Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,832 recruiting studies in this area right now.
By phase
- Not applicable3,967
- Phase 2222
- Phase 4195
- Phase 1191
- Phase 3151
- Phase 1/Phase 273
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee73
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain34
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California208
- New York94
- Florida80
- Arizona76
- Massachusetts76
- Maryland73
- Texas64
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,832 total
- NCT06138106Recruiting
Nutritional supplement for collagen in young adults
This study tests a nutritional supplement designed to help your body make more collagen, which is important for skin, joints, and bones. It is for healthy young adults to see if the supplement can safely boost collagen production.
Davis, CaliforniaAges 18–30 - NCT06101108Recruiting
Early heart screening in back surgery patients
This trial checks people having back surgery for spinal stenosis to see if they have an early sign of heart amyloidosis (a protein buildup in the heart). The goal is to find this condition early so it can be treated before it causes problems.
BrugesAges 60 years+ - NCT06075901Enrolling by invitation
Flossing for blood flow: muscle study
This trial tests whether wrapping a floss band around your leg can safely and effectively restrict blood flow. It aims to help people who may benefit from muscle training with reduced blood flow.
Presidente Prudente, São PauloAges 18–30 - NCT05898581Recruiting
Compare two pain block methods for hip replacement surgery
This trial studies whether one type of numbing injection (a PENG block) works better than another method (local anesthetic injected into the surgical area) to control pain during and after total hip replacement. It may help choose the best pain plan for people having a specific surgical approach.
London, OntarioAges 19 years+ - NCT05844098Recruiting
Fixing a shoulder AC joint injury with or without extra pins
This trial compares two surgical options for a recent shoulder AC joint injury: one method uses arthroscopy-assisted stabilization alone, and the other adds an extra K-wire (small metal pin) for fixation. The goal is to see which approach leads to better healing and shoulder recovery.
Chon BuriAges 18–45 - NCT05778604Recruiting
Technology-based body and mind program for older adults
This trial tests a technology-based program aimed at improving “body and mind” health in people age 60 and older. It may be helpful if you can safely do some physical activity and are not already getting rehab therapy.
Orlando, FloridaAges 60 years+ - NCT05694494Enrolling by invitation
Online exercise program to prevent falls and cut costs
This study tests an internet-based exercise program designed to improve strength, balance, and daily movement in older adults who have recently fallen. It also looks at whether the program is cost-effective compared with usual care, so it may help you and caregivers prevent future falls in a practical way.
Hong KongAges 65 years+ - NCT05519332Recruiting
Procedure to stabilize very severe osteoporotic spine fractures
This trial studies a minimally invasive procedure to treat very severe, unstable compression fractures in the spine caused by osteoporosis. It may help people who have trouble tolerating standard open spine surgery, by aiming to restore stability and alignment.
Nantong, JiangsuAges 58–84 - NCT05367609Recruiting
Personalized pain plan for kids getting spine fusion surgery
This trial tests a personalized plan to manage pain around the time of pediatric posterior-lateral spinal fusion surgery. It aims to improve comfort and reduce the chance of pain or opioid problems after surgery by tailoring pain medicines to the child.
San Francisco, CaliforniaAges 10–21 - NCT05290818Recruiting
Robotic vs standard knee replacement for inner-joint wear
This trial compares robotic-assisted knee replacement with the usual (non-robotic) approach for people with severe arthritis on the inner (medial) side of the knee. It aims to see which method works better for pain and function while matching the right knee anatomy for certain implant types.
Edinburgh, LothianAges 50–75 - NCT05202964Recruiting
Study comfort and safety with oral antibiotics for bone joint infection
This trial studies how tolerable (comfortable) and safe oral antibiotic treatment is for infections in bones or joints. It may help confirm whether taking antibiotics by mouth for at least 6 weeks is well tolerated during treatment.
LyonAges 18 years+ - NCT05168943Recruiting
Comparing nylon and polyurethane epidural tubes for major surgery
This trial compares two types of epidural catheters (nylon vs polyurethane) in people having major orthopedic surgery. It may help find which catheter type is safer and works better for pain control during and after surgery.
Damanhūr, El-BeheiraAges 21–60 - NCT05062252Recruiting
Study of a new mirrored shoulder replacement system
This trial looks at a “mirror” shoulder replacement system for adults with painful shoulder arthritis who need their shoulder replaced. It aims to see how well the implant works and how safely it can be used for people who can follow study instructions.
BernAges 18 years+ - NCT05020158Recruiting
Family Talk support after a serious illness in the family
This trial tests a “Family Talk” support program for families dealing with a child’s life-threatening or life-limiting illness. It aims to help families talk and cope together during the early period after diagnosis or relapse.
StockholmAges 6 years+ - NCT05002439Recruiting
Exercise program to reduce frailty in older adults
This trial tests whether a Spanish health-clinic–guided exercise program can improve frailty in people who are starting to become frail (“pre-frail”). It may help you build strength and walking ability through supervised physical activity.
AlbaceteAges 70–100 - NCT04828954Recruiting
Testing different immobilization plans after thumb joint surgery
This study compares different ways of keeping your thumb still (immobilizing it) after thumb base joint surgery. It aims to see which immobilization approach leads to better recovery and hand function.
Chicago, IllinoisAges 40 years+ - NCT04801654Recruiting
Knee replacement study using a specific metal implant coating
This study looks at outcomes after a primary knee replacement using the GMK Sphere TiNb implant. It may help researchers learn how well this specific implant works and how patients do over time.
Milan, MIAges 18 years+ - NCT04749511Recruiting
Digital support to track hip replacement recovery in PROMs
This trial tests whether digital tools can help detect and track how well people recover after hip replacement surgery, compared with usual in-person tracking. It may help faster, clearer monitoring of recovery from the patient’s point of view.
Bologna, ItaliaAges 18–78 - NCT04677907Recruiting
Testing a metal knee implant feature in osteoarthritis surgery
This trial studies a specific type of knee replacement and how well it works after surgery for people with knee osteoarthritis. It may help doctors understand which implant approach leads to better outcomes and recovery.
Glasgow, ScotlandAges 18 years+ - NCT04441554Recruiting
Ultra-high-resolution MRI of the spine
This study uses a very powerful 7 Tesla MRI scanner to take detailed pictures of the spine. It compares people with long-term back pain to healthy volunteers to better understand normal spine anatomy.
Zurich, Canton of ZurichAges 18 years+ - NCT04430218Recruiting
Peripheral interfaces for better prosthetic arm control
This trial tests a surgically placed device that connects to arm nerves to improve control and feeling in a prosthetic arm. It may help people with upper limb amputations who already use or are prescribed a myoelectric prosthesis.
Cleveland, OhioAges 21 years+ - NCT04416191Recruiting
Immune cells study during inactivity and recovery
This study looks at how your immune system changes when you are inactive and then become more active again. It may help researchers understand how recovery affects immune health after disuse.
Salt Lake City, UtahAges 18–85 - NCT04327115Recruiting
Exercise program study for hospitalized adults age 75+
This study tests whether a guided physical exercise program during a short hospital stay can help older adults (75 and older) safely stay strong and move better. It may be helpful if you’re currently admitted to a geriatric short-stay unit and can safely do exercises based on your fall risk.
AngersAges 75 years+ - NCT04226534Recruiting
Join a study measuring effort in healthy trained people
This study builds a database by having healthy, trained volunteers do maximal effort physical tests while measuring how the body responds. It may help researchers better understand exercise performance and safety, though you’re likely not receiving a treatment for an illness.
BrusselsAges 18–65
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,832 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,923 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.