Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,834 recruiting studies in this area right now.
By phase
- Not applicable3,970
- Phase 2222
- Phase 4195
- Phase 1191
- Phase 3150
- Phase 1/Phase 273
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis183
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee73
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain34
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California208
- New York95
- Florida80
- Arizona76
- Massachusetts76
- Maryland73
- Texas64
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,834 total
- NCT07137598RecruitingPhase 2
A study of RO7790121 for moderate to severe rheumatoid arthritis
This study tests a new drug, RO7790121, for people with rheumatoid arthritis (RA) who have not gotten better with or could not tolerate common treatments like TNF inhibitors or JAK inhibitors. It aims to see if the drug is safe and can help reduce joint pain and swelling.
Peoria, ArizonaAges 18 years+ - NCT07159867Enrolling by invitation
Hypermobility-related problems in young women with anorexia
This study is for young women with anorexia nervosa or atypical anorexia nervosa. It explores whether they also have joint hypermobility (loose, flexible joints) and related problems, to help improve care for both conditions.
Gothenburg, Västra Götaland CountyAges 13–25 - NCT07406685RecruitingPhase 4
Comparing two bone medicines after stopping denosumab
This study compares two medicines (ibandronate and zoledronic acid) to see which one works better at keeping bones strong after stopping denosumab (Prolia). It's for postmenopausal women with mild to moderate bone thinning.
TaipeiAges 50–85 - NCT07782723Recruiting
Shock wave and blood-flow therapy for tennis elbow
This study tests two treatments for tennis elbow (lateral epicondylitis): shock wave therapy, which uses sound waves to help healing, and blood flow restriction therapy, which uses a cuff to increase blood flow during exercise. It aims to see if combining them works better than either alone, which might help reduce pain and improve your arm's function.
AnkaraAges 18–60 - NCT07641179RecruitingPhase 2
Testing MAR002 for Acromegaly (a Pituitary Tumor Condition)
This study tests a new drug called MAR002 to treat acromegaly, a hormone disorder caused by a pituitary tumor that makes too much growth hormone. The drug is designed to help lower hormone levels and improve symptoms.
Phoenix, ArizonaAges 18–75 - NCT06668805RecruitingPhase 2
Study of vosoritide for children with Noonan syndrome and short stature
This trial tests a new drug, vosoritide, to help children with Noonan syndrome who are still growing but are shorter than expected despite growth hormone treatment. It aims to see if the drug can improve their growth.
Los Angeles, CaliforniaAges 3–11 - NCT07587242RecruitingPhase 3
Testing a New Therapy for DMD with Exon 44 Mutations
This study tests whether a new medicine called AOC 1044 (delpacibart zotadirsen) can help boys with Duchenne muscular dystrophy (DMD) who have a specific genetic mutation. The medicine works by helping the body skip a damaged part of the gene to make a functional protein.
LeuvenAges 7–16 - NCT07552415Recruiting
Joint Immobilization After Knee Replacement Revision Surgery
This study tests whether keeping your knee still for a period after revision knee replacement surgery helps improve how well you can bend and straighten it. Researchers want to see if immobilization (using a brace or cast) helps you regain better movement compared to standard care.
New York, New YorkAges 18 years+ - NCT07412704RecruitingPhase 1/Phase 2
Study of BMS-986528 for hard-to-treat rheumatoid arthritis
This trial tests a new drug called BMS-986528 for people with rheumatoid arthritis that is difficult to treat. It aims to see if the drug can help when other treatments haven't worked well.
La Jolla, CaliforniaAges 18–65 - NCT07404514Recruiting
Study of Long-Term Ulnar Hand Deficit
This study looks at how a rare hand condition (ulnar deficiency) changes over time. It may help doctors better understand the long-term outcomes for people with this condition.
Saint-MauriceAges 3–18 - NCT06293352Recruiting
Comparing two antibiotic spacers for knee infection
This trial compares two types of antibiotic spacers for people with a long-term knee replacement infection. It tests whether a spacer made entirely of antibiotic cement or one with a metal core works better to treat the infection before a new knee replacement.
