Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,838 recruiting studies in this area right now.
By phase
- Not applicable3,969
- Phase 2224
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 276
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis87
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,838 total
- NCT05906147Recruiting
Bone health improvement program for adults over 40
This study tests a structured bone health improvement program for adults over age 40 who are attending a health checkup at the hospital. It aims to improve or maintain bone strength, using bone density measurements as part of the study.
Changsha, HunanAges 40–100 - NCT05907239Recruiting
Shock wave therapy for jaw muscle pain
This trial tests whether focused shock wave treatment can reduce chronic jaw pain caused by jaw muscle problems. You might qualify if you have moderate to severe temporomandibular (jaw) pain for at least 3 months.
São Paulo, São PauloAges 18 years+ - NCT05908214Recruiting
Electrical stimulation for leg stiffness and overactive nerves
This study tests a treatment using high-frequency electrical stimulation to reduce overactive nerve signals that can cause stiff legs, poor ankle control, cramps, or restless legs. It may help improve movement and comfort during walking or at night, depending on the condition.
LausanneAges 18 years+ - NCT05912153Recruiting
SPECT-CT vs MRI to diagnose foot and ankle arthritis
This study compares two imaging tests—SPECT-CT and MRI—to see which one best helps diagnose osteoarthritis (wear-and-tear joint arthritis) in the ankle and midfoot/hindfoot. It may help confirm the right diagnosis so treatment can be better targeted.
GroningenAges 18 years+ - NCT05917028Recruiting
Nonsurgical injections to reduce knee osteoarthritis pain
This study tests a procedure called transcatheter arterial micro-embolization (a targeted injection done through blood vessels) to lessen pain from knee osteoarthritis. It may help people who still have significant pain despite standard “non-surgical” treatments like therapy and joint injections.
Seoul, Seodaemun-guAges 50 years+ - NCT05917262Recruiting
Mindfulness breathing vs heart-rate training after shoulder surgery pain
This trial compares two non-drug techniques—mindful breathing and heart-rate (HR) biofeedback—to see which helps reduce pain after shoulder surgery. You may be able to join if you have ongoing shoulder pain after surgery and haven’t been using these practices very often.
TaoyuanAges 18 years+ - NCT05922462Recruiting
Greek yogurt study in young athletes
This study tests whether eating more Greek yogurt affects health in youth and young adult athletes. It may help researchers understand benefits and safety for active people.
St. Catharines, OntarioAges 15–22 - NCT05923736Recruiting
Study of cardiovascular risk in people with digital osteoarthritis
This study looks at how heart-and-blood-vessel risk differs in people with digital osteoarthritis (arthritis affecting the fingers). It may help doctors understand whether finger osteoarthritis is linked with higher cardiovascular risk.
Clermont-FerrandAges 18 years+ - NCT05924347Recruiting
Imaging study to spot early spine changes in at-risk children
This study uses MRI and physical measurements to look for early signs of scoliosis (a side-bending of the spine) in children who are at higher risk. It may help doctors understand when scoliosis starts and improve early monitoring.
UtrechtAges 8–11 - NCT05924386Recruiting
Testing dental implants for jawbone change in full dentures
This study looks at how a specific implant connection (“OT bridge attachment system”) affects changes in the lower jawbone over time in people who have no teeth. You might benefit by getting a fixed All-on-Four style set of lower teeth, with close monitoring of your jawbone and fit.
CairoAges 40 years+ - NCT05926596Recruiting
Leg stretching with an on-demand exoskeleton for spasticity
This trial studies whether a wearable exoskeleton that helps with leg stretching can reduce stiffness and improve movement in people with spasticity after a spinal cord injury. It may help you stretch more safely and comfortably, but you must meet specific health and device-wear requirements.
Syracuse, New YorkAges 18 years+ - NCT05926622Recruiting
Testing a Medacta shoulder replacement system for pain relief
This trial studies how well a Medacta shoulder replacement works by looking at clinical results and X-ray/scan findings after surgery. It may help people with certain shoulder conditions who need shoulder replacement or revision surgery.
