Clinical trials
Heart Failure, Systolic clinical trials
Below are recruiting heart failure, systolic clinical trials, each written for real people, not researchers. We’re tracking 181 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03268135Recruiting
Study gene activity in people with heart failure or aortic stenosis
This trial looks at patterns in your blood or heart-related “gene activity” (transcriptome) after heart procedures. It may help doctors understand why some people with heart failure or aortic valve narrowing (stenosis) do better than others.
San Donato Milanese, MilanAges 40–75 - NCT06307652RecruitingPhase 3
Testing a new heart failure and kidney treatment combo
This study tests a new combination of two medicines (balcinrenone and dapagliflozin) for people with heart failure and reduced kidney function. The goal is to see if this combination helps improve heart and kidney health better than current treatments.
Alexander City, AlabamaAges 18–130 - NCT06166654RecruitingPhase 4
Better water pill therapy for acute heart failure
This trial tests different water pill (diuretic) strategies for people hospitalized with acute heart failure and too much fluid. It is designed for patients who may not respond well to standard water pills, to find a more effective way to relieve symptoms.
Hvidovre, Capital Region of DenmarkAges 18 years+ - NCT06128980RecruitingPhase 2/Phase 3
Stopping heart meds after recovery from fast heartbeat damage
This trial tests if patients whose heart function returned to normal after treating a fast heartbeat can safely stop their heart failure medications. It aims to see if treatment can be withdrawn without the heart problems coming back.
CopenhagenAges 18 years+ - NCT03836482Recruiting
SCD test for people with heart and kidney failure awaiting LVAD
This study looks at whether a treatment called SCD is safe and workable in people who have worsening heart failure along with kidney problems, and who are waiting to get an LVAD (a mechanical heart pump). It is mainly a feasibility study, meaning the researchers want to see if this approach can be used in real hospital care and monitor effects on key health measures.
Ann Arbor, MichiganAges 18 years+ - NCT06055452RecruitingPhase 4
SGLT2 Inhibitors for Pre-Heart Failure with Hypertension
This trial tests if a medicine (SGLT2 inhibitor) given to people with high blood pressure and early signs of heart stress can help prevent heart failure. You may join if your blood pressure is controlled but tests show your heart is beginning to struggle.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06174103Recruiting
BiVACOR total artificial heart early feasibility study
This study tests a new total artificial heart called BiVACOR for people with severe heart failure that cannot be helped by standard pumps. It is designed to keep you alive while you wait for a heart transplant.
Phoenix, ArizonaAges 18–70 - NCT07057466Recruiting
Checking heart scans with artificial intelligence
This study uses AI to read electrocardiograms (heart rhythm tests) to see if they can detect certain heart structure problems earlier. If you are already scheduled for an echocardiogram (heart ultrasound), your data may be used to help improve detection.
BristolAges 18–90 - NCT06964464RecruitingPhase 4
Comparing two heart failure medications in ICD patients
This trial compares two beta-blocker medications, carvedilol and metoprolol succinate, to see which one works better for people with heart failure who have an implantable cardioverter defibrillator (ICD). If you are currently taking metoprolol succinate, you may be able to switch to carvedilol and help researchers find the best treatment.
Scottsdale, ArizonaAges 18 years+ - NCT06465498Recruiting
Lung ultrasound for heart failure congestion treatment
This trial tests whether using lung ultrasound to guide decongestion treatment improves outcomes for patients hospitalized with congestive heart failure. It may help doctors tailor your care more precisely.
Geneva, Canton of GenevaAges 18 years+ - NCT05508035RecruitingPhase 3
Testing sacubitril/valsartan vs ramipril for heart failure
This trial compares two blood-pressure and heart-failure medicines: sacubitril/valsartan versus ramipril, to see which improves heart pumping and heart structure over time. It’s aimed at people with ischemic (blocked-artery) heart failure with mid-range ejection fraction and ongoing symptoms.