Chicago, IllinoisAges 18 years+ - NCT06930625RecruitingPhase 3
Study of Debio 4126 for acromegaly patients on current therapy
This trial tests a new medication, Debio 4126, for people with acromegaly who are already being treated with octreotide or lanreotide. The goal is to see if it can help control hormone levels and is safe to use.
Los Angeles, CaliforniaAges 18 years+ - NCT04660955Enrolling by invitation
10-year follow-up MRI after ACL surgery in young athletes
This study uses an MRI scan to look at knees 10 years after ACL reconstruction. It helps researchers understand how the knee changes over time after sports-related ACL injury, and how well reconstruction lasts.
Cleveland, OhioAges 22–45 - NCT06842355RecruitingPhase 2
TYRA-300 for children with achondroplasia (BEACH301)
This study tests an experimental oral medication (TYRA-300) for children with achondroplasia, a common form of dwarfism. The goal is to see if it can safely improve growth in children whose growth plates are still open.
Torrance, CaliforniaAges 3–10 - NCT06338488Recruiting
Dry needling for shoulder pain from muscle knots
This trial tests if dry needling (inserting thin needles into muscle knots) can reduce shoulder pain caused by a condition called myofascial pain syndrome. It may help if you have a specific muscle knot in your shoulder blade area and significant pain.
Kütahya, TürkiyeAges 18–80 - NCT07696650Recruiting
Choose to Move Replacement Ready study
This study looks at a program called Choose to Move Replacement Ready (CTM-RR) for older adults and the people who help them get active. It tests how well the program works for activity coaches, participants, and healthcare referral partners.
Vancouver, British ColumbiaAges 50 years+ - NCT07218757Recruiting
Trial of emotional awareness therapy for veterans with chronic pain
This study tests if a type of therapy that helps you understand and express emotions related to pain (called Emotional Awareness and Expression Therapy) can reduce chronic pain in veterans. It is designed for veterans who have had muscle or joint pain for at least 3 months and rate their pain as moderate or greater.
Los Angeles, CaliforniaAges 18 years+ - NCT06520085Recruiting
Using a phone app to improve recovery after shoulder surgery
This trial tests whether a personalized mobile app helps people recover better after reverse shoulder replacement surgery. If you use a smartphone or tablet, the app may guide your recovery and track your progress.
Venlo, LimburgAges 18 years+ - NCT06338514Recruiting
Dry needling for upper back muscle pain
This study tests if dry needling helps reduce shoulder pain caused by muscle knots in the upper back. It may be an option if you have not had recent back surgery or treatments.
KütahyaAges 18–80 - NCT06720948Enrolling by invitation
Study of ION facet screw in spine surgery
This study is for adults who have already had a specific type of spinal fusion using the ION Facet Screw system, along with additional hardware. It looks at how well this procedure works over time. You must be 21 to 80 years old, have no active cancer or severe bone disease, and not be on medications that affect bone healing.
Fort Wayne, IndianaAges 21–80 - NCT03511586Recruiting
Shoulder replacement outcomes registry
This study collects information from people having shoulder replacement surgery with an Arthrex implant. It helps doctors learn how well these implants work over time.
Phoenix, ArizonaAges 18–100 - NCT07774507Recruiting
Daily movement and artery health in rheumatoid arthritis
This study looks at how daily movement patterns (like sitting, standing, and walking) relate to the buildup of plaque in arteries (atherosclerosis) in people with rheumatoid arthritis. It aims to understand if certain activity levels can lower heart risks.
Presidente Prudente, São PauloAges 18–65 - NCT07226648Recruiting
Ultrasound brain treatment for fibromyalgia pain
This study tests a non-invasive ultrasound treatment aimed at a part of the brain involved in pain. It may help people with fibromyalgia who haven't found enough relief from standard treatments.
Ann Arbor, MichiganAges 22 years+ - NCT07775248RecruitingPhase 4
Long-lasting pain relief after knee replacement
This trial tests a new type of pain medicine that is given during knee replacement surgery and slowly releases pain relief over several days. It may help reduce the need for opioid painkillers after surgery.
Grosse Pointe Farms, MichiganAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,834 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,906 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.