Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,832 recruiting studies in this area right now.
By phase
- Not applicable3,967
- Phase 2222
- Phase 4195
- Phase 1191
- Phase 3151
- Phase 1/Phase 273
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee73
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain34
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California208
- New York94
- Florida80
- Arizona76
- Massachusetts76
- Maryland73
- Texas64
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,832 total
- NCT07321483Recruiting
Reflex therapy for jaw pain
This trial tests if a special reflex therapy can help people with jaw muscle pain that isn't caused by joint damage. It might be a new way to reduce discomfort and improve function.
OlomoucAges 18 years+ - NCT07681999Recruiting
Detecting early shoulder blade problems in ankylosing spondylitis
This study uses ultrasound to look for early signs of shoulder blade (scapular) movement issues in people with ankylosing spondylitis (AS), a type of arthritis that affects the spine. It also includes people without AS who have activity-related discomfort to compare results.
TantaAges 18 years+ - NCT07580365Recruiting
Virtual Reality Training for Kids With Muscle Diseases
This study tests whether a virtual reality-based exercise program can help children and teens with diagnosed muscle diseases improve their strength and function. Participants use a special exercise bike while wearing a VR headset to make training more engaging.
Bosisio Parini, LCAges 6–18 - NCT07397884Recruiting
Bone loss and stress markers in implant gum disease
This study looks at markers of bone damage and stress in people with gum disease around dental implants (peri-implantitis). It aims to understand how the body responds, which could help improve treatment.
Keçiören, AnkaraAges 18–65 - NCT07754175Recruiting
Stem cell knee treatment for osteoarthritis patients
This study tests a stem cell injection for knee osteoarthritis in patients who previously received a placebo. It aims to see if the treatment is safe and effective over a longer period.
SeoulAges 19 years+ - NCT07754214Recruiting
Exercise program for chronic heel pain
This study tests a supervised exercise program that combines balance (proprioception) and strengthening exercises to relieve chronic heel pain from plantar fasciitis. It may help improve foot function and reduce pain.
KaramanAges 18–65 - NCT07287202RecruitingPhase 1/Phase 2
A study of SVG103 for people with certain brain conditions and seizures
This trial tests a drug called SVG103 (Paxalisib) in adults with brain conditions that cause hard-to-control seizures: Focal Cortical Dysplasia Type II, Tuberous Sclerosis Complex, or Hemimegalencephaly. The goal is to see if SVG103 is safe and helps reduce seizures.
Heidelberg, VictoriaAges 18–65 - NCT06832878RecruitingPhase 4
Tranexamic Acid Pills After Hip Replacement
This study tests whether taking tranexamic acid (TXA) pills after hip replacement can reduce bleeding and the need for blood transfusions. It is for people having a first-time hip replacement due to severe arthritis who stay one night in the hospital.
Scottsdale, ArizonaAges 18 years+ - NCT07167927Recruiting
Decision support tool for children with neuromuscular scoliosis
Researchers are developing a decision support tool to help parents and doctors make decisions about surgery for children with neuromuscular scoliosis. The tool aims to provide clear information and support during the consultation.
Los Angeles, CaliforniaAges 8 years+ - NCT07756307Recruiting
Shock wave therapy for calcium deposits in the shoulder
This trial tests whether a non-invasive treatment called shock wave therapy can reduce pain and improve function in people with calcium deposits in the shoulder tendon. It uses sound waves to break up the deposits, which may relieve pain and help you move better.
Taipei, TaipeiAges 20–70 - NCT03965234RecruitingPhase 1/Phase 2
Lung infusion for colorectal cancer that has spread to the lungs
This trial tests a procedure where chemotherapy is delivered directly into the lungs during surgery to remove or destroy lung tumors. It aims to reduce the chance of cancer returning after surgery for people with colorectal cancer that has spread to the lungs.
