Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,838 recruiting studies in this area right now.
By phase
- Not applicable3,969
- Phase 2224
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 276
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis87
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,838 total
- NCT05800457Recruiting
Test synovectomy to reduce pain after knee replacement
This study looks at whether a procedure called synovectomy (removing inflamed joint lining) can reduce pain after a first knee replacement on one side. It focuses on people with clear signs of inflammation on ultrasound and checks follow-up outcomes after surgery.
London, OntarioAges 41–80 - NCT05802121RecruitingEarly Phase 1
Testing a gut bacteria supplement side effects during prostate hormone therapy
This early-phase study looks at how changing gut bacteria (especially Akkermansia) affects metabolic side effects in men starting prostate hormone therapy (ADT). It may help researchers understand how to reduce or manage side effects for people on ADT.
London, OntarioAges 18 years+ - NCT05807256Recruiting
Fertility treatments for people with immune system joint diseases
This trial looks at fertility (“medically assisted fertilization,” such as IVF) for people with certain immune-related rheumatology conditions (like lupus, rheumatoid arthritis, or vasculitis). It may help patients and their clinicians understand which fertility approach works best and is safe for this group.
MilanAges 18–50 - NCT05809323Recruiting
Trial testing moderate exercise in teens with Marfan syndrome
This trial studies whether doing moderate exercise is safe and helpful for people with Marfan syndrome. It aims to see how exercise affects heart and health measures, like how the aorta and body respond over time.
Houston, TexasAges 10–25 - NCT05809622Recruiting
Arm and elbow exercises for a sore tennis elbow
This study compares two exercise programs to see which helps people with long-lasting pain on one elbow (tennis elbow). If you have symptoms for at least 3 months, the trial may help improve pain and function using supervised, elbow-focused training.
IstanbulAges 18–65 - NCT05814497Recruiting
Brain scan study of how kids process chronic pain
This study looks at how the brain processes pain sensations in children with certain long-lasting pain conditions. It may help researchers understand what’s happening in the nervous system and guide better treatments.
Cincinnati, OhioAges 10–17 - NCT05816226RecruitingPhase 3
Topical cream for jaw joint pain
This Phase 3 study tests a skin-applied treatment (a cream or gel) to reduce pain in the jaw joint (TMJ). You may benefit if you have TMJ pain and can safely use the study medication without conflicting treatments.
San Francisco, CaliforniaAges 18 years+ - NCT05817747Recruiting
Using big data to predict outcomes after spine surgery
This study collects information from people having surgery for problems in the lower (lumbar) or neck (cervical) spine. It tests whether using “big data” from routine care can help predict surgical outcomes and improve future decisions.
Ängelholm, Skåne CountyAges 18 years+ - NCT05819034Recruiting
Non-surgical care for mild adolescent scoliosis
This trial looks at a non-surgical (conservative) approach to managing mild scoliosis in teens. It may help by improving comfort, posture control, and how the curve changes over time without surgery.
Mecca, Mecca RegionAges 10–17 - NCT05820672Recruiting
Study of people using Skytrofa in the United States
This study looks at how well and how safely Skytrofa (lonapegsomatropin) works for real-world patients in the U.S. It mainly gathers information from routine care to help doctors understand expected benefits and side effects.
Phoenix, ArizonaAges Any age - NCT05821972RecruitingPhase 4
Breathing-mist medicines for cleft palate surgery pain control
This trial tests whether a breathing mist of two medicines (dexmedetomidine plus ketamine) works better than dexmedetomidine alone during cleft palate repair surgery. It may help improve comfort and safety around anesthesia for eligible patients.
AsyutAges 1–4 - NCT05823727Recruiting
Collagen supplement study before and after knee replacement
This study tests whether taking collagen peptides can improve how knee tissues heal and remodel after total knee arthroplasty (knee replacement). It also looks at functional recovery and wound healing, especially during the physical therapy period in Little Rock.
