Clinical trials · Georgia
Depression clinical trials in Georgia
We’re tracking 48 recruiting depression studies with a site in Georgia — including Early Phase 1, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Georgia
- NCT06547489RecruitingPhase 2
Testing zelquistinel for major depression
This study tests whether zelquistinel, an investigational drug, can reduce symptoms of major depressive disorder (a type of clinical depression). It is for people who are currently experiencing a moderate to severe depressive episode and are not taking other antidepressants.
Savannah, GeorgiaAges 18–64 - NCT06559306RecruitingPhase 3
Seltorexant for depression with insomnia symptoms
This trial tests if adding seltorexant to your current antidepressant can improve depression and sleep problems. It is for people with major depressive disorder who still have symptoms, especially insomnia, despite trying at least one antidepressant.
Atlanta, GeorgiaAges 18–74 - NCT06580145RecruitingPhase 2
Leucine for midlife depression
This study tests whether leucine, a common amino acid supplement, can help treat moderate to severe depression in people aged 40–65. You'll have blood tests, an MRI, and a lumbar puncture to measure changes in your brain.
Atlanta, GeorgiaAges 35–65 - NCT06633016RecruitingPhase 2
ABX-002 for major depression (add-on treatment)
This trial tests a new medication called ABX-002 as an add-on to your current antidepressant. It's for people with moderate to severe depression who haven't gotten enough help from their current antidepressant alone.
Atlanta, GeorgiaAges 18–65 - NCT06372964RecruitingPhase 3
Lumateperone for pediatric bipolar depression
This study tests a new medication called lumateperone for treating depression in children and teens with bipolar disorder. It aims to see if this drug can help improve mood and daily functioning.
Atlanta, GeorgiaAges 10–17 - NCT07003997RecruitingPhase 2
JAK inhibitor for depression with inflammation
This trial tests a JAK inhibitor (a type of anti-inflammatory drug) for depression that is linked to inflammation. If you have depression or bipolar depression and a high CRP level (a marker of inflammation), you may be eligible.
Atlanta, GeorgiaAges 25–55 - NCT07115329RecruitingPhase 2
Testing Zelquistinel for major depression
This study tests a new oral medication called Zelquistinel (taken as a tablet) against a placebo for treating major depressive disorder. Researchers want to see if it can reduce depression symptoms, especially when other antidepressants haven't been tried or haven't worked.
Stone Mountain, GeorgiaAges 18–64 - NCT07276997RecruitingPhase 2
Study of Icalcaprant for major depressive disorder
This trial tests an oral medication called icalcaprant for adults with major depressive disorder (MDD). It aims to see if the drug can reduce depression symptoms and what side effects may occur.
Norcross, GeorgiaAges 18–65 - NCT07300969RecruitingPhase 2
Testing DT-101 for adults with depression
This trial tests a new medicine called DT-101 to see if it helps people with depression. It is for adults who have had more than one depressive episode in their life.
Atlanta, GeorgiaAges 18–75 - NCT07553637RecruitingPhase 2
ALTO-207 for Adults With Hard-to-Treat Depression
This study tests whether a new medication called ALTO-207 can help people with depression that hasn't improved with standard antidepressants. You may qualify if you've tried multiple antidepressants without enough relief and are willing to add this experimental treatment to your current medication.
Albany, GeorgiaAges 18–75 - NCT07217860Enrolling by invitationPhase 3
Long-term safety study of azetukalner for bipolar depression
This study is looking at the long-term safety of azetukalner for people with bipolar I or II depression who have already completed a previous trial of this drug. It is an open-label study, meaning everyone will receive the active medication.
Atlanta, GeorgiaAges 18–75 - NCT04099056Recruiting
Brain scanning and stimulation to study decision-making
This trial uses brain scans and noninvasive brain stimulation to study how people make decisions. It may help researchers understand brain signals involved in choices and potentially improve future treatments.
Atlanta, GeorgiaAges 18–50 - NCT07220460RecruitingPhase 2
Study of an oral drug for bipolar depression
This trial tests an experimental pill (ABB-932) for people with bipolar I or II disorder who are currently in a depressive episode. The goal is to see if the drug is safe and helps improve mood.