Krakow, Lesser Poland VoivodeshipAges 18 years+ - NCT07636759Recruiting
AI Heart Rhythm Test for Heart Pump Weakness
This study tests whether an artificial intelligence system can detect a weakened heart pump using an ECG (heart rhythm test). If successful, it could help doctors diagnose heart problems faster and more easily.
Suwon, Gyeonggi-doAges 19 years+ - NCT06377761Recruiting
Qishen granules for heart failure with preserved pumping function
This trial tests a Chinese herbal medicine called Qishen Granules for people with heart failure who still have a normal pumping ability (ejection fraction 50% or higher). It may help reduce symptoms and improve heart function.
Guangzhou, GuangdongAges 18–85 - NCT05583773RecruitingPhase 4
Herbal medicine for heart failure with lower pumping strength
This trial tests SHengXIaN-QuYu decoction (an herbal treatment) in people with symptomatic heart failure and reduced pumping function. It looks to see whether the herbal formula is safe and helpful for heart failure symptoms and heart function.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06704633RecruitingPhase 4
Heart failure drug study for rural Tanzanians
This trial tests a medicine called sacubitril-valsartan for people in rural Tanzania with heart failure and reduced pumping strength. It aims to see if switching to this drug can improve symptoms and outcomes.
Ifakara, MorogoroAges 18 years+ - NCT05507879Recruiting
Breast cancer heart monitoring to predict heart damage risk
This trial studies how a blood test marker (TRPC6) may help predict and prevent heart muscle damage and heart failure related to some breast cancer medicines. You may join if you’re starting or have received treatment that can stress the heart, or if you already have signs of treatment-related heart problems.
Gainesville, FloridaAges 18 years+ - NCT07491237Recruiting
Heart rhythm and function study
This study looks at how heart rhythm problems affect heart function. It may help doctors better understand and treat these conditions.
RomaAges 18 years+ - NCT06435156RecruitingPhase 2
Sotagliflozin for Heart Failure in Type 1 Diabetes
This trial tests a medication called sotagliflozin for people who have both type 1 diabetes and heart failure symptoms. The goal is to see if it can improve how you feel and manage your heart and diabetes.
AberdeenAges 18–84 - NCT07318103RecruitingPhase 2
Study of HRS-9057 for fluid retention in heart failure
This trial tests an investigational drug, HRS-9057, in people hospitalized with heart failure who still have fluid buildup despite taking standard diuretics. The goal is to see if HRS-9057 helps remove excess fluid better than current treatments.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06811519Recruiting
AI predicts heart function from ultrasound and body scans
This study uses artificial intelligence to predict how well your heart is pumping by looking at your heart ultrasound results and body composition (like body fat and muscle). The goal is to see if adding body composition data makes the AI predictions more accurate.
Yongin, Gyeonggi-doAges 20 years+ - NCT06360380Recruiting
Wearable device for fluid removal in heart failure
This trial tests a wearable device that removes extra fluid from your body without using the kidneys. It may help people with heart failure who still have fluid buildup despite taking high doses of water pills.
La Jolla, CaliforniaAges 21–79 - NCT07490067RecruitingPhase 4
Metoprolol for heart failure: genes and drug response
This trial tests how the drug metoprolol works in people with heart failure and reduced pumping function. It looks at whether your genetic makeup affects how the drug is processed and how well it helps your heart.
Ann Arbor, MichiganAges 18 years+ - NCT06702501Recruiting
Shunt device to treat heart failure with preserved ejection fraction
This trial tests a tiny tube (shunt) placed in the heart to relieve pressure and ease severe shortness of breath. It's for people with a type of heart failure where the heart pumps well but doesn't relax enough.
Rochester, MinnesotaAges 30 years+ - NCT06898515Recruiting
Fluid removal study for acute heart failure patients
This trial tests a device designed to safely remove extra fluid from patients hospitalized with worsening heart failure. It may help those who are not responding well to standard water pills (diuretics).
Irvine, CaliforniaAges 22 years+
Hear when a new Heart Failure, Systolic trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for heart failure, systolic?
- Yes. Clin2 currently lists 181 recruiting heart failure, systolic studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure, systolic trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure, systolic trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.