Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT07853976Recruiting
UV-treated dental implants with or without melatonin
This study tests two types of dental implant treatments for replacing missing back teeth in the upper jaw. One uses special UV light to clean the implant surface, and the other adds melatonin to help healing. It aims to see which works better for long-term success.
Al Mansurah, Dakahlia GovernorateAges 18–60 - NCT07856173Recruiting
Comparing two hands-on therapies for frozen shoulder pain
This study compares two gentle hands-on therapies to see which works better for reducing pain, improving movement, and helping you use your shoulder again. It is for people with frozen shoulder who have had pain for more than 6 months.
Islamabad, Punjab ProvinceAges 40–60 - NCT06130592Recruiting
Ultrasound muscle imaging in pregnancy
This study tests a new ultrasound technique to look at fetal muscles in pregnant women, which might help detect joint or movement problems early. It aims to see if the technique is feasible and could improve prenatal diagnosis.
La Tronche, IsèreAges 18–55 - NCT05408065Recruiting
Compare pain relief from two shoulder injections for arthritis
This study compares how well two different shoulder injections reduce pain from moderate-to-severe shoulder osteoarthritis. You would receive injections in only one shoulder and answer questionnaires about pain and function.
Montreal, QuebecAges 20 years+ - NCT05887284Recruiting
Low-dose radiation study for osteoarthritis pain relief
This study tests whether giving a small amount of radiation to an osteoarthritis joint can improve symptoms. It’s designed for people who are newly starting this kind of treatment and can return for follow-up visits.
Erlangen, BavariaAges 39 years+ - NCT04955899Recruiting
Testing a device that stimulates the spleen in rheumatoid arthritis
This trial studies whether splenic stimulation (using a medical device to stimulate the spleen) is safe for people with active rheumatoid arthritis. It may help some patients who have not improved enough after at least two other advanced arthritis medicines.
AmsterdamAges 22–75 - NCT05638724Recruiting
Long COVID health registry for people of all ages
This study builds a health registry to learn how long COVID affects children, teens, and adults over time. It may help by improving understanding of symptoms and care, even if it does not test a new drug.
Munich, BavariaAges Any age - NCT07872839Enrolling by invitation
Study of arm muscle activity in spinal cord injury
This study looks at how arm muscles work together in people with spinal cord injury. It involves mild electrical stimulation to help understand muscle control, which may lead to better treatments.
TaipeiAges 20–65 - NCT07858591Recruiting
Eye scans for people with psoriatic arthritis
This study uses eye scans to look at tiny blood vessels in the back of the eye and a small area called the fovea, to see if they are different in people with psoriatic arthritis compared to people without it. This might help doctors understand more about psoriatic arthritis and its effects on the body.
Bursa, YıldırımAges 18–75 - NCT07853677Recruiting
How extra myoglobin levels affect kidney recovery in severe muscle damage
This study looks at whether clearing more of a muscle protein called myoglobin from the blood helps kidneys recover faster in people with severe muscle breakdown and kidney injury. Your existing medical records will be used; no extra tests or visits are needed.
StrasbourgAges 18 years+ - NCT07855367Recruiting
Knee pain relief study for osteoarthritis patients
This study compares two procedures that use extreme cold or heat to target the nerves around the knee, with the goal of reducing pain from knee osteoarthritis. It is specifically for people with advanced knee osteoarthritis who also have bladder cancer.
CairoAges 40 years+ - NCT07857460Recruiting
German registry for low parathyroid hormone levels
This study is a registry that collects health information from people with chronic low parathyroid hormone (hypoparathyroidism) or pseudohypoparathyroidism. It aims to better understand these conditions and improve future care. You may join if you are an adult living in Germany.
Augsburg, BavariaAges 18 years+ - NCT07855445Recruiting
Nerve pain and MRI findings in lumbar spinal stenosis
This study looks at how nerve pain relates to MRI results in people with lumbar spinal stenosis, a condition where the spinal canal narrows and presses on nerves. It aims to better understand the link between symptoms and imaging, which could help improve care.
Istanbul, IstanbulAges 18 years+ - NCT07864948Recruiting
Shock wave therapy with or without taping for heel pain
This study tests two treatments for heel pain caused by plantar fasciitis. You'll get either shock wave therapy alone, or shock wave therapy plus special tape (kinesiotaping), to see which is better for reducing pain.
Ankara, ÇankayaAges 18–65 - NCT06265038Recruiting
Study of a new implant for lower back fusion surgery
This study tests a new implant called ReSpace TiCell Cage for TLIF surgery, which is a procedure to stabilize the lower back by fusing two vertebrae. It may be a good option if you have a degenerative spine condition causing pain or instability and are a candidate for this type of surgery.
Budapest, Pest CountyAges 18–80 - NCT06269354Recruiting
3D-printed implant for large lower-limb bone defects
This trial is testing a new way to treat large bone defects in the lower leg or thigh using a custom 3D-printed titanium implant. It may help people whose bone didn't heal after injury, infection, or tumor removal.
Beijing, HaidianAges 18–90 - NCT04505579Recruiting
Study of a spinal tether to treat worsening scoliosis
This trial studies a surgically placed “tether” system to help stop or slow worsening in certain types of scoliosis in growing teens. It’s for people whose curve is moderate-to-severe and who could not tolerate or didn’t respond to bracing.
San Diego, CaliforniaAges Any age - NCT04031287Recruiting
Riordan com disease life story study
This study collects health information from children and young adults with a rare genetic condition called rhizomelic chondrodysplasia punctata (RCDP) to learn more about how the condition affects people over time. By participating, you can help doctors better understand the condition and improve future care.
Wilmington, DelawareAges 6 months–21 years - NCT07861906Recruiting
Wearable device for jaw muscle pain
This study tests a 24-hour wearable device that tracks jaw muscle activity to better understand and manage chronic jaw muscle pain. You would wear the device for a day to see how your muscles behave, which could help improve future treatments.
Downers Grove, IllinoisAges 18 years+ - NCT07863557RecruitingPhase 4
Early wear of hip replacement liners
This trial tests how well a type of hip replacement called a dual mobility cup holds up over time, focusing on early signs of wear in the plastic liner. It aims to see if this implant lasts longer and works better for people with hip arthritis or other hip conditions.
Uppsala, Uppsala CountyAges 18–75 - NCT03491761RecruitingPhase 2
PRP injection versus hyaluronic acid shots for knee arthritis
This trial tests whether a platelet-rich plasma (PRP) shot works better than a standard hyaluronic acid (“gel”) injection to reduce knee osteoarthritis pain. It may help people with ongoing knee pain choose the treatment that relieves symptoms more effectively.
Skokie, IllinoisAges 18–75 - NCT07860697Recruiting
MRI study of back pain and spine changes
This study looks at MRI images of the lower back to see how body fat, back muscles, and small spine joints relate to long-term back pain. It may help doctors understand back pain better and improve future treatments.
Istanbul, IstanbulAges 18–75 - NCT07862257Recruiting
Checking brain oxygen during spine surgery lying face-down
This study measures how lying face-down during lumbar disc surgery affects your breathing and the oxygen levels in your brain. The researchers want to see if this position is safe and how it changes blood flow and oxygen to your brain during the operation.
Istanbul, IstanbulAges 18–75 - NCT05108948Recruiting
Study factors linked to better quality of life after spine surgery
This study looks at what helps adults with spinal deformity have a better quality of life one year after surgery. It may help doctors understand which patients benefit most and how to improve follow-up care.
BrugesAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.