Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,832 recruiting studies in this area right now.
By phase
- Not applicable3,967
- Phase 2222
- Phase 4195
- Phase 1191
- Phase 3151
- Phase 1/Phase 273
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee73
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain34
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California208
- New York94
- Florida80
- Arizona76
- Massachusetts76
- Maryland73
- Texas64
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,832 total
- NCT05016908RecruitingTeam says not enrolling
Testing blood and other fluid markers in Duchenne or Becker
This study looks for signals in blood and other body fluids that may help track Duchenne or Becker muscular dystrophy. It may be helpful for patients by improving how future monitoring tests are developed.
Boston, MassachusettsAges 5 years+ - NCT05584046Recruiting
Herbal patch for heel pain
This trial tests a new herbal patch for treating heel pain (plantar fasciitis). The patch is applied to the skin, and the study aims to see if it helps reduce pain.
ShatinAges 18–70 - NCT07760662Recruiting
Oxidative stress and heart risk in rheumatoid arthritis
This study looks at how oxidative stress (an imbalance of harmful molecules in the body) relates to cardiovascular risk in people with rheumatoid arthritis. It aims to see if these factors are linked, which could help in better managing heart health for RA patients.
Santa Cruz de Tenerife, Canary IslandsAges 18 years+ - NCT07154550Recruiting
Comparing Mastisol bandage for clubfoot casting
This study compares two types of sticky bandage (Mastisol vs. standard) used during Ponseti casting for babies with clubfoot in both feet. It aims to see which one works better for keeping the casts on and preventing skin problems.
Madison, WisconsinAges birth–3 months - NCT07469020Recruiting
Cle-pad study: Checking leg artery health in spine surgery patients
This study is looking at how common blockages in leg arteries (peripheral artery disease, or PAD) are in people who are having surgery for lumbar spinal stenosis or had surgery less than 3 months ago. If you qualify, it may help doctors better understand and treat this condition.
LilleAges 18 years+ - NCT06423716RecruitingPhase 4
Duloxetine to reduce opioid use after knee replacement
This study tests whether taking the pain medication duloxetine before and after knee replacement surgery can reduce the need for opioid painkillers. It may help patients manage pain with fewer side effects from strong narcotics.
Toronto, OntarioAges 50 years+ - NCT06641089RecruitingPhase 3
Sonelokimab for psoriatic arthritis after TNF inhibitor failure
This study tests an investigational drug called sonelokimab for people with active psoriatic arthritis who have already tried a TNF-alpha inhibitor (like adalimumab) and it didn't work well enough. The goal is to see if sonelokimab can reduce joint pain and swelling and improve skin symptoms.
Avondale, ArizonaAges 18 years+ - NCT06371833Recruiting
Shoulder replacement study for arthritis or rotator cuff tears
This study is testing two types of shoulder replacement implants (one for arthritis and one for rotator cuff tears) to see how well they work over time. It may be a good option if you have severe shoulder pain from arthritis or a torn rotator cuff.
Cattolica, RiminiAges 18 years+ - NCT07756203Recruiting
Comparing two hand-held treatments for shoulder pain
This study tests two non-surgical treatments for shoulder pain caused by shoulder impingement. Both treatments use hand-held tools to ease pain and improve movement.
IstanbulAges 40–60 - NCT06581146Recruiting
Liver health study for boys with XLMTM
This study looks at how the liver works in boys with a serious muscle condition called XLMTM. It checks whether their liver is healthy, which may help doctors better understand the condition and guide future treatments.
Santa Monica, CaliforniaAges Up to 17 years - NCT07724977Recruiting
Comparing two arm exercises for shoulder stability in bowlers
This trial compares two sets of exercises to see which better helps bowlers with shoulder instability. If you are a male bowler aged 16 to 25 with at least 2 years of experience and no recent shoulder injuries, this study may be right for you.
Lahore, Punjab ProvinceAges 16–25 - NCT07583563Recruiting
Observational study of octreotide depot injections for acromegaly
This study watches how patients with acromegaly respond to octreotide, a medication given as injections under the skin. Researchers will collect information about how well the treatment works and any side effects you experience.