AnnecyAges 18 years+ - NCT05927454Recruiting
RaDiCo Acostill study for inflammatory fevers and arthritis
This is a long-term study that collects health information and lab samples from people who have certain diagnoses of recurring (coming and going) inflammatory fevers and related joint or immune conditions. It may help researchers better understand these diseases and how they work over time.
Paris, Île-de-France RegionAges Any age - NCT05927389Recruiting
Exercise program for kids with osteogenesis imperfecta
This trial tests an adapted physical activity program to help children and teenagers rebuild strength and improve effort/fitness. It may be helpful if you want a tailored exercise approach that is safe for osteogenesis imperfecta.
MontpellierAges 7–18 - NCT05927688Recruiting
Using patient reports to adjust treatment for autoimmune diseases
This study looks at whether doctors consider patient “electronic reports” (completed online/phone) when deciding how often to change treatment. It may help improve how well treatment plans match how patients feel over time.
StrasbourgAges 18 years+ - NCT05929755RecruitingPhase 4
Depo-Medrol after lumbar surgery through the psoas muscle
This trial studies whether a steroid shot called Depo-Medrol, given after a specific type of lower-back surgery, can improve recovery and outcomes. It’s only for people who are having a certain lumbar fusion procedure at specific spinal levels.
Farmington, ConnecticutAges 18–75 - NCT05933434RecruitingPhase 1/Phase 2
Stem cell injection trial for chronic knee osteoarthritis
This early-phase study tests an injection of donor stem cells placed into the knee joint to help reduce symptoms of knee osteoarthritis. You may be eligible if you have long-lasting knee pain from mild-to-moderate arthritis and meet safety and imaging requirements.
Aarhus NAges 40–75 - NCT05935709Recruiting
Danish database study for GCA or PMR
This study builds and uses a Danish database for people diagnosed with giant cell arteritis (GCA) or polymyalgia rheumatica (PMR). It may help doctors learn more about these conditions over time and improve care.
AarhusAges 50 years+ - NCT05936814Recruiting
Study measures knee alignment in severe varus osteoarthritis
This study focuses on people age 65+ with severe “varus” knee alignment osteoarthritis (wear-and-tear arthritis that affects how the knee lines up). It aims to use your knee measurements and data to better understand the condition and guide care.
AnkaraAges 65 years+ - NCT05945576Recruiting
RaDiCo IDMet study for people with inherited ID
This study enrolls people of all ages who have a confirmed inherited condition called ID. It collects information to better understand the condition and support future care.
AngersAges Any age - NCT05946044Recruiting
Preventing Knee Arthritis in People at Higher Risk
This study looks at ways to help prevent knee osteoarthritis before it starts. It is designed for women with higher body weight who currently have no arthritis signs on scans and do not have much knee pain.
Boston, MassachusettsAges 50 years+ - NCT05946278Recruiting
Study genes that may affect bone health after major spine surgery
This study looks at genetic (inherited) factors that may influence bone healing in people undergoing major spine procedures. It may help researchers understand why some people heal differently and could guide better care in the future.
Aurora, ColoradoAges 18–85 - NCT05950022Recruiting
Endoscopic release of the iliopsoas tendon during hip replacement pain
This study looks at whether an endoscopic “cut/release” of the iliopsoas tendon can improve hip symptoms caused by rubbing against a hip prosthesis. It is meant for adults whose first non-surgical treatments did not help.
LyonAges 18 years+ - NCT05954364Recruiting
Study of advanced treatments for psoriatic arthritis based on sex and gender
This study looks at how well advanced treatments work for people with psoriatic arthritis, and whether results differ for sex and gender. You may be eligible if your psoriatic arthritis is active and you are planning to start an advanced treatment for symptoms in the joints and surrounding areas.
Toronto, OntarioAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,838 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,965 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.