Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT02329093Recruiting
Hip osteoarthritis with pain, testing non-weight bearing
This study looks at whether reducing weight on the hip can help slow how hip arthritis shows up on X-rays in people who have hip joint pain. It may be an option if your pain is from hip arthritis rather than a clear fracture.
Matsumoto, NaganoAges Any age - NCT01277419Recruiting
Study of new cases of several spine, joint, and eye diseases
This study enrolls people who have recently been diagnosed with certain inflammatory conditions affecting the spine, joints, or the eye. Researchers are looking to better understand how these illnesses start and how they may be linked, which could help guide future care.
BerlinAges Any age - NCT05062421Recruiting
Study how well arthritis treatments keep working over time
This study looks at people with adult rheumatoid arthritis to see how long biological medicines and “JAK inhibitors” keep helping. It uses routine clinic follow-up records to understand how well treatment persists over time and how outcomes change.
SevilleAges 18 years+ - NCT05132348Recruiting
Studying immune markers in people with osteoporosis
This study looks at immune system “fingerprints” (immunophenotyping) in adults who have been diagnosed with osteoporosis. It may help researchers understand what drives osteoporosis and could guide better future treatments.
Bonn, Northrhine WestfaliaAges 18 years+ - NCT04917705Recruiting
Blood and tissue tests to find markers in muscle and skin disease
This study looks for blood and tissue “biomarkers” (measurable clues in samples) to help diagnose and predict outcomes in inflammatory muscle diseases and systemic sclerosis (a skin/organ condition). If you’re being evaluated for myopathy or early scleroderma, it may help doctors sort out the cause and follow your health more closely.
Strasbourg, Bas-RhinAges 18 years+ - NCT05127005Recruiting
Compare thumb arthritis surgery versus placebo surgery
This study compares a real thumb basal joint surgery (trapeziectomy) with a sham/placebo operation to see which option helps pain and daily function better. It is for people with thumb arthritis who have tried non-surgical treatments but still have significant thumb pain.
HelsinkiAges 45 years+ - NCT04716803Recruiting
BMAC injection for severe knee osteoarthritis before knee surgery
This trial studies injecting “bone marrow aspirate concentrate” (BMAC) into the knee to help relieve pain from severe knee osteoarthritis. It’s for people who have strong signs of advanced arthritis on X-ray and still have ongoing pain despite usual treatments, before a planned knee procedure.
La Jolla, CaliforniaAges 45–75 - NCT04007783Recruiting
Test of a new plan for jaw reconstruction and implants
This study checks whether the “O-bridge protocol” helps people who need jaw surgery—either for osteonecrosis of the jaw or for oral/jaw tumors—followed by dental implant placement to support fixed teeth (not removable dentures). The goal is to improve your ability to eat, speak, and get a stable tooth replacement plan after surgery.
AntwerpAges 18 years+ - NCT02661139Recruiting
Registry of jaw reconstruction for cancer patients who need implants
This study is a “real-world” registry that follows people with jaw problems related to cancer or cancer treatment. It looks at how well jaw reconstruction with dental implants and fixed teeth works when removable dentures are not suitable.
BrugesAges Any age - NCT03158090Recruiting
Study of treatment patterns for acromegaly over time
This study follows people with acromegaly to better understand how treatments are used in real life and how well they work over time. It may help improve future treatment choices by comparing outcomes across different care patterns.
Guangzhou, GuangdongAges 18–75 - NCT05284318Recruiting
Antibiotic plans and outcomes after two-stage joint revision
This study looks at how antibiotic treatment (especially the course length and approach) relates to infection control and results after a two-step surgery for joint infections. If you’ve had a spacer placed, finished at least 6 weeks of antibiotics, and then had the second surgery, the research team may want to follow your outcomes over time.
Fuzhou, FujianAges 18 years+ - NCT02801253Recruiting
Study of infections around hip, knee, or shoulder implants
This study follows people who have an infection around a hip, knee, or shoulder implant (prosthesis). It uses standard infection tests (like cultures and blood tests) to confirm the diagnosis and better understand this problem after surgery.
