Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT05003310Recruiting
Splenic stimulation study for active rheumatoid arthritis
This study tests a treatment that stimulates the spleen to help calm symptoms of active rheumatoid arthritis (RA). It’s mainly for people whose RA has not improved enough after several newer arthritis medicines.
Anniston, AlabamaAges 22–75 - NCT06134908Recruiting
Preventing another fracture after first hip or spine break
This study aims to prevent another fracture in older adults who have just had their first hip or spine fracture from a minor fall. Participants will receive guidance to help strengthen bones and reduce future fracture risk.
ChangshaAges 50 years+ - NCT05710952Recruiting
Orthodontic braces study and how they affect jaw joints
This study looks at whether multi-attachment orthodontic treatment (either on the front or back of teeth) changes the temporomandibular joint, which is the jaw joint. The researchers will assess your jaw joint using a tool called Modjaw.
MontpellierAges 18 years+ - NCT06430762Recruiting
Study of risk factors for jaw bone damage from certain drugs
This study looks at people who have jaw bone damage (osteonecrosis) caused by medications. Researchers want to understand what treatments and risk factors are linked to this condition to help improve care.
IstanbulAges 18–110 - NCT06383377Recruiting
New bone graft for tooth extraction and implant
This study tests a new bone graft material called Wishbone HA used after tooth extraction to prepare for a dental implant. It is for people who need a tooth pulled and have healthy gums and good bone support.
Louvain-la-Neuve, Brabant WallonAges 18–80 - NCT06426251Recruiting
Light therapy for knee replacement recovery
This trial tests whether a special light therapy (photobiomodulation) can help reduce pain and speed healing after total knee replacement. If you're having knee replacement and don't have complications like infection or open wounds, you may be eligible.
HsinchuAges 20 years+ - NCT05300893Recruiting
Night splinting after a minimally invasive hand release
This trial checks whether wearing a night splint after a specific procedure for Dupuytren’s contracture helps keep your fingers straighter. It’s meant to reduce the chance of the hand contracting again during recovery.
Falun, Dalarna CountyAges 18 years+ - NCT07849244Enrolling by invitation
Sacroiliac joint fusion for mobility and pain relief
This study tests a surgical procedure to fuse the sacroiliac joint (the joint connecting your lower spine and pelvis) to reduce pain and improve mobility and function. It is for people with one-sided SI joint pain that has not improved with other treatments.
Post Falls, IdahoAges 21 years+ - NCT07843342Recruiting
How well the body absorbs liposomal glucosamine supplements
This study tests a special form of glucosamine (a supplement often used for joint health) to see how well the body absorbs it. Liposomal means the supplement is wrapped in a protective layer that may help your body take it in better.
TaipeiAges 18 years+ - NCT06440148Recruiting
Sclerostin and bone lesions in mastocytosis
This study explores how a protein called sclerostin relates to bone problems in people with mastocytosis. By understanding this link, researchers hope to improve bone health for patients with this rare condition.
Lublin, Lublin VoivodeshipAges 18 years+ - NCT06442319Recruiting
PRP after ACL reconstruction
This trial tests if injecting platelet-rich plasma (a concentration of your own blood platelets) after ACL reconstruction helps with healing and reduces pain. It's for people who recently had ACL surgery and want to try an extra treatment to improve recovery.
TorunAges 18–45 - NCT07844577Recruiting
Zero Echo Time MRI for spinal bone assessment
This trial tests whether a new MRI technique, called zero echo time (ZTE), can replace some CT scans for diagnosing spinal bone problems. If successful, you may not need a CT scan, which exposes you to radiation, and instead get all the needed information from this MRI scan.
BrusselsAges 18 years+ - NCT07845838Recruiting
Exercise training for knee osteoarthritis
This trial tests whether a structured exercise program can reduce oxidative stress in people with knee osteoarthritis, potentially helping to manage symptoms and improve joint health.
Capelle aan den IJsselAges 18 years+ - NCT07850674Recruiting
Spinal stiffness and fear of movement in Parkinson's
This study looks at how Parkinson's disease affects neck and back movement, stiffness, and fear of movement, in relation to jaw joint problems. The results may help improve therapies that target flexibility and quality of life.
HatayAges 35–75 - NCT07843381Recruiting
Testing a new drug for Sjögren's syndrome with lung disease
This clinical trial tests a new drug called telitacicept for people who have both Sjögren's syndrome and interstitial lung disease. The drug aims to reduce the immune system's attack on your body and may help improve lung symptoms.
BeijingAges 18–70 - NCT07848126Recruiting
Foam rolling after knee replacement surgery
This study tests whether using a foam roller after knee replacement surgery helps reduce pain and improve movement. If you are having your first knee replacement, this may help you recover faster.
Izmir, BalçovaAges 40 years+ - NCT07845942Recruiting
Donor stem cell transplant for stubborn systemic juvenile arthritis
This study tests a bone marrow transplant (using donor cells) to treat severe systemic juvenile idiopathic arthritis (sJIA) that has not responded to other treatments. The goal is to reset the immune system to stop the disease and its complications, like lung problems or recurrent macrophage activation syndrome.
Cincinnati, OhioAges Up to 35 years - NCT07846501Enrolling by invitation
How thoughts and feelings affect fibromyalgia impact
This study looks at how your thoughts, emotions, and attitudes about your illness affect how fibromyalgia impacts your daily life. By filling out questionnaires, you can help doctors understand what matters most to people with fibromyalgia.
Bilecik, BilecikAges 18 years+ - NCT07843784Enrolling by invitation
Chatbot pain management for knee osteoarthritis
This trial tests a chatbot program to help people manage knee osteoarthritis pain. You’d use your smartphone to get support and exercises at home, which might help reduce pain and improve daily life.
Hong Kong, Hong KongAges 18 years+ - NCT07845695Recruiting
Music before joint replacement surgery to ease anxiety
This study tests whether listening to music just before hip or knee replacement surgery can help reduce anxiety. If you are having surgery for arthritis and are comfortable listening to music, you may be able to join.
New York, New YorkAges 18 years+ - NCT07845656Recruiting
Home exercise program for weak muscles and bones in older adults
This study tests a home exercise program designed for older adults with both weak muscles and weak bones who also feel frail. The program uses a smartphone to guide your exercises, aiming to make you stronger and more steady in your daily life.
Nantong, JiangsuAges 60–85 - NCT07849374Recruiting
Hands-on therapy for recent ankle sprains
This trial tests a type of physical therapy called Mulligan mobilization for recent ankle sprains. It may help you recover faster and restore ankle movement without surgery.
Gistoux, Chaumont-GistouxAges 18 years+ - NCT07842913Recruiting
Hybrid telerehabilitation for anterior knee pain
This study tests a hybrid telerehabilitation program for people with anterior knee pain. It combines at-home exercises with remote physiotherapy sessions using a smartphone app. The goal is to see if this approach is effective in routine clinical practice.
BrusselsAges 18 years+ - NCT07846618Recruiting
Mental fatigue and leg strength study
This study looks at how mental tiredness affects leg muscle strength. You will do some mental tasks and then leg exercises to see if your strength changes.
Pensacola, FloridaAges 18–39
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.