Clinical trials
Ventilation clinical trials
Below are recruiting ventilation clinical trials, each written for real people, not researchers. We’re tracking 523 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04801589RecruitingPhase 3
Guided sedation for children on a breathing machine
This study tests a “goal-directed” approach to sedation (giving the right amount based on target goals) for children who need a breathing machine in the pediatric ICU. The goal is to reduce brain and recovery side effects while keeping children comfortable and safe.
Nashville, TennesseeAges 10 months–11 years - NCT04903951RecruitingPhase 2
Check if early breathing support after stroke helps sleep apnea
This trial tests whether starting a breathing-support treatment soon after a first stroke improves outcomes in people who also have sleep apnea. It may help reduce complications and support recovery if you meet the specific timing and health criteria.
Matosinhos MunicipalityAges 18–80 - NCT05027035Recruiting
Compare diaphragm surgery versus breathing machine support
This trial is studying whether surgery, instead of using a breathing machine, works better for people with one-sided diaphragm paralysis. It aims to improve breathing comfort and function in the right patients.
GroningenAges 18 years+ - NCT05136222Recruiting
Testing a night breathing machine setting for muscle-nerve disease
This study helps find the best night-time settings for a non-invasive breathing support device (a machine that helps breathing without a tube). It may help people with motor neurone disease start long-term breathing support more comfortably and effectively.
AdelaideAges 18 years+ - NCT05160987Recruiting
Sedation choice for ICU patients on breathing machines
This study compares two sedation medicines—remimazolam vs midazolam—for very sick ICU patients who are on a breathing machine. It looks at whether one sedative works better or is safer for keeping patients comfortable while they’re critically ill.
Guangzhou, GuangdongAges 18–80 - NCT05207046Recruiting
Study for people on a breathing machine after spine trauma
This trial studies how care is given to people who have a traumatic injury to the spine and need a breathing machine. It may help improve treatment and recovery for people who are ventilated after injury, including those with or without spinal cord damage.
Toronto, OntarioAges 16 years+ - NCT05224323Recruiting
Testing a lung opening breathing pattern in early ARDS
This study looks at a specific breathing event (“avalanche phenomenon”) when the lungs are opened in people with early, moderate-to-severe ARDS. The goal is to understand what’s happening in the lungs and whether it can guide better care.
PoitiersAges 18 years+ - NCT05226247Recruiting
Check whether careful weaning prevents lung fluid buildup
This study looks at people on a breathing machine for more than 48 hours who are starting a “spontaneous breathing trial,” a test used to see if they can breathe on their own. It focuses on those at higher risk of “weaning-induced pulmonary edema,” meaning fluid can collect in the lungs during the weaning process.
DijonAges 18 years+ - NCT05237505RecruitingPhase 2
Sleep apnea plus COPD study to check heart and breathing effects
This Phase 2 study looks at the cardiovascular (heart/blood vessel) effects of having both sleep apnea and COPD. It may help doctors better understand who is at risk and how to manage these breathing problems together.
La Jolla, CaliforniaAges 40–79 - NCT05350332Recruiting
Testing how lung air volume affects airway narrowing during sleep testing
This study looks at whether changing lung air volume affects how open or blocked your upper airway is during a drug-induced sleep test (DISE). It may help guide surgical choices for people with obstructive sleep apnea (OSA).
Atlanta, GeorgiaAges 18 years+ - NCT05354778Recruiting
Hydrocortisone vs placebo for severe hospital lung infection
This trial studies whether hydrocortisone (a steroid medicine) helps adults with severe bacterial pneumonia that starts in the hospital. Participants get either hydrocortisone or a placebo to see if it improves outcomes in ICU patients.
São Paulo, Sao Paulo SPAges 18 years+ - NCT05371886Recruiting
Testing how morphine (with or without midazolam) behaves in NICU babies
This study measures how morphine works in very young babies, and whether adding midazolam changes how the medicines behave and affect the body. It may help doctors better choose and dose pain/sedation medicines for babies in intensive care.