Little Rock, ArkansasAges 50–75 - NCT05829733Recruiting
Synolis injection for 6 months in hip arthritis pain
This trial studies whether a treatment injection (Synolis VA 80/160) can safely reduce hip arthritis pain and improve function over 6 months. You may be eligible if you have confirmed hip osteoarthritis, ongoing pain despite common pain medicines, and no recent steroid or “visco-supplement” injections in that hip.
BelfortAges 18 years+ - NCT05830721Recruiting
Monitoring leg pressure in adults on life-support
This trial tests a device that continuously measures pressure in an arm or leg to help detect compartment syndrome in people on a heart-lung machine (VA-ECMO). It may help clinicians act sooner if pressure becomes dangerous, potentially reducing complications.
Baltimore, MarylandAges 18 years+ - NCT05835518Recruiting
Study of Adalloce safety and effects in rheumatoid or ankylosing arthritis
This is an observational study that follows people with rheumatoid arthritis (RA) or ankylosing spondylitis (AS) who are planning to start Adalloce. It aims to understand how safe the medicine is and how well it works in real-world care.
DaeguAges 19–74 - NCT05837286Recruiting
Conservative care for trigger finger after steroid shots
This study looks at non-surgical (conservative) treatment options for trigger finger after you’ve already had a cortisone shot in the affected finger(s). It may help determine what approach works best to reduce symptoms without more invasive procedures.
Los Angeles, CaliforniaAges 18–100 - NCT05838235Recruiting
Exercise program for kids with Marfan syndrome
This trial studies an adapted physical activity (exercise) program to support effort rehabilitation in children and teens with Marfan syndrome. It may help safely improve activity and fitness while monitoring heart-related risks.
ToulouseAges 7–17 - NCT05839535RecruitingPhase 2
Baduanjin plus brain stimulation for knee osteoarthritis pain
This Phase 2 study tests whether combining Baduanjin (a guided mind-body movement) with neuromodulation can improve knee osteoarthritis symptoms and function. It compares education-based stretching/control and uses MRI scanning as part of the research.
Charlestown, MassachusettsAges 45–75 - NCT05840887Recruiting
Knee realignment surgery with donor meniscus transplant
This trial studies whether combining knee bone realignment surgery (osteotomy) with a donor meniscus transplant can improve knee pain and function in people with arthritis from uneven leg alignment. You would need to commit to physical therapy and repeat checkups with X-rays and MRI scans.
BolognaAges 20–60 - NCT05842538Recruiting
Robotic surgery for total knee replacement in arthritis
This trial studies whether robotic-assisted surgery can improve or standardize outcomes for people getting a total knee replacement for severe arthritis. It may help by using a robot to assist during the knee operation, but you must meet specific knee and health criteria.
GothenburgAges 18–80 - NCT05842915Recruiting
Join a national survey database for musculoskeletal care
This trial builds and studies a national database that collects patient-reported outcomes (answers about symptoms and function) and patient/clinic information for musculoskeletal (muscle and joint) care. It may help improve how these services are delivered by showing what works in real-world primary/community care.
Keele, StaffordshireAges 18 years+ - NCT05845021Recruiting
Screening and referral for bone health after hip or knee surgery
This study looks at a simple plan for surgeons to identify people with low bone strength (osteoporosis) and refer them for bone health care after hip or knee replacement surgery. It may help you get evaluated and treated earlier if you have osteoporosis.
Columbia, MarylandAges 50 years+ - NCT05848271Recruiting
Natural history study for people with HPDL gene changes
This study follows people who have an HPDL gene change to better understand how symptoms and health progress over time. It may help clinicians learn more about the condition and plan future treatments.
San Diego, CaliforniaAges Any age - NCT05848622Recruiting
Gait retraining after ACL surgery for fast knee recovery
This trial tests a walking (gait) rehabilitation program to improve how you move after ACL reconstruction. It may help if you are still having walking mechanics issues in the months to years after surgery.
Chapel Hill, North CarolinaAges 16–35
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,838 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,965 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.