Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,834 recruiting studies in this area right now.
By phase
- Not applicable3,970
- Phase 2222
- Phase 4195
- Phase 1191
- Phase 3150
- Phase 1/Phase 273
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis183
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee73
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain34
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California208
- New York95
- Florida80
- Arizona76
- Massachusetts76
- Maryland73
- Texas64
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,834 total
- NCT06462729RecruitingPhase 1/Phase 2
Testing a new bone graft for lower back fusion surgery
This trial tests a new bone graft material called LDGraft for people who need a single-level lower back fusion (anterior lumbar interbody fusion). It aims to see if the new graft is as good as or better than current options for helping bones heal together.
Fort Wayne, IndianaAges 22–80 - NCT06066853RecruitingEarly Phase 1
MDMA plus therapy for fibromyalgia pain
This trial tests whether MDMA (a drug sometimes called 'ecstasy') can help people with fibromyalgia when used alongside therapy sessions. The goal is to see if it reduces pain and improves quality of life.
Charlestown, MassachusettsAges 21–65 - NCT00024804Recruiting
Understanding Bone and Mineral Health Disorders
This study tracks people with bone diseases or problems with how their body handles calcium, phosphorus, and other minerals. Researchers want to understand how these conditions develop and change over time to help improve future treatments.
Bethesda, MarylandAges 1 day–100 years - NCT05238740Recruiting
Compare fusion results after two spine surgeries with added biologics
This study compares two types of spine surgery (ALIF or XLIF) for one spinal level, and tests how well the bones fuse when a specific bone-forming product is used. It also looks at how patients feel and function after surgery.
BernAges 18–70 - NCT06619574Recruiting
Testing the dental compass for jaw joint positioning
This study tests a new tool called a Dental Compass that helps dentists place your jaw joint back in the right position more accurately and quickly. It may help relieve TMJ pain and improve jaw function.
Gainesville, TexasAges 18–90 - NCT06949995Recruiting
Blood flow restriction for recovery in amateur runners
This study tests whether using a special band to slow blood flow during recovery can help amateur runners recover better after a workout. It is for healthy runners who do not have certain health conditions or recent injuries.
Presidente Prudente, São PauloAges 18–40 - NCT06938048Enrolling by invitation
Comparing bandages for hand swelling
This study tests two types of bandages to see which works better for reducing hand swelling (edema). It may be an option if your hand is swollen from an injury, surgery, a rheumatologic condition, or being unable to move it.
Bassano, ItalyAges Any age - NCT06870149Recruiting
Dance program to improve mobility in older adults at risk
This study tests whether a structured dance program (called GERAS DANCE) can help older adults who are frail or at risk of losing mobility. You would attend dance sessions at the YMCA twice a week, and researchers will see if it improves your walking and daily function.
Hamilton, OntarioAges 65–100 - NCT06845969Recruiting
Physiotherapy dry needling accuracy study
This study tests how accurately physiotherapists can place dry needling needles. If you are a licensed physiotherapist or a volunteer who can safely receive dry needling, you may be able to join.
Edmonton, AlbertaAges 18 years+ - NCT06826300Enrolling by invitation
Elbow treatment study for archers and kart drivers
This study tests a special elbow technique on healthy 18-year-old archers who also race go-karts. It looks at how the elbow treatment might affect performance.
GdanskAges 18 years+ - NCT06819982Recruiting
Home support with occupational therapy for older adults
This trial tests whether having an occupational therapist help you at home with assistive devices can keep you independent longer. It is for people 65 or older who are starting to feel a bit frail or at risk of frailty.
YvoirAges 65 years+ - NCT06740266Recruiting
Parenting support for mothers and their babies
This study tests if a specially designed parenting program can help mothers and their babies bond better and possibly affect the baby's cells in a positive way. If you are a mother with a baby between 3 and 12 months old, receiving Medicaid, and getting care at WakeMed, you may be able to join.
