Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT07132762Recruiting
Shock wave therapy for chronic low back pain
This study tests whether adding a special sound wave therapy (called ESWT) to standard care (like exercise and education) can reduce pain and improve daily function in people with long-term low back pain. It is designed for people whose back pain does not have a specific known cause.
DenizliAges 18–65 - NCT07132736Recruiting
Underwater vs. regular exercise for quality of life and muscle power
This trial compares exercising underwater to doing regular aerobic exercise on land. It aims to see which type of exercise better improves muscle strength, energy levels, and overall quality of life in people with excess weight.
AmmanAges 18–50 - NCT07126431Recruiting
Study of hard-to-treat rheumatoid arthritis
This study is observing people with a hard-to-treat form of rheumatoid arthritis (RA). Researchers want to understand what treatments and outcomes are like for people whose RA doesn't get better with standard medications like methotrexate.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07134244Recruiting
Predicting cartilage damage and pain after knee injury or early arthritis
This study uses computer models and MRI scans to predict how knee cartilage and pain may change over time in people with early osteoarthritis or a recent ACL tear. It aims to find better ways to manage these conditions and prevent long-term damage.
Aalborg, North DenmarkAges 18–70 - NCT07131787Recruiting
Blood flow restriction training after Achilles tendon repair
This study tests whether adding blood flow restriction training to standard rehab helps your Achilles tendon and calf muscle heal better after surgery. You would do exercises with a special cuff that gently limits blood flow to your leg.
Ghent, East-FlandersAges 18 years+ - NCT07127380Recruiting
Comparing two types of spine surgery for disc-related low back pain
This study compares two different surgery methods (Mini-TLIF and MIDLIF) for treating low back pain caused by worn-out discs in the lower back. The goal is to see which one offers better recovery, fewer complications, and lower costs.
Lodz, Łódź VoivodeshipAges 18 years+ - NCT06963983Recruiting
Virtual Reality Rehab for Shoulder Recovery
This study tests whether virtual reality rehabilitation helps people recover after shoulder surgery. It focuses on three shoulder conditions: instability, rotator cuff repair, and frozen shoulder.
Meyrin, Canton of GenevaAges 18 years+ - NCT06956950RecruitingPhase 2/Phase 3
Magnesium Added to Numbing Medicine for Hip Replacement Pain
This study tests whether adding magnesium sulfate to a numbing medicine (bupivacaine) can provide better pain relief after hip replacement surgery. The medicine is given as a shot in the back near the hip muscles.
Tanta, El-GharbiaAges 18 years+ - NCT05741112Recruiting
Long COVID wearable study to track symptoms and help daily management
This study uses a wearable device to track symptoms and patterns in people with Long COVID, ME/CFS, and/or POTS. The goal is to see how wearable feedback and tracking tools may help you manage your symptoms.
La Jolla, CaliforniaAges 18 years+ - NCT07125794Recruiting
Brace comparison for children with relapsed clubfoot
This trial tests whether a modified version of the Denis Brawn brace works better than the original for treating relapsed clubfoot in young children who were previously treated with the Ponseti casting method.
CairoAges 2–5 - NCT07121777Recruiting
CAR T cell therapy for autoimmune diseases
This study tests a new type of cell therapy (CAR T cells) that targets certain immune cells to treat autoimmune diseases like rheumatoid arthritis, lupus, Sjögren's syndrome, and systemic sclerosis. It may help people whose disease is not well controlled with standard treatments.
Hefei, AnhuiAges 18 years+ - NCT07118280Recruiting
Oral health and saliva study in OPMD patients and families
This study looks at the mouth health and saliva of people with OPMD and their household members. By understanding saliva changes, researchers hope to learn more about the disease and find ways to help manage symptoms.
Ramat GanAges 18 years+ - NCT07123519RecruitingPhase 1
YTS109 cell therapy for hard-to-treat autoimmune diseases
This trial tests a new cell therapy called YTS109 for people with certain severe autoimmune diseases that have not responded to standard treatments, such as lupus, Sjögren's syndrome, systemic sclerosis, inflammatory myopathy, vasculitis, and antiphospholipid syndrome. The goal is to see if it can safely reduce disease activity.
TianjinAges 18–65 - NCT07123038Recruiting
Long-term safety study for gene-modified Treg therapy recipients
This study follows people who previously received a gene-modified Treg (regulatory T cell) therapy from Sonoma Biotherapeutics. It checks for long-term safety and does not involve any new treatment.
San Francisco, CaliforniaAges 18–71 - NCT07115745RecruitingPhase 1
Donor CAR T cells for severe autoimmune diseases
This study tests a new type of CAR T-cell therapy made from healthy donor cells. It is designed to help people with severe autoimmune diseases that have not improved with standard treatments.
Boston, MassachusettsAges 18 years+ - NCT07118241RecruitingPhase 2
Testing a new eye drop for Sjögren's dry eye
This trial tests a new eye drop made from a natural protein (rhPRG4) to see if it safely and effectively relieves dry eye symptoms in people with Sjögren's syndrome. You'll be randomly assigned to receive the study drop or a placebo (inactive) drop for several weeks.
Sydney, New South WalesAges 18–80 - NCT07118501Recruiting
Study of the Incompass total ankle system
This study is testing a new ankle replacement device called Incompass. It aims to see how well the device works and how safe it is for people who need ankle replacement surgery.
Morton Grove, IllinoisAges 21 years+ - NCT07122323Enrolling by invitation
Robot-assisted hip replacement for Legg-Calve-Perthes disease
This trial compares robot-assisted total hip replacement to the usual surgery for people with Legg-Calve-Perthes disease. It aims to see if the robotic arm helps the surgery go more smoothly.
Hangzhou, ZhejiangAges 18–80 - NCT07121556Recruiting
Fat tissue vs fat tissue plus gel for knee osteoarthritis
This trial compares two injections for knee arthritis: one uses your own fat tissue, the other adds a lubricating gel. Researchers want to see if the combination helps pain and function more than fat tissue alone.
BolognaAges 18–75 - NCT07125040Recruiting
Understanding LAMA2 muscle disease over time
This study follows people with LAMA2-related muscular dystrophy (a genetic muscle-weakening condition) to learn how it changes over time and find better ways to measure it. By participating, you help researchers identify new disease markers that could improve future treatments.
MilanAges Any age - NCT07123532Recruiting
Shoulder blade movement study in physical therapists
This trial looks at how common a certain shoulder blade movement problem (scapular dyskinesis) is among physical therapists. It will help researchers understand why some therapists might have shoulder issues and how to prevent them.
CairoAges 27–40 - NCT07117643Enrolling by invitation
Testing a blood flow technique for athletes and non-athletes
This study looks at a method called ischemic preconditioning, where brief periods of reduced blood flow might help the body. Researchers want to see how it affects both people who don't exercise much and long-distance runners who have completed at least 5 marathons.
Gdansk, Pomeranian VoivodeshipAges 18–49 - NCT07120659Recruiting
Comparing vacuum and tactile massage for chronic neck pain
This study compares two types of massage (vacuum massage and tactile massage) to see which one works better for people with long-term neck pain. If you have had neck pain for at least 3 months, you may be able to join.
Tromsø, TromsAges 21–75 - NCT07123805Recruiting
Acupuncture for knee replacement recovery
This study tests if adding acupuncture before and after knee replacement surgery helps reduce pain and improve recovery. It may be an option for people having planned knee replacement for osteoarthritis.
Pavia, PaviaAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.