Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT07674758Recruiting
Understanding heart risk in Duchenne and Becker muscular dystrophy
This study looks at heart health in people with Duchenne or Becker muscular dystrophy to find better ways to predict and track heart problems. The goal is to improve future treatment trials.
Sacramento, CaliforniaAges Any age - NCT06168201Recruiting
Virtual study on achondroplasia in the US
This study uses a virtual (online) approach to better understand achondroplasia across all ages. By collecting medical records from people in the US, researchers hope to learn more about the condition and improve care.
Oakland, CaliforniaAges birth–18 years - NCT07676058Recruiting
Massage vs. tool therapy for heel pain in pregnancy
This trial compares two types of hands-on therapy—myofascial release and instrument-assisted tissue mobilization—to see which works better for pregnant women who have heel pain from plantar fasciitis. It aims to find a safe and effective treatment during pregnancy.
Lahore, Punjab ProvinceAges 20–40 - NCT07675967Recruiting
Blood Cell Changes During Cancer Treatment
This study is for people with solid tumors who are about to start chemotherapy or radiation. It looks at how these treatments affect blood cells and may help doctors understand changes in blood health over time.
Boston, MassachusettsAges 18 years+ - NCT07037888RecruitingPhase 4
Ketorolac for pain after hip arthroscopy
This study tests whether ketorolac, a nonsteroidal anti-inflammatory drug (NSAID), helps manage pain after hip surgery. It may offer an opioid-sparing option for patients with femoroacetabular impingement (FAI).
Detroit, MichiganAges 18–89 - NCT07675655Recruiting
Mulligan vs. PNF exercises for shoulder pain
This trial compares two hands-on therapy techniques for people with shoulder impingement (pain when lifting the arm). It tests if one method works better for reducing pain and improving movement.
Sohag, TahtaAges 20–40 - NCT07677072Recruiting
Studying a blood protein to detect hidden bone fragility
This study looks at a protein called lumican in the blood to see if it can help find women who have fragile bones even if their bone density test looks normal. It's for postmenopausal women who are already getting a bone density scan as part of their routine care.
Küçükçekmece, IstanbulAges 45 years+ - NCT07515638Recruiting
Immune System Study for Autoimmune Diseases
This research study collects samples and information from people with rheumatoid arthritis, lupus, or scleroderma, plus healthy volunteers, to better understand how the immune system works in these conditions. By comparing these groups, researchers hope to find new ways to treat and manage autoimmune diseases.
MontpellierAges 18 years+ - NCT03083405Enrolling by invitation
Study of tooth grinding during sleep
This study is for adults who have been diagnosed with sleep bruxism (tooth grinding during sleep). Researchers want to understand it better using sleep testing, and it may help refine how this condition is evaluated.
WroclawAges 18–70 - NCT03359109Enrolling by invitation
Checking metal levels in children with metal implants
This trial studies how much metal can build up in the body and in the blood in children and teens who will receive certain metal implants during surgery. It may help doctors better understand potential metal exposure and how to monitor it.
Rochester, MinnesotaAges 4–18 - NCT02664337Enrolling by invitation
Study of what people prefer in joint and fracture treatments
This study asks patients (or parents/caregivers, for children’s injuries) about their preferences for different treatment options for certain joint and fracture problems. It may help clinicians choose care plans that match what patients value.
Durham, North CarolinaAges 18–85 - NCT02283229Enrolling by invitation
Early newborn head shaping after birth study
This study looks at how gently shaping a newborn’s head in the first days after birth might affect head shape later. It may help researchers understand how to reduce uneven head shape in babies.
OuluAges 1 day–6 days - NCT02377245Enrolling by invitation
Study of inflammatory rheumatism in youth
This study follows children and teens who have an inflammatory rheumatism condition that started in childhood. It aims to better understand these illnesses and how they affect young people over time.
BrusselsAges Any age - NCT02422875Enrolling by invitation
Study of immune markers in autoimmune disease and lupus
This study looks at blood and immune cell markers (autoantibodies and immune cell “signatures”) to better understand autoimmune conditions, including lupus. It may help researchers identify which markers are linked to disease and how immune cells respond after vaccination.
Atlanta, GeorgiaAges 18 years+ - NCT02530268Enrolling by invitation
Registry for psoriatic arthritis and spine arthritis patients starting treatment
This is a patient registry that tracks people with psoriatic arthritis or spine inflammatory arthritis when they start a specific new treatment. It helps researchers learn about real-world outcomes and safety as patients receive care over time.
Ages 18 years+ - NCT02413450Enrolling by invitation
Using patient DNA cells to study inherited heart rhythm risks
This study uses your blood or genetic information to make “iPS cells,” lab-grown cells that can help researchers study inherited heart rhythm problems like LQTS, Brugada syndrome, CPVT, or early repolarization syndrome. It may help improve understanding of why these rhythms happen and guide future treatments.
Baltimore, MarylandAges 18–85 - NCT02610855Enrolling by invitation
Study of activity and muscle function in children with scoliosis
This study looks at how children’s activity levels and muscle performance change in different scoliosis treatments (surgery, bracing, or healthy peers). It uses motion sensors and an ultrasound-based test to better understand what treatments may do to the body’s muscles.
Rochester, MinnesotaAges 9–16 - NCT02702869Enrolling by invitation
Study of improving care for common facial clefts
This trial is part of a quality-improvement and research program for people with typical facial clefts. It aims to help improve how care is organized and measured across treatment centers, which may benefit future patients and help your team deliver coordinated care.
Gainesville, FloridaAges 1 day–22 years - NCT01803906Enrolling by invitation
Tissue sample study for suspected mitochondrial disorders
This study collects tissue samples to help researchers learn more about mitochondrial disorders—conditions related to how the body makes energy. It may help by improving genetic understanding for families who suspect an inherited cause.
New York, New YorkAges Any age - NCT01402661Enrolling by invitation
Rheumatoid arthritis drug safety and effectiveness registry
This registry collects real-world information about people with rheumatoid arthritis (RA) to help doctors understand how RA medicines work and their safety. You may be able to join if you’re newly diagnosed or starting certain RA treatments and you’re willing to share consent and basic personal details.
Waltham, MassachusettsAges 18 years+ - NCT01575964Enrolling by invitation
Tests how hip mechanics change with femoroacetabular impingement
This study measures how your hip moves (the “mechanics”) using clinical exams and imaging. It may help researchers understand hip movement problems in femoroacetabular impingement (FAI) before major joint damage develops.
Salt Lake City, UtahAges 18–35 - NCT00313677Recruiting
Trial readiness for dystroglycan-related muscle conditions
This trial is for people who have signs that they may have a dystroglycanopathy—a group of muscle conditions. It helps study how ready participants are for care and possibly future treatments by using lab and genetic/pathology information to confirm the condition.
Iowa City, IowaAges Any age - NCT02040714Enrolling by invitation
Study of current treatments for Perthes hip disease
This study follows children (and teens) with Legg-Calvé-Perthes disease to learn about how today’s treatments work in real life. It may help doctors choose the best next steps for your child’s hip health.
Birmingham, AlabamaAges 1–18 - NCT07400848Recruiting
Symptoms and recovery after COVID-19 vaccine
This study looks at people who developed new, long-lasting symptoms after a COVID-19 vaccine. It aims to understand their symptoms, do lab tests, and see how they recover over time.
BernAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.