Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,838 recruiting studies in this area right now.
By phase
- Not applicable3,969
- Phase 2224
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 276
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis87
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,838 total
- NCT05848895Recruiting
Osteopathy treatment for infants with positional head shape
This study tests an osteopathic manual therapy plan (hands-on treatment) for babies with positional plagiocephaly, aiming to improve head shape and comfort. It also asks families to attend multiple treatment and measurement visits so researchers can track change over time.
San Diego, CaliforniaAges 1 day–4 months - NCT05849389RecruitingPhase 2
Vosoritide for taller growth in girls with Turner syndrome
This Phase 2 study tests vosoritide to help children with Turner syndrome grow taller before puberty. You may be able to join if your child is pre-pubertal, has short height for age, and either has not tried growth hormone or has not responded well to it.
Washington D.C., District of ColumbiaAges 3–11 - NCT05851326Recruiting
Ultrasound and gentle stimulation for stubborn muscle pain
This trial tests whether low-energy ultrasound and electrical/magnetic stimulation can reduce long-lasting myofascial pain in the low back, neck, or tension-type headaches. It may help if your pain has lasted at least 3 months and is still noticeable despite your current treatment plan.
GrazAges 18–99 - NCT05853640Recruiting
Education and exercise for long-term hip or groin pain
This trial tests whether a program of education plus exercise can reduce long-term hip or groin pain. It may help by improving movement and function, especially when pain has lasted more than 3 months.
MalmöAges 18–55 - NCT05858528Recruiting
Study following adults with skin psoriasis over time
This observational study is looking at adults with skin psoriasis and collecting real-world information about their condition and experiences. It may help researchers better understand psoriasis and how it affects people, without giving a new treatment.
Oxford, OxfordshireAges 18 years+ - NCT05866029Recruiting
Prevention and treatment study for new brittle bone fractures
This study looks at ways to prevent and treat “brittle bone” refractures after a recent fracture in people with osteoporosis. If you’ve had a new hip, spine, or other bone fracture, the trial may test strategies to lower the chance of another fracture.
BeijingAges 45–90 - NCT05869851Recruiting
Infant hip ultrasound study: observe vs bracing
This study looks at babies under 3 months old with certain ultrasound findings of an underdeveloped hip (“hip dysplasia”). It compares outcomes between simply watching the hip and using a brace (when recommended).
Vancouver, British ColumbiaAges Up to 3 months - NCT05871216Recruiting
Study of joint instability in people with loose joints
This trial is testing how to assess and manage joint instability in people who have unusually loose (hypermobile) joints. If you have moderate to severe loose joints, you may be able to join after screening checks like movement tests and health history.
BolognaAges 18–60 - NCT05877846Recruiting
Personalized care to improve physical function in older adults
This study looks at precision (personalized) approaches to help older adults improve physical function. It may include giving a specific supplement depending on lab results, and it requires regular study visits and ability to complete procedures.
Chapel Hill, North CarolinaAges 65–85 - NCT05878223Recruiting
Testing different shockwave doses for ankle stiffness after stroke
This study compares different doses of shockwave treatment to reduce ankle muscle tightness (spasticity) after stroke. If you have persistent ankle stiffness and can safely receive the treatment, your results may help find the best dose for symptom relief.
HsinchuAges 20 years+ - NCT05880407Recruiting
Minimally invasive procedure to correct bunion alignment
This pilot study tests a minimally invasive (through small skin openings) correction to improve the alignment of a bunion (hallux valgus). It may help people who are already being advised to have bunion surgery, but who fit specific bone alignment measurements and safety criteria.
BolognaAges 18–65 - NCT05880914Recruiting
Personalized treatment study for bone disease in kidney failure
This trial looks at a personalized approach to diagnosing and treating bone problems caused by long-term kidney disease. It may help by matching treatment plans to the type of bone turnover found in your tests or biopsy.
St Louis, MissouriAges 18 years+ - NCT05883371Recruiting
IMPACT autoimmune study registry for people on biologic medicines
This study is a registry that collects health information from adults with certain autoimmune conditions who are currently using (or have been recommended) biologic or DMARD medicines. It may help researchers better understand these diseases and how treatments affect people over time.
Columbus, OhioAges 18–70 - NCT05887284Recruiting
Low-dose radiation study for osteoarthritis pain relief
This study tests whether giving a small amount of radiation to an osteoarthritis joint can improve symptoms. It’s designed for people who are newly starting this kind of treatment and can return for follow-up visits.
Erlangen, BavariaAges 39 years+ - NCT05888038Recruiting
Virtual reality to reduce pain after scoliosis surgery
This trial looks at whether virtual reality can lower pain for children and teens after scoliosis repair surgery, which may also reduce how much opioid pain medicine they need. If you join, you would use a virtual reality experience during the post-operative period.
Staten Island, New YorkAges 7–21 - NCT05892133Recruiting
Exercise program before knee replacement to improve recovery
This trial studies whether doing a structured exercise or “prehab” program before total knee replacement can improve knee function and patient satisfaction after surgery. It may help you recover better and feel more confident in your outcome.
Molde, Møre og RomsdalAges 50–80 - NCT05895032Recruiting
Exercise program for children with hemophilia A or B
This trial studies whether a structured exercise program helps children with hemophilia A or B safely. It looks at children’s ability to exercise and function, while aiming to avoid complications like leg bleeds or injuries.
Canterbury, KentAges 6–12 - NCT05895786RecruitingPhase 3
Study drug for active dermatomyositis or polymyositis
This Phase 3 trial tests how an investigational medicine (PF-06823859) works in adults with active dermatomyositis or polymyositis. It aims to improve disease control by targeting the immune system, but you must meet several safety and diagnosis requirements.
Glendale, ArizonaAges 18 years+ - NCT05900466RecruitingPhase 2
Metformin for fibromyalgia symptom relief
This study tests whether metformin, a diabetes medicine, can reduce fibromyalgia symptoms. If you have fibromyalgia and can take pills safely, you may be able to join and help answer whether metformin can help.
Salt Lake City, UtahAges 18–75 - NCT05901259Recruiting
Tracking routine outcomes using a mobility suit database
This trial sets up a database to follow routine health and mobility outcomes over time. You may be included if you have certain neurological conditions and can safely use the EXOPULSE suit.
Bergshamra, Stockholm CountyAges 2 years+ - NCT05904301Recruiting
Registry for autoimmune and autoinflammatory disease patients
This study builds a nationwide list (registry) of people with certain autoimmune or inflammation-related illnesses. It helps researchers understand these diseases better over time, which can guide future care.
YerevanAges Any age - NCT05904353Recruiting
Care coordination program after hip fracture and osteoporosis
This trial aims to improve how primary care and hospital care work together to treat osteoporosis after a hip fracture. It may help by making follow-up treatment plans and communication clearer after your hip injury.
Lørenskog, AkershusAges 75 years+ - NCT05905419Recruiting
Brain scan study of opioid effects in women with pain
This study uses brain imaging (MRI) to understand how opioid medications may affect the brain in women. People with chronic pain who take opioids (or do not) and healthy women without chronic pain may be invited to participate.
Durham, North CarolinaAges 18 years+ - NCT05906433RecruitingPhase 1
Best type of numbing medicine for knee steroid shots
This early (Phase 1) study looks at which anesthetic (numbing medicine) works best and is safest during steroid injections for knee osteoarthritis. It may help improve comfort and effectiveness of these common pain-relief shots.
Tampa, FloridaAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,838 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,965 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.