Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,832 recruiting studies in this area right now.
By phase
- Not applicable3,967
- Phase 2222
- Phase 4195
- Phase 1191
- Phase 3151
- Phase 1/Phase 273
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee73
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain34
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California208
- New York94
- Florida80
- Arizona76
- Massachusetts76
- Maryland73
- Texas64
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,832 total
- NCT06061003Recruiting
3D printed wrist models for anatomy learning
This study tests whether 3D-printed models of wrist bones help students learn anatomy better than traditional methods. You'll need good depth perception and no recent wrist injuries to join.
Bolu, MerkezAges 18–40 - NCT05946109Recruiting
Exercise program for frail older adults over 70
This trial studies whether a structured exercise program can improve health and function in frail adults age 70 and older. It may help you build strength, energy, and mobility if you meet frailty and safety requirements.
Brussels, Brussels CapitalAges 70 years+ - NCT05520593Recruiting
Drinking plan before surgery to support same-day joint replacement
This trial tests whether a specific pre-surgery oral drinking (hydration) plan can help people feel and recover better after outpatient (same-day) hip or knee replacement surgery. It may help support safe same-day discharge for the right patients.
New York, New YorkAges 18–75 - NCT04137939Recruiting
Smart exercise program for seniors to improve balance
This trial tests whether an internet-connected (“smart”) exercise program can help adults age 50+ move safely and improve exercise/balance. It may help seniors who currently do not have major movement problems, heart conditions, or recent dizziness-related balance issues.
Tainan, TaiwanAges 50 years+ - NCT03882073Recruiting
Upper arm amputation rehab study to improve hand control and feel
This trial tests a new approach for rehabilitation after an upper-limb amputation to help improve your ability to intentionally control a prosthetic and regain a sense of position (“proprioception”). You may be considered if you are planning an elective upper-arm or below-elbow amputation and can safely have surgery and follow up closely.
Bethesda, MarylandAges 18–65 - NCT06451588RecruitingPhase 2
Fecal transplant for inflammatory back pain
This study tests whether a fecal microbiota transplant (a procedure that transfers healthy bacteria into your gut) can reduce inflammation and improve symptoms in people with inflammatory back pain (axial spondyloarthritis). It may help if your current treatments are not working well enough.
TromsøAges 18–65 - NCT06573983Recruiting
Fall prevention program for older veterans
This study aims to improve fall prevention for older veterans. It tests a program that combines telehealth check-ins with a caregiver-supported physical assessment to reduce fall risk. Participation may help you feel safer and more stable.
Aurora, ColoradoAges 65 years+ - NCT05412394RecruitingPhase 4
Once-weekly steroid for very young children with DMD
This trial tests whether a steroid taken once each week is safe and useful for children with Duchenne muscular dystrophy (DMD). It aims to help slow disease effects in very young children whose diagnosis and lab tests confirm DMD.
Chicago, IllinoisAges 1 month–2.5 years - NCT06617494Recruiting
Study of pain control in chronic jaw pain
This study looks at how well the body's natural pain control system works in people with long-term jaw pain (TMD). It compares people with and without jaw pain to better understand why some have trouble turning off pain signals.
Minneapolis, MinnesotaAges 18–74 - NCT07523113Recruiting
Brain Fog Treatment for ME/CFS Using Cognitive Training
This study tests whether a computerized cognitive training program combined with a mild electrical nerve stimulation device (worn on the ear) can help improve thinking and memory problems in people with ME/CFS. The goal is to see if this approach helps with brain fog and daily functioning.
Birmingham, AlabamaAges 18 years+ - NCT07391605RecruitingPhase 2
Descartes-08 for treatment-resistant myositis
This trial tests a new treatment called Descartes-08 for people with dermatomyositis or antisynthetase syndrome whose disease hasn't responded well to standard therapies. It aims to see if this treatment can help control muscle and skin symptoms.
