Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT04801654Recruiting
Knee replacement study using a specific metal implant coating
This study looks at outcomes after a primary knee replacement using the GMK Sphere TiNb implant. It may help researchers learn how well this specific implant works and how patients do over time.
Milan, MIAges 18 years+ - NCT04801680Recruiting
3D metal hip cup for painful hip arthritis
This trial studies a specific type of 3D metal cup used during hip replacement surgery. It aims to see how well it works over time in people who need a first (primary) total hip replacement.
Milan, MIAges 18–75 - NCT05785364Recruiting
Study of a hip implant used in total hip replacement
This study follows people who get a specific hip socket implant (the Mpact 3D Metal MonoCER) after total hip replacement. It’s mainly to monitor how the device is working in real-world use.
GenevaAges 18–75 - NCT06143813Recruiting
Precision treatment for lumbar nerve pain with targeted block
This trial tests if a targeted nerve root injection can improve outcomes for people with persistent leg pain from a compressed nerve in the lower back, with the goal of tailoring surgery more precisely.
Aarhus CAges 18 years+ - NCT06397677Recruiting
Study of Progressive RA Interstitial Lung Disease
This study is looking at people with rheumatoid arthritis (RA) who also have interstitial lung disease (ILD), a condition that causes scarring in the lungs. It aims to understand how the disease changes over time by using imaging and blood tests, without providing any new treatments right now.
San Francisco, CaliforniaAges 18–90 - NCT06400862RecruitingPhase 1
Treating knee cartilage damage with lab-grown bone marrow tissue
This trial tests a new treatment that uses your own bone marrow cells to grow a piece of tissue to repair damaged knee cartilage. It's for people with a single, medium-sized cartilage injury on the thigh bone part of the knee joint that hasn't gotten better with other treatments.
JordonAges 18–60 - NCT06319911Recruiting
Testing a new shoulder replacement implant system
This study tests a new shoulder implant system for people who need their first shoulder replacement due to arthritis or a shoulder deformity. It helps researchers see how well the implant works and if it improves shoulder function and pain.
San Francisco, CaliforniaAges 18 years+ - NCT04173715Recruiting
Study measuring movement and behavior in older adults
This study checks how well you move and how you behave during simple tasks. It may help researchers understand physical function and activity patterns in older adults.
ToledoAges 65 years+ - NCT05559463Recruiting
Anti-inflammatory diet for knee arthritis pain relief
This trial studies whether an anti-inflammatory eating plan (the “ITIS diet”) can improve symptoms in people with knee osteoarthritis. It is meant to see if changing what you eat can help reduce pain and improve function.
La Jolla, CaliforniaAges 18 years+ - NCT06226168Recruiting
Hypoxia exercise for bone health in premenopausal women
This study looks at how an exercise program done in low-oxygen (hypoxia) conditions affects bone health and metabolism in premenopausal women. It could help if you're interested in improving your bone density naturally.
KrakowAges 50–59 - NCT04250454Recruiting
Early treatment for babies at risk of cerebral palsy
This trial looks at an early intervention for very young babies who show signs they may develop cerebral palsy. The goal is to improve development as early as possible, especially in babies with concerning brain scan findings or movement patterns.
Charlottenlund, København CityAges 2 months–5 months - NCT05701046Recruiting
Front vs back surgery for a slipped lower-back vertebra
This trial compares two surgical approaches—operating from the front/side versus from the back—for a specific type of lower-back slip called lumbar isthmic spondylolisthesis. You may be eligible if you need surgery at a single level and have not had prior spine surgery, and if your back condition matches their exact limits.
Vancouver, British ColumbiaAges 18 years+ - NCT06345625Recruiting
Balance and walking with head movement in older adults
This study looks at how older adults keep their balance and walk when their head is moving. You may be asked to stand or walk while your head gently moves, so researchers can understand how your body reacts.
AntwerpAges 65–100 - NCT06195423Recruiting
Stopping knee arthritis after an ACL tear
This study tests a home exercise program to prevent knee arthritis after an ACL tear. If you had ACL surgery 9 to 36 months ago and still have some knee symptoms, this program may help protect your knee in the long run.
Vancouver, British ColumbiaAges 16–35 - NCT05167656Recruiting
Manual therapy for one-sided jaw pain
This study compares two types of hand-based therapy to see which helps people with jaw (temple/ear-area) pain on one side. You may be eligible if your jaw pain has lasted more than a month and you have not had recent jaw-related treatment or procedures.
Alcalá de Henares, MadridAges 18–75 - NCT06413667Recruiting
Chronic whiplash and headache study
This study uses MRI to look at the alignment of the atlas (the top bone in your neck) and nearby tissues in people with chronic whiplash or tension headaches. The results may help researchers better understand these conditions.
AmsterdamAges 18–75 - NCT06410833RecruitingPhase 4
Combination therapy for resistant Sjögren's in children
This trial tests a combination of two medicines, rituximab then belimumab, for children and teens with Sjögren's syndrome that hasn't improved with other treatments. The goal is to see if this two-step approach can better control symptoms like joint pain, skin rashes, and blood problems.
Beijing, Beijing MunicipalityAges 5–18 - NCT06416761Recruiting
Genetics and kidney disease progression study
This study looks at how genetics affect the progression of kidney diseases. Joining may help researchers understand your condition better and find better treatments.
MilanAges 18 years+ - NCT06417502Recruiting
China pediatric rheumatic disease registry study
This study collects information from children with rheumatic and immune system diseases in China to better understand these conditions. By participating, you help researchers learn more about how to diagnose and treat these diseases.
Beijing, Beijing MunicipalityAges Up to 18 years - NCT07851233Enrolling by invitation
Patient education on sling use after shoulder surgery
This study looks at how different ways of teaching patients about sling use after shoulder surgery may affect their recovery. If you join, you may receive extra education materials to help you use your sling correctly.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07852806Recruiting
Bone marrow cells for repairing severe jaw bone defects
This trial tests whether using your own bone marrow cells can help repair severe bone loss in the jaw. It may offer a new way to rebuild bone for people who need a bone graft.
Nanjing, JiangsuAges 16–60 - NCT07850830Recruiting
Virtual reality rehab survey for arm and shoulder conditions
This study asks people using virtual reality for arm or shoulder rehabilitation to answer questions about how they feel about it. Your responses help improve VR rehab for conditions like shoulder pain or stroke recovery.
CairoAges 20–50 - NCT07853170Recruiting
Comparing 3 vs 5-needle knee nerve blocks for arthritis pain
This study compares two ways of numbing the nerves around the knee to see which gives better pain relief and improves quality of life for people with knee osteoarthritis. It might help you decide if a nerve block is a good option for your knee pain.
Tanta, El-GharbiaAges 18 years+ - NCT07851597Recruiting
Comparing surgical approaches for hip replacement surgery
This study compares two different surgical approaches for total hip replacement in people with hip osteoarthritis. Both approaches are standard, and the study looks to see if one leads to better recovery and long-term outcomes.
GävleAges 60–80
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.