and improve daily activities.
Cleveland, OhioAges 21 years+ - NCT06330870Recruiting
How breast cancer spreads to the brain
This study looks at how breast cancer spreads to the brain in people who had surgery to remove brain tumors. It helps doctors understand why some women get brain metastases.
SeoulAges Any age - NCT06333990RecruitingPhase 3
Quetiapine for concussion symptoms in veterans
This study tests whether quetiapine (a medication that can help with mood, sleep, and thinking) reduces ongoing concussion symptoms in veterans who had a mild traumatic brain injury (mTBI) at least 6 months ago. You may join if you are already taking at least three medications for your brain or mental health symptoms and have some PTSD symptoms.
Albuquerque, New MexicoAges 18–65 - NCT06378515Recruiting
Physical activity, sleep, and brain health in students
This study looks at how physical activity and sleep affect your brain health, especially the glymphatic system — a system that helps clear waste from your brain. It is for university students and could help you understand how your daily habits influence your brain.
ValenciaAges 18–40 - NCT06381531Recruiting
Tracing brain tumors through imaging over time
This study looks at CT or MRI scans of people with primary brain tumors to understand how these tumors change over time. It may help you if you have imaging before and after surgery or before radiation.
Mumbai, MaharashtraAges Any age
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Common questions
- Are there clinical trials for brain?
- Yes. Clin2 currently lists 2,059 recruiting brain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.