Orange, CaliforniaAges 18 years+ - NCT05609630RecruitingPhase 3
Testing two medicines for active systemic juvenile arthritis
This Phase 3 trial studies how well upadacitinib (a pill) and tocilizumab (a shot/IV medicine) improve symptoms and inflammation in children with active systemic juvenile idiopathic arthritis (sJIA). It also looks at side effects and how these medicines move through the body.
Phoenix, ArizonaAges 1–17 - NCT05067543Recruiting
Shoulder replacement study using a new humerus implant device
This study tests a specific device used for shoulder arthroplasty (shoulder replacement) in adults. You may be able to join if you need a shoulder replacement and meet safety checks around infection, bone quality, and allergies.
Lexington, KentuckyAges 18 years+ - NCT07762170RecruitingPhase 4
Steroid injections for back and pelvic pain
This study is testing how well and how safely steroid injections work for different types of back pain. If you join, you'll receive the injection as part of your care and fill out surveys about your pain and ability to do daily activities before and after.
Thornhill, OntarioAges 18 years+ - NCT07160634RecruitingPhase 3
Gene therapy for ambulant males with Duchenne muscular dystrophy
This trial tests a new gene therapy called SGT-003 in boys and men with Duchenne muscular dystrophy who are still able to walk. The treatment aims to deliver a working version of the dystrophin gene to help muscle cells produce the protein they are missing.
Little Rock, ArkansasAges 7–11 - NCT07202273Recruiting
One-time radiation treatment for painful bone metastases
This trial tests a single session of radiation therapy to relieve pain and improve stability in up to two bone spots where cancer has spread. The goal is to make treatment faster and more convenient for patients.
Salt Lake City, UtahAges 18 years+ - NCT07763158Recruiting
Treatment for severe knee pain using artery embolization
This study tests a procedure that blocks tiny arteries in the knee to reduce pain from severe arthritis. It is for people who cannot have knee replacement surgery because of other health issues.
Jeddah, Mecca RegionAges 18 years+ - NCT07763522Enrolling by invitation
Measuring ankle strength in people with herniated disc weakness
This study tests a new way to measure ankle strength in people who have weakness from a herniated disc in the lower back. The goal is to confirm the measurement tool works well for tracking such weakness.
Helsinki, UusimaaAges 18–65 - NCT06677320Recruiting
What really matters in rotator cuff disease
This study looks at what it means for rotator cuff problems to be clinically important—how they affect your daily life and what counts as meaningful improvement. It helps doctors better understand your symptoms and recovery.
KırklareliAges 18 years+ - NCT03921944Recruiting
CT and nerve tests after shoulder replacement for arthritis
This study checks how well the rotator cuff (the shoulder’s key tendons/muscles) is working after a total shoulder replacement done for arthritis. It uses CT scans and nerve testing to see what affects shoulder structure and function, which may help improve future care.
Hershey, PennsylvaniaAges 45 years+ - NCT06162195Recruiting
Comparing a new hip implant to standard hip replacement
This trial compares a new hip implant (H1) to a standard total hip replacement. It is for people who need hip replacement on one side due to arthritis or other hip conditions and can commit to long-term follow-up.
BournemouthAges Any age - NCT04094701Recruiting
Study of opioid needs after hip arthroscopy surgery
This study looks at how much pain medicine (opioids) people actually need after hip arthroscopy and what factors may affect it. It may help improve safer, more personalized pain control after surgery.
Chicago, IllinoisAges 18–80 - NCT07322705Recruiting
Reducing groin injury during hip scope surgery
This study tests a new way to position patients during hip keyhole surgery to reduce injury to the groin area from pulling. If you are having hip arthroscopy for a condition called femoroacetabular impingement, this trial might help make your recovery smoother.
Beijing, Beijing MunicipalityAges 15–60 - NCT07522489Recruiting
New knee replacement surgery guidance methods compared
This study compares two ways doctors use computer guidance during robotic knee replacement surgery for severe knee arthritis. The trial tests whether both methods work equally well or if one is better for patient recovery and results.
Warsaw, MazovianAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,832 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,923 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.