Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT03949400Recruiting
Exercise therapy and a soft knee brace for knee arthritis
This study tests whether an exercise program plus education, along with a soft brace, helps improve symptoms and function in adults with knee osteoarthritis. It may help people who have knee pain by combining movement training with daily support.
Aalborg, NothernAges 18 years+ - NCT02423395RecruitingPhase 3
Orphenadrine for muscle cramps in people with cirrhosis
This trial tests whether orphenadrine (a medication used to reduce muscle cramping) can lessen muscle cramps in people who have cirrhosis of the liver. It may help if your cramps happen often, but you must avoid certain medication conflicts and health situations.
TantaAges Any age - NCT02814149Recruiting
Compare early vs delayed dental implant placement
This trial studies whether placing a dental implant right away or after a delay leads to better appearance and healing. It looks at cosmetic results and X-ray findings, and is for people missing one front upper tooth.
Guangzhou, GuangdongAges 18–80 - NCT02362685Recruiting
Metabolic exercise testing study
This study is about doing a breathing-and-heart performance test while you exercise to better understand how your body uses energy. You may join if you’re referred for this type of test and can safely complete it.
BrestAges 5 years+ - NCT04348253Recruiting
Study of surgery for scapholunate ligament wrist instability
This study looks at people aged 18–60 who have ongoing, painful wrist instability from a fully torn scapholunate ligament. It may help improve surgical approaches by carefully selecting patients whose ligament tear is complete and causing measurable joint looseness.
AarhusAges 18–60 - NCT04467944Recruiting
Lumbar fusion outcomes with arthritis in nearby spine segments
This study looks at how well lumbar fusion surgery works long-term when the joint just above or below (adjacent segment) already shows wear-and-tear. It may help predict who benefits most and guide treatment planning.
Beijing, Beijing MunicipalityAges 18–80 - NCT04394052Recruiting
Imaging tests for suspected bone or soft-tissue tumors
This trial studies new imaging methods to better identify and stage (find how far it has spread) suspected bone or soft-tissue tumors. It may help your care team choose the most accurate next steps based on your scans.
Nancy, LorraineAges 18 years+ - NCT02511158Recruiting
Knee ligament surgery study after ACL reconstruction
This study follows people who have a knee ligament tear and undergo surgery to rebuild the ligament. It may help doctors better understand recovery and outcomes after different surgical techniques.
ParisAges 7 years+ - NCT02906865Recruiting
Study of surgery outcomes for hamstring rupture
This study follows people who had a hamstring muscle tear near the hip that was repaired with surgery. It aims to better understand recovery after surgery in cases confirmed by MRI.
ParisAges 10 years+ - NCT03328611Recruiting
Joint replacement outcomes database for degenerative joint disease
This study collects information about people with “wear-and-tear” joint disease who need joint replacement. The goal is to better understand outcomes after surgery and improve future care.
Indianapolis, IndianaAges Any age - NCT04469387Recruiting
Reduce adjacent back pain after lumbar surgery
This trial looks at whether a limited decompression (a careful nerve-space “freeing” procedure) can help prevent future problems in the spinal level next to your planned surgery. It targets people with spinal canal narrowing next to the surgery level but who do not yet have symptoms there.
Beijing, Beijing MunicipalityAges 18–80 - NCT04571918Recruiting
Arthroscopic repair using a biodegradable spacer for severe shoulder tears
This study looks at an arthroscopic procedure (a minimally invasive surgery) that includes cleaning the tear and placing a biodegradable spacer to treat painful, severe rotator cuff tears. It may help reduce pain and improve shoulder function in people who have tried non-surgical treatments but still have symptoms.
ArendalAges 60–85 - NCT04704947RecruitingPhase 3
Beta blockers and fracture risk in osteoporosis
This study tests whether using beta blocker blood pressure medicines affects the risk of fractures in people with osteoporosis. It may help doctors understand which medication choices lower fracture risk.
TantaAges 50 years+ - NCT04704297RecruitingPhase 4
Trigger point shots for low back muscle pain
This trial tests whether injecting sore “trigger points” in low back muscles helps improve chronic low back pain. It compares treatments in people with specific low back muscle pain patterns and excludes several other causes of pain.
Tacoma, WashingtonAges 18 years+ - NCT04260165Recruiting
Wrist surgery options for certain wrist arthritis
This trial compares two types of wrist surgery for osteoarthritis in the wrist bones (SLAC/SNAC stage II–III). It may help you and your surgeon choose the procedure that best improves pain and wrist function for your specific wrist arthritis pattern.
HelsinkiAges 18–75 - NCT01604395Recruiting
Long-term growth hormone check for children with short stature
This study follows children who are short for their age and checks how safe and effective growth hormone is over the long term. It may help families understand expected benefits and side effects for their specific growth-related condition.
SeoulAges 2 years+ - NCT04012671Recruiting
Study of Duchenne muscular dystrophy in children and carriers
This is a research study that follows people with Duchenne muscular dystrophy and female genetic carriers to better understand the condition. It may help researchers measure health patterns over time, which can support future treatments.
FuzhouAges 2 years+ - NCT04230616Recruiting
Testing a knee device to ease osteoarthritis pain
This study tests how well and how safely a knee treatment works for adults with painful knee osteoarthritis seen on X-ray. You might join if you need meaningful pain relief and help with daily function, and can complete required scans and study instructions.
Sint-Truiden, LimburgAges 18 years+ - NCT04800289Recruiting
Joint skin and joint clinic satisfaction and impact study
This study looks at how patients feel about a combined skin-and-joint doctor visit and whether that visit helps. It mainly involves people who attend the hospital’s joint rheumatologist/dermatologist consultation.
Le MansAges 18 years+ - NCT04960098Recruiting
Survey after hip or knee replacement surgery
This study asks people who have had a hip or knee replacement to share how they’re doing over time. It’s testing whether patient-reported survey answers can help measure recovery and outcomes.
MilanAges 18 years+ - NCT01403402Recruiting
Study of congenital muscle disease patients and their families
This trial collects health information from patients with certain inherited (genetic) muscle diseases and from their families. It may help researchers better understand the disease and improve care by learning what symptoms and treatments patients experience over time.
Lakewood, CaliforniaAges Any age - NCT03755193RecruitingPhase 2
Testing another osteoporosis medicine after 2 years of denosumab
This study looks at how well and how safely another osteoporosis medicine works for people who have already taken denosumab for 2 years. It may help find the best next step to strengthen bones and lower fracture risk after denosumab.
Matsumoto, NaganoAges 20–120 - NCT02958020Recruiting
Osteoporosis study for adults age 45 to 79
This study collects health information to learn more about osteoporosis and who is most at risk. It may help researchers better understand prevention and early detection, based on your survey responses and basic health details.
Shenzhen, GuangdongAges 45–79 - NCT05047133RecruitingPhase 2/Phase 3
Early TXA treatment for adult hip fracture surgery
This study tests whether giving a blood-clot-reducing medicine (TXA) early after an adult hip fracture helps reduce bleeding and related problems around surgery. It may help some patients getting operative fixation by improving safety during recovery.
Grand Blanc, MichiganAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.