BrestAges 5 months–10 months - NCT05379673Recruiting
Breathing changes with extra oxygen after surgery
This study looks at whether giving extra oxygen during recovery from general anesthesia changes how you breathe after surgery. You may be offered different oxygen levels around the time you wake up to see what helps your breathing most comfortably.
Stanford, CaliforniaAges 18–70 - NCT05459116Recruiting
Record breathing effort to protect lungs during ventilation
This trial studies a way to measure how hard a patient is breathing and how the lungs and diaphragm are working while someone is on a breathing machine. The goal is to help the team use a “lung- and diaphragm-protective” ventilation strategy and see if it improves care.
Edegem, AntwerpAges 4 weeks+ - NCT05513508Recruiting
Tested a protective breathing mask in COPD and respiratory failure
This study tests how well a specific breathing mask setup works in people who need noninvasive ventilation (breathing support without a breathing tube), especially during COPD flare-ups or certain kinds of breathing failure. It may help reduce complications related to the mask while supporting breathing for at least a day.
NovaraAges 18 years+ - NCT05534243Recruiting
A breathing and brain-signal study for adults on ventilators
This study looks at brain activity during care for adults who are on a breathing machine through a tube in the windpipe. It may help doctors understand how to monitor recovery and guide care after intubation.
Iowa City, IowaAges 18 years+ - NCT05535543Recruiting
Prone breathing position test for severe lung failure
This trial studies whether turning patients onto their stomach (a positioning technique called prone positioning) changes a breathing-monitoring measure in people with severe acute respiratory distress syndrome (ARDS). If you qualify, the goal is to see if this positioning can improve how well your lungs exchange oxygen while you are on a breathing machine.
IstanbulAges 18 years+ - NCT05536531Recruiting
NMES therapy to help prevent ICU muscle weakness
This trial tests whether a device that delivers small electrical pulses to muscles can help prevent breathing and muscle weakness in very sick ICU patients. It also looks at changes in blood markers that may relate to muscle weakness and recovery.
Santiago, Santiago MetropolitanAges 18 years+ - NCT05562505Recruiting
Using ECMO to help you breathe, sit up, and come off a ventilator
This trial tests whether a heart-lung machine called venovenous ECMO can help people with severe breathing failure get less sedated, get extubated (have the breathing tube removed), and start moving. It’s for certain adults who are on a ventilator for a short time and have specific oxygenation problems.
Darlinghurst, New South WalesAges 18–65 - NCT05591924Recruiting
Bioinformatics study in adults with very early severe ICU illness
This trial studies how early severe illness in the ICU can be understood and tracked using health data (bioinformatics/informatics). It may help improve care decisions for people who arrive to the ICU soon after an emergency department visit.
London, OntarioAges 18 years+ - NCT05602662Recruiting
Music to help sedate adults on a breathing machine
This trial looks at whether listening to music can help make “pharmacological sedation” (medicine to help you relax/sleep) easier or more comfortable for adults in the ICU who are on a ventilator (breathing machine). It may help improve comfort during critical care treatment.
Karlstad, Värmland CountyAges 18–100 - NCT05640635Recruiting
Testing inflammation changes in people on ECMO
This study looks at inflammation during ECMO (a heart-lung bypass machine) and while people are being weaned off it. It may help doctors better understand which patients are improving safely during ECMO and when to reduce support.
Tübingen, Baden-WurttembergAges 18 years+ - NCT05668637Recruiting
AI tool to support care decisions for ventilated adults
This study tests an artificial intelligence (AI) software that helps clinicians make care decisions for people who are on a breathing machine. It may help teams respond faster and more consistently when complex breathing support is needed.
Cleveland, OhioAges 18 years+ - NCT05689476Recruiting
Measuring diaphragm breathing signals during ICU ventilation
This study measures electrical activity of the diaphragm and how your breathing system works while you are on a breathing machine in the ICU. It may help doctors better understand breathing during recovery after major lung events.
Padova, ItalyAges 18 years+
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Common questions
- Are there clinical trials for ventilation?
- Yes. Clin2 currently lists 523 recruiting ventilation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a ventilation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a ventilation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.