Atlanta, GeorgiaAges 18–65 - NCT06713616RecruitingPhase 3
Esketamine vs. ketamine for hard-to-treat depression
This study compares the effectiveness of esketamine (Spravato) and another similar drug, ketamine, for adults with major depression that has not improved after trying at least two other antidepressants. It aims to find out which treatment works better.
Atlanta, GeorgiaAges 18 years+ - NCT06725277Recruiting
Observing ketamine and Spravato for depression
This study follows people who are already taking or about to start IV ketamine or Spravato® for hard-to-treat depression. Researchers want to learn more about how these treatments work in real life.
Atlanta, GeorgiaAges Any age - NCT05548244Recruiting
Testing behavioral activation for teens with depression
This study looks at how a therapy approach called behavioral activation may affect depression in teens. It also uses brief daily check-ins on a phone to understand what changes during treatment.
Atlanta, GeorgiaAges 15–17 - NCT06639477Recruiting
Mood and sleep improvement study for older adults
This study tests whether adding a sleep treatment to regular depression medication can improve both mood and sleep in adults aged 55 and older. It may help if you have ongoing depression, sleep problems, and are already taking antidepressant medication.
Augusta, GeorgiaAges 55 years+ - NCT06748222RecruitingPhase 3
Online mindfulness program for breast cancer survivors
This trial tests a 6-week online mindfulness program to help breast cancer survivors manage mild to moderate depression. You may qualify if you finished active treatment within the last 5 years and can use a digital device.
Atlanta, GeorgiaAges 18–50 - NCT06605105Enrolling by invitationPhase 3
Long-term extension trial of CYB003 for depression
This long-term study is for people who already completed an earlier trial of the experimental drug CYB003 for major depression and who stayed on their regular antidepressant. It looks at the safety and effects of taking CYB003 again over many months.
Atlanta, GeorgiaAges 18–85 - NCT05327699RecruitingEarly Phase 1
Ketamine study for depression with reduced pleasure
This early-phase study tests whether ketamine can help people with major depression who have trouble feeling pleasure. It also studies how the brain may change in response to stress, to better understand who might respond to treatment.
Atlanta, GeorgiaAges 18–65 - NCT05922878RecruitingPhase 2
ALTO-300 study for moderate to severe depression
This trial tests ALTO-300 as an add-on treatment for people with moderate to severe major depressive disorder (MDD). It aims to see whether ALTO-300 helps improve depression symptoms when you’re already on a stable antidepressant.
Savannah, GeorgiaAges 18–70 - NCT06075771RecruitingPhase 4
Testing a Parkinson's drug for depression-related loss of interest
This trial tests whether a medication used for Parkinson's disease (carbidopa-levodopa) can help people with major depression who have lost interest or pleasure in things. It is for adults who have not been helped enough by other treatments and have signs of inflammation.
Atlanta, GeorgiaAges 25–55 - NCT07105111RecruitingPhase 4
Valbenazine for tardive dyskinesia after other treatment
This study tests if valbenazine helps adults with tardive dyskinesia whose symptoms continue even after taking or stopping another similar medication. Tardive dyskinesia involves uncontrollable movements from long-term use of certain mental health drugs.
Marietta, GeorgiaAges 18 years+ - NCT02604277Recruiting
Study of suicidal behavior in people with bipolar disorder
This study looks at suicidal thoughts or behaviors in people diagnosed with bipolar disorder. It may help researchers understand what leads to suicidal risk and how to better support safety and treatment.
Atlanta, GeorgiaAges 18–64
Depression trials by city in Georgia
Where these studies are running in Georgia
Institutions with a site for the recruiting depression studies listed above.
- Emory University · 9 studies
- CenExel iResearch, LLC · 5 studies
- Advanced Discovery Research · 2 studies
- Atlanta Center for Medical Research · 2 studies
- Denali Health Atlanta, LLC · 2 studies
- Grady Health System · 2 studies
- Trialmed · 2 studies
- Accelerated Clinical Research Group LLC
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Depression trials in other states
Common questions
- Are there depression clinical trials in Georgia?
- Yes. We're currently tracking 48 recruiting depression studies with a site in Georgia, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study in Georgia?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Georgia to take part?
- Not necessarily. These studies have a site in Georgia, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open in Georgia regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.