Buffalo, New YorkAges 18 years+ - NCT07486960RecruitingPhase 2
Study of Tulisokibart for Psoriatic Arthritis
This trial tests a new drug called tulisokibart for people with psoriatic arthritis (PsA), a condition that causes joint pain and skin plaques. It may help if you have not tried certain biologic medications or if they did not work well.
Sun City, ArizonaAges 18–80 - NCT07375290RecruitingPhase 1
Zoledronate for Bone Health After Stem Cell Transplant
This trial tests if a bone-strengthening medicine called zoledronate can help prevent bone problems in children and teens who have had a stem cell transplant. It may be an option for patients with low bone density or those who develop graft-versus-host disease after transplant.
Cincinnati, OhioAges 5–18 - NCT07435259Recruiting
Treating jaw bone problems around dental implants: keep or remove?
This study compares two ways to treat a jaw bone problem caused by medications (called MRONJ) when it happens around a dental implant. One option is to keep the implant and treat the bone, the other is to remove the implant. The goal is to see which approach leads to better healing.
Seoul, SeoulAges 20 years+ - NCT06020508Recruiting
Light device to help place epidural needles
This trial tests a new device that uses light to help doctors place an epidural needle more accurately in your lower back. It may make the procedure safer and more comfortable.
New York, New YorkAges 18–99 - NCT07103746RecruitingPhase 2
Ublituximab for antibody-positive IMNM
This study tests an investigational medication called ublituximab (an infusion) for people with a rare autoimmune muscle disease called IMNM. It aims to reduce muscle weakness and damage by targeting specific immune cells (B cells). To join, you need a recent diagnosis (within 1 year), specific antibodies, and be on limited other medications.
Birmingham, AlabamaAges 18 years+ - NCT07111494RecruitingPhase 4
GLP-1 medication for psoriatic arthritis outcomes
This study tests if adding a GLP-1 medication (a type of drug that helps with weight and blood sugar) to your usual psoriatic arthritis treatment can improve your joint and skin symptoms. It is for people with psoriatic arthritis who have not yet achieved good control of their disease and have a higher body weight.
Milwaukee, WisconsinAges 18 years+ - NCT06926621Enrolling by invitationPhase 2
Long-term safety and effectiveness of VX-670 for myotonic dystrophy
This study is for people who already received VX-670 in a previous trial and want to continue treatment. It will check the drug's long-term safety and how well it works for myotonic dystrophy type 1.
St Louis, MissouriAges 18 years+ - NCT05731141Recruiting
Study of lymphatic birthmarks and related genetic conditions
This study follows people who have lymphatic anomalies (lymphatic birthmarks) and sometimes related vascular or genetic conditions. It aims to better understand how these problems develop and what genetic causes may be involved.
Bethesda, MarylandAges 1 day–100 years - NCT06842212Enrolling by invitation
Balance training for athletes across the menstrual cycle
This study looks at whether special balance exercises can help female athletes stay stable and perform better at different points in their menstrual cycle.
CairoAges 18–22 - NCT06834048Recruiting
Balance test for posture pain and muscle tension
This study tests if a balance scale works well for Albanian people with posture-related pain or muscle tension. It helps figure out if your balance is affected by these issues.
MurciaAges 50–80 - NCT06815367Recruiting
Compression vs Blood Flow Restriction for Muscle Recovery
This study compares two methods to help muscles recover after exercise: pneumatic compression (like a gentle massage sleeve) versus blood flow restriction (using a cuff). It aims to find which works better for healthy, active young adults.
Los Angeles, CaliforniaAges 18–30 - NCT06750601Recruiting
Using rehab data for research on physical disabilities
This study collects information from people receiving rehabilitation care. The data may be used to improve treatments for physical disabilities and chronic diseases.
GroningenAges Any age - NCT06727695Recruiting
BioStrength training for muscle strength and satisfaction
This study tests a special strength training program called BioStrength to see if it improves muscle strength and overall satisfaction in healthy adults. The program lasts 12 weeks and is for people who are new to strength training.
Leibnitz, Styria, StyriaAges 30–65
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,832 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,923 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.