AachenAges 18 years+ - NCT06464705Recruiting
PEMF Therapy for Hamstring Strength After ACL Surgery
This study tests whether wearing a special device (PEMF) for a few minutes each day can help you regain hamstring strength more quickly after ACL surgery. If your hamstring is still weaker than your other leg at 4 months, this may help you recover better.
ShatinAges 18 years+ - NCT06138743RecruitingPhase 1/Phase 2
Investigational treatment for adult-onset myotonic dystrophy type 1
This trial is testing a new drug called SRP-1003 for people with myotonic dystrophy type 1 (DM1) who developed symptoms after age 12. The goal is to see if it can reduce muscle problems like myotonia (difficulty relaxing muscles) and improve daily function.
Liverpool, New South WalesAges 18–65 - NCT06131983RecruitingPhase 1/Phase 2
Study drug for facioscapulohumeral muscular dystrophy type 1
This trial is testing an investigational drug, SRP-1001, to see if it helps people with facioscapulohumeral muscular dystrophy type 1 (FSHD1), a condition that causes muscle weakness. The study will check if the drug is safe and if it can slow down the loss of muscle function.
Liverpool, New South WalesAges 16–70 - NCT07664371Recruiting
Cold therapy versus heat therapy for knee arthritis pain
This study compares two minimally invasive treatments for knee pain caused by arthritis when other treatments haven't worked. One uses cold (cryoneurolysis) and the other uses heat (radiofrequency) to calm nerves and reduce pain.
TantaAges 18 years+ - NCT07435129RecruitingPhase 2
Study of apitegromab for people with FSHD
This study tests whether a drug called apitegromab can help improve muscle function in people with facioscapulohumeral muscular dystrophy (FSHD). It is for adults aged 18-60 who have mild to moderate symptoms and can walk or run 10 meters in 5 seconds or less.
Austin, TexasAges 18–60 - NCT02257866Recruiting
Study of blood vessel inflammation over time
This study looks at different types of blood vessel inflammation (vasculitis) to learn more about why they happen and how they progress. By joining, you may help doctors better understand these conditions and improve future treatments.
Bethesda, MarylandAges 3 years+ - NCT07704580RecruitingPhase 1/Phase 2
Sarilumab for active rheumatoid arthritis
This trial tests sarilumab, an injected antibody that blocks a key protein involved in inflammation, for people with moderate-to-severe rheumatoid arthritis (RA) who haven't had success with standard treatments. The goal is to see if adding sarilumab can help control joint pain and swelling.
Hollywood, FloridaAges 18 years+ - NCT07562425Recruiting
Knee Strengthening Exercises for Patellofemoral Pain
This study compares three types of thigh muscle exercises to help reduce knee pain in people with patellofemoral pain syndrome (pain around the kneecap). Researchers want to see which exercise style—holding steady, moving through motion, or lowering slowly—works best for your pain.
Elâzığ, MErkezAges 18–50 - NCT07041099RecruitingPhase 1
Study of CLN-978 for Sjögren's disease
This trial tests an experimental drug called CLN-978, given as a shot under the skin, that helps your immune system target and destroy disease-causing B cells. It's for people with moderate to severe Sjögren's disease who haven't had success with other treatments.
Orlando, FloridaAges 18 years+ - NCT06747884Recruiting
Study for children with myotonic dystrophy
This study looks at how to best measure muscle health and function in children with myotonic dystrophy. It may help prepare for future treatment trials.
Little Rock, ArkansasAges 3–17 - NCT07245992RecruitingPhase 1
Study of F8IL10 injections for rheumatoid arthritis
This trial tests if a new drug called F8IL10, given as an injection directly into an inflamed joint, can help people with rheumatoid arthritis. It is for adults who have had RA for more than 6 months and still have joint swelling despite their current medications.
Reggio Emilia, Reggio EmiliaAges 18–80 - NCT07341399Enrolling by invitation
Amino acid supplement study for spinal deformity surgery
This trial tests whether taking essential amino acid supplements before and after surgery can help adults recovering from spinal deformity correction. It is for patients who are scheduled for surgery at UAMS and will attend physical therapy in Little Rock.
Little Rock, ArkansasAges 40–65
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,832 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,923 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.