Clinical trials
Stereotactic Body Radiation Therapy (SBRT) clinical trials
Below are recruiting stereotactic body radiation therapy (sbrt) clinical trials, each written for real people, not researchers. We’re tracking 106 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05624996RecruitingPhase 3
Targeted high-dose radiation added to standard lung cancer treatment
This trial tests whether adding high-dose, targeted radiation to the usual treatment helps people with locally advanced, non-operable lung cancer live longer or better control the cancer. It may help shrink tumors in the chest and improve outcomes when surgery can’t be done.
Birmingham, AlabamaAges 18 years+ - NCT05582499RecruitingPhase 2
Neoadjuvant treatment study for certain breast cancers
This Phase 2 study tests a “precision platform” approach—treatment before surgery—based on specific test results from your breast tumor. It may help determine whether the treatment plan works better for people with particular breast cancer subtypes and healthy organ function.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT04563507RecruitingPhase 2
Immunotherapy plus hormone therapy for metastatic ER-positive breast cancer
This Phase 2 study tests a combination of immune-based treatments along with hormone (endocrine) therapy to slow or shrink advanced, hormone-receptor positive, HER2-negative breast cancer. You may be a candidate if your cancer has progressed after standard hormone-blocking medicines and you can start treatment with CDK4/6 medicine plus an aromatase inhibitor.
New York, New YorkAges 18–90 - NCT05371132RecruitingPhase 1
PET scan study to track immune response after SBRT
This early (Phase 1) study uses a special PET scan to measure how your immune system responds after stereotactic body radiation therapy (SBRT). The goal is to see whether the scan result can serve as a marker of immune response, which may help future treatment planning.
Duarte, CaliforniaAges 18 years+ - NCT05384496RecruitingPhase 2
Axitinib and nivolumab for advanced mucosal melanoma
This trial studies how well two medicines—axitinib and nivolumab—work for people with advanced melanoma that starts in moist “mucosal” areas (like the mouth, nose, throat, or bowel). It may help shrink tumors and control the disease by boosting the immune system and targeting tumor growth.
Harrison, New YorkAges 18 years+ - NCT05361798RecruitingPhase 2
Testing immune response after prostate radiation with or without a drug
This study checks how your immune system’s cancer-fighting cells change after stereotactic body radiation (SBRT) to the prostate. It compares SBRT alone versus SBRT plus an immunotherapy drug (PDS01ADC) in men with intermediate- or high-risk localized prostate cancer treated with hormone therapy (ADT).
Bethesda, MarylandAges 18 years+ - NCT05317026Recruiting
Test adding cement injection to SBRT for spine pain
This study tests whether adding a vertebroplasty procedure (a cement injection to stabilize a spine bone) to standard SBRT radiation can reduce pain from spinal metastases. It may help people with painful, possibly unstable spine lesions by improving early pain relief.
Montreal, QuebecAges 18 years+ - NCT05155046RecruitingPhase 2
Scan to check prostate cancer response after focused radiation
This study tests whether a special PET scan tracer (18F-DCFPyL) can show how well focused radiation (SBRT) is working for localized prostate cancer. It may help doctors spot treatment response earlier and tailor follow-up care.
Bethesda, MarylandAges 18–120 - NCT05096715RecruitingPhase 1
Testing atezolizumab plus bevacizumab with SBRT for advanced liver cancer
This Phase 1 trial tests how well a combination treatment works for liver cancer that cannot be removed with surgery or other local treatments. It combines two immune/targeted medicines with a focused type of radiation (SBRT) to control the tumors.
Boston, MassachusettsAges 18 years+ - NCT05027711RecruitingPhase 2
MRI-guided precise radiation for liver metastases
This Phase 2 trial tests an MRI-guided, highly targeted radiation treatment (SBRT) for tumors that have spread to the liver. It may help shrink 1–3 liver metastases while using imaging to better guide treatment.
HeidelbergAges 18 years+ - NCT05038332RecruitingPhase 2
Testing two types of radiation after prostate surgery
This Phase 2 study compares two schedules of radiation treatment after prostate surgery in men whose PSA starts rising again. It aims to see which radiation approach works well while tracking quality of life and safety.
Ann Arbor, MichiganAges 18 years+ - NCT04996914Recruiting
Radiation after chemo-embolization for liver cancer patients
This trial studies giving targeted radiation after a liver procedure called trans-arterial chemoembolization for hepatocellular carcinoma (HCC). It may help control the cancer in people who cannot have surgery or transplant.