Raleigh, North CarolinaAges 18 years+ - NCT05751408Recruiting
Testing wearable sensors for gait analysis during walking rehab
This study checks how well commercially available wearable sensors (IMUs) can measure walking problems during a clinic gait analysis. It may help your care team get more accurate information about your walking patterns, falls risk, and fatigue during walking.
EnschedeAges 18 years+ - NCT05615259Recruiting
Compare personalized shoulder surgery with standard tools
This trial compares a personalized, guided approach to shoulder replacement (reverse shoulder arthroplasty) versus the usual surgical tools. It aims to see whether the guided method improves outcomes and implant performance over at least 2 years.
HoornAges 21 years+ - NCT03208062Recruiting
Biobank study using samples from hip or knee conditions
This study collects and stores biological samples to help researchers better understand muscle and bone problems like osteoarthritis, bone tumors, and infected joint implants. If you are eligible, your samples may support future research that could lead to better prevention or treatments.
MilanAges 18 years+ - NCT07785401Recruiting
Platelet-rich plasma plus hyaluronic acid for knee osteoarthritis
This study tests whether adding platelet-rich plasma (PRP) to hyaluronic acid injections improves knee osteoarthritis pain and function better than hyaluronic acid alone. You may be eligible if you have moderate knee osteoarthritis and no other knee problems.
Warsaw, Masovian VoivodeshipAges 18 years+ - NCT07784907Recruiting
Platelet-rich plasma and hyaluronic acid for knee arthritis
This trial tests whether a combination of platelet-rich plasma (a concentrate from your own blood) and hyaluronic acid (a joint lubricant) helps reduce pain and improve function in people with knee arthritis. You may be eligible if you have moderate knee pain but your other knee is relatively pain-free.
Chełm, Lublin VoivodeshipAges 18 years+ - NCT07541274Recruiting
Thigh Muscle Quality and Knee Osteoarthritis Outcomes
This study looks at how the strength and quality of your thigh muscles relate to how well your knee osteoarthritis improves. Researchers will measure your muscle and track your knee function to understand this connection better.
Izmir, Bayraklı/izmirAges 40–70 - NCT07784998Recruiting
Weight-bearing physiotherapy for knee osteoarthritis
This study compares how men and women respond to a special type of physiotherapy that uses gradual weight-bearing exercises to reduce knee pain and improve function. It may help you if you have moderate knee osteoarthritis and are looking for a non-surgical treatment option.
Gujar Khan, Punjab ProvinceAges 40–60 - NCT07226258RecruitingPhase 3
Testing SL1002 for knee pain caused by osteoarthritis
This trial tests a study drug called SL1002 to see if it reduces knee pain from osteoarthritis. It may be an option for people with chronic knee pain who haven't found enough relief from current treatments.
Roseville, CaliforniaAges 40 years+ - NCT07785362Enrolling by invitation
Brain stimulation for teens with fibromyalgia or chronic pain
This study tests a non-invasive brain stimulation technique to see if it can reduce pain in teenagers and young adults with fibromyalgia or other long-lasting muscle and bone pain that hasn't responded to usual treatments. It aims to help calm overactive pain signals in the brain.
Genova, GEAges 10–21 - NCT07458360Recruiting
Front block for better recovery after hip replacement
This study tests if a special nerve block called the front block (pericapsular nerve group block) improves recovery after hip replacement surgery. You may be eligible if you are having hip replacement under spinal anesthesia and do not have certain health issues.
KonyaAges 18 years+ - NCT06698796RecruitingPhase 3
Study of dazukibart for ongoing idiopathic inflammatory myopathies
This trial studies the long-term effects of dazukibart in people who completed an earlier study for idiopathic inflammatory myopathies (a group of rare conditions causing muscle inflammation and weakness). It helps researchers understand how well the medicine works over a longer period.
Glendale, ArizonaAges 18 years+ - NCT07486869RecruitingPhase 2
Emapalumab study for MDA5-related lung disease
This trial tests if emapalumab can help people with a serious lung condition linked to MDA5 antibodies. It may be an option for those with worsening breathing despite other treatments.
Miami, FloridaAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,834 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,906 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.