Paris, Île-de-France RegionAges 18 years+ - NCT05228340Recruiting
Treating toe ulcers by releasing tight tendons to prevent recurrence
This study looks at whether a minor procedure on a toe (called a flexor tenotomy) can reduce the chance that diabetic toe ulcers come back. It is for adults with diabetes who have nerve damage in the feet and have had toe ulcers before.
Amsterdam, North HollandAges 18 years+ - NCT03425812Recruiting
NSAID medicines to prevent flares in spondyloarthritis after remission
This trial tests whether taking nonsteroidal anti-inflammatory drugs (NSAIDs) helps people with axial spondyloarthritis stay in remission and avoid future flare-ups. It’s meant to see if NSAIDs can reduce the chance of symptoms returning and keep disease activity low over time.
Xiamen, FujianAges 18 years+ - NCT04247672Recruiting
Study of knee replacement outcomes using a specific knee implant
This study follows people who need knee replacement for “end-stage” knee osteoarthritis and will receive a specific knee implant system as part of routine care. It aims to measure how well the knee replacement works for patients over time, which may help improve future care.
Hoofddorp, North HollandAges 21–90 - NCT04684602RecruitingPhase 1/Phase 2
Study of stem cells for several short- and long-term illnesses
This early-stage study tests whether injections of mesenchymal stem cells can be safe and helpful for certain chronic (long-term) and acute (short-term) conditions. You might be considered if you can consent, are able to return for follow-up visits, and do not have key reasons that would make stem-cell treatment unsafe.
Culver City, CaliforniaAges 18 years+ - NCT05328050Recruiting
Registry for people with achondroplasia or hypochondroplasia
This is a research registry that enrolls people with achondroplasia or hypochondroplasia. It helps researchers collect information about the condition to improve understanding and future studies.
MilanAges Any age - NCT03096366Recruiting
Blood flow restriction rehab after ACL knee surgery
This trial studies whether a special exercise method that limits blood flow to the thigh (called blood flow restriction training) can improve quadriceps strength and function during recovery after arthroscopic ACL surgery. If you qualify, you would join a structured physical therapy program and follow the study’s rehab plan.
Houston, TexasAges 14–55 - NCT04275362Recruiting
Walking analysis after a specific knee replacement design
This study looks at how people walk after receiving a particular total knee replacement design. It compares movement patterns (gait analysis) to help understand how well the knee works in real life.
Phoenix, ArizonaAges 50 years+ - NCT05242055Recruiting
Tracking and treating chronic kidney disease risk
This trial looks at how well an integrated program for identifying and treating people at risk for chronic kidney disease (CKD) can improve outcomes. It may help by catching problems earlier and guiding treatment sooner.
Beijing, Beijing MunicipalityAges 18–100 - NCT05365009Recruiting
Autoimmune lung scarring registry for adults with recent diagnosis
This registry collects health and breathing test information from adults with autoimmune-related lung scarring (interstitial lung disease) diagnosed recently. It helps researchers better understand who has this condition and how it changes over time.
Buenos AiresAges 18 years+ - NCT04672525RecruitingPhase 3
Rifabutin versus rifampicin for knee or hip staph implant infection
This Phase 3 trial compares two antibiotics—rifabutin and rifampicin—for treating staphylococcal (staph) infections around hip or knee joint implants when the implant is kept in place after cleaning (DAIR). It aims to see which drug works better to stop the infection from coming back.
AmiensAges 18 years+ - NCT05391100Recruiting
Screening people with rheumatoid arthritis for lung scarring
This study looks for early lung scarring in people who have rheumatoid arthritis. It may help find a serious lung condition earlier so doctors can watch or treat it sooner.
BudapestAges 40 years+ - NCT01601171Recruiting
Genetic study of reproductive problems and cleft lip or palate
This study looks at genetic (inherited) causes of certain hormone and reproductive conditions, including Kallmann syndrome and cleft lip/palate. You might be asked for medical and family history and possibly a DNA sample, helping researchers find what drives these conditions.
Lausanne, Canton of VaudAges Any age
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.