Aachen, North Rhine-WestphaliaAges 18–80 - NCT04693377Recruiting
Freezing tumor treatment plus targeted radiation for painful bone spread
This study tests whether combining a “freezing” procedure (cryoablation) with focused external radiation (SBRT) can reduce pain from bone metastases. It’s for people with certain cancers that have spread to bone and are having significant pain in a specific bone spot.
Houston, TexasAges 18 years+ - NCT04402151RecruitingPhase 2
PSMA scan–guided targeted radiation for higher-risk prostate cancer
This trial uses a special PET/MR scan to help doctors aim stereotactic radiation more precisely for certain higher-risk or unfavorable intermediate prostate cancers. It studies whether this targeted approach can safely treat the prostate (and specific areas needing extra treatment) without spreading to the body.
New York, New YorkAges 21–90 - NCT04068649RecruitingPhase 2
Single high-dose radiation vs standard palliative radiation
This Phase 2 study compares a one-time, high-dose radiation treatment (SBRT) with the usual, shorter-course palliative radiation. The goal is to see which approach better relieves symptoms from metastatic (spread) cancer.
Buffalo, New YorkAges 18 years+ - NCT04020276Recruiting
Adaptive MRI radiation for liver metastases
This study tests a radiation treatment that uses real-time MRI (an imaging scan) to guide the dose for liver metastases. It may help control tumors while aiming to better protect nearby healthy liver tissue.
Madison, WisconsinAges 18 years+ - NCT03808337RecruitingPhase 2
SBRT radiation plus standard treatment for spread cancer
This trial looks at adding a focused radiation treatment called SBRT to standard care for cancers that have spread to a limited number of spots. It aims to control those spread-out tumors while still using the usual cancer treatment plan.
San Carlos, CaliforniaAges 18 years+ - NCT05727787Recruiting
Radiation trial for liver cancer that cannot be removed
This Phase I study tests a specific radiation approach (vGRID SBRT) for hepatocellular carcinoma (and some mixed types) that is advanced and cannot be cured with surgery or transplant. It aims to control tumors while staying within safety limits for the liver and nearby organs.
Kansas City, KansasAges 18 years+ - NCT05880667RecruitingPhase 1
Adaptive focused radiation for belly and pelvic cancer spread
This Phase 1 study tests an “adaptive” form of focused radiation (SBRT) for cancers that have spread in the abdomen or pelvis. It aims to treat metastatic tumor spots safely while adjusting the plan as needed during treatment.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06048484RecruitingPhase 2
Combination therapy for localized pancreatic cancer
This trial tests a combination of drugs for people with localized pancreatic cancer who have already completed 8 cycles of modified FOLFIRINOX chemotherapy before surgery. The goal is to see if adding these drugs after chemo and radiation helps improve outcomes.
Lake Success, New YorkAges 18 years+ - NCT07075120RecruitingPhase 1
Immunotherapy and radiation for advanced liver cancer
This trial tests a combination of two immunotherapy drugs (ipilimumab and nivolumab) plus targeted radiation (SBRT) for people with liver cancer that is advanced but has not spread outside the liver. The goal is to see if this approach can shrink tumors and make them easier to remove with surgery.
Honolulu, HawaiiAges 18 years+ - NCT07167459Enrolling by invitationPhase 2
Personalized radiation for early stage lung cancer
This trial tests a personalized radiation treatment called SBRT for early-stage non-small cell lung cancer that is located in the outer part of the lung and cannot be removed with surgery. The goal is to see if this approach works well for people who cannot have surgery or choose not to.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT07117032RecruitingPhase 1
Radiation therapy for cancer-related stomach pain
This trial tests a type of radiation therapy (SBRT) to treat severe stomach pain caused by cancer pressing on nerves near the stomach. It aims to provide pain relief without the need for a standard nerve block procedure.
Cleveland, OhioAges 18 years+ - NCT04883671Recruiting
SBRT to treat a few spots of adenoid cystic cancer
This trial tests whether focused radiation (SBRT) can help control adenoid cystic carcinoma that has spread to a small number of places (oligometastatic disease). If you qualify, the study will treat up to 1–5 metastatic spots that doctors think can be safely targeted, to help control the cancer locally.
San Francisco, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for stereotactic body radiation therapy (sbrt)?
- Yes. Clin2 currently lists 106 recruiting stereotactic body radiation therapy (sbrt) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a stereotactic body radiation therapy (sbrt) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a stereotactic body radiation therapy (sbrt) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.