Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT05145725Recruiting
Surgery study for teens with scoliosis needing spinal fusion
This trial looks at a specific surgical technique for teens whose scoliosis is severe enough that doctors have recommended surgery. It may help doctors compare approaches and improve outcomes after spinal fusion.
BrugesAges 12–20 - NCT06970470Recruiting
Back brace study for older adults with stooped posture
This study tests whether wearing a back brace can improve mobility in older adults with a stooped posture (hyperkyphosis). It may help participants walk better and maintain independence.
Porto Alegre, Rio Grande do SulAges 60 years+ - NCT03839862Recruiting
Stool tests in people starting anti-TNF treatment
This study looks at stool (poop) samples to better understand therapy in people with spondyloarthritis (inflammatory joint conditions). You may be asked to provide stool samples right as you start anti-TNF treatment, which could help researchers tailor or improve care.
LundAges 18 years+ - NCT05593146RecruitingPhase 2
3D hip reconstruction surgery to prevent dislocation
This trial compares a modified hip implant positioning method to lower the chance of the hip “slipping out of place” (dislocation) after major hip tumor surgery and reconstruction. If you qualify, you may help test whether a small change in implant angle improves stability and function.
Ningbo, ZhejiangAges 16 years+ - NCT06287840Recruiting
Canadian Bone Strength Development Study for Kids with Type 1 Diabetes
This study looks at how bones grow stronger in children with type 1 diabetes compared to typically developing children. Researchers will measure bone strength using special scans and other simple tests.
Saskatoon, SaskatchewanAges 10–12 - NCT06151028Recruiting
Menopause Symptoms in Women After Ovary Removal for Gynecologic Cancer
This study looks at menopause symptoms in women who have had their ovaries removed as part of gynecologic cancer treatment. It aims to understand how these symptoms affect patients over time.
Hefei, AnhuiAges 18–55 - NCT05081453Recruiting
Early testing and treatment for a specific hip-knee problem
This trial focuses on healthy newborns who were born breech to identify early signs of a knee-tilt/track problem and start treatment sooner if needed. It may help reduce how much the condition affects walking later by addressing it early.
MurciaAges birth–6 months - NCT06261645Recruiting
Exercise program for non-traumatic shoulder instability
This study tests a new exercise program for people with non-traumatic shoulder instability (looseness without injury). It focuses on improving how well your rotator cuff muscles control shoulder rotation.
Gothenburg, MölndalAges 16–35 - NCT06074744Recruiting
Nerve blocks for knee replacement pain relief
This study compares two types of nerve blocks (subsartorial and femoral) to see which provides better pain control after knee replacement surgery. Both are injections that numb the nerves around your knee to help with recovery.
LucerneAges 18 years+ - NCT06108063RecruitingPhase 1/Phase 2
Losartan to prevent knee stiffness after replacement
This study tests whether losartan, a blood pressure medicine, can prevent excessive scar tissue (arthrofibrosis) after a total knee replacement. Participants receive losartan or a placebo for 6 months after surgery to see if it improves knee motion and reduces stiffness.
Vail, ColoradoAges 18 years+ - NCT06249906Recruiting
Bioceramic material for bone defect repair
This trial tests a new bioceramic material to repair bone defects. It is for adults aged 18 to 65 who are generally healthy and can follow the study plan.
Nanjing, JiangsuAges 18–65 - NCT05677152RecruitingPhase 2
Anti-bone-drug test to help shoulder tendon healing after surgery
This Phase 2 trial studies whether an anti-osteoporosis medicine (zoledronic acid) can improve healing after surgery for a chronic rotator cuff tear in the shoulder. If you qualify, you would also follow a specific 4-week physical therapy plan using a shoulder support pad.
ViennaAges 50–70 - NCT06250023Recruiting
Oral antibiotics for spinal infection treatment
This trial tests whether oral antibiotics, taken as pills, work as well as IV antibiotics for treating spinal infections. It may be an option if your infection is already improving with a short course of IV antibiotics.
CopenhagenAges 18 years+ - NCT06322654Recruiting
Comparing two types of robotic rehab for spinal muscular atrophy
This study compares two robot-assisted rehabilitation programs to see which one helps children and young adults with spinal muscular atrophy (SMA) improve their movement and function better. You may join if you have SMA (types 1-4), are up to 21 years old, and are already receiving medication for SMA.
PoznanAges Up to 21 years - NCT06334159Recruiting
Comparing two collagen membranes for bone grafting before dental implants
This study compares two types of collagen membranes used in guided bone regeneration to rebuild jawbone so dental implants can be placed. If you need a bone graft for missing back teeth and are generally healthy, this trial may be a good fit.
Barcelona, Sant Cugat Del VallèsAges 18 years+ - NCT06302465Recruiting
Narlumosbartmab plus chemo for bone cancers with giant cells
This trial tests a new drug called Narlumosbartmab added to standard chemotherapy for certain types of bone cancer that have eaten away at the bone and contain large, abnormal cells. It is for people who have not yet started standard treatment and whose tumors can be removed with surgery.
Beijing, Beijing MunicipalityAges 8 years+ - NCT05110729Recruiting
Check how injuries affect quality of life in young gymnasts
This study looks at how musculoskeletal injuries change quality of life and life satisfaction for gymnasts ages 8 to 18. It may help sports medicine teams understand what young gymnasts need to feel better and keep doing their sport.
Denver, ColoradoAges 8–18 - NCT05923736Recruiting
Study of cardiovascular risk in people with digital osteoarthritis
This study looks at how heart-and-blood-vessel risk differs in people with digital osteoarthritis (arthritis affecting the fingers). It may help doctors understand whether finger osteoarthritis is linked with higher cardiovascular risk.
Clermont-FerrandAges 18 years+ - NCT05946278Recruiting
Study genes that may affect bone health after major spine surgery
This study looks at genetic (inherited) factors that may influence bone healing in people undergoing major spine procedures. It may help researchers understand why some people heal differently and could guide better care in the future.
Aurora, ColoradoAges 18–85 - NCT06233539Recruiting
Study on diagnosis and treatment for neck bone dislocation
This trial aims to find the best ways to diagnose and treat a specific type of neck bone problem called atlantoaxial dislocation. It is for people who have this condition and are having surgery.
Beijing, Beijing MunicipalityAges Any age - NCT05761314Recruiting
Study treatments for cancers in people with RASopathy
This study looks at people who have a RASopathy—a genetic condition—and also have solid tumors (tumor growths not in blood). To join, your RASopathy must be confirmed by genetic testing, not only by symptoms.
RomaAges Any age - NCT04117841Recruiting
Registry study following children with slipped hip
This study keeps track of children diagnosed with slipped capital femoral epiphysis (SCFE) over time. It helps doctors better understand how SCFE progresses and how different treatments affect outcomes.
Vancouver, British ColumbiaAges birth–18 years - NCT06323018Recruiting
Remote preconditioning for cemented hip replacement recovery
This trial tests whether a simple, safe treatment called remote ischemic preconditioning (using a blood pressure cuff on your arm just before surgery) can help people recover better after cemented hip replacement. It is for patients aged 66 and older who are scheduled for this surgery.
Tartu, TartuAges 65–90 - NCT06349629Recruiting
Testing a new dissolving metal implant for joint fractures
This trial tests a new 3D-printed metal implant made of a special magnesium alloy that dissolves over time. It is designed to help mend broken bones near joints, such as wrist, shoulder, or knee fractures, where there is a missing piece of bone.
Beijing, HaidianAges